Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

Cell

Volumn 62, Issue 1, 1990, Pages 175-185

  Laiho, Marikki ^a   DeCaprio, James A ^b   Ludlow, John W ^b   Livingston, David M ^b   Massague, Joan ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL CULTURE; CELL CYCLE PHASE; CELL GROWTH; GENETIC ENGINEERING; GROWTH INHIBITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RETINOBLASTOMA;

ANIMAL; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL DIVISION; CELL LINE; DNA REPLICATION; INTERPHASE; LUNG; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; SIMIAN VIRUS 40; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; TRANSFORMING GROWTH FACTORS;

EID: 0025326725     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(90)90251-9     Document Type: Article

References (73)

1. Membrane-anchored and soluble forms of betaglycan, a polymorphic proteolglycan that binds transforming growth factor-β
2. Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein
3. Human retinoblastoma gene: long-range mapping and analysis of its deletion in breast cancer cell line
4. Transforming growth factor-β inhibition of epithelial cell proliferation linked to the expression of a 53-kD membrane receptor
5. Transforming growth factor-β decreases the proliferation of human bone marrow fibroblasts by inhibiting the platelet-derived growth factor binding
6. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
7. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
8. Transforming growth factor β is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone
9. TGF-β inhibits growth factor-induced DNA synthesis in hamster fibroblasts without affecting the early mitogenic events
10. The TGF-β receptor proteoglycan
11. The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors
12. High-efficiency transformation of mammalian cells by plasmid DNA
13. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
14. Separation of SV-40 T antigen-transforming and origin-binding functions from the ability to block differentiation
15. Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor β
16. Fragments of the simian virus 40 transforming gene facilitate transformation of chick embryo cells
17. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
18. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element
19. Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells
20. Molecular detection of deletions involving band q14 of chromosome 13 in retinoblastomas
21. The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus
22. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
23. Binding of the Rb1 protein to E1A products is required for adenovirus transformation
24. Rb and a second cellular protein, p120
25. Suppression of the EGF-dependent induction of c-myc protooncogene expression by transforming growth factor β in a human breast carcinoma cell line
26. Transforming growth factor-β inhibits endothelial cell proliferation
27. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
28. Structural evidence for the authenticity of the human retinoblastoma gene
29. Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells
30. Differential regulation of expression of two platelet-derived growth factor receptor subunits by transforming growth factor-β
31. Amino acid sequence of the BSC-1 cell growth inhibitor (polyergin) deduced from the nucleotide sequence of the cDNA
32. Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition
33. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC
34. Regulation of cell adhesion receptors by transforming growth factor-β
35. Point mutational inactivation of the retinoblastoma antioncogene
36. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells
37. Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix
38. Cell adhesion protein receptors as targets for transforming growth factor-β action
39. Complementary deoxyribonucleic acid cloning of a messenger ribonucleic acid encoding transforming growth factor beta 4 from chicken embryo chondrocytes
40. In vitro mutagenesis of a putative DNA binding domain of SV40 large-T
41. Transforming growth factor β is an important immunomodulatory protein for human B lymphocytes
42. Absence of TGF-β receptors and growth inhibitory responses in retinoblastoma cells
43. Mutation and cancer: statistical study of retinoblastoma
44. Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-β
45. Human retinoblastoma susceptibility gene: cloning, identification, and sequence
46. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity
47. Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor β: a proposed model for indirect mitogenesis involving autocrine activity
48. The antiproliferative effect of type β transforming growth factor occurs at a level distal from receptors for growth-activating factors
49. SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family
50. The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation binding to and release from SV40 large T
51. The TGF-β family of growth and differentiation factors
52. The transforming growth factor-β family
53. Mediators of TGF-β action TGF-β receptors and TGF-β-binding proteoglycans
54. Cell cycle-dependent regulation of phosphorylation of the human retinblastoma gene product
55. Type β transforming growth factor is a growth stimulator and growth inhibitor
56. Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells
57. A fragment of the simian virus 40 early genome can induce tumors in nude mice
58. Automatic microinjection system facilitates detection of growth inhibitory mRNA
59. Enhanced jun gene expression is an early genomic response to transforming growth factor β stimulation
60. The transforming growth factor-betas
61. Type-β transforming growth factor: a bifunctional regulator of cellular growth
62. Purification and characterization of two cartilage-inducing factors from bovine demineralized bone
63. Type β-transforming growth factor/growth inhibitor stimulates entry of monolayer cultures of AKR-2B cells into S-phase after prolonged prereplicative interval
64. Reversible inhibition of normal human prokeratinocyte proliferation by type β transforming growth factor-growth inhibitor in serum-free medium
65. TGFβ inhibits G0/S-phase transition in primary fibroblasts
66. Structural rearrangement of the retinoblastoma gene in human breast carcinoma
67. TGF-β inhibition of endothelial cell proliferation: alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression
68. Identification of another member of the transforming growth factor type β gene family
69. Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma
70. Growth inhibitor from BSC-1 cells is closely related to the platelet type β transforming growth factor
71. Association between an oncogene and an antioncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product
72. Cellular targets for transformation by the E1A proteins
73. The retinoblastoma susceptibility gene product: a characteristic pattern in normal cells and abnormal expression in malignant cells