Retinoblastoma protein family in cell cycle and cancer: A review

Journal of Cellular Biochemistry

Volumn 62, Issue 3, 1996, Pages 418-430

  Paggi, Marco G ^a   Baldi, Alfonso ^b   Bonetto, Francesco ^a   Giordano, Antonio ^b,c  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

cell cycle; p107; pocket protein; Rb2 p130; retinoblastoma gene; tumor suppressor genes

Indexed keywords

ONCOPROTEIN; RETINOBLASTOMA PROTEIN;

CANCER; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE; CELL DIFFERENTIATION; EMBRYO DEVELOPMENT; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; REVIEW; TUMOR SUPPRESSOR GENE;

CELL CYCLE; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, TUMOR SUPPRESSOR; HUMANS; NEOPLASMS; NUCLEAR PROTEINS; ONCOGENE PROTEINS; PHOSPHOPROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P107; RETINOBLASTOMA-LIKE PROTEIN P130;

EID: 0029739541     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(199609)62:3<418::AID-JCB12>3.0.CO;2-E     Document Type: Review

References (159)

1. Afshari CA, Barrett JC (1994): Disruption of G0-G1 arrest in quiescent and senescent cells treated with phosphatase inhibitors. Cancer Res 54:2317-2321.
2. Ahuja HG, Jat PS, Foti A, Bar Eli M, Cline MJ (1991): Abnormalities of the retinoblastoma gene in the pathogenesis of acute leukemia. Blood 78:3259-3268.
3. Akiyama T, Toyoshima K (1990): Marked alteration in phosphorylation of the RB protein during differentiation of human promyelocytic HL60 cells. Oncogene 5:179-183.
4. RB, the retinoblastoma tumor suppressor protein. Oncogene 10:697-704.
5. Arany Z, Newsome D, Oldread E, Livingston, DM, Eckner R (1995): A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature 374:81-84.
6. Baldi A, De Luca A, Claudio PP, Baldi F, Giordano GG, Tommasino M, Paggi MG, Giordano A (1995): The Rb2/ p10 gene product is a nuclear protein whose phosphorylation is cell cycle regulated. J Cell Biochem 59:402-408.
7. Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (1996a): Genomic structure of the human retinoblastoma-related Rb2/p130 gene. Proc Natl Acad Sci USA (in press).
8. Baldi A, Esposito V, De Luca A, Howard CM, Mazzarella G, Baldi F, Caputi M, Giordano A (1996b): Differential expression of the retinoblastoma gene family members, Rb, p107 and Rb2/p130 in lung cancer. Clin Cancer Res 2:1239-1245.
9. Bandara LR, Adamczewski JP, Hunt T, La Thangue NB (1991): Cyclin A and the retinoblastoma gene product complex with a common transcription factor. Nature 352:249-251.
10. Bandara LR, Lam EW-F, Sorensen TS, Zamanian M, Girling R, La Thangue NB (1994): DP-1: A cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. EMBO J 13:3104-3114.
11. Beijersbergen RL, Kerkhoven RM, Zhu L, Cariée L, Voorhoeve PM, Bernards R (1994): E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev 8:2680-2690.
12. 1 cyclin complexes. Genes Dev 9:1340-1353.
13. Benedict WF, Fung YK, Murphree AL (1988): The gene responsible for the development of retinoblastoma and osteosarcoma. Cancer 62:1691-1694.
14. Bernards R, Schackleford GM, Gerber MR, Horowitz JM, Friend SH, Schartl M, Bogenmann E, Rapaport JM, McGee T, Dryja TP (1989): Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein. Proc Natl Acad Sci USA 86:6474-6478.
15. Biggs PJ, Wooster R, Ford D, Chapman P, Mangion J, Quirk Y, Easton DF, Burn J, Stratton MR (1995): Familial cylindromatosis (turban tumour syndrome) gene localised to chromosome 16q12-q13: Evidence for its role as a tumour suppressor gene. Nat Genet 11:441-443.
16. Bookstein R, Lee EY, To H, Young LJ, Sery TW, Hayes RC, Friedmann T, Lee WH (1988): Human retinoblastoma susceptibility gene: Genomic organization and analysis of heterozygous intragenic deletion mutants. Proc Natl Acad Sci USA 85:2210-2214.
17. Bookstein R, Rio P, Madreperla SA, Hong F, Allred C, Grizzle WE, Lee WH (1990a): Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma. Proc Natl Acad Sci USA 87:7762-7766.
18. Bookstein R, Shew JY, Chen PL, Scully P, Lee WH (1990b): Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science 247:712-715.
19. Buchkovich K, Duffy LA, Harlow E (1989): The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58:1097-1105.
20. Cao L, Faha B, Dembski M, Tsai LH, Harlow E, Dyson N (1992): Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. Nature 355:176-179.
21. Caruso M, Martelli F, Giordano A, Felsani A (1993): Regulation of MyoD gene transcription and protein function by the transforming domains of the adenovirus E1A oncoprotein. Oncogene 8:267-278.
22. Cavenee WK, Dryja TP, Phillips RA, Benedict WF, Godbout R, Gallie BL, Murphree AL, Strong LC, White RL (1983): Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 305:779-784.
23. Chellappan SP (1994): The E2F transcription factor: role in cell cycle regulation and differentiation. Mol Cell Differ 2:201-220.
24. Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR (1991): The E2F transcription factor is a cellular target for the RB protein. Cell 65:1053-1061.
25. Chen PL, Scully P, Shew JY, Wang JY, Lee WH (1989): Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58:1193-1198.
26. Chen PL, Riley DJ, Lee WH (1995): The retinoblastoma protein as a fundamental mediator of growth and differentiation signals. Crit Rev Eukaryot Gene Expr 5:79-95.
27. Chen PL, Riley DJ, Chen-Kiang S, Lee WH (1996): Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc Natl Acad Sci USA 93:465-469.
28. Cheng J, Scully P, Shew JY, Lee WH, Vila V, Haas M (1990): Homozygous deletion of the retinoblastoma gene in an acute lymphoblastic leukemia (T) cell line. Blood 75:730-735.
29. Chittenden T, Livingston DM, DeCaprio JA (1993): Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F. Mol Cell Biol 13:3975-3983.
30. Claudio PP, Howard CM, Baldi A, De Luca A, Fu Y, Condorelli G, Sun Y, Colburn N, Calabretta B, Giordano A (1994): p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res 54:5556-5560.
31. Claudio PP, De Luca A, Howard CM, Baldi A, Firpo EJ, Paggi MG, Giordano A (1996): Functional analysis of pRb2/p130 interaction with cyclins. Cancer Res 56:2003-2008.
32. Cobrinik D, Whyte P, Peeper DS, Jacks T, Weinberg RA (1993): Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev 7:2392-2404.
33. Cobrinik D, Lee M-H, Hannon G, Mulligan G, Bronson TR, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T (1996): Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev 10:1633-1644.
34. Corbeil HB, Whyte P, Branton PE (1995): Characterization of transcription factor E2F complexes during muscle and neuronal differentiation. Oncogene 11:909-920.
35. Corradini P, Inghirami G, Astolfi M, Ladetto M, Voena C, Ballerini P, Gu W, Nilsson K, Knowles DM, Boccadoro M, Pileri A, Dalla-Favera R (1994): Inactivation of tumor suppressor genes, p53 and Rb1, in plasma cell dyscrasias. Leukemia 8:758-767.
36. Cox LA, Chen G, Lee EY-HP (1994): Tumor suppressor genes and their roles in breast cancer. Breast Cancer Res Treat 32:19-38.
37. DeCaprio JA, Ludlow JW, Figge J, Shew JY, Huang CM, Lee WH, Marsilio E, Paucha E, Livingston DM (1988): SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54:275-283.
38. DeCaprio JA, Ludlow JW, Lynch D, Furukawa Y, Griffin J, Piwnica Worms, Huang CM, Livingston DM (1989): The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell 58:1085-1095.
39. Dryja TP, Rapaport JM, Joyce JM, Petersen RA (1986): Molecular detection of deletions involving band q14 of chromosome 13 in retinoblastomas. Proc Natl Acad Sci USA 83:7391-7394.
40. Durfee T, Becherer K, Chen PL, Yeh SH, Yang Y, Kilburn AE, Lee WH, Elledge SJ (1993): The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev 7:555-569.
41. Dyson N, Buchkovich K, Whyte P, Harlow E (1989a): The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell 58:249-255.
42. Dyson N, Howley PM, Munger K, Harlow E (1989b): The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934-937.
43. Dyson N, Guida P, Munger K, Harlow E (1992): Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J Virol 66:6893-6902.
44. Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen ME, Helin K (1993): Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. J Virol 67:7641-7647.
45. Ewen ME, Xing YG, Lawrence JB, Livingston DM (1991): Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene productrelated protein. Cell 66:1155-1164.
46. Ewen ME, Sluss HK, Sherr CJ, Matsushime H, Kato J, Livingston DM (1993): Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73:487-497.
47. Faha B, Ewen ME, Tsai LH, Livingston DM, Harlow E (1992): Interaction between human cyclin A and adenovirus E1A-associated p107 protein. Science 255:87-90.
48. Fattaey AR, Harlow E, Helin K (1993): Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol Cell Biol 13:7267-7277.
49. Friend SH, Horowitz JM, Gerber MR, Wang XF, Bogenmann E, Li FP, Weinberg RA (1987): Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: Organization of the sequence and its encoded protein [published erratum appears in Proc Natl Acad Sci USA 1988 85:2234]. Proc Natl Acad Sci USA 84:9059-9063.
50. Fung YK, T'Ang A (1992): The role of the retinoblastoma gene in breast cancer development. Cancer Treat Res 61:59-68.
51. Fung YK, Murphree AL, T'Ang A, Qian J, Hinrichs SH, Benedict WF (1987): Structural evidence for the authenticity of the human retinoblastoma gene. Science 236:1657-1661.
52. Ginsberg AM, Raffeld M, Cossman J (1991): Inactivation of the retinoblastoma gene in human lymphoid neoplasms. Blood 77:833-840.
53. Ginsberg D, Vairo G, Chittenden T, Xiao Z-X, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM (1994): E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev 8:2665-2679.
54. Giordano A, Whyte P, Harlow E, Franza BR Jr, Beach D, Draetta G (1989): A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus infected cells. Cell 58:981-990.
55. Giordano A, Lee JH, Scheppler JA, Herrmann C, Harlow E, Deuschle V, Beach D, Franza BR Jr (1991a): Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A. Science 253:1271-1275.
56. Giordano A, McCall C, Whyte P, Franza BR Jr (1991b): Human cyclin A and the retinoblastoma protein interact with similar but distinguishable sequences in the adenovirus E1A gene product. Oncogene 6:481-485.
57. Giordano A, Kaiser H (1996): The retinoblastoma gene: its role in cell cycle and cancer. In vivo. 10:223-228.
58. Girling R, Partridge JF, Bandara LR, Burden N, Totty NF, Hsuan JJ, La Thangue NB (1993): A new component of the transcription factor DRTF1/E2F. Nature 362:83-87.
59. Godbout R, Miyakoshi J, Dobler KD, Andison R, Matsuo K, Allalunis Turner MJ, Takebe H, Day RS (1992): Lack of expression of tumor-suppressor genes in human malignant glioma cell lines. Oncogene 7:1879-1884.
60. Gottardis MM, Saceda M, Garcia-Morales P, Fung YK, Solomon H, Sholler PF, Lippman ME, Martin MB (1995): Regulation of retinoblastoma gene expression in hormone-dependent breast cancer. Endocrinology 136:5659-5665.
61. Grana X, De Luca A, Sang N, Fu Y, Claudio PP, Rosenblatt J, Morgan DO, Giordano A (1994): PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc Natl Acad Sci USA 91:3834-3838.
62. Gu W, Schneider JW, Condorelli G, Kaushal S, Mahdavi V, Nadal Ginard B (1993): Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72:309-324.
63. Hannon GJ, Demetrick D, Beach D (1993): Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev 7:2378-2391.
64. Hansen MF (1989): Loss of the retinoblastoma susceptibility gene is heterogeneous in osteosarcomas. In Cavenee W, Hashe N, Stanbridge E (eds): Recessive Oncogene and Tumor Suppression. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, pp 125-131.
65. Hansen MF, Cavenee WK (1988): Retinoblastoma and the progression of tumor genetics. Trends Genet 4:125-128.
66. Harbour JW, Lai SL, Whang Peng J, Gazdar AF, Minna JD, Kaye FJ (1988): Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 241:353-357.
67. Harlow E (1992): Retinoblastoma. For our eyes only [news; comment]. Nature 359:270-271.
68. Harlow E, Whyte P, Franza BR Jr, Schley C (1986): Association of adenovirus early-region 1A proteins with cellular polypeptides. Mol Cell Biol 6:1579-1589.
69. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (1993): The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816.
70. Helin K, Harlow E, Fattaey A (1993a): Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol Cell Biol 13:6501-6508.
71. Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E (1993b): Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative transactivation. Genes Dev 7:1850-1861.
72. Hensel CH, Hsieh CL, Gazdar AF, Johnson BE, Sakaguchi AY, Naylor SL, Lee WH, Lee EY (1990): Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer. Cancer Res 50:3067-3072.
73. Hiebert SW, Chellappan SP, Horowitz JM, Nevins JR (1992): The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev 6:177-185.
74. Hijmans EM, Voorhoeve PM, Beijersbergen RL, Van't Veer LJ, Bernards R (1995): E2F-5, a new E2F family member that interacts with p130 in vivo. Mol Cell Biol 15:3082-3089.
75. Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA (1992): Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70:993-1006.
76. Holm R, Nesland JM (1994): Retinoblastoma and p53 tumour suppressor gene protein expression in carcinomas of the thyroid gland. J Pathol 172:267-272.
77. Hoppe-Seyler F, Butz K (1995): Molecular mechanisms of virus-induced carcinogenesis: The interaction of viral factors with cellular tumor suppressor proteins. J Mol Med 73:529-538.
78. Horowitz JM (1993): Regulation of transcription by the retinoblastoma protein. Genes Chromosom. Cancer 6:124-131.
79. Horowitz JM, Park SH, Bogenmann E, Cheng JC, Yandell DW, Kaye FJ, Minna JD, Dryja TP, Weinberg RA (1990): Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc Natl Acad Sci USA 87:2775-2779.
80. Huang HJ, Yee JK, Shew JY, Chen PL, Bookstein R, Friedmann T, Lee EY, Lee WH (1988): Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 242:1563-1566.
81. Ishikawa J, Xu HJ, Hu SX, Yandell DW, Maeda S, Kamidono S, Benedict WF, Takahashi R (1991): Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas. Cancer Res 51:5736-5743.
82. Ivey-Hoyle M, Conroy R, Huber HE, Goodhart PJ, Oliff A, Heimbrook DC (1993): Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. Mol Cell Biol 13:7802-7812.
83. Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA (1992): Effects of an Rb mutation in the mouse. Nature 359:295-300.
84. Jiang H, Lin J, Young SM, Goldstein NI, Waxman S, Davila V, Chellappan SP, Fisher PB (1995): Cell cycle gene expression and E2F transcription factor complexes in human melanoma cells induced to terminally differentiate. Oncogene 11:1179-1189.
85. Johnson DG (1995): Regulation of E2F-1 gene expression by p130 (Rb2) and D-type cyclin kinase activity. Oncogene 11:1685-1692.
86. Jooss K, Lam EW-F, Bybee A, Girling R, Müller R, La Thangue NB (1995): Proto-oncogenic properties of the DP family of proteins. Oncogene 10:1529-1536.
87. Kim KK, Soonpaa MH, Wang H, Field LJ (1995): Developmental expression of p107 mRNA and evidence for alternative splicing of the p107 (RBL1) gene product. Genomics 28:520-529.
88. Klein G (1987): The approaching era of the tumor suppressor genes. Science 238:1539-1545.
89. Knudson AG Jr (1989): Hereditary cancers disclose a class of cancer genes. Cancer 63:1888-1891.
90. Kornblau SM, Xu HJ, del Giglio A, Hu SX, Zhang W, Calvert L, Beran M, Estey E, Andreeff M, Trujillo J (1992): Clinical implications of decreased retinoblastoma protein expression in acute myelogenous leukemia. Cancer Res 52:4587-4590.
91. Kornblau SM, Chen N, del Giglio A, O'Brien S, Deisseroth AB (1994): Retinoblastoma protein expression is frequently altered in chronic lymphocytic leukemia. Cancer Res 54:242-246.
92. Krek W, Livingston DM, Shirodkar S (1993): Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members. Science 262:1557-1560.
93. Kyritsis AP, Saya H (1993): Epidemiology, cytogenetics, and molecular biology of brain tumors. [Review]. Curr Opin Oncol 5:474-480.
94. Lee EY, Chang CY, Hu N, Wang YC, Lai CC, Herrup K, Lee WH, Bradley A (1992): Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis [see comments]. Nature 359:288-294.
95. Lee M-H, Williams BO, Mulligan G, Mukai S, Bronson RT, Dyson N, Harlow E, Jacks T (1996): Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev 10:1621-1632.
96. Lee WH, Bookstein R, Hong F, Young LJ, Shew JY, Lee EY (1987a): Human retinoblastoma susceptibility gene: Cloning, identification, and sequence. Science 235:1394-1399.
97. Lee WH, Shew JY, Hong FD, Sery TW, Donoso LA, Young LJ, Bookstein R, Lee EY (1987b): The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity. Nature 329:642-645.
98. Lee WH, Bookstein R, Lee EY (1988): Studies on the human retinoblastoma susceptibility gene. J Cell Biochem 38:213-227.
99. Lees E, Faha B, Dulic V, Reed SI, Harlow E (1992): Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev 6:1874-1885.
100. Lees JA, Saito M, Vidai M, Valentine M, Look T, Harlow E, Dyson N, Helin K (1993): The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol 13:7813-7825.
101. Li Y, Graham C, Lacy S, Duncan AM, Whyte P (1993): The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes Dev 7:2366-2377.
102. Ludlow JW, Skuse GR (1995): Viral oncoprotein binding to pRB, p107, p130, and p300. Virus Res 35:113-121.
103. Ludlow JW, Glendening CL, Livingston DM, DeCaprio JA (1993): Specific enzymatic dephosphorylation of the retinoblastoma protein. Mol Cell Biol 13:367-372.
104. Ludwig CU, Gencik M, Shipman R (1993): Multistep transformation in low-grade lymphoproliferative diseases. [Review]. Ann Oncol 4:825-830.
105. Lukas J, Parry D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G, Bartek J (1995): Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 375:503-506.
106. MacLachlan TK, Sang N, Giordano A (1995): Cyclins, cyclin-dependent kinases and Cdk inhibitors: Implications in cell cycle control and cancer. Eukariotic Gene Expr.
107. Marsilio E, Cheng SH, Schaffhausen B, Paucha E, Livingston DM (1991): The T/t common region of simian virus 40 large T antigen contains a distinct transformationgoverning sequence. J Virol 65:5647-5652.
108. Martelli F, Cenciarelli C, Santarelli G, Polikar B, Felsani A, Caruso M (1994): MyoD induces retinoblastoma gene expression during myogenic differentiation. Oncogene 9:3579-3590.
109. Mayol X, Graña X, Baldi A, Sang N, Hu Q, Giordano A (1993): Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. Oncogene 8:2561-2566.
110. Mihara K, Cao XR, Yen A, Chandler S, Driscoll B, Murphree AL, T'Ang A, Fung YK (1989): Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product. Science 246:1300-1303.
111. Muncaster MM, Cohen BL, Phillips RA, Gallie BL (1992): Failure of RB1 to reverse the malignant phenotype of human tumor cell lines. Cancer Res 52:654-661.
112. Natsuka S, Akira S, Nishio Y, Hashimoto S, Sugita T, Isshiki H, Kishimoto T (1992): Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. Blood 79:460-466.
113. Neubauer A, de Kant E, Rochlitz C, Laser J, Zanetta AM, Gallardo J, Herrmann R, Huhn D (1993): Altered expression of the retinoblastoma susceptibility gene in chronic lymphocytic leukaemia. Br J Haematol 85:498-503.
114. Nevins JR (1992): E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
115. Paggi MG, Martelli F, Fanciulli M, Felsani A, Sciacchitano S, Varmi M, Bruno T, Carapella CM, Floridi A (1994): Defective human retinoblastoma protein identified by lack of interaction with the E1A oncoprotein. Cancer Res 54: 1098-1104.
116. Paggi MG, De Fabritiis P, Bonetto F, Amadio L, Santarelli G, Spadea A, Gentile FP, Floridi A, Felsani A (1995): The retinoblastoma gene product in acute myeloid leukemia: A possible involvement in promyelocytic leukemia. Cancer Res 55:4552-4556.
117. Pertile P, Baldi A, De Luca A, Bagella L, Virgilio L, Pisano MM, Giordano A (1995): Molecular cloning, expression, and developmental characterization of the murine retinoblastoma-related gene Rb2/p130. Cell Growth Differ 6:1659-1664.
118. Peters G (1994): The D-type cyclins and their role in tumorigenesis. J Cell Sci 107(Suppl. 18):89-96.
119. Phillips SMA, Barton CM, Lee SJ, Morton DG, Wallace DMA, Lemoine NR, Neoptolemos JP (1994): Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis. Br J Cancer 70: 1252-1257.
120. Pietiläinen T, Lipponen P, Aaltomaa S, Eskelinen M, Kosma V-M, Syrjänen K (1995): Expression of retinoblastoma gene protein (Rb) in breast cancer as related to established prognostic factors and survival. Eur J Cancer [A] 31A:329-333.
121. Pines J, Hunter T (1990): Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature 346:760-763.
122. Reissmann PT, Simon MA, Lee WH, Slamon DJ (1989): Studies of the retinoblastoma gene in human sarcomas. Oncogene 4:839-843.
123. Riley DJ, Lee EY-HP, Lee W-H (1994): The retinoblastoma protein: More than a tumor suppressor. Annu Rev Cell Biol 10:1-29.
124. Saenz Rubles MT, Symonds H, Chen J, Van Dyke T (1994): Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen. Mol Cell Biol 14:2686-2698.
125. Sala A, Nicolaides NC, Engelhard C, Bellon T, Lawe DC, Arnold A, Grana X, Giordano A, Calabretta C (1994): Correlation between E2F-1 requirement in S phase and E2F-1 transactivation of cell cycle-related genes in human cells. Cancer Res 54:1402-1406.
126. Sang N, Baldi A, Giordano A (1995): The roles of tumor suppressors pRb and p53 in cell proliferation and cancer. Mol Cell Differ 3:1-29.
127. Sardet C, Vidai M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (1995): E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci USA 92:2403-2407.
128. Schwartz JK, devoto SH, Smith ERJ, Chellappan SP, Jakoi L, Nevins JR (1993): Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. EMBO J 12:1013-1020.
129. Serrano M, Hannon GJ, Beach D (1993): A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 [see comments]. Nature 366:704-707.
130. Shew JY, Lin BT, Chen PL, Tseng BY, Yang Feng TL, Lee WH (1990): C-terminal truncation of the retinoblastoma gene product leads to functional inactivation. Proc Natl Acad Sci USA 87:6-10.
131. Shimizu E, Coxon A, Otterson GA, Steinberg SM, Kratzke RA, Kim YW, Fedorko J, Oie H, Johnson BE, Mulshine JL, et al (1994): RB protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma. Oncogene 9:2441-2448.
132. Shirodkar S, Ewen ME, DeCaprio JA, Morgan J, Livingston DM, Chittenden T (1992): The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell 68:157-166.
133. Steeg PS (1992): Suppressor genes in breast cancer: An overview. Cancer Treat Res 61:45-57.
134. Stein GH, Beeson M, Gordon L (1990): Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 249:666-669.
135. Szekely L, Jiang WQ, Bulic Jakus F, Rosen A, Ringertz N, Klein G, Wiman KG (1992): Cell type and differentiation dependent heterogeneity in retinoblastoma protein expression in SCID mouse fetuses. Cell Growth Differ 3:149-156.
136. Takahashi R, Hashimoto T, Xu HJ, Hu SX, Matsui T, Miki T, Bigo Marshall H, Aaronson SA, Benedict WF (1991): The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cells. Proc Natl Acad Sci USA 88:5257-5261.
137. T'Ang A, Varley JM, Chakraborty S, Murphree AL, Fung YK (1988): Structural rearrangement of the retinoblastoma gene in human breast carcinoma. Science 242:263-266.
138. Tonini GP, Casalaro A, Cara A, Di Martino D (1991): Inducible expression of calcyclin, a gene with strong homology to S-100 protein, during neuroblastoma cell differentiation and its prevalent expression in Schwann-like cell lines. Cancer Res 51:1733-1737.
139. Vairo G, Livingston DM, Ginsberg D (1995): Functional interaction between E2F-4 and p130: Evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev 9:869-881.
140. Varley JM, Armour J, Swallow JE, Jeffreys AJ, Ponder BA, T'Ang A, Fung YK, Brammar WJ, Walker RA (1989): The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours. Oncogene 4:725-729.
141. Venter DJ, Bevan KL, Ludwig RL, Riley TE, Jat PS, Thomas DG, Noble MD (1991): Retinoblastoma gene deletions in human glioblastomas. Oncogene 6:445-448.
142. Walther MM, Gnarra JR, Elwood L, Xu H-J, Florence C, Anglard P, Hu S-X, King C, Trahan E, Hurley K, Sens D, Venzon D, Liu S, Jaffe GS, Benedict WF, Linehan WM (1995): Loss of heterozygosity occurs centromeric to RB without associated abnormalities in the retinoblastoma gene in tumors from patients with metastatic renal cell carcinoma. J Urol 153:2050-2054.
143. Weide R, Parviz B, Pfluger KH, Havemann K (1993): Altered expression of the human retinoblastoma gene in monocytic leukaemias. Br J Haematol 83:428-432.
144. Weide R, Tiemann M, Pfluger KH, Koppler H, Parvizl B, Wacker HH, Havemann K, Parwaresch MR (1994): Altered expression of the retinoblastoma gene product in human high grade non-Hodgkin's lymphomas. Leukemia 8:97-101.
145. Weinberg RA (1991): Tumor suppressor genes. Science 254: 1138-1146.
146. Weinberg RA (1995): The retinoblastoma protein and cell cycle control. Cell 81:323-330.
147. Weintraub SJ, Chow KNB, Luo RX, Zhang SH, He S, Dean DC (1995): Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375:812-815.
148. Welch PJ, Wang JY (1993): A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell 75:779-790.
149. Whyte P, Eisenman RN (1992): Dephosphorylation of the retinoblastoma protein during differentiation of HL60 cells. Biochem Cell Biol 70:1380-1384.
150. Whyte P, Buchkovich KJ, Horowitz JM, Friend SH, Raybuck M, Weinberg RA, Harowitz E (1988): Association between an oncogene and an anti-oncogene: The adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 334:124-129.
151. Wolff JM, Stephenson RN, Jakse G, Habib FK (1994): Retinoblastoma and p53 genes as prognostic indicators in urological oncology. Urol Int 53:1-5.
152. Wu C-L, Zukerberg LR, Ngwu C, Harlow E, Lees JA (1995): In vivo association of E2F and DP family proteins. Mol Cell Biol 15:2536-2546.
153. Yee SP, Branton PE (1985): Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides. Virology 147:142-153.
154. Yeung RS, Bell DW, Testa JR, Mayol X, Baldi A, Graña X, Klinga Levan K, Knudson AG, Giordano A (1993): The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19. Oncogene 8:3465-3468.
155. Yuan W, Condorelli G, Caruso M, Felsani A, Giordano A (1996): Human p300 protein is a coactivator for the transcription factor MyoD. J Biol Chem 271:9009-9013.
156. Zerfass K, Levy LM, Cremonesi C, Ciccolini F, Jansen-Dürr P, Crawford L, Ralston R, Tommasino M (1995): Cell cycle-dependent disruption of E2F-p107 complexes by human papillomavirus type 16 E7. J Gen Virol 76:1815-1820.
157. Zhang Y, Chellappan SP (1995): Cloning and characterization of human DP2, a novel dimerization partner of E2F. Oncogene 10:2085-2093.
158. Zhu L, van den Heuvel S, Helin K, Fattaey A, Ewen ME, Livingston DM, Dyson N, Harlow E (1993): Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev 7:1111-1125.
159. Zhu Y-M, Haynes AP, Keith FJ, Russell NH (1995): Abnormalities of retinoblastoma gene expression in hematological malignancies. Leuk Lymphoma 18:61-67.