WAF1, a potential mediator of p53 tumor suppression

Cell

Volumn 75, Issue 4, 1993, Pages 817-825

  El Deiry, Wafik S ^a   Tokino, Takashi ^a   Velculescu, Victor E ^a   Levy, Daniel B ^a   Parsons, Ramon ^a   Trent, Jeffrey M ^b   Lin, David ^c   Mercer, W Edward ^c   Kinzler, Kenneth W ^a   Vogelstein, Bert ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; DNA; MESSENGER RNA; PROTEIN P53;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CANCER INHIBITION; CHROMOSOMAL LOCALIZATION; CHROMOSOME 6P; CONTROLLED STUDY; DNA BINDING; DNA PROBE; DNA SEQUENCE; EXON; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE SEQUENCE; GENE STRUCTURE; HUMAN; HUMAN CELL; HYBRIDIZATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPORTER GENE; TUMOR CELL;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; CELL CYCLE; CHROMOSOMES, HUMAN, PAIR 6; CLONING, MOLECULAR; CYCLINS; DNA PRIMERS; GENE EXPRESSION REGULATION; GENES, STRUCTURAL; GENES, TUMOR SUPPRESSOR; HUMAN; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; NUCLEIC ACID HYBRIDIZATION; PROMOTER REGIONS (GENETICS); PROTEIN P53; RATS; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; ZINC FINGERS;

ANIMALIA; RODENTIA;

EID: 0027359827     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(93)90500-P     Document Type: Article

References (73)

1. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
2. Suppression of human colorectal carcinoma cell growth by wild-type p53
3. Mdm-2 expression is induced by wild-type p53 activity
4. Potential metal-binding domains in nucleic acid binding proteins
5. Thymocyte apoptosis induced by p53-dependent and independent pathways
6. Human epithelial ovarian cancer allelotype
7. High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer
8. Definition of a consensus binding site for p53
9. λYES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations
10. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
11. Wild-type p53 activates transcription in vitro
12. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity
13. Presence of a potent transcription activating sequence in the p53 protein
14. The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth
15. A transcriptionally active DNA-binding site for human p53 protein complexes
16. Wild-type p53 can down-modulate the activity of various promoters
17. Frequent p53 mutations in chemically induced murine fibrosarcoma
18. Chemical cross linking subtraction (CCLS): a new method for the generation of subtractive hybridisation probes
19. The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
20. p53 mutation in human cancers
21. Participation of p53 protein in the cellular response to DNA damage
22. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
23. Identification of p53 as a sequence specific DNA binding protein
24. Oncogenic forms of p53 inhibit p53-regulated gene expression
25. Whole genome PCR: application to the identification of sequences bound by gene regulatory proteins
26. Repression of the basal c-fos promoter by wild-type p53
27. p53, guardian of the genome
28. Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1-phase
29. The p53 activation domain binds the TATA box-binding polypeptide in holo-TFIID, and a neighboring p53 domain inhibits transcription
30. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
31. p53 is required for radiation-induced apoptosis in mouse thymocytes
32. Cytogenetics of non-small cell lung cancer: analysis of consistent non-random abnormalities
33. Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53
34. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
35. p53 binds to the TATA-binding protein-TATA complex
36. Micro-FISH: a novel strategy to identify cryptic chromosomal rearrangements
37. Cell cycle regulation and the p53 tumor suppressor protein
38. Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53
39. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
40. The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein
41. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
42. Allelotype of renal cell carcinoma
43. Cell specificity of transcription regulation by papovavirus T antigens and DNA replication
44. Human p53 and CDC2Hs genes combine to inhibit the proliferation of Saccharomyces cerevisiae
45. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
46. p53: the ultimate tumor suppressor gene?
47. Tumor-suppressor p53 and the cell cycle
48. The p53 tumor suppressor protein
49. Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif
50. Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene
51. Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence
52. Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product
53. Allelotype of human ovarian cancer
54. Mammalian p53 can function as a transcription factor in yeast
55. Wild-type p53 binds to the TATA-binding protein and represses transcription
56. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line
57. Guanine nucleotide biosynthesis is regulated by the cellular p53 concentration
58. The APC gene product in normal and tumor cells
59. Chromosome aberrations and cancer
60. In vivo recognition of a vertebrate mini-exon as an exon-intron-exon unit
61. Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein
62. Human wild-type p53 adopts a unique conformation and phosphorylation state in vivo during growth arrest of glioblastoma cells
63. p53 function and dysfunction
64. Allelotype of colorectal carcinomas
65. The MCK enhancer contains a. p53 responsive element
66. Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector
67. Identification of the DNA binding site for NGFI-B by genetic selection in yeast
68. The p53-mdm-2 autoregulatory feedback loop
69. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
70. Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element
71. Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53-MDM2 complexes
72. Induction of cellular p53 activity by DNA-damaging agents and growth arrest