The retinoblastoma protein and cell cycle control

Cell

Volumn 81, Issue 3, 1995, Pages 323-330

  Weinberg, Robert A ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; RETINOBLASTOMA PROTEIN;

CELL CYCLE PHASE; CELL PROLIFERATION; GROWTH INHIBITION; MOLECULAR BIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RETINOBLASTOMA; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

BIOLOGICAL CLOCKS; CELL CYCLE; CELL NUCLEUS; G1 PHASE; GENE EXPRESSION REGULATION; HUMAN; NEOPLASMS; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTORS;

EID: 0029033861     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(95)90385-2     Document Type: Review

References (83)

1. Absence of cyclin D/cdk complexes in cell lacking functional retinoblastoma protein
2. ESF-4 a new member of the E2F gene family has oncogenic activity and associates with p107 in vivo
3. Frequent somatic mutations and homozygous deletions of the p16(MTS1) gene in pancreatic adenocarcinoma
4. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F
5. The E2F transcription factor is a cellular target for the RB protein
6. Requirement for a functional Rb-1 gene in murine development
7. The retinoblastoma protein and the regulation of cell cycling
8. Cell cycle-specific association of E2F with the p130 E1Abinding protein
9. The product of the retinoblastoma gene has properties of a cell cycle regulatory element
10. Activation of human cyclin-dependent kinases in vitro
11. Mice deficient for p53 are developmentally normal but suceptible to spontaneous tumors
12. Physical interaction of the retinoblastoma protein with human cyclins
13. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
14. Differential regulation of E2 F transactivation by cyclin/cdk2 complexes
15. Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1
16. The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
17. WAF1, a potential mediator of p53 tumor suppression
18. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
19. TGFO inhibition of Cdk4 synthesis is linked to cell cycle arrest
20. A novel cyclin associates with MO151CDK7 to form the CDK-activating kinase
21. E2F-4, a new E2F transcription factor family member, interacts with p107 and has transforming potential
22. INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function
23. High levels of p53 protein in UV-irradiated normal human skin
24. INK4B is a potential effector of TGFO induced cell cycle arrest
25. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
26. Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein
27. The limited in vitro lifetime of human diploid cell strains
28. CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines
29. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
30. Frequent inactivation of the retinoblastoma antioncogene is restricted to a subset of human tumor cells
31. Germline p16 mutations in familial melanoma
32. Effects of an RB mutation in the mouse
33. Deletion of p15 and p16 genes in brain tumors
34. Amplification and expression of the human cyclin D gene in esophageal cancer
35. Expression of transcription factor E2F1 induces quiescent cells to enter S phase
36. Virus-encoded cyclin
37. A cell cycle regulator potentially involved in genesis of many tumor types
38. Analysis of the pl6 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus
39. Participation of p53 protein in the cellular response to DNA damage
40. Klp1) of cyclin-dependent kinase 4 activation
41. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase, CDK4
42. Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells
43. Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family
44. An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription
45. D11S287, a putative oncogene on chromosome 11 q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1
46. DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control
47. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation
48. The retinoblastoma protein is phosphorylated on multiple sites by human cdc2
49. The retinoblastoma protein binds to a family of E2F transcription factors
50. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast
51. Transcriptional repression of the D-type cyclin-dependent kinase inhibitor pl6 by the retinoblastoma susceptibility gene product pRb
52. A cyclin associated with the CDK-activating kinase M015
53. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle
54. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
55. Frequent somatic mutation of the MTS1/CDK4l (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma
56. A novel cyclin encoded by a bcl1-linked candidate oncogene
57. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins
58. Deletion of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
59. lnk4 protein is restricted to the subset of lung cancer lines that retains wildtype RB
60. G1 events and regulation of cell proliferation
61. INK4/MTS1 tumour suppressor gene product
62. KIP1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
63. Deregulated E2F-1 transcription factor expression leads to S-phase entry and p53-mediated apoptosis
64. The transcription factor E2F-1 is a downstream target of RB action
65. CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas
66. A new regulatory motif in cell-cycle control causing specific inihibition of cyclin D/CDK4
67. INK4
68. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
69. A role for both RB and p53 in the regulation of human cellular senescence
70. Mammalian G1 cyclins
71. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner
72. A novel inhibitor of cyclin-cdk activity detected in transforming growth factor β-arrested epithelial cells
73. cdc2 activation
74. Cell type and differentiation dependent heterogeneity in retinoblastoma protein expression in SCID mouse fetuses
75. Ink4
76. p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21
77. The retinoblastoma tumor suppressor protein
78. The retinoblastoma gene and gene product
79. Retinoblastoma protein switches the E2F site from positive to negative element
80. A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle
81. Disruption of retinoblastoma protein function by coexpression of its C pocket fragment
82. The MTS1 gene is frequently mutated in primary human esophageal tumors
83. Viruses in human cancer