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Volumn 9, Issue 15, 1995, Pages 1831-1845

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β

Author keywords

Cdk inhibitors; cell cycle arrest; p15(Ink4B); p21(Cip1); p27(Kip1); TGF

Indexed keywords

PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA;

EID: 0029153609     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.9.15.1831     Document Type: Article
Times cited : (895)

References (64)
  • 1
    • 0027525105 scopus 로고
    • Identification of human activin and TGF-β type I receptors that form heteromeric kinase complexes with type II receptors
    • Attisano, L., J. Cárcamo, F. Ventura, F.M.B. Weis, J. Massagué, and J.L. Wrana. 1993. Identification of human activin and TGF-β type I receptors that form heteromeric kinase complexes with type II receptors. Cell 75: 671-680.
    • (1993) Cell , vol.75 , pp. 671-680
    • Attisano, L.1    Cárcamo, J.2    Ventura, F.3    Weis, F.M.B.4    Massagué, J.5    Wrana, J.L.6
  • 3
    • 0024538265 scopus 로고
    • Growth inhibitory response to transforming growth factor-β linked to expression of a 53 kDa cell surface TGF-β receptor
    • Boyd, F.T. and J. Massagué. 1989. Growth inhibitory response to transforming growth factor-β linked to expression of a 53 kDa cell surface TGF-β receptor. J. Biol. Chem. 274: 2272-2278.
    • (1989) J. Biol. Chem. , vol.274 , pp. 2272-2278
    • Boyd, F.T.1    Massagué, J.2
  • 4
    • 0025998840 scopus 로고
    • Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
    • Boyle, W.J., P. van der Geer, and T. Hunter. 1991. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol. 201B: 110-149.
    • (1991) Methods Enzymol. , vol.201 B , pp. 110-149
    • Boyle, W.J.1    Van Der Geer, P.2    Hunter, T.3
  • 7
    • 0028899480 scopus 로고
    • Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
    • Chen, J., P.K. Jackson, M.W. Kirschner, and A. Dutta. 1995. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374: 386-388.
    • (1995) Nature , vol.374 , pp. 386-388
    • Chen, J.1    Jackson, P.K.2    Kirschner, M.W.3    Dutta, A.4
  • 8
    • 0027083108 scopus 로고
    • Activation of human cyclin-dependent kinases in vitro
    • Desai, D., Y. Gu, and D.O. Morgan. 1992. Activation of human cyclin-dependent kinases in vitro. Mol. Biol. Cell 3: 571-582.
    • (1992) Mol. Biol. Cell , vol.3 , pp. 571-582
    • Desai, D.1    Gu, Y.2    Morgan, D.O.3
  • 9
    • 0028092122 scopus 로고
    • Transforming growth factor β1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells
    • Elbendary, A., A. Berchuck, P. Davis, L. Havrilesky, R.C. Bast Jr., I.D. Iglehart, and J.R. Marks. 1994. Transforming growth factor β1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells. Cell Growth Differ. 5: 1301-1307.
    • (1994) Cell Growth Differ. , vol.5 , pp. 1301-1307
    • Elbendary, A.1    Berchuck, A.2    Davis, P.3    Havrilesky, L.4    Bast Jr., R.C.5    Iglehart, I.D.6    Marks, J.R.7
  • 12
    • 0027374766 scopus 로고
    • TGF-β inhibition of Cdk4 synthesis is linked to cell cycle arrest
    • Ewen, M.E., H.K. Sluss, L.L. Whitehouse, and D.M. Livingston. 1993. TGF-β inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell 74: 1009-1020.
    • (1993) Cell , vol.74 , pp. 1009-1020
    • Ewen, M.E.1    Sluss, H.K.2    Whitehouse, L.L.3    Livingston, D.M.4
  • 14
    • 0027981476 scopus 로고
    • Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase 5 holoenzyme
    • Flores-Rozas, H., Z. Kelman, F.B. Dean, Z.-Q. Pan, J.W. Harper, S.J. Elledge, M. O'Donnel, and I. Hurwitz. 1994. Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase 5 holoenzyme. Proc. Natl. Acad. Sci. 91: 8655-8659.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 8655-8659
    • Flores-Rozas, H.1    Kelman, Z.2    Dean, F.B.3    Pan, Z.-Q.4    Harper, J.W.5    Elledge, S.J.6    O'Donnel, M.7    Hurwitz, I.8
  • 15
    • 0027486303 scopus 로고
    • Transforming growth factor β effects on expression of G1 cyclins and cyclin-dependent protein kinases
    • Geng, Y. and R.A. Weinberg. 1993. Transforming growth factor β effects on expression of G1 cyclins and cyclin-dependent protein kinases. Proc. Natl. Acad. Sci. 90: 10315-10319.
    • (1993) Proc. Natl. Acad. Sci. , vol.90 , pp. 10315-10319
    • Geng, Y.1    Weinberg, R.A.2
  • 16
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen, M. and H. Bujard. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. 89: 5547-5551.
    • (1992) Proc. Natl. Acad. Sci. , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 17
    • 0027731971 scopus 로고
    • Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
    • Gu, Y., C.W. Turck, and D.O. Morgan. 1993. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 366: 707-710.
    • (1993) Nature , vol.366 , pp. 707-710
    • Gu, Y.1    Turck, C.W.2    Morgan, D.O.3
  • 19
    • 0028168242 scopus 로고
    • INK4B is a potential effector of TGF-β-induced cell cycle arrest
    • INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature 371: 257-261.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 23
    • 0028918388 scopus 로고
    • Novel Ink4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
    • Hirai, H., M.F. Roussel, J.-Y. Kato, R.A. Ashmun, and C.J. Sherr. 1995. Novel Ink4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell Biol. 15: 2672-2681.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 2672-2681
    • Hirai, H.1    Roussel, M.F.2    Kato, J.-Y.3    Ashmun, R.A.4    Sherr, C.J.5
  • 24
    • 0025967749 scopus 로고
    • Transforming growth factor β1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest
    • Howe, P.H., G. Draetta, and E.B. Leof. 1991. Transforming growth factor β1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest. Mol. Cell. Biol. 11: 1185-1194.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 1185-1194
    • Howe, P.H.1    Draetta, G.2    Leof, E.B.3
  • 25
    • 0027938209 scopus 로고
    • Cylins and cancer II: Cyclin D and CDK inhibitiors come of age
    • Hunter, T. and J. Pines. 1994. Cylins and cancer II: Cyclin D and CDK inhibitiors come of age. Cell 79: 573-582.
    • (1994) Cell , vol.79 , pp. 573-582
    • Hunter, T.1    Pines, J.2
  • 28
    • 0028270189 scopus 로고
    • Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase
    • Kato, J-Y., M. Matsuoka, D.K. Strom, C.J. Sherr. 1994b. Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. Mol. Cell. Biol. 14: 2713-2721.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 2713-2721
    • Kato, J.-Y.1    Matsuoka, M.2    Strom, D.K.3    Sherr, C.J.4
  • 29
    • 0027318843 scopus 로고
    • Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGF-β
    • Koff, A., M. Ohtsuki, K. Polyak, J.M. Roberts, and J. Massagué. 1993. Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGF-β. Science 260: 536-539.
    • (1993) Science , vol.260 , pp. 536-539
    • Koff, A.1    Ohtsuki, M.2    Polyak, K.3    Roberts, J.M.4    Massagué, J.5
  • 30
    • 0025326725 scopus 로고
    • Growth inhibition by TGF-β1 linked to suppression of retinoblastoma protein phosphorylation
    • Laiho, M., J.A. DeCaprio, J.W. Ludlow, D.M. Livingston, and J. Massagué. 1990. Growth inhibition by TGF-β1 linked to suppression of retinoblastoma protein phosphorylation. Cell 62: 175-185.
    • (1990) Cell , vol.62 , pp. 175-185
    • Laiho, M.1    Decaprio, J.A.2    Ludlow, J.W.3    Livingston, D.M.4    Massagué, J.5
  • 31
    • 0028988158 scopus 로고
    • Kip2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution
    • Kip2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes & Dev. 9: 639-649.
    • (1995) Genes & Dev. , vol.9 , pp. 639-649
    • Lee, M.-H.1    Reynisdóttir, I.2    Massagué, J.3
  • 34
    • 0025222517 scopus 로고
    • The transforming growth factor-β1 family
    • Massagué, J. 1990. The transforming growth factor-β1 family. Annu. Rev. Cell Biol. 6: 597-641.
    • (1990) Annu. Rev. Cell Biol. , vol.6 , pp. 597-641
    • Massagué, J.1
  • 36
    • 0026778547 scopus 로고
    • Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins
    • Matsushime, H., M.E. Ewen, D.K. Strom, J.-Y. Kato, S.K. Hanks, M.F. Roussel, and C.J. Sherr. 1992. Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell 71: 323-334.
    • (1992) Cell , vol.71 , pp. 323-334
    • Matsushime, H.1    Ewen, M.E.2    Strom, D.K.3    Kato, J.-Y.4    Hanks, S.K.5    Roussel, M.F.6    Sherr, C.J.7
  • 38
    • 0028181760 scopus 로고
    • Identification of G1 kinase activity for cdk6, a novel cyclin D partner
    • Meyerson, M. and Harlow, E. 1994. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol. Cell. Biol. 14: 2077-2086.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 2077-2086
    • Meyerson, M.1    Harlow, E.2
  • 39
    • 0028338514 scopus 로고
    • Frequent somatic mutation of MTS1/CDK4I gene in esophageal squamous cell carcinoma
    • Mori, T., K. Miura, T. Aoki, T. Nishihara, S. Mori, and M. Nakamura. 1994. Frequent somatic mutation of MTS1/CDK4I gene in esophageal squamous cell carcinoma. Cancer Res. 54: 3396-3397.
    • (1994) Cancer Res. , vol.54 , pp. 3396-3397
    • Mori, T.1    Miura, K.2    Aoki, T.3    Nishihara, T.4    Mori, S.5    Nakamura, M.6
  • 40
    • 0025104027 scopus 로고
    • TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights
    • Moses, H.L., E.Y. Yang, and J. Pietenpol. 1990. TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights. Cell 63: 245-247.
    • (1990) Cell , vol.63 , pp. 245-247
    • Moses, H.L.1    Yang, E.Y.2    Pietenpol, J.3
  • 42
    • 0028275733 scopus 로고
    • Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    • Nobori, T., K. Miura, D.J. Wu, A. Lois, K. Takabayashi, and D.A. Carson. 1994. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368: 753-756.
    • (1994) Nature , vol.368 , pp. 753-756
    • Nobori, T.1    Miura, K.2    Wu, D.J.3    Lois, A.4    Takabayashi, K.5    Carson, D.A.6
  • 43
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda, A., Y. Ning, S.F. Venable, O.M. Pereira-Smith, and J.R. Smith. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:90-98.
    • (1994) Exp. Cell Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 45
    • 0027193034 scopus 로고
    • Cyclin dependent regulation of G1 in mammalian fibroblasts
    • Ohtsubo, M. and J.M. Roberts. 1993. Cyclin dependent regulation of G1 in mammalian fibroblasts. Science 259: 1908-1912.
    • (1993) Science , vol.259 , pp. 1908-1912
    • Ohtsubo, M.1    Roberts, J.M.2
  • 47
    • 0028085427 scopus 로고
    • Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Far1
    • Peter, M. and I. Herskowitz. 1994a. Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Far1. Science 265: 1228-1231.
    • (1994) Science , vol.265 , pp. 1228-1231
    • Peter, M.1    Herskowitz, I.2
  • 48
    • 0028072520 scopus 로고
    • Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle
    • _. 1994b. Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle. Cell 79: 181-184.
    • (1994) Cell , vol.79 , pp. 181-184
  • 49
    • 0028105914 scopus 로고
    • Stifled by inhibitions
    • Peters, G. 1994. Stifled by inhibitions. Nature 371: 204-205.
    • (1994) Nature , vol.371 , pp. 204-205
    • Peters, G.1
  • 50
  • 54
    • 0028102203 scopus 로고
    • Inhibition of cell growth by TGFβ is associated with inhibition of B-myb and cyclin A in both BALB/MK and Mv1Lu cells
    • Satterwhite, D.J., M.E. Aakre, A.E. Gorska, and H.L. Moses. 1994. Inhibition of cell growth by TGFβ is associated with inhibition of B-myb and cyclin A in both BALB/MK and Mv1Lu cells. Cell Growth Differ. 5: 789-799.
    • (1994) Cell Growth Differ. , vol.5 , pp. 789-799
    • Satterwhite, D.J.1    Aakre, M.E.2    Gorska, A.E.3    Moses, H.L.4
  • 55
    • 0027769876 scopus 로고
    • A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano, M., G.J. Hannon, and D. Beach. 1993. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 56
    • 0027336491 scopus 로고
    • Mammalian G1 cyclins
    • Sherr, C.J. 1993. Mammalian G1 cyclins. Cell 73: 1059-1065.
    • (1993) Cell , vol.73 , pp. 1059-1065
    • Sherr, C.J.1
  • 57
    • 0028171292 scopus 로고
    • G1 phase progression: Cycling on cue
    • _. 1994. G1 phase progression: Cycling on cue. Cell 79: 551-555.
    • (1994) Cell , vol.79 , pp. 551-555
  • 59
    • 0028227197 scopus 로고
    • A novel inhibitor of cyclin-cdk activity detected in transforming growth factor β-arrested epithelial cells
    • Slingerland, J.M., L. Hengst, C. Pan, D. Alexander, M. Stampfer, and S.I. Reed. 1994. A novel inhibitor of cyclin-cdk activity detected in transforming growth factor β-arrested epithelial cells. Mol. Cell. Biol. 14: 3683-3694.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3683-3694
    • Slingerland, J.M.1    Hengst, L.2    Pan, C.3    Alexander, D.4    Stampfer, M.5    Reed, S.I.6
  • 60
    • 0028363519 scopus 로고
    • p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    • Toyoshima, H. and T. Hunter. 1994. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78: 67-74.
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 61
    • 0028352434 scopus 로고
    • The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
    • Waga, S., G.J. Hannon, D. Beach, and B. Stillman. 1994. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369: 574-578.
    • (1994) Nature , vol.369 , pp. 574-578
    • Waga, S.1    Hannon, G.J.2    Beach, D.3    Stillman, B.4
  • 62
    • 0029257341 scopus 로고
    • A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen
    • Warbrick, E., D.P. Lane, D.M. Glover, and L.S. Cox. 1995. A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen. Curr. Biol. 5: 275-282.
    • (1995) Curr. Biol. , vol.5 , pp. 275-282
    • Warbrick, E.1    Lane, D.P.2    Glover, D.M.3    Cox, L.S.4
  • 64
    • 0026055060 scopus 로고
    • Early gene responses to transforming growth factor-β in cells lacking growth suppressive RB function. Mol
    • Zentella, A., F.M.B. Weis, D.A. Ralph, M. Laiho, and J. Massagué. 1991. Early gene responses to transforming growth factor-β in cells lacking growth suppressive RB function. Mol. Cell. Biol. 11: 4952-4958.
    • (1991) Cell. Biol. , vol.11 , pp. 4952-4958
    • Zentella, A.1    Weis, F.M.B.2    Ralph, D.A.3    Laiho, M.4    Massagué, J.5


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