Kampeferol protects against oxidative stress and apoptotic damage in experimental model of isoproterenol-induced cardiac toxicity in rats

Phytomedicine

Volumn 23, Issue 12, 2016, Pages 1401-1408

  Suchal, Kapil ^a   Malik, Salma ^a   Gamad, Nanda ^a   Malhotra, Rajiv Kumar ^a   Goyal, Sameer N ^b   Bhatia, Jagriti ^a   Arya, Dharamvir Singh ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b R C PATEL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

Author keywords

Apoptosis; Cardiotoxicity; Inflammation; Isoproterenol; Kaempferol; Oxidative stress

Indexed keywords

ANTIOXIDANT; CATALASE; CREATINE KINASE MB; FLAVONOID; GLUTATHIONE; INTERLEUKIN 6; ISOPRENALINE; KAEMPFEROL; LACTATE DEHYDROGENASE; MALONALDEHYDE; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER; KAEMPFEROL DERIVATIVE; PLANT EXTRACT; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTERIAL PRESSURE; ARTICLE; CARDIAC MUSCLE; CARDIOTOXICITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; HEART INFARCTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE INJURY; HEART PROTECTION; HEMODYNAMIC PARAMETERS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPID PEROXIDATION; LOW DRUG DOSE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RIGHT CORONARY ARTERY; ULTRASTRUCTURE; ANIMAL; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; HEART; HEART LEFT VENTRICLE FUNCTION; METABOLISM; MYOCARDIAL INFARCTION; PATHOLOGY; PHYTOTHERAPY; THEORETICAL MODEL; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BIOMARKERS; CARDIOTOXICITY; CATALASE; GLUTATHIONE; HEART; INTERLEUKIN-6; ISOPROTERENOL; KAEMPFEROLS; LIPID PEROXIDATION; MALE; MODELS, THEORETICAL; MYOCARDIAL INFARCTION; MYOCARDIUM; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; RATS, WISTAR; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA; VENTRICULAR FUNCTION, LEFT;

EID: 84982263748     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2016.07.015     Document Type: Article

References (37)

1. Aebi, H., Catalase in vitro. Methods Enzymol 105 (1984), 121–126.
2. Al-Numair, K.S., Chandramohan, G., Veeramani, C., Alsaif, M.A., Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats. Redox. Rep. 20 (2015), 198–209.
3. Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976), 248–254.
4. Buwa, C.C., Mahajan, U.B., Patil, C.R., Goyal, S.N., Apigenin attenuates β-receptor-stimulated myocardial injury via safeguarding cardiac functions and escalation of antioxidant defence system. Cardiovas. Toxicol., 2015 [Epub ahead of print].
5. Calderón-Montaño, J.M., Burgos-Morón, E., Pérez-Guerrero, C., López-Lázaro, M., A review on the dietary flavonoid kaempferol. Mini. Rev. Med. Chem. 11 (2011), 298–344.
6. Chen, H., Xu, Y., Wang, J., Zhao, W., Ruan, H., Baicalin ameliorates isoproterenol-induced acute myocardial infarction through iNOS, inflammation and oxidative stress in rat. Int. J. Clin. Exp. Pathol. 8 (2015), 10139–10147.
7. Chugh, S.S., Reinier, K., Teodorescu, C., Evanado, A., Kehr, E., Al Samara, M., Mariani, R., Gunson, K., Jui, J., Epidemiology of sudden cardiac death: clinical and research implications. Prog. Cardiovasc. Dis. 51 (2008), 213–228.
8. Derbali, A., Mnafgui, K., Affes, M., Derbali, F., Hajji, R., Gharsallah, N., Allouche, N., El Feki, A., Cardioprotective effect of linseed oil against isoproterenol-induced myocardial infarction in Wistar rats: a biochemical and electrocardiographic study. J. Physiol. Biochem. 71 (2015), 281–288.
9. Garson, C., Kelly-Laubscher, R., Blackhurst, D., Gwanyanya, A., Lack of cardioprotection by single-dose magnesium prophylaxis on isoprenaline-induced myocardial infarction in adult Wistar rats. Cardiovasc. J. Afr. 26 (2015), 242–249.
10. Goyal, S.N., Sharma, C., Mahajan, U.B., Patil, C.R., Agrawal, Y.O., Kumari, S., Arya, D.S., Ojha, S., Protective effects of cardamom in isoproterenol-induced myocardial infarction in rats. Int. J. Mol. Sci. 16 (2015), 27457–27469.
11. Guo, Z., Liao, Z., Huang, L., Liu, D., Yin, D., He, M., Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1. Eur. J. Pharmacol. 761 (2015), 45–53.
12. Haidari, F., Heybar, H., Jalali, M.T., Ahmadi Engali, K., Helli, B., Shirbeigi, E., Hesperidin supplementation modulates inflammatory responses following myocardial infarction. J. Am. Coll. Nutr. 34 (2015), 205–211.
13. Hassan, M.Q., Akhtar, M.S., Akhtar, M., Ansari, S.H., Ali, J., Haque, S.E., Najmi, A.K., Benidipine prevents oxidative stress, inflammatory changes and apoptosis related myofibril damage in isoproterenol-induced myocardial infarction in rats. Toxicol. Mech. Methods. 25 (2015), 26–33.
14. Hori, M., Nishida, K., Oxidative stress and left ventricular remodelling after myocardial infarction. Cardiovasc. Res. 81 (2009), 457–464.
15. Huang, D.S., Lin, H.Y., Lee-Chen, G.J., Hsieh-Li, H.M., Wu, C.H., Lin, J.Y., Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17. Drug Des. Devel. Ther. 10 (2016), 723–731.
16. Jo, E., Park, S.J., Choi, Y.S., Jeon, W.K., Kim, B.C., Kaempferol Suppresses Transforming Growth Factor-β1-Induced Epithelial-to-Mesenchymal Transition and Migration of A549 Lung Cancer Cells by Inhibiting Akt1-Mediated Phosphorylation of Smad3 at Threonine-179. Neoplasia. 17 (2015), 525–537.
17. Lim, S., Yoon, J.W., Kang, S.M., Choi, S.H., Cho, B.J., Kim, M., Park, H.S., Cho, H.J., Shin, H., Kim, Y.B., Kim, H.S., Jang, H.C., Park, K.S., EGb761, a Ginkgo biloba extract, is effective against atherosclerosis in vitro, and in a rat model of type 2 diabetes. PLoS One, 6, 2011, e20301.
18. Luo, C., Yang, H., Tang, C., Yao, G., Kong, L., He, H., Zhou, Y., Kaempferol alleviates insulin resistance via hepatic IKK/NF-κB signal in type 2 diabetic rats. Int. Immunopharmacol. 28 (2015), 744–750.
19. Marklund, S., Marklund, G., Involvement of the superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47 (1974), 469–474.
20. Moron, M.S., Depierre, J.W., Manmerik, B., Level of glutathione, glutathione reductase and glutathione-s-transferase activity in rat lung and liver. Biochem. Biophys. Acta. 82 (1979), 67–78.
21. Mukherjee, D., Ghosh, A.K., Dutta, M., Mitra, E., Mallick, S., Saha, B., Reiter, R.J., Bandyopadhyay, D., Mechanisms of isoproterenol-induced cardiac mitochondrial damage: protective actions of melatonin. J. Pineal Res. 58 (2015), 275–290.
22. Oboh, G., Ademiluyi, A.O., Ademosun, A.O., Olasehinde, T.A., Oyeleye, S.I., Boligon, A.A., Athayde, M.L., Phenolic extract from moringa oleifera leaves inhibits key enzymes linked to erectile dysfunction and oxidative stress in rats' penile tissues. Biochem. Res. Int., 2015, 175950 2015.
23. Ohkawa, H., Ohishi, N., Yagi, K., Assay of lipid peroxide in animal tissue by thiobarbituric acid reaction. Anal. Biochem. 95 (1979), 351–358.
24. Oltvai, Z.N., Milliman, C.L., Korsmeyer, S.J., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74 (1993), 609–619.
25. Prabhu, S.D., Wang, G., Luo, J., Gu, Y., Ping, P., Chandrasekar, B., Beta-adrenergic receptor blockade modulates Bcl-X(S) expression and reduces apoptosis in failing myocardium. J. Mol. Cell. Cardiol. 35 (2003), 483–493.
26. Reddy, N.M., Mahajan, U.B., Patil, C.R., Agrawal, Y.O., Ojha, S., Goyal, S.N., Eplerenone attenuates cardiac dysfunction and oxidative stress in β-receptor stimulated myocardial infarcted rats. Am. J. Transl. Res. 7 (2015), 1602–1611.
27. Rona, G., Catecholamine cardiotoxicity. J. Mol. Cell. Cardiol. 17 (1985), 291–306.
28. Sachdeva, J., Tanwar, V., Golechha, M., Siddiqui, K.M., Nag, T.C., Ray, R., Kumari, S., Arya, D.S., Crocus sativus L. (saffron) attenuates isoproterenol-induced myocardial injury via preserving cardiac functions and strengthening antioxidant defense system. Exp. Toxicol. Pathol. 64 (2012), 557–564.
29. Shaik, A.H., Rasool, S.N., Vikram Kumar Reddy, A., Abdul Kareem, M., Saayi Krushna, G., Lakshmi Devi, K., Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats. J. Ethnopharmacol. 141 (2012), 33–40.
30. Singh, B.N., Singh, B.R., Singh, R.L., Prakash, D., Dhakarey, R., Upadhyay, G., Singh, H.B., Oxidative DNA damage protective activity, antioxidant and anti-quorum sensing potentials of Moringa oleifera. Food Chem. Toxicol. 47 (2009), 1109–1116.
31. Singh, D., Arya, P.V., Aggarwal, V.P., Gupta, R.S., Evaluation of antioxidant and hepatoprotective activities of moringa oleifera lam. leaves in carbon tetrachloride-intoxicated rats. Antioxidants (Basel). 3 (2014), 569–591.
32. Stanely Mainzen Prince, P., Dhanasekar, K., Rajakumar, S., Vanillic acid prevents altered ion pumps, ions, inhibits Fas-receptor and caspase mediated apoptosis-signaling pathway and cardiomyocyte death in myocardial infarcted rats. Chem. Biol. Interact. 232 (2015), 68–76.
33. Stanely Mainzen Prince, P., Roy, A.J., p-Coumaric acid attenuates apoptosis in isoproterenol induced myocardial infarcted rats by inhibiting oxidative stress. Int. J. Cardiol. 168 (2013), 3259–3266.
34. Todd, G.L., Baroldi, G., Pieper, G.M., Clayton, F.C., Eliot, R.S., Experimental catecholamine-induced myocardial necrosis: II. Temporal development of isoproterenol-induced contraction band lesions correlated with ECG, hemodynamic and biochemical changes. J. Mol. Cell. Cardiol. 17 (1985), 647–656.
35. Xiao, J., Sun, G.B., Sun, B., Wu, Y., He, L., Wang, X., Chen, R.C., Cao, L., Ren, X.Y., Sun, X.B., Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro. Toxicology 292 (2012), 53–62.
36. Yang, E.J., Kim, G,S., Jun, M., Song, K.S., Kaempferol attenuates the glutamate-induced oxidative stress in mouse-derived hippocampal neuronal HT22 cells. Food Funct 5 (2014), 1395–1402.
37. Yang, T.H., Young, Y.H., Liu, S.H., EGb 761 (Ginkgo biloba) protects cochlear hair cells against ototoxicity induced by gentamicin via reducing reactive oxygen species and nitric oxide-related apoptosis. J. Nutr. Biochem. 22 (2011), 886–894.