Kaempferol slows intervertebral disc degeneration by modifying LPS-induced osteogenesis/adipogenesis imbalance and inflammation response in BMSCs

International Immunopharmacology

Volumn 43, Issue , 2017, Pages 236-242

  Zhu, Jun ^a   Tang, Haoyu ^a   Zhang, Zhenhua ^a   Zhang, Yong ^a   Qiu, Chengfeng ^a   Zhang, Ling ^a   Huang, Pinge ^a   Li, Feng ^a  

^a First People's Hospital of Huaihua   (China)

Author keywords

Adipogenesis; BMSCs; Inflammation; IVD degeneration; Kaempferol; Osteogenesis

Indexed keywords

AGGRECAN; AGGRECANASE 1; AGGRECANASE 2; ANTIINFLAMMATORY AGENT; CARNITINE PALMITOYLTRANSFERASE I; COLLAGEN TYPE 2; COLLAGENASE 3; CYCLINE; FAS ANTIGEN; GELATINASE B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; KAEMPFEROL; KI 67 ANTIGEN; LIPOPOLYSACCHARIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STROMELYSIN; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR SOX9; TUMOR NECROSIS FACTOR; AUTACOID; CARNITINE PALMITOYLTRANSFERASE; CYTOKINE; KAEMPFEROL DERIVATIVE;

ADIPOGENESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; BONE DEVELOPMENT; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL COUNT; CELL DIFFERENTIATION; CELL GROWTH; CELL NUCLEUS; CELL PROLIFERATION; CELL VIABILITY; CHONDROGENESIS; CONTROLLED STUDY; DRUG CYTOTOXICITY; FEMALE; GENE EXPRESSION; INFLAMMATION; INTERVERTEBRAL DISK DEGENERATION; LIPID STORAGE; LIPOGENESIS; LIPOLYSIS; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; WESTERN BLOTTING; ANIMAL; BONE MARROW CELL; CELL CULTURE; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; INTERVERTEBRAL DISC DEGENERATION; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY; RABBIT;

ADIPOGENESIS; ANIMALS; APOPTOSIS; BONE MARROW CELLS; CARNITINE O-PALMITOYLTRANSFERASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERVERTEBRAL DISC DEGENERATION; KAEMPFEROLS; LIPOPOLYSACCHARIDES; MATRIX METALLOPROTEINASE 3; MESENCHYMAL STROMAL CELLS; OSTEOGENESIS; PPAR GAMMA; RABBITS; SOX9 TRANSCRIPTION FACTOR;

EID: 85007477141     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2016.12.020     Document Type: Article

References (41)

1. [1] Dasari, V.R., Veeravalli, K.K., Dinh, D.H., Mesenchymal stem cells in the treatment of spinal cord injuries: a review. World J. Stem Cells 6 (2014), 120–133.
2. [2] Xu, J., E, X.Q., Wang, N.X., Wang, M.N., Xie, H.X., Cao, Y.H., et al. BMP7 enhances the effect of BMSCs on extracellular matrix remodeling in a rabbit model of intervertebral disc degeneration. FEBS J. 283 (2016), 1689–1700.
3. [3] Gou, S., Oxentenko, S.C., Eldrige, J.S., Xiao, L., Pingree, M.J., Wang, Z., et al. Stem cell therapy for intervertebral disk regeneration. Am. J. Phys. Med. Rehabil., 93, 2014 (0000000000000152).
4. [4] Luoma, K., Riihimaki, H., Luukkonen, R., Raininko, R., Viikari-Juntura, E., Lamminen, A., Low back pain in relation to lumbar disc degeneration. Spine 25 (1976), 487–492.
5. [5] Sobajima, S., Vadala, G., Shimer, A., Kim, J.S., Gilbertson, L.G., Kang, J.D., Feasibility of a stem cell therapy for intervertebral disc degeneration. Spine J. 8 (2008), 888–896.
6. [6] Wei, A., Shen, B., Williams, L., Diwan, A., Mesenchymal stem cells: potential application in intervertebral disc regeneration. Transl. Pediatr. 3 (2014), 71–90.
7. [7] Hu, H., Zou, C., Mesenchymal stem cells in renal ischemia-reperfusion injury: biological and therapeutic perspectives. Curr. Stem Cell. Res. Ther., 24, 2016, 24.
8. [8] Fortier, L.A., Stem cells: classifications, controversies, and clinical applications. Vet. Surg. 34 (2005), 415–423.
9. [9] Uccelli, A., Mancardi, G., Chiesa, S., Is there a role for mesenchymal stem cells in autoimmune diseases?. Autoimmunity 41 (2008), 592–595.
10. [10] Steck, E., Fischer, J., Lorenz, H., Gotterbarm, T., Jung, M., Richter, W., Mesenchymal stem cell differentiation in an experimental cartilage defect: restriction of hypertrophy to bone-close neocartilage. Stem Cells Dev. 18 (2009), 969–978.
11. [11] Freeman, B.J., Kuliwaba, J.S., Jones, C.F., Shu, C.C., Colloca, C.J., Zarrinkalam, M.R., et al. Allogeneic mesenchymal precursor cells promote healing in postero-lateral annular lesions and improve indices of lumbar intervertebral disc degeneration in an ovine model. Spine 41 (1976), 1331–1339.
12. [12] Skovrlj, B., Cunn, G., Guzman, J.Z., Qureshi, S.A., Mesenchymal stem cell technology in the treatment of degenerative disc disease. J. Neurosurg. Sci. 59 (2015), 25–35.
13. [13] Fierabracci, A., Del Fattore, A., Luciano, R., Muraca, M., Teti, A., Recent advances in mesenchymal stem cell immunomodulation: the role of microvesicles. Cell Transplant. 24 (2015), 133–149.
14. [14] Vadala, G., Russo, F., Ambrosio, L., Loppini, M., Denaro, V., Stem cells sources for intervertebral disc regeneration. World J. Stem Cells 8 (2016), 185–201.
15. [15] Rodriguez, J.P., Astudillo, P., Rios, S., Seitz, G., Pino, A.M., Adipogenesis and osteoporosis. Rev. Med. Chil. 137 (2009), 827–836.
16. [16] Yang, F., Yuan, P.W., Hao, Y.Q., Lu, Z.M., Emodin enhances osteogenesis and inhibits adipogenesis. BMC Complement. Altern. Med. 14 (2014), 1472–6882.
17. [17] Wang, H., Zhou, Y., Chu, T.W., Li, C.Q., Wang, J., Zhang, Z.F., et al. Distinguishing characteristics of stem cells derived from different anatomical regions of human degenerated intervertebral discs. Eur. Spine J. 25 (2016), 2691–2704.
18. [18] Lee, W.S., Lee, E.G., Sung, M.S., Yoo, W.H., Kaempferol inhibits IL-1beta-stimulated, RANKL-mediated osteoclastogenesis via downregulation of MAPKs, c-Fos, and NFATc1. Inflammation 37 (2014), 1221–1230.
19. [19] Nepal, M., Li, L., Cho, H.K., Park, J.K., Soh, Y., Kaempferol induces chondrogenesis in ATDC5 cells through activation of ERK/BMP-2 signaling pathway. Food Chem. Toxicol. 62 (2013), 238–245.
20. [20] Xia, C.S., Zuo, A.J., Wang, C.Y., Wang, Y.Z., Isolation of rabbit bone marrow mesenchymal stem cells using density gradient centrifugation and adherence screening methods. Minerva Med. 104 (2013), 519–525.
21. [21] Li, Y., Li, K., Hu, Y., Xu, B., Zhao, J., Piperine mediates LPS induced inflammatory and catabolic effects in rat intervertebral disc. Int. J. Clin. Exp. Pathol. 8 (2015), 6203–6213.
22. [22] Li, Y., Li, K., Mao, L., Han, X., Zhang, K., Zhao, C., et al. Cordycepin inhibits LPS-induced inflammatory and matrix degradation in the intervertebral disc. Peer J., 10, 2016.
23. [23] Li, K., Li, Y., Ma, Z., Zhao, J., Crocin exerts anti-inflammatory and anti-catabolic effects on rat intervertebral discs by suppressing the activation of JNK. Int. J. Mol. Med. 36 (2015), 1291–1299.
24. [24] Li, Z., Wang, X., Pan, H., Yang, H., Li, X., Zhang, K., et al. Resistin promotes CCL4 expression through toll-like receptor-4 and activation of the p38-MAPK and NF-kappaB signaling pathways: implications for intervertebral disc degeneration. Osteoarthr. Cartil. 11 (2016), 30310–30317.
25. [25] Lee, J., Kim, J.H., Kaempferol inhibits pancreatic cancer cell growth and migration through the blockade of EGFR-related pathway in vitro. PLoS One, 11, 2016.
26. [26] Qin, Y., Cui, W., Yang, X., Tong, B., Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo. Acta Biochim. Biophys. Sin. 48 (2016), 238–245.
27. [27] Kim, S.H., Hwang, K.A., Choi, K.C., Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models. J. Nutr. Biochem. 28 (2016), 70–82.
28. [28] Yao, S., Wang, X., Li, C., Zhao, T., Jin, H., Fang, W., Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway. Tumour Biol. 37 (2016), 10247–10256.
29. 2 induced cytotoxicity in lung and liver cells. BMC Complement. Altern. Med., 16, 2016, 376.
30. [30] Wu, Y., Sun, J., George, J., Ye, H., Cui, Z., Li, Z., et al. Study of neuroprotective function of Ginkgo biloba extract (EGb761) derived-flavonoid monomers using a three-dimensional stem cell-derived neural model. Biotechnol. Prog. 32 (2016), 735–744.
31. [31] Kim, I.R., Kim, S.E., Baek, H.S., Kim, B.J., Kim, C.H., Chung, I.K., et al. The role of kaempferol-induced autophagy on differentiation and mineralization of osteoblastic MC3T3-E1 cells. BMC Complement. Altern. Med. 16 (2016), 016–1320.
32. [32] Mwale, F., Wang, H.T., Roughley, P., Antoniou, J., Haglund, L., Link N and mesenchymal stem cells can induce regeneration of the early degenerate intervertebral disc. Tissue Eng. Part A. 20 (2014), 2942–2949.
33. [33] Sui, B., Hu, C., Liao, L., Chen, Y., Zhang, X., Fu, X., et al. Mesenchymal progenitors in osteopenias of diverse pathologies: differential characteristics in the common shift from osteoblastogenesis to adipogenesis. Sci. Rep., 6, 2016.
34. [34] Nuttall, M.E., Shah, F., Singh, V., Thomas-Porch, C., Frazier, T., Gimble, J.M., Adipocytes and the regulation of bone remodeling: a balancing act. Calcif. Tissue Int. 94 (2014), 78–87.
35. [35] Jang, Y.S., Wang, Z., Lee, J.M., Lee, J.Y., Lim, S.S., Screening of Korean natural products for anti-adipogenesis properties and isolation of kaempferol-3-O-rutinoside as a potent anti-adipogenetic compound from Solidago virgaurea. Molecules, 21, 2016.
36. [36] Trivedi, R., Kumar, S., Kumar, A., Siddiqui, J.A., Swarnkar, G., Gupta, V., et al. Kaempferol has osteogenic effect in ovariectomized adult Sprague–Dawley rats. Mol. Cell. Endocrinol. 289 (2008), 85–93.
37. [37] Abraham, A.C., Liu, J.W., Tang, S.Y., Longitudinal changes in the structure and inflammatory response of the intervertebral disc due to stab injury in a murine organ culture model. J. Orthop. Res. 34 (2016), 1431–1438.
38. [38] Ellman, M.B., Kim, J.S., An, H.S., Chen, D., Kc, R., An, J., et al. Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disk homeostasis: in vitro, ex vivo studies. Gene 505 (2012), 283–290.
39. [39] Kepler, C.K., Ponnappan, R.K., Tannoury, C.A., Risbud, M.V., Anderson, D.G., The molecular basis of intervertebral disc degeneration. Spine J. 13 (2013), 318–330.
40. [40] Yang, F., Shi, H., Zhang, X., Yang, H., Zhou, Q., Yu, L.L., Two new saponins from tetraploid jiaogulan (Gynostemma pentaphyllum), and their anti-inflammatory and alpha-glucosidase inhibitory activities. Food Chem. 141 (2013), 3606–3613.
41. [41] Park, M.J., Lee, E.K., Heo, H.S., Kim, M.S., Sung, B., Kim, M.K., et al. The anti-inflammatory effect of kaempferol in aged kidney tissues: the involvement of nuclear factor-kappaB via nuclear factor-inducing kinase/IkappaB kinase and mitogen-activated protein kinase pathways. J. Med. Food 12 (2009), 351–358.