Kaempferol inhibits the production of ROS to modulate OPN–αvβ3 integrin pathway in HUVECs

Journal of Physiology and Biochemistry

Volumn 72, Issue 2, 2016, Pages 303-313

  Xiao, Hong Bo ^a   Lu, Xiang Yang ^b,c   Liu, Zi Kui ^a   Luo, Zhi Feng ^d,e  

^a HUNAN AGRICULTURAL UNIVERSITY   (China)

^b HUNAN UNIVERSITY   (China)

^c National Res Center of Engineering Tech for Utilization of Functional Ingredients from Botanicals   (China)

^d XIANGNAN UNIVERSITY   (China)

^e Third Hospital of Changsha   (China)

Author keywords

Aldosterone; Human umbilical vein endothelial cells; Kaempferol; Nuclear factor B; Osteopontin; v 3 Integrin

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; KAEMPFEROL; OSTEOPONTIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TUMOR NECROSIS FACTOR ALPHA; VITRONECTIN RECEPTOR; ALDOSTERONE; ANTIOXIDANT; ASCORBIC ACID; AUTACOID; BETA3 INTEGRIN; CD51 ANTIGEN; ITGB3 PROTEIN, HUMAN; KAEMPFEROL DERIVATIVE; LM609 MONOCLONAL ANTIBODY; MINERALOCORTICOID ANTAGONIST; MONOCLONAL ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT; SPIRONOLACTONE; SPP1 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; METABOLISM; VASCULAR ENDOTHELIUM;

ALDOSTERONE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODIES, MONOCLONAL; ANTIOXIDANTS; ASCORBIC ACID; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION MEDIATORS; INTEGRIN ALPHAV; INTEGRIN ALPHAVBETA3; INTEGRIN BETA3; KAEMPFEROLS; MINERALOCORTICOID RECEPTOR ANTAGONISTS; NF-KAPPA B; OSTEOPONTIN; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SPIRONOLACTONE;

EID: 84961789510     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-016-0479-3     Document Type: Article

References (33)

1. Anilkumar N, San Jose G, Sawyer I, Santos CX, Sand C, Brewer AC, Warren D, Shah AM (2013) A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells. Arterioscler Thromb Vasc Biol 33:e104–112
2. Antonov AS, Antonova GN, Munn DH, Mivechi N, Lucas R, Catravas JD, Verin AD (2011) αVβ3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt-dependent NF-κB activation. J Cell Physiol 226:469–476
3. Das R, Mahabeleshwar GH, Kundu GC (2003) Osteopontin stimulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through phosphatidylinositol 3-kinase/Akt signaling pathways in breast cancer cells. J Biol Chem 278:28593–28606
4. Farjo KM, Farjo RA, Halsey S, Moiseyev G, Ma JX (2012) Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism. Mol Cell Biol 32:5103–5115
5. Gilbert KC, Brown NJ (2010) Aldosterone and inflammation. Curr Opin Endocrinol Diabetes Obes 17:199–204
6. Gong JH, Shin D, Han SY, Kim JL, Kang YH (2012) Kaempferol suppresses eosinophil infiltration and airway inflammation in airway epithelial cells and in mice with allergic asthma. J Nutr 142:47–56
7. Goodwin JE, Feng Y, Velazquez H, Sessa WC (2013) Endothelial glucocorticoid receptor is required for protection against sepsis. Proc Natl Acad Sci U S A 110(1):306–11
8. Guaiquil VH, Vera JC, Golde DW (2001) Mechanism of vitamin C inhibition of cell death induced by oxidative stress in glutathione-depleted HL-60 cells. J Biol Chem 276:40955–40961
9. Hayashi H, Kobara M, Abe M, Tanaka N, Gouda E, Toba H, Yamada H, Tatsumi T, Nakata T, Matsubara H (2008) Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis. Hypertens Res 31:363–375
10. Higashiyama M, Ito T, Tanaka E, Shimada Y (2007) Prognostic significance of osteopontin expression in human gastric carcinoma. Ann Surg Oncol 14:3419–3427
11. Ichioka S, Sekiya N, Shibata M, Nakatsuka T (2007) AlphaV beta3 (alphavbeta3) integrin inhibition reduces leukocyte-endothelium interaction in a pressure-induced reperfusion model. Wound Repair Regen 15:572–576
12. Isoda K, Kamezawa Y, Ayaori M, Kusuhara M, Tada N, Ohsuzu F (2003) Osteopontin transgenic mice fed a high-cholesterol diet develop early fatty-streak lesions. Circulation 107:679–681
13. Johnson P, Ruffell B (2009) CD44 and its role in inflammation and inflammatory diseases. Inflamm Allergy Drug Targets 8:208–220
14. Kim TH, Ku SK, Lee IC, Bae JS (2012) Anti-inflammatory effects of kaempferol-3-O-sophoroside in human endothelial cells. Inflamm Res 61:217–224
15. Kumar R, Harris-Hooker S, Kumar R, Sanford G (2011) Co-culture of retinal and endothelial cells results in the modulation of genes critical to retinal neovascularization. Vasc Cell 23:27
16. Kumar V, Behera R, Lohite K, Karnik S, Kundu GC (2010) p38 kinase is crucial for osteopontin-induced furin expression that supports cervical cancer progression. Cancer Res 70:10381–10391
17. Leibovitz E, Ebrahimian T, Paradis P, Schiffrin EL (2009) Aldosterone induces arterial stiffness in absence of oxidative stress and endothelial dysfunction. J Hypertens 27:2192–2200
18. Li CH, Cheng YW, Hsu YT, Hsu YJ, Liao PL, Kang JJ (2010) Benzo[a]pyrene inhibits angiogenic factors-induced alphavbeta3 integrin expression, neovasculogenesis, and angiogenesis in human umbilical vein endothelial cells. Toxicol Sci 118:544–553
19. Matsui Y, Rittling SR, Okamoto H, Inobe M, Jia N, Shimizu T, Akino M, Sugawara T, Morimoto J, Kimura C, Kon S, Denhardt D, Kitabatake A, Uede T (2003) Osteopontin deficiency attenuates atherosclerosis in female apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 23:1029–1034
20. McNeill AM, Zhang C, Stanczyk FZ, Duckles SP, Krause DN (2002) Estrogen increases endothelial nitric oxide synthase via estrogen receptors in rat cerebral blood vessels: effect preserved after concurrent treatment with medroxyprogesterone acetate or progesterone. Stroke 33:1685–1691
21. Philip S, Kundu GC (2003) Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha /IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways. J Biol Chem 278:14487–14497
22. Poggio P, Grau JB, Field BC, Sainger R, Seefried WF, Rizzolio F, Ferrari G (2011) Osteopontin controls endothelial cell migration in vitro and in excised human valvular tissue from patients with calcific aortic stenosis and controls. J Cell Physiol 226:2139–2149
23. Queisser N, Oteiza PI, Stopper H, Oli RG, Schupp N (2011) Aldosterone induces oxidative stress, oxidative DNA damage and NF-κB-activation in kidney tubule cells. Mol Carcinog 50:123–135
24. Quintero M, Colombo SL, Godfrey A, Moncada S (2006) Mitochondria as signaling organelles in the vascular endothelium. Proc Natl Acad Sci U S A A103:5379–5384
25. Schildberger A, Rossmanith E, Eichhorn T, Strassl K, Weber V (2013) Monocytes, peripheral blood mononuclear cells, and THP-1 cells exhibit different cytokine expression patterns following stimulation with lipopolysaccharide. Mediat Inflamm 2013:697972
26. Steffen Y, Vuillaume G, Stolle K, Roewer K, Lietz M, Schueller J, Lebrun S, Wallerath T (2012) Cigarette smoke and LDL cooperate in reducing nitric oxide bioavailability in endothelial cells via effects on both eNOS and NADPH oxidase. Nitric Oxide 27:176–184
27. Sugiyama T, Yoshimoto T, Hirono Y, Suzuki N, Sakurada M, Tsuchiya K, Minami I, Iwashima F, Sakai H, Tateno T, Sato R, Hirata Y (2005) Aldosterone increases osteopontin gene expression in rat endothelial cells. Biochem Biophys Res Commun 336:163–167
28. Talmor Y, Bernheim J, Klein O, Green J, Rashid G (2008) Calcitriol blunts pro-atherosclerotic parameters through NFkappaB and p38 in vitro. Eur J Clin Invest 38:548–554
29. Urtasun R, Lopategi A, George J, Leung TM, Lu Y, Wang X, Ge X, Fiel MI, Nieto N (2012) Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling. Hepatology 55:594–608
30. Wang S, Kotamraju S, Konorev E, Kalivendi S, Joseph J, Kalyanaraman B (2002) Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide. Biochem J 367:729–740
31. Ward PA (2012) Inflammation and αvβ3 integrin. Am J Respir Crit Care Med 185:5–6
32. Xiao HB, Lu XY, Sun ZL, Zhang HB (2011) Kaempferol regulates OPN-CD44 pathway to inhibit the atherogenesis of apolipoprotein E deficient mice. Toxicol Appl Pharmacol 257:405–411
33. Zhang G, He B, Weber GF (2003) Growth factor signaling induces metastasis genes in transformed cells: molecular connection between Akt kinase and osteopontin in breast cancer. Mol Cell Biol 23:6507–6519