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Volumn 115, Issue , 2015, Pages 177-186

Kaempferol inhibits thrombosis and platelet activation

Author keywords

Flavonoid; Kaempferol; Platelet activation; Thromboembolism; Thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; ADRENALIN; BLOOD CLOTTING FACTOR 10; COLLAGEN; KAEMPFEROL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; POLYMER; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE 1; SYNAPTOPHYSIN; THROMBIN; TISSUE PLASMINOGEN ACTIVATOR; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; FIBRIN; KAEMPFEROL DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE;

EID: 84934886613     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2015.06.001     Document Type: Article
Times cited : (89)

References (47)
  • 2
    • 34250818668 scopus 로고    scopus 로고
    • Adhesion mechanisms in platelet function
    • Z.M. Ruggeri, and G.L. Mendolicchio Adhesion mechanisms in platelet function Circ. Res. 100 2007 1673 1685
    • (2007) Circ. Res. , vol.100 , pp. 1673-1685
    • Ruggeri, Z.M.1    Mendolicchio, G.L.2
  • 5
    • 0027158765 scopus 로고
    • Antiplatelet effects and vasorelaxing action of some constituents of Formosan plants
    • M.I. Chung, K.H. Gan, C.N. Lin, F.N. Ko, and C.M. Teng Antiplatelet effects and vasorelaxing action of some constituents of Formosan plants J. Nat. Prod. 56 1993 929 934
    • (1993) J. Nat. Prod. , vol.56 , pp. 929-934
    • Chung, M.I.1    Gan, K.H.2    Lin, C.N.3    Ko, F.N.4    Teng, C.M.5
  • 6
    • 2142837124 scopus 로고    scopus 로고
    • Potential impact of strawberries on human health: A review of the science
    • S.M. Hannum Potential impact of strawberries on human health: a review of the science Crit. Rev. Food Sci. Nutr. 44 2004 1 17
    • (2004) Crit. Rev. Food Sci. Nutr. , vol.44 , pp. 1-17
    • Hannum, S.M.1
  • 7
    • 84876315182 scopus 로고    scopus 로고
    • Effect of quercetin-rich onion peel extracts on arterial thrombosis in rats
    • S.M. Lee, J.Y. Moon, J.H. Chung, Y.J. Cha, and M.J. Shin Effect of quercetin-rich onion peel extracts on arterial thrombosis in rats Food Chem. Toxicol. 57 2013 99 105
    • (2013) Food Chem. Toxicol. , vol.57 , pp. 99-105
    • Lee, S.M.1    Moon, J.Y.2    Chung, J.H.3    Cha, Y.J.4    Shin, M.J.5
  • 8
    • 78649635059 scopus 로고    scopus 로고
    • Flavonols and cardiovascular disease
    • F. Perez-Vizcaino, and J. Duarte Flavonols and cardiovascular disease Mol. Asp. Med. 31 2010 478 494
    • (2010) Mol. Asp. Med. , vol.31 , pp. 478-494
    • Perez-Vizcaino, F.1    Duarte, J.2
  • 9
    • 0027504187 scopus 로고
    • Dietary antioxidant flavonoids and risk of coronary heart disease: The zutphen elderly study
    • M.G. Hertog, E.J. Feskens, P.C. Hollman, M.B. Katan, and D. Kromhout Dietary antioxidant flavonoids and risk of coronary heart disease: the zutphen elderly study Lancet 342 1993 1007 1011
    • (1993) Lancet , vol.342 , pp. 1007-1011
    • Hertog, M.G.1    Feskens, E.J.2    Hollman, P.C.3    Katan, M.B.4    Kromhout, D.5
  • 10
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • E. Middleton Jr., C. Kandaswami, and T.C. Theoharides The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer Pharmacol. Rev. 52 2000 673 751
    • (2000) Pharmacol. Rev. , vol.52 , pp. 673-751
    • Middleton, Jr.E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 12
    • 20444371369 scopus 로고    scopus 로고
    • The effect of short-term kaempferol exposure on reactive oxygen levels and integrity of human (HL-60) leukaemic cells
    • C.S. Bestwick, L. Milne, L. Pirie, and S.J. Duthie The effect of short-term kaempferol exposure on reactive oxygen levels and integrity of human (HL-60) leukaemic cells Biochim. Biophys. Acta 1740 2005 340 349
    • (2005) Biochim. Biophys. Acta , vol.1740 , pp. 340-349
    • Bestwick, C.S.1    Milne, L.2    Pirie, L.3    Duthie, S.J.4
  • 14
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    • M. Harwood, B. Danielewska-Nikiel, J.F. Borzelleca, G.W. Flamm, G.M. Williams, and T.C. Lines A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties Food Chem. Toxicol. 45 2007 2179 2205
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 2179-2205
    • Harwood, M.1    Danielewska-Nikiel, B.2    Borzelleca, J.F.3    Flamm, G.W.4    Williams, G.M.5    Lines, T.C.6
  • 15
    • 34250884053 scopus 로고    scopus 로고
    • Phenolic constituents in dried flowers of Aloe vera (Aloe barbadensis) and their in vitro antioxidative capacity
    • S. Keyhanian, and E. Stahl-Biskup Phenolic constituents in dried flowers of Aloe vera (Aloe barbadensis) and their in vitro antioxidative capacity Planta Med. 73 2007 599 602
    • (2007) Planta Med. , vol.73 , pp. 599-602
    • Keyhanian, S.1    Stahl-Biskup, E.2
  • 17
    • 14044267753 scopus 로고    scopus 로고
    • Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity
    • K. Brusselmans, R. Vrolix, G. Verhoeven, and J.V. Swinnen Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity J. Biol. Chem. 280 2005 5636 5645
    • (2005) J. Biol. Chem. , vol.280 , pp. 5636-5645
    • Brusselmans, K.1    Vrolix, R.2    Verhoeven, G.3    Swinnen, J.V.4
  • 18
    • 0035122662 scopus 로고    scopus 로고
    • Antibacterial action of tryptanthrin and kaempferol, isolated from the indigo plant (Polygonum tinctorium Lour.), against Helicobacter pylori-infected Mongolian gerbils
    • M. Kataoka, K. Hirata, T. Kunikata, S. Ushio, K. Iwaki, K. Ohashi, M. Ikeda, and M.J. Kurimoto Antibacterial action of tryptanthrin and kaempferol, isolated from the indigo plant (Polygonum tinctorium Lour.), against Helicobacter pylori-infected Mongolian gerbils Gastroenterology 36 2001 5 9
    • (2001) Gastroenterology , vol.36 , pp. 5-9
    • Kataoka, M.1    Hirata, K.2    Kunikata, T.3    Ushio, S.4    Iwaki, K.5    Ohashi, K.6    Ikeda, M.7    Kurimoto, M.J.8
  • 20
    • 33846640446 scopus 로고    scopus 로고
    • Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excels (Roxb) (Simaroubaceae)
    • M.R. Loizzo, A. Said, R. Tundis, K. Rashed, G.A. Statti, A. Hufner, and F. Menichini Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Ailanthus excels (Roxb) (Simaroubaceae) Phytother. Res. 21 2007 32 36
    • (2007) Phytother. Res. , vol.21 , pp. 32-36
    • Loizzo, M.R.1    Said, A.2    Tundis, R.3    Rashed, K.4    Statti, G.A.5    Hufner, A.6    Menichini, F.7
  • 22
    • 0029248203 scopus 로고
    • Identification of anticoagulant activities in the salivary glands of the soft tick, Ornithodoros savignyi
    • A.R. Gaspar, J.C. Crause, and A.W. Neitz Identification of anticoagulant activities in the salivary glands of the soft tick, Ornithodoros savignyi Exp. Appl. Acarol. 19 1995 117 127
    • (1995) Exp. Appl. Acarol. , vol.19 , pp. 117-127
    • Gaspar, A.R.1    Crause, J.C.2    Neitz, A.W.3
  • 23
    • 84921674046 scopus 로고    scopus 로고
    • Novel thrombolytic protease from edible and medicinal plant Aster yomena (Kitam.) Honda with anticoagulant activity: Purification and partial characterization
    • J.H. Choi, D.W. Kim, S.E. Park, B.S. Choi, K. Sapkota, S. Kim, and S.J. Kim Novel thrombolytic protease from edible and medicinal plant Aster yomena (Kitam.) Honda with anticoagulant activity: purification and partial characterization J. Biosci. Bioeng. 118 2014 372 377
    • (2014) J. Biosci. Bioeng. , vol.118 , pp. 372-377
    • Choi, J.H.1    Kim, D.W.2    Park, S.E.3    Choi, B.S.4    Sapkota, K.5    Kim, S.6    Kim, S.J.7
  • 26
    • 0025780346 scopus 로고
    • Antithrombotic and anticoagulant activity of depolymerized fragment of the glycosaminoglycan extracts from Stcjops japonicas Slenka
    • N. Suzki, K. Kitazoto, J. Takamatsu, and H. Saito Antithrombotic and anticoagulant activity of depolymerized fragment of the glycosaminoglycan extracts from Stcjops japonicas Slenka Thromb. Haemost. 65 1991 369 373
    • (1991) Thromb. Haemost. , vol.65 , pp. 369-373
    • Suzki, N.1    Kitazoto, K.2    Takamatsu, J.3    Saito, H.4
  • 27
    • 0020582095 scopus 로고
    • Mouse antithrombotic assay: A simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by ethyl alcohol
    • G. DiMinno, and M.J. Silver Mouse antithrombotic assay: a simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by ethyl alcohol J. Pharmacol. Exp. Ther. 225 1983 57 60
    • (1983) J. Pharmacol. Exp. Ther. , vol.225 , pp. 57-60
    • Diminno, G.1    Silver, M.J.2
  • 30
    • 84874652556 scopus 로고    scopus 로고
    • Purification and characterization of AHPM, a novel non-hemorrhagic P-IIIc metalloproteinase with α-fibrinogenolytic and platelet aggregation-inhibition activities from Agkistrodon halys pallas venom
    • J. Song, X. Xu, Y. Zhang, M. Guo, X. Yan, S. Wang, and S. Gao Purification and characterization of AHPM, a novel non-hemorrhagic P-IIIc metalloproteinase with α-fibrinogenolytic and platelet aggregation-inhibition activities from Agkistrodon halys pallas venom Biochimie 95 2013 709 718
    • (2013) Biochimie , vol.95 , pp. 709-718
    • Song, J.1    Xu, X.2    Zhang, Y.3    Guo, M.4    Yan, X.5    Wang, S.6    Gao, S.7
  • 33
    • 21644433234 scopus 로고    scopus 로고
    • Isolation of angiotensin converting enzyme (ACE) inhibitory flavonoids from Sedum sarmentosum
    • H. Oh, D.G. Kang, J.W. Kwon, T.O. Kwon, S.Y. Lee, D.B. Lee, and H.S. Lee Isolation of angiotensin converting enzyme (ACE) inhibitory flavonoids from Sedum sarmentosum Biol. Pharm. Bull. 27 2004 2035 2037
    • (2004) Biol. Pharm. Bull. , vol.27 , pp. 2035-2037
    • Oh, H.1    Kang, D.G.2    Kwon, J.W.3    Kwon, T.O.4    Lee, S.Y.5    Lee, D.B.6    Lee, H.S.7
  • 34
    • 33745937103 scopus 로고    scopus 로고
    • Kaempferol enhances endothelium-independent and dependent relaxation in the porcine coronary artery
    • Y.C. Xu, D.K. Yeung, R.Y. Man, and S.W. Leung Kaempferol enhances endothelium-independent and dependent relaxation in the porcine coronary artery Mol. Cell. Biochem. 287 2006 61 67
    • (2006) Mol. Cell. Biochem. , vol.287 , pp. 61-67
    • Xu, Y.C.1    Yeung, D.K.2    Man, R.Y.3    Leung, S.W.4
  • 36
    • 77249120609 scopus 로고    scopus 로고
    • Lipid-lowering and antioxidant effects of an ethyl acetate extract of fenugreek seeds in high-cholesterol fed rats
    • O. Belguith-Hadriche, M. Bouaziz, K. Jamoussi, A. El Feki, S. Sayadi, and F.J. Makni-Ayedi Lipid-lowering and antioxidant effects of an ethyl acetate extract of fenugreek seeds in high-cholesterol fed rats Agric. Food Chem. 58 2010 2116 2122
    • (2010) Agric. Food Chem. , vol.58 , pp. 2116-2122
    • Belguith-Hadriche, O.1    Bouaziz, M.2    Jamoussi, K.3    El Feki, A.4    Sayadi, S.5    Makni-Ayedi, F.J.6
  • 37
    • 78149285873 scopus 로고    scopus 로고
    • A series of natural flavonoids as thrombin inhibitors: Structure-activity relationships
    • L. Liu, H. Ma, N. Yang, Y. Tang, J. Guo, W. Tao, and J. Duan A series of natural flavonoids as thrombin inhibitors: structure-activity relationships Thromb. Res. 126 2010 e365 e378
    • (2010) Thromb. Res. , vol.126 , pp. e365-e378
    • Liu, L.1    Ma, H.2    Yang, N.3    Tang, Y.4    Guo, J.5    Tao, W.6    Duan, J.7
  • 38
    • 0020323468 scopus 로고
    • Inhibition of aggregation and secretion of human platelets by quercetin and other flavonoids: Structure-activity relationships
    • A. Beretz, J.P. Cazenave, and R. Anton Inhibition of aggregation and secretion of human platelets by quercetin and other flavonoids: structure-activity relationships Agents Actions 12 1982 3
    • (1982) Agents Actions , vol.12 , pp. 3
    • Beretz, A.1    Cazenave, J.P.2    Anton, R.3
  • 39
    • 0025941984 scopus 로고
    • Inhibition of platelet aggregation by some flavonoids
    • S.H. Tzeng, W.C. Ko, F.N. Ko, and C.M. Teng Inhibition of platelet aggregation by some flavonoids Thromb. Res. 64 1991 91 100
    • (1991) Thromb. Res. , vol.64 , pp. 91-100
    • Tzeng, S.H.1    Ko, W.C.2    Ko, F.N.3    Teng, C.M.4
  • 40
    • 24344437334 scopus 로고    scopus 로고
    • Inhibitiory effect of kaempferol against binding of platelet activating factor to its receptor
    • B.X. Zang, M. Jin, W. Wu, W.M. Chen, Y.Z. Piao, and J.R. Li Inhibitiory effect of kaempferol against binding of platelet activating factor to its receptor China J. Chin. Mater. Medica 29 2004 789 791
    • (2004) China J. Chin. Mater. Medica , vol.29 , pp. 789-791
    • Zang, B.X.1    Jin, M.2    Wu, W.3    Chen, W.M.4    Piao, Y.Z.5    Li, J.R.6
  • 41
    • 36148962373 scopus 로고    scopus 로고
    • A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids
    • B.L. Henry, B.H. Monien, P.E. Bock, and U.R. Desai A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids J. Biol. Chem. 282 2007 31891 31899
    • (2007) J. Biol. Chem. , vol.282 , pp. 31891-31899
    • Henry, B.L.1    Monien, B.H.2    Bock, P.E.3    Desai, U.R.4
  • 42
    • 34047229067 scopus 로고    scopus 로고
    • Thrombin generation and fibrin clot structure
    • A.S. Wolberg Thrombin generation and fibrin clot structure Blood Rev. 21 2007 131 142
    • (2007) Blood Rev. , vol.21 , pp. 131-142
    • Wolberg, A.S.1
  • 43
    • 77954985845 scopus 로고    scopus 로고
    • Platelet P2Y12 receptor inhibition: An update on clinical drug development
    • D. Vivas, and D.J. Angiolillo Platelet P2Y12 receptor inhibition: an update on clinical drug development Am. J. Cardiovasc. Drugs 10 2010 217 226
    • (2010) Am. J. Cardiovasc. Drugs , vol.10 , pp. 217-226
    • Vivas, D.1    Angiolillo, D.J.2
  • 45
    • 33846616434 scopus 로고    scopus 로고
    • Effect of diallyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats
    • K.C. Chan, M.C. Yin, and W.J. Chao Effect of diallyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats Food Chem. Toxicol. 45 2007 502 507
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 502-507
    • Chan, K.C.1    Yin, M.C.2    Chao, W.J.3
  • 46
    • 0034527312 scopus 로고    scopus 로고
    • Contribution of in vivo models of thrombosis to the discovery and development of novel antithrombotic agents
    • R.J. Leadley, L. Chi Jr., S.S. Rebello, and A. Gagnon Contribution of in vivo models of thrombosis to the discovery and development of novel antithrombotic agents J. Pharmacol. Toxicol. Methods 43 2000 101 116
    • (2000) J. Pharmacol. Toxicol. Methods , vol.43 , pp. 101-116
    • Leadley, R.J.1    Chi, Jr.L.2    Rebello, S.S.3    Gagnon, A.4
  • 47
    • 33744530746 scopus 로고    scopus 로고
    • Transendothelial migration of ferric ion in FeCl3 injured murine common carotid artery
    • M.T. Tseng, A. Dozier, B. Haribabu, and U.M. Graham Transendothelial migration of ferric ion in FeCl3 injured murine common carotid artery Thromb. Res. 118 2006 275 280
    • (2006) Thromb. Res. , vol.118 , pp. 275-280
    • Tseng, M.T.1    Dozier, A.2    Haribabu, B.3    Graham, U.M.4


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