Kaempferol suppresses collagen-induced platelet activation by inhibiting NADPH oxidase and protecting SHP-2 from oxidative inactivation

Free Radical Biology and Medicine

Volumn 83, Issue , 2015, Pages 41-53

  Wang, Su Bin ^a   Jang, Ji Yong ^a   Chae, Yun Hee ^a   Min, Ji Hyun ^a   Baek, Jin Young ^a   Kim, Myunghee ^a   Park, Yunjeong ^a   Hwang, Gwi Seo ^b   Ryu, Jae Sang ^a   Chang, Tong Shin ^a  

^a Ewha Womans University   (South Korea)

^b Gachon University College of Medicine   (South Korea)

Author keywords

Anti platelet; Free radicals; Kaempferol; NADPH oxidase; Oxidative inactivation; p47phox; phosphatase 2; Reactive oxygen species; Redox regulation; SH2 domain containing protein tyrosine

Indexed keywords

BRUTON TYROSINE KINASE; CALCIUM; COLLAGEN; KAEMPFEROL; PADGEM PROTEIN; PROTEIN KINASE SYK; PROTEIN P47; PROTEIN TYROSINE PHOSPHATASE SHP 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; UNCLASSIFIED DRUG; VAV1 PROTEIN; AGAMMAGLOBULINAEMIA TYROSINE KINASE; CHLORIDE; FERRIC CHLORIDE; FERRIC ION; KAEMPFEROL DERIVATIVE; PHOSPHOLIPASE C GAMMA; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE; VAV PROTEIN; VAV1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ARTERY THROMBOSIS; ARTICLE; BIOTINYLATION; CALCIUM CELL LEVEL; CAROTID ARTERY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; MALE; METABOLISM; OXIDATION REDUCTION REACTION; PHOSPHORYLATION; THROMBOSIS;

MUS;

ANIMALS; CHLORIDES; COLLAGEN; FERRIC COMPOUNDS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KAEMPFEROLS; MALE; MICE; MICE, INBRED C57BL; NADPH OXIDASE; OXIDATION-REDUCTION; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PLATELET ACTIVATION; PLATELET AGGREGATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-VAV; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THROMBOSIS;

EID: 84961289132     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.01.018     Document Type: Article

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