Preventive and curative glycoside kaempferol treatments attenuate the TH2-driven allergic airway disease

International Immunopharmacology

Volumn 9, Issue 13-14, 2009, Pages 1540-1548

  Medeiros, K C P ^a,b   Faustino, L ^a   Borduchi, E ^a   Nascimento, R J B ^b   Silva, T M S ^c   Gomes, E ^a   Piuvezam, M R ^b   Russo, M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

^c FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

Airway hyperresponsiveness; Airway inflammation; Flavonoid; Kaempferol glycoside; Ovalbumin

Indexed keywords

3 O [BETA DEXTRO GLYCOPIRANOSIL (1-6) ALPHA LEVO RAMNOPIRANOSIL] 7 O ALPHA LEVO RAMNOPIRANOSIL KAEMPFEROL; DEXAMETHASONE; FLAVONOID GLYCOSIDE; KAEMPFEROL DERIVATIVE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OVALBUMIN; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG ISOLATION; EOSINOPHIL COUNT; FEMALE; GENE REPRESSION; LEUKOCYTE COUNT; LUNG LAVAGE; LUNG MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; TH2 CELL;

ANIMALS; ANTIGENS, CD; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; DISACCHARIDES; EOSINOPHILS; FEMALE; GLYCOSIDES; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERLEUKIN-13; INTERLEUKIN-5; KAEMPFEROLS; LEUKOCYTES; LUNG; MICE; MICE, INBRED BALB C; MUCUS; OVALBUMIN; TH2 CELLS;

EID: 70350567788     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.09.005     Document Type: Article

References (49)

1. Factor P. Gene therapy for asthma. Mol Ther 7 (2003) 148-152
2. Gonzalo J.A., Tian J., Delaney T., Corcoran J., and Rottman J.B. ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nat Immunol 2 (2001) 597-604
3. Schramm C.M., Puddington L., Wu C., Guernsey L., Gharaee-Kermani M., Phan S.H., et al. Chronic inhaled ovalbumin exposure induces antigen-dependent but not antigen-specific inhalational tolerance in a murine model of allergic airway disease. Am J Pathol 164 (2004) 295-304
4. Schramm C.M., Puddington L., Yiamouyiannis C.A., Lingenheld E.G., Whiteley H.E., Wolyniec W.W., et al. Proinflammatory roles of T-cell receptor (TCR)gammadelta and TCRalphabeta lymphocytes in a murine model of asthma. Am J Respir Cell Mol Biol 22 (2000) 218-225
5. Yiamouyiannis C.A., Schramm C.M., Puddington L., Stengel P., Baradaran-Hosseini E., Wolyniec W.W., et al. Shifts in lung lymphocyte profiles correlate with the sequential development of acute allergic and chronic tolerant stages in a murine asthma model. Am J Pathol 154 (1999) 1911-1921
6. Clardy J., and Walsh C. Lessons from natural molecules. Nature 432 (2004) 829-837
7. Kawai M., Hirano T., Higa S., Arimitsu J., Maruta M., Kuwahara Y., et al. Flavonoids and related compounds as anti-allergic substances. Allergol Int 56 (2007) 113-123
8. Havsteen B.H. The biochemistry and medical significance of the flavonoids. Pharmacol Ther 96 (2002) 167-202
9. Lotito S.B., and Frei B. Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells structure-function relationships and activity after first pass metabolism. J Biol Chem 281 (2006) 37102-37110
10. Middleton Jr. E., Kandaswami C., and Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52 (2000) 673-751
11. Kimata M., Shichijo M., Miura T., Serizawa I., Inagaki N., and Nagai H. Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clin Exp Allergy 30 (2000) 501-508
12. Shichijo M., Yamamoto N., Tsujishita H., Kimata M., Nagai H., and Kokubo T. Inhibition of Syk activity and degranulation of human mast cells by flavonoids. Biol Pharm Bull 26 (2003) 1685-1690
13. Teixeira M.M., Williams T.J., and Hellewell P.G. Mechanisms and pharmacological manipulation of eosinophil accumulation in vivo. Trends Pharmacol Sci 16 (1995) 418-423
14. Hirano T., Higa S., Arimitsu J., Naka T., Shima Y., Ohshima S., et al. Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. Int Arch Allergy Immunol 134 (2004) 135-140
15. Das M., Ram A., and Ghosh B. Luteolin alleviates bronchoconstriction and airway hyperreactivity in ovalbumin sensitized mice. Inflamm Res 52 (2003) 101-106
16. Funaguchi N., Ohno Y., La B.L., Asai T., Yuhgetsu H., Sawada M., et al. Narirutin inhibits airway inflammation in an allergic mouse model. Clin Exp Pharmacol Physiol 34 (2007) 766-770
17. Rogerio A.P., Kanashiro A., Fontanari C., da Silva E.V., Lucisano-Valim Y.M., Soares E.G., et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res 56 (2007) 402-408
18. Wu Y.Q., Zhou C.H., Tao J., and Li S.N. Antagonistic effects of nobiletin, a polymethoxyflavonoid, on eosinophilic airway inflammation of asthmatic rats and relevant mechanisms. Life Sci 78 (2006) 2689-2696
19. Hamalainen M., Nieminen R., Vuorela P., Heinonen M., and Moilanen E. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediat Inflamm 3 (2007) 45673-47680
20. Noulin N., Quesniaux V.F., Schnyder-Candrian S., Schnyder B., Maillet I., Robert T., et al. Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin. J Immunol 175 (2005) 6861-6869
21. Keller A.C., Mucida D., Gomes E., Faquim-Mauro E., Faria A.M., Rodriguez D., et al. Hierarchical suppression of asthma-like responses by mucosal tolerance. J Allergy Clin Immunol 117 (2006) 283-290
22. Duan W., Kuo I.C., Selvarajan S., Chua K.Y., Bay B.H., and Wong W.S. Antiinflammatory effects of genistein, a tyrosine kinase inhibitor, on a guinea pig model of asthma. Am J Respir Crit Care Med 167 (2003) 185-192
23. Higa S., Hirano T., Kotani M., Matsumoto M., Fujita A., Suemura M., et al. Fisetin, a flavonol, inhibits TH2-type cytokine production by activated human basophils. J Allergy Clin Immunol 111 (2003) 1299-1306
24. + T cell engraftment. Clin Immunol 103 (2002) 132-144
25. Oku H., and Ishiguro K. Antipruritic and antidermatitic effect of extract and compounds of Impatiens balsamina L in atopic dermatitis model NC mice. Phytother Res 15 (2001) 506-510
26. Tu Y.C., Lian T.W., Yen J.H., Chen Z.T., and Wu M.J. Antiatherogenic effects of kaempferol and rhamnocitrin. J Agric Food Chem 55 (2007) 9969-9976
27. Kim A.S., Park A.H., Lee C., Choic I.W., Moonb D., Rohd H., et al. Epigallocatechin-3-gallate protects toluene diisocyanate-induced airway inflammation in a murine model of asthma. FEBS Lett 580 (2006) 1883-1890
28. Park S., Shin W., Seo J., and Kim E. Anthocyanins inhibit airway inflammation and hyperresponsiveness in a murine asthma model. Food Chem Toxicol 45 (2007) 1459-1467
29. Shi H., Qin S., Huang G., Chen Y., Xiao C., Xu H., et al. Infiltration of eosinophils into the asthmatic airways caused by interleukin 5. Am J Respir Cell Mol Biol 16 (1997) 220-224
30. Foster P.S., Hogan S.P., Ramsay A.J., Matthaei K.I., and Young I.G. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med 183 (1996) 195-201
31. Wang J., Palmer K., Lotvall J., Milan S., Lei X.F., Matthaei K.I., et al. Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia. J Clin Invest 102 (1998) 1132-1141
32. Kung T.T., Jones H., Adams III G.K., Umland S.P., Kreutner W., Egan R.W., et al. Characterization of a murine model of allergic pulmonary inflammation. Int Arch Allergy Immunol 105 (1994) 83-90
33. Keller A.C., Rodriguez D., and Russo M. Nitric oxide paradox in asthma. Mem Inst Oswaldo Cruz 100 1 (2005) 19-23
34. Blanchard C., Mishra A., Saito-Akei H., Monk P., Anderson I., and Rothenberg M.E. Inhibition of human interleukin-13-induced respiratory and esophageal inflammation by anti-human-interleukin-13 antibody (CAT-354). Clin Exp Allergy 35 (2005) 1096-1103
35. Bodey K.J., Semper A.E., Redington A.E., Madden J., Teran L.M., Holgate S.T., et al. Cytokine profiles of BAL T cells and T-cell clones obtained from human asthmatic airways after local allergen challenge. Allergy 54 (1999) 1083-1093
36. Hamelmann E., Schwarze J., Takeda K., Oshiba A., Larsen G.L., Irvin C.G., et al. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 156 (1997) 766-775
37. Kips J.C., Brusselle G.G., Joos G.F., Peleman R.A., Devos R.R., Tavernier J.H., et al. Importance of interleukin-4 and interleukin-12 in allergen-induced airway changes in mice. Int Arch Allergy Immunol 107 (1995) 115-118
38. Mattes J., Yang M., Mahalingam S., Kuehr J., Webb D.C., Simson L., et al. Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J Exp Med 195 (2002) 1433-1444
39. + T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am Rev Respir Dis 146 (1992) 374-377
40. Laprise C., Laviolette M., Boutet M., and Boulet L.P. Asymptomatic airway hyperresponsiveness: relationships with airway inflammation and remodeling. Eur Respir J 14 (1999) 63-73
41. Haselden B.M., Kay A.B., and Larche M. Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions. J Exp Med 189 (1999) 1885-1894
42. Brusselle G.G., Kips J.C., Tavernier J.H., Van Der Heyden J.G., Cuvelier C.A., Pauwels R.A., et al. Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin Exp Allergy 24 (1994) 73-80
43. Bureau F., Seumois G., Jaspar F., Vanderplasschen A., Detry B., Pastoret P., et al. CD40 engagement enhances eosinophil survival through induction of cellular inhibitor of apoptosis protein 2 expression: possible involvement in allergic inflammation. J Allergy Clin Immunol 110 (2002) 443-449
44. Coyle A.J., Lehar S., Lloyd C., Tian J., Delaney T., and Manning S. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity 13 (2000) 95-105
45. Calixto M.C., Triches K.M., and Calixto J.B. Analysis of the inflammatory response in the rat paw caused by the venom of Apis melifera bee. Inflamm Res 52 (2003) 132-139
46. Calixto J.B., Beirith A., Ferreira J., Santos A.R., Filho V.C., and Yunes R.A. Naturally occurring antinociceptive substances from plants. Phytother Res 14 (2000) 401-418
47. Cortes J.R., Perez G.M., Rivas M.D., and Zamorano J. Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3. J Immunol 179 (2007) 3881-3887
48. Brown G.R., Bamford A.M., Bowyer J., James D.S., Rankine N., Tang E., et al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett 10 (2000) 575-579
49. Theoharides T.C., Alexandrakis M., Kempuraj D., and Lytinas M. Anti-inflammatory actions of flavonoids and structural requirements for new design. Int J Immunopathol Pharmacol 14 (2001) 119-127