Cytoprotective effect of kaempferol against palmitic acid-induced pancreatic β-cell death through modulation of autophagy via AMPK/mTOR signaling pathway

Molecular and Cellular Endocrinology

Volumn 448, Issue , 2017, Pages 1-20

  Varshney, Ritu ^a   Gupta, Sumeet ^b   Roy, Partha ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

^b MAHARISHI MARKANDESHWAR DEEMED TO BE UNIVERSITY   (India)

Author keywords

AMPK mTOR; Apoptosis; Autophagy; Kaempferol; Palmitic acid; Pancreatic cell

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; KAEMPFEROL; MAMMALIAN TARGET OF RAPAMYCIN; PALMITIC ACID; SEQUESTOSOME 1; KAEMPFEROL DERIVATIVE; PROTECTIVE AGENT; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; LIMIT OF QUANTITATION; LIPOTOXICITY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; ANIMAL; APOPTOSIS; BIOLOGICAL MODEL; CELL PROLIFERATION; CELL SEPARATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LYSOSOME; METABOLISM; PATHOLOGY; PHAGOSOME; PHYSIOLOGICAL STRESS; SPRAGUE DAWLEY RAT; TUMOR CELL LINE; ULTRASTRUCTURE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SEPARATION; CELL SURVIVAL; CYTOPROTECTION; FEMALE; GENE EXPRESSION REGULATION; INSULIN-SECRETING CELLS; KAEMPFEROLS; LYSOSOMES; MODELS, BIOLOGICAL; PALMITIC ACID; PHAGOSOMES; PROTECTIVE AGENTS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TOR SERINE-THREONINE KINASES;

EID: 85017137771     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2017.02.033     Document Type: Article

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