Kaempferol induces ATM/p53-mediated death receptor and mitochondrial apoptosis in human umbilical vein endothelial cells

International Journal of Oncology

Volumn 48, Issue 5, 2016, Pages 2007-2014

  Lee, Chiu Fang ^a   Yang, Jai Sing ^b   Tsai, Fuu Jen ^b,c   Chiang, Ni Na ^a   Lu, Chi Cheng ^d   Huang, Yu Syuan ^e   Chen, Chun ^e   Chen, Fu An ^e  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e TAJEN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Extrinsic pathway; Human umbilical vein endothelial cells; Kaempferol; P53 ATM death receptor signaling; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ATM PROTEIN; CAFFEINE; CASPASE 3; CASPASE 8; CASPASE 8 INHIBITOR; CASPASE 9; DEATH RECEPTOR; DEATH RECEPTOR 4; DEATH RECEPTOR 5; FAS ANTIGEN; KAEMPFEROL; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; ATM PROTEIN, HUMAN; KAEMPFEROL DERIVATIVE; TP53 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG EXPOSURE; DRUG MECHANISM; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; MITOCHONDRION; TIME FACTOR; UMBILICAL VEIN ENDOTHELIAL CELL;

APOPTOSIS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELL SURVIVAL; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; KAEMPFEROLS; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84962568892     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2016.3420     Document Type: Article

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