Syk and Src are major pharmacological targets of a Cerbera manghas methanol extract with kaempferol-based anti-inflammatory activity

Journal of Ethnopharmacology

Volumn 151, Issue 2, 2014, Pages 960-969

  Jeong, Hye Yoon ^a   Sung, Gi Ho ^b   Kim, Ji Hye ^a   Yoon, Ju Young ^a   Yang, Yanyan ^a   Park, Jae Gwang ^a   Kim, Shi Hyoung ^a   Yi, Young Su ^a   Yang, Woo Seok ^a   Yoon, Deok Hyo ^c   Kim, Tae Woong ^c   Kim, Jong Hoon ^d   Cho, Jae Youl ^a  

^a Sungkyunkwan University   (South Korea)

^b Rural Development Administration   (South Korea)

^c Kangwon National University   (South Korea)

^d Chonbuk National University   (South Korea)

Author keywords

Anti inflammatory effect; Apocynaceae; Cerbera manghas L.; Inflammatory mediator; Src; Syk

Indexed keywords

CERBERA MANGHAS EXTRACT; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; KAEMPFEROL; LUCIFERASE; PLANT EXTRACT; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE SRC; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; APOCYNACEAE; ARTICLE; CERBERA MANGHAS; CONTROLLED STUDY; DRUG EFFECT; DRUG TARGETING; EMBRYO; ENZYME ACTIVITY; ENZYME ASSAY; GASTRITIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN TARGETING; REPORTER GENE;

APOCYNACEAE; CERBERA MANGHAS; MUS;

3-4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE, A TETRAZOLE; ACTIVATOR PROTEIN-1; ANTI-INFLAMMATORY EFFECT; AP-1; APOCYNACEAE; C-JUN N-TERMINAL KINASE; CERBERA MANGHAS L.; CMC; COX; CYCLOOXYGENASE; EIA; ENZYME IMMUNOASSAY; IKK; INDUCIBLE NO SYNTHASE; INFLAMMATORY MEDIATOR; INHIBITOR OF KAPPA B ALPHA; INOS; IΚB KINASE; IΚBΑ; JNK; LIPOPOLYSACCHARIDE; LPS; MTT; MYD88; MYELOID DIFFERENTIATION PRIMARY RESPONSE GENE (88); NF-ΚB; NITRIC OXIDE; NO; NUCLEAR FACTOR-ΚB; PEI; PG; PHORBOL 12-MYRISTATE 13-ACETATE; PHOSPHOINOSITIDE-3-KINASE; PI3K; PMA; POLYETHYLENIMINE.; PROSTAGLANDIN; REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION; RT-PCR; SODIUM CARBOXYMETHYLCELLULOSE; SPLEEN TYROSINE KINASE; SRC; SYK; TLR; TOLL-LIKE RECEPTORS (TLR);

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOCYNACEAE; CELL LINE; CELLS, CULTURED; CYCLOOXYGENASE 2; ETHANOL; GASTRITIS; HEK293 CELLS; HUMANS; HYDROCHLORIC ACID; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KAEMPFEROLS; MACROPHAGES; MALE; METHANOL; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; PROTEIN-TYROSINE KINASES; RNA, MESSENGER; SOLVENTS; SRC-FAMILY KINASES;

EID: 84895076421     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.12.009     Document Type: Article

References (49)

1. N. Bektas, R. Arslan, F. Goger, N. Kirimer, and Y. Ozturk Investigation for anti-inflammatory and anti-thrombotic activities of methanol extract of Capparis ovata buds and fruits J. Ethnopharmacol. 142 2012 48 52
2. S.E. Byeon, Y.S. Yi, J. Oh, B.C. Yoo, S. Hong, and J.Y. Cho The role of Src kinase in macrophage-mediated inflammatory responses Mediators Inflamm. 2012 2012 512926
3. A. Chaudhary, T.M. Fresquez, and M.J. Naranjo Tyrosine kinase Syk associates with toll-like receptor 4 and regulates signaling in human monocytic cells Immunol. Cell Biol. 85 2007 249 256
4. S. Cheenpracha, C. Karalai, A.P.Y. Rat, C. Ponglimanont, and K. Chantrapromma New cytotoxic cardenolide glycoside from the seeds of Cerbera manghas Chem. Pharm. Bull. 52 2004 1023 1025
5. J.Y. Cho, K.U. Baik, J.H. Jung, and M.H. Park In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa Eur. J. Pharmacol. 398 2000 399 407
6. J.Y. Cho, J.S. Park, K.U. Baik, J.G. Lee, H.P. Kim, E.S. Yoo, and M.H. Park Differential effect of phosphodiesterase IV inhibitor RP73401 on various inflammatory and immune responses relevent to rheumatoid arthritis Pharmacol. Res. 49 2004 423 431
7. G. Courtois, and T.D. Gilmore Mutations in the NF-kappaB signaling pathway: implications for human disease Oncogene 25 2006 6831 6843
8. K.M. Dennehy, G. Ferwerda, I. Faro-Trindade, E. Pyz, J.A. Willment, P.R. Taylor, A. Kerrigan, S.V. Tsoni, S. Gordon, F. Meyer-Wentrup, G.J. Adema, B.J. Kullberg, E. Schweighoffer, V. Tybulewicz, H.M. Mora-Montes, N.A. Gow, D.L. Williams, M.G. Netea, and G.D. Brown Syk kinase is required for collaborative cytokine production induced through dectin-1 and toll-like receptors Eur. J. Immunol. 38 2008 500 506
9. M. Eddleston, and H. Persson Acute plant poisoning and antitoxin antibodies J. Toxicol. Clin. Toxicol. 41 2003 309 315
10. D. Gerlier, and N. Thomasset Use of MTT colorimetric assay to measure cell activation J. Immunol. Methods 94 1986 57 63
11. L.C. Green, D.A. Wagner, J. Glogowski, P.L. Skipper, J.S. Wishnok, and S.R. Tannenbaum Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids Anal. Biochem. 126 1982 131 138
12. L.A. Griffiths, and G.E. Smith Metabolism of apigenin and related compounds in the rat. metabolite formation in vivo and by the intestinal microflora in vitro Biochem. J. 128 1972 901 911
13. H.E. Han, T.K. Kim, H.J. Son, W.J. Park, and P.L. Han Activation of autophagy pathway suppresses the expression of iNOS, IL6 and cell death of LPS-stimulated microglia cells Biomol. Ther. 21 2013 21 28
14. T.T. Hien, C. Navarro-Delmasure, and T. V.y. Toxicity and effects on the central nervous system of a Cerbera odollam leaf extract J. Ethnopharmacol. 34 1991 201 206
15. M.Z. Imam, N. Nahar, S. Akter, and M.S. Rana Antinociceptive activity of methanol extract of flowers of Impatiens balsamina J. Ethnopharmacol. 142 2012 804 810
16. W. m.; J.Y. Chung, J. Bhan, J. Lim, S.T. Lee, K. Chu, and M. Kim Sun ginseng protects endothelial progenitor cells from senescence associated apoptosis J. Ginseng Res. 36 2012 78 85
17. T. Ismail, P. Sestili, and S. Akhtar Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects J. Ethnopharmacol. 143 2012 397 405
18. H.Y. Jeong, S.H. Moh, Y. Yang, T. Yu.; J. Oh.; D. Jeong, D.H. Yoon, K.M. Park, S. Lee, T.W. Kim, S. Hong, S.Y. Kim, and J.Y. Cho Src and Syk are targeted to an anti-inflammatory ethanol extract of Aralia continentalis J. Ethnopharmacol. 143 2012 746 753
19. S. Kumar-Roine, M. Matsui, K. Reybier, H.T. Darius, M. Chinain, S. Pauillac, and D. Laurent Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages J. Ethnopharmacol. 123 2009 369 377
20. E.H. Lee, and S.J. Lim Cyclooxygenase-2/prostaglandin E2 inducing effects of α-tocopheryl polyethylene glycol succinate in lung epithelial cells Arch. Pharmacal Res. 35 2012 1639 1644
21. Y.G. Lee, B.M. Chain, and J.Y. Cho Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappaB alpha via activation of the phosphoinositide-3-kinase and Akt pathways Int. J. Biochem. Cell Biol. 41 2009 811 821
22. Y.C. Lin, D.Y. Huang, C.L. Chu, and W.W. Lin Anti-inflammatory actions of Syk inhibitors in macrophages involve non-specific inhibition of toll-like receptors-mediated JNK signaling pathway Mol. Immunol. 47 2010 1569 1578
23. L. Liu, M. Heinrich, S. Myers, and S.A. Dworjanyn Towards a better understanding of medicinal uses of the brown seaweed sargassum in traditional Chinese medicine: a phytochemical and pharmacological review J. Ethnopharmacol. 142 2012 591 619
24. C.W. Lukhoba, M.S.J. Simmonds, and A.J. Paton Plectranthus: a review of ethnobotanical uses J. Ethnopharmacol. 103 2006 1 24
25. M. Magnani, R. Crinelli, M. Bianchi, and A. Antonelli The ubiquitin-dependent proteolytic system and other potential targets for the modulation of nuclear factor-kB (NF-kB) Curr. Drug Targets 1 2000 387 399
26. E.M. Massarotti Clinical and patient-reported outcomes in clinical trials of abatacept in the treatment of rheumatoid arthritis Clin. Ther. 30 2008 429 442
27. P.L. McGeer, and E.G. McGeer Glial reactions in Parkinson's disease Mov. Disord. 23 2008 474 483
28. T.R. Norton, M.L. Bristol, G.W. Read, O.A. Bushnell, M. Kashiwagi, C.M. Okinaga, and C.S. Oda Pharmacological evaluation of medicinal plants from Western Samoa Thai J. Pharm. Sci. 62 1973 1077 1082
29. P.H. Park, J. Hur, D.S. Lee, Y.C. Kim, G.S. Jeong, and D.H. Sohn Inhibition of nitric oxide production by ethyl digallates isolated from Gal la Rhois in RAW 264.7 macrophages Biomol. Ther. 19 2011 419 424
30. D.J. Radford, A.D. Gillies, J.A. Hinds, and P. Duffy Naturally occurring cardiac glycosides Med. J. Aust. 144 1986 540 544
31. A. Ray, K. Chakraborty, and P. Ray Immunosuppressive MDSCs induced by TLR signaling during infection and role in resolution of inflammation Front. Cell. Infect. Microbiol. 3 2013 52
32. A.J. Samuel, S. Mohan, D.K. Chellappan, A. Kalusalingam, and S. Ariamuthu Hibiscus vitifolius (Linn.) root extracts shows potent protective action against anti-tubercular drug induced hepatotoxicity J. Ethnopharmacol. 141 2012 396 402
33. W. Seok Yang, J. Lee, T. Woong Kim, J. Hye Kim, S. Lee, M. Hee Rhee, S. Hong, and J. Youl Cho Src/NF-kappaB-targeted inhibition of LPS-induced macrophage activation and dextran sodium sulphate-induced colitis by Archidendron clypearia methanol extract J. Ethnopharmacol. 142 2012 287 293
34. T. Shen, J. Lee, M.H. Park, Y.G. Lee, H.S. Rho, Y.S. Kwak, M.H. Rhee, Y.C. Park, and J.Y. Cho Ginsenoside Rp(1), a Ginsenoside derivative, blocks promoter activation of iNOS and COX-2 genes by suppression of an IKK beta-mediated NF-kappa B pathway in HEK293 cells J. Ginseng Res. 35 2011 200 208
35. M.K. Shim, and Y.J. Lee Estrogen receptor is activated by Korean red ginseng in vitro but not in vivo J. Ginseng Res. 36 2012 169 175
36. S.B. Song, N.H. Tung, T.H. Quang, N.T. Ngan, K.E. Kim, and Y.H. Kim Inhibition of TNF-α-mediated NF-κB transcriptional activity in HepG2 cells by dammarane-type saponins from Panax ginseng leaves J. Ginseng Res. 36 2012 146 152
37. V.A. Vo, J.W. Lee, J.E. Chang, J.Y. Kim, N.H. Kim, H.J. Lee, S.S. Kim, W. Chun, and Y.S. Kwon Avicularin inhibits lipopolysaccharide-induced inflammatory response by suppressing ERK phosphorylation in RAW 264.7 macrophages Biomol. Ther. 20 2012 532 537
38. G.F. Wang, Y.W. Guo, B. Feng, L. Li, C.G. Huang, and B.H. Jiao Tanghinigenin from seeds of Cerbera manghas L. induces apoptosis in human promyelocytic leukemia HL-60 cells Environ. Toxicol. Pharmacol. 30 2010 31 36
39. M. Xiang, J. Wang, Y. Zhang, J. Ling, and X. Xu Attenuation of aortic injury by ursolic acid through RAGE-Nox-NF-κB pathway in streptozocin-induced diabetic rats Arch. Pharmacal Res. 35 2012 877 886
40. W.S. Yang, D. Jeong, G. Nam, Y.S. Yi, D.H. Yoon, T.W. Kim, Y.C. Park, H. Hwang, M.H. Rhee, S. Hong, and J.Y. Cho AP-1 pathway-targeted inhibition of inflammatory responses in LPS-treated macrophages and EtOH/HCl-treated stomach by Archidendron clypearia methanol extract J. Ethnopharmacol. 146 2013 637 644
41. Y. Yang, T. Yu, H.J. Jang, S.E. Byeon, S.Y. Song, B.H. Lee, M.H. Rhee, T.W. Kim, J. Lee, S. Hong, and J.Y. Cho In vitro and in vivo anti-inflammatory activities of Polygonum hydropiper methanol extract J. Ethnopharmacol. 139 2012 616 625
42. Y. Yang, T. Yu, Y.G. Lee, W.S. Yang, J. Oh, D. Jeong, S. Lee, T.W. Kim, Y.C. Park, G.H. Sung, and J.Y. Cho Methanol extract of Hopea odorata suppresses inflammatory responses via the direct inhibition of multiple kinases J. Ethnopharmacol. 145 2013 598 607
43. D.S. Yoe, H.S. Rho, Y.G. Lee, M.H. Yeom, D.H. Kim, S.J. Lee, S. Hong, J. Lee, and J.Y. Cho Ginsenoside F1 modulates cellular responses of skin melanoma cells J. Ginseng Res. 35 2011 86 91
44. T. Yu, H.M. Ahn, T. Shen, K. Yoon, H.J. Jang, Y.J. Lee, H.M. Yang, J.H. Kim, C. Kim, M.H. Han, S.H. Cha, T.W. Kim, S.Y. Kim, J. Lee, and J.Y. Cho Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans J. Ethnopharmacol. 137 2011 1197 1206
45. T. Yu, H.M. Ahn, T. Shen, K. Yoon, H.J. Jang, Y.J. Lee, H.M. Yang, J.H. Kim, C. Kim, M.H. Han, S.H. Cha, T.W. Kim, S.Y. Kim, J. Lee, and J.Y. Cho Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans J. Ethnopharmacol. 137 2011 1197 1206
46. T. Yu, J. Lee, Y.G. Lee, S.E. Byeon, M.H. Kim, E.H. Sohn, Y.J. Lee, S.G. Lee, and J.Y. Cho In vitro and in vivo anti-inflammatory effects of ethanol extract from Acer tegmentosum J. Ethnopharmacol. 128 2010 139 147
47. T. Yu, J. Shim, Y. Yang, S.E. Byeon, J.H. Kim, H.S. Rho, H. Park, G.H. Sung, T.W. Kim, M.H. Rhee, and J.Y. Cho 3-(4-(tert-Octyl)phenoxy)propane-1,2- diol suppresses inflammatory responses via inhibition of multiple kinases Biochem. Pharmacol. 83 2012 1540 1551
48. T. Yu, Y.S. Yi, Y. Yang, J. Oh, D. Jeong, and J.Y. Cho The pivotal role of TBK1 in inflammatory responses mediated by macrophages Mediators Inflamm. 2012 2012 979105
49. R. Zhou, Z.H. Lin, C.S. Jiang, J.X. Gong, L.L. Chen, Y.W. Guo, and X. Shen Marine natural product des-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice via ameliorating inflammation Acta Pharmacol. Sin. 34 2013 1325 1336