메뉴 건너뛰기




Volumn 38, Issue 1, 2015, Pages 94-101

Protective Effect of Kaempferol on LPS plus ATP-Induced Inflammatory Response in Cardiac Fibroblasts

Author keywords

Akt; cardiac fibroblasts; inflammatory response; kaempferol; NF B

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIINFLAMMATORY AGENT; DRUG THERAPY; DRUG TOXICITY; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; KAEMPFEROL; KAEMPFEROL DERIVATIVE; LIPOPOLYSACCHARIDE; PHARMACOLOGY; PROTECTIVE AGENT; PROTEIN KINASE B; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84964255463     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-0011-2     Document Type: Article
Times cited : (72)

References (31)
  • 1
    • 84856620089 scopus 로고    scopus 로고
    • Inflammation and related biomarkers in cardiovascular disease
    • PID: 22296190
    • Bartunek, J., and M. Vanderheyden. 2012. Inflammation and related biomarkers in cardiovascular disease. Biomarkers in Medicine 6: 1–3.
    • (2012) Biomarkers in Medicine , vol.6 , pp. 1-3
    • Bartunek, J.1    Vanderheyden, M.2
  • 2
    • 79951677392 scopus 로고    scopus 로고
    • Inflammasome activation in reperfusion injury: friendly fire on myocardial infarction?
    • PID: 21282497
    • Grundmann, S., C. Bode, and M. Moser. 2011. Inflammasome activation in reperfusion injury: friendly fire on myocardial infarction? Circulation 123: 574–576.
    • (2011) Circulation , vol.123 , pp. 574-576
    • Grundmann, S.1    Bode, C.2    Moser, M.3
  • 4
    • 84899081318 scopus 로고    scopus 로고
    • Fibroblasts in myocardial infarction: a role in inflammation and repair
    • COI: 1:CAS:528:DC%2BC2cXhtFSmsLg%3D, PID: 24321195
    • Shinde, A.V., and N.G. Frangogiannis. 2014. Fibroblasts in myocardial infarction: a role in inflammation and repair. Journal of Molecular and Cellular Cardiology 70: 74–82.
    • (2014) Journal of Molecular and Cellular Cardiology , vol.70 , pp. 74-82
    • Shinde, A.V.1    Frangogiannis, N.G.2
  • 10
    • 79951923564 scopus 로고    scopus 로고
    • The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux
    • COI: 1:CAS:528:DC%2BC3MXivVWitb0%3D, PID: 21139040
    • An, G.H., J. Gallegos, and M.E. Morris. 2011. The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux. Drug Metabolism and Disposition 39: 426–432.
    • (2011) Drug Metabolism and Disposition , vol.39 , pp. 426-432
    • An, G.H.1    Gallegos, J.2    Morris, M.E.3
  • 11
    • 10944235044 scopus 로고    scopus 로고
    • Anti-inflammatory plant flavonoids and cellular action mechanisms
    • COI: 1:CAS:528:DC%2BD2cXhtVequ7jL, PID: 15539763
    • Kim, H.P., K.H. Son, H.W. Chang, and S.S. Kang. 2004. Anti-inflammatory plant flavonoids and cellular action mechanisms. Journal of Pharmacological Sciences 96: 229–245.
    • (2004) Journal of Pharmacological Sciences , vol.96 , pp. 229-245
    • Kim, H.P.1    Son, K.H.2    Chang, H.W.3    Kang, S.S.4
  • 12
    • 80052560168 scopus 로고    scopus 로고
    • Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells
    • COI: 1:CAS:528:DC%2BC3MXhtF2hsb%2FM, PID: 21449918
    • Park, S.E., K. Sapkota, S. Kim, H. Kim, and S.J. Kim. 2011. Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells. British Journal of Pharmacology 164: 1008–1025.
    • (2011) British Journal of Pharmacology , vol.164 , pp. 1008-1025
    • Park, S.E.1    Sapkota, K.2    Kim, S.3    Kim, H.4    Kim, S.J.5
  • 14
    • 84918815015 scopus 로고    scopus 로고
    • Protective effects of kaempferol on lipopolysaccharide-induced mastitis in mice
    • Cao, R.F., K.Q. Fu, X.P. Lv, W.S. Li, and N.S. Zhang. 2014. Protective effects of kaempferol on lipopolysaccharide-induced mastitis in mice. Inflammation. doi:10.1007/s10753-014-9870-9.
    • (2014) Inflammation
    • Cao, R.F.1    Fu, K.Q.2    Lv, X.P.3    Li, W.S.4    Zhang, N.S.5
  • 15
    • 84904727195 scopus 로고    scopus 로고
    • Kaempferol inhibits IL-1β-stimulated, RANKL-mediated osteoclastogenesis via downregulation of MAPKs, c-Fos, and NFATc1
    • Lee, W.S., E.G. Lee, M.S. Sung, and W.H. Yoo. 2014. Kaempferol inhibits IL-1β-stimulated, RANKL-mediated osteoclastogenesis via downregulation of MAPKs, c-Fos, and NFATc1. Inflammation. doi:10.1007/s10753-014-9849-6.
    • (2014) Inflammation
    • Lee, W.S.1    Lee, E.G.2    Sung, M.S.3    Yoo, W.H.4
  • 16
    • 63449137137 scopus 로고    scopus 로고
    • Treatment with TNF-α or bacterial lipopolysaccharide attenuates endocardial endothelial cell-mediated stimulation of cardiac fibroblasts
    • Kuruvilla, L., and C.C. Kartha. 2009. Treatment with TNF-α or bacterial lipopolysaccharide attenuates endocardial endothelial cell-mediated stimulation of cardiac fibroblasts. Journal of Biomedical Science 16. doi: 10.1186/1423-0127-16-21
    • (2009) Journal of Biomedical Science , pp. 16
    • Kuruvilla, L.1    Kartha, C.C.2
  • 17
    • 9744247507 scopus 로고    scopus 로고
    • Anoxia-reoxygenation stimulates collagen type-I and MMP-1 expression in cardiac fibroblasts modulation by the PPAR-γ ligand pioglitazone
    • Chen, K., D.Y. Li, X.J. Zhang, P.L. Hermonat, and J.L. Mehta. 2012. Anoxia-reoxygenation stimulates collagen type-I and MMP-1 expression in cardiac fibroblasts modulation by the PPAR-γ ligand pioglitazone. Journal of Cardiovascular Pharmacology 44: 682–687.
    • (2012) Journal of Cardiovascular Pharmacology , vol.44 , pp. 682-687
    • Chen, K.1    Li, D.Y.2    Zhang, X.J.3    Hermonat, P.L.4    Mehta, J.L.5
  • 19
    • 78649819208 scopus 로고    scopus 로고
    • Chemical probing reveals insights into the signaling mechanism of inflammasome activation
    • COI: 1:CAS:528:DC%2BC3cXhsFWqu7nP, PID: 20856264
    • Gong, Y.N., X.M. Wang, J.Y. Wang, Z.X. Yang, S. Li, J.L. Yang, L.P. Liu, X.G. Lei, and F. Shao. 2010. Chemical probing reveals insights into the signaling mechanism of inflammasome activation. Cell Research 20: 1289–1305.
    • (2010) Cell Research , vol.20 , pp. 1289-1305
    • Gong, Y.N.1    Wang, X.M.2    Wang, J.Y.3    Yang, Z.X.4    Li, S.5    Yang, J.L.6    Liu, L.P.7    Lei, X.G.8    Shao, F.9
  • 20
    • 0042009399 scopus 로고    scopus 로고
    • Maturation and release of interleukin-1beta by lipopolysaccharide-primed mouse Schwann cells require the stimulation of P2X7 receptors
    • COI: 1:CAS:528:DC%2BD3sXmtFeqsLs%3D, PID: 12796490
    • Colomar, A., V. Marty, C. Médina, C. Combe, P. Parnet, and T. Amédée. 2003. Maturation and release of interleukin-1beta by lipopolysaccharide-primed mouse Schwann cells require the stimulation of P2X7 receptors. Journal of Biological Chemistry 278: 30732–30740.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 30732-30740
    • Colomar, A.1    Marty, V.2    Médina, C.3    Combe, C.4    Parnet, P.5    Amédée, T.6
  • 22
    • 72449194919 scopus 로고    scopus 로고
    • Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt
    • COI: 1:CAS:528:DC%2BD1MXhtlSqsLnL
    • Bai, D., L. Ueno, and P.K. Vogt. 2009. Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt. International Journal of Cancer 125: 2863–2870.
    • (2009) International Journal of Cancer , vol.125 , pp. 2863-2870
    • Bai, D.1    Ueno, L.2    Vogt, P.K.3
  • 23
    • 0035379555 scopus 로고    scopus 로고
    • Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-κB through utilization of the IκB kinase and activation of the mitogen-activated protein kinase p38
    • COI: 1:CAS:528:DC%2BD3MXkt12kur8%3D, PID: 11259436
    • Madrid, L.V., M.W. Mayo, J.Y. Reuther, and A.S. Baldwin Jr. 2001. Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-κB through utilization of the IκB kinase and activation of the mitogen-activated protein kinase p38. Journal of Biological Chemistry 276: 18934–18940.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 18934-18940
    • Madrid, L.V.1    Mayo, M.W.2    Reuther, J.Y.3    Baldwin, A.S.4
  • 24
    • 84886042230 scopus 로고    scopus 로고
    • IL-1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium
    • COI: 1:CAS:528:DC%2BC3sXhs1eqs7%2FL
    • Saxena, A., W. Chen, Y. Su, V. Rai, O.U. Uche, N. Li, and N.G. Frangogiannis. 2013. IL-1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium. Journal of Immunology 191: 4838–4848.
    • (2013) Journal of Immunology , vol.191 , pp. 4838-4848
    • Saxena, A.1    Chen, W.2    Su, Y.3    Rai, V.4    Uche, O.U.5    Li, N.6    Frangogiannis, N.G.7
  • 25
    • 84875069394 scopus 로고    scopus 로고
    • Fibroblasts in post-infarction inflammation and cardiac repair
    • COI: 1:CAS:528:DC%2BC38XhtlKrt77J, PID: 22982064
    • Chen, W., and N.G. Frangogiannis. 2013. Fibroblasts in post-infarction inflammation and cardiac repair. Biochimica et Biophysica Acta 1833: 945–953.
    • (2013) Biochimica et Biophysica Acta , vol.1833 , pp. 945-953
    • Chen, W.1    Frangogiannis, N.G.2
  • 26
    • 0037451357 scopus 로고    scopus 로고
    • Transcriptional activation of the NF-kappaB p65 subunit by mitogen-and stress-activated protein kinase-1 (MSK1)
    • COI: 1:CAS:528:DC%2BD3sXit1yrsbc%3D, PID: 12628924
    • Vermeulen, L., G. De Wilde, P. Van Damme, W. Vanden Berghe, and G. Haegeman. 2003. Transcriptional activation of the NF-kappaB p65 subunit by mitogen-and stress-activated protein kinase-1 (MSK1). The EMBO Journal 22: 1313–1324.
    • (2003) The EMBO Journal , vol.22 , pp. 1313-1324
    • Vermeulen, L.1    De Wilde, G.2    Van Damme, P.3    Vanden Berghe, W.4    Haegeman, G.5
  • 27
    • 84877699705 scopus 로고    scopus 로고
    • Anti-inflammatory effect of Ginsenoside Rg5 in lipopolysaccharide-stimulated BV2 microglial cells
    • PID: 23698769
    • Lee, Y.Y., J.S. Park, J.S. Jung, D.H. Kim, and H.S. Kim. 2013. Anti-inflammatory effect of Ginsenoside Rg5 in lipopolysaccharide-stimulated BV2 microglial cells. International Journal of Molecular Sciences 14: 9820–9833.
    • (2013) International Journal of Molecular Sciences , vol.14 , pp. 9820-9833
    • Lee, Y.Y.1    Park, J.S.2    Jung, J.S.3    Kim, D.H.4    Kim, H.S.5
  • 28
    • 84939881560 scopus 로고    scopus 로고
    • MAPK and NF-κB pathways are involved in bisphenol A-induced TNF-α and IL-6 production in BV2 microglial cells
    • Zhu, J.Y., L. Jiang, Y.Q. Liu, W.Y. Qian, J.L. Liu, J. Zhou, R. Gao, H. Xiao, and J. Wang. 2014. MAPK and NF-κB pathways are involved in bisphenol A-induced TNF-α and IL-6 production in BV2 microglial cells. Inflammation. doi:10.1007/s10753-014-9971-5.
    • (2014) Inflammation
    • Zhu, J.Y.1    Jiang, L.2    Liu, Y.Q.3    Qian, W.Y.4    Liu, J.L.5    Zhou, J.6    Gao, R.7    Xiao, H.8    Wang, J.9
  • 29
    • 84936769156 scopus 로고    scopus 로고
    • Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor Kappa B (NF-κB) signaling pathway
    • Li, G.F., J.H. Fu, Y. Zhao, K.Q. Ji, T. Luan, and B. Zang. 2014. Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor Kappa B (NF-κB) signaling pathway. Inflammation. doi:10.1007/s10753-014-9957-3.
    • (2014) Inflammation
    • Li, G.F.1    Fu, J.H.2    Zhao, Y.3    Ji, K.Q.4    Luan, T.5    Zang, B.6
  • 31
    • 79955039886 scopus 로고    scopus 로고
    • Hyaluronan inhibits Akt, leading to nuclear factor-κB down-regulation in lipopolysaccharide-stimulated U937 macrophages
    • COI: 1:CAS:528:DC%2BC3MXls1GntLg%3D, PID: 21422731
    • Yasuda, T. 2011. Hyaluronan inhibits Akt, leading to nuclear factor-κB down-regulation in lipopolysaccharide-stimulated U937 macrophages. Journal of Pharmacological Sciences 115: 509–515.
    • (2011) Journal of Pharmacological Sciences , vol.115 , pp. 509-515
    • Yasuda, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.