Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB

Journal of Nutritional Biochemistry

Volumn 24, Issue 4, 2013, Pages 638-646

  Zhang, Yanling ^a,b   Zhen, Wei ^b   Maechler, Pierre ^c   Liu, Dongmin ^b  

^a NORTHWESTERN POLYTECHNICAL UNIVERSITY   (China)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

cells; CAMP; CREB; Islets; Kaempferol; Palmitate; PDX 1

Indexed keywords

CASPASE 3; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; INSULIN; KAEMPFEROL; PALMITIC ACID; PROTEIN BCL 2; PROTEIN KINASE B; TRANSCRIPTION FACTOR PDX 1;

APOPTOSIS; ARTICLE; CELL FUNCTION; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; GINKGO BILOBA; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERLIPIDEMIA; INSULIN RELEASE; INSULIN SYNTHESIS; LIPOTOXICITY; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL LINE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; HOMEODOMAIN PROTEINS; HUMANS; ISLETS OF LANGERHANS; KAEMPFEROLS; PALMITIC ACID; PHOSPHORYLATION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

GINKGO BILOBA;

EID: 84875069606     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2012.03.008     Document Type: Article

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