메뉴 건너뛰기




Volumn 9, Issue OCT, 2018, Pages

Diamonds in the rough: Harnessing tumor-Associated myeloid cells for cancer therapy

Author keywords

Cancer immunotherapy; Myeloid derived suppressor cells; Tumor microenvironment; Tumor Associated dendritic cells; Tumor Associated macrophages; Tumor Associated neutrophils

Indexed keywords

BONE MARROW CELL; DENDRITIC CELL; HUMAN; IMMUNOLOGY; IMMUNOTHERAPY; MACROPHAGE; MYELOID-DERIVED SUPPRESSOR CELL; NEOPLASM; NEUTROPHIL; PATHOLOGY; PROCEDURES; T LYMPHOCYTE; TUMOR MICROENVIRONMENT;

EID: 85055207942     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2018.02250     Document Type: Review
Times cited : (31)

References (249)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell (2011) 144:646-74. doi: 10.1016/j.cell.2011.02.013.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 5
    • 85017333050 scopus 로고    scopus 로고
    • Myeloid cells that impair immunotherapy are restored in melanomas with acquired resistance to braf inhibitors
    • Steinberg SM, Shabaneh TB, Zhang P, Martyanov V, Li Z, Malik BT, et al. Myeloid cells that impair immunotherapy are restored in melanomas with acquired resistance to BRAF inhibitors. Cancer Res. (2017) 77:1599-610. doi:10.1158/0008-5472.CAN-16-1755.
    • (2017) Cancer Res. , vol.77 , pp. 1599-1610
    • Steinberg, S.M.1    Shabaneh, T.B.2    Zhang, P.3    Martyanov, V.4    Li, Z.5    Malik, B.T.6
  • 6
    • 85016111488 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells
    • Gabrilovich DI. Myeloid-derived suppressor cells. Cancer Immunol Res. (2017) 5:3-8. doi:10.1158/2326-6066.CIR-16-0297.
    • (2017) Cancer Immunol Res. , vol.5 , pp. 3-8
    • Gabrilovich, D.1
  • 7
    • 85043501427 scopus 로고    scopus 로고
    • Targeting macrophages in cancer: From bench to bedside
    • Poh AR, Ernst M. Targeting macrophages in cancer: from bench to bedside. Front Oncol. (2018) 8:1-16. doi:10.3389/fonc.2018.00049.
    • (2018) Front Oncol. , vol.8 , pp. 1-16
    • Poh, A.R.1    Ernst, M.2
  • 8
    • 84876424760 scopus 로고    scopus 로고
    • Macrophage regulation of tumor responses to anticancer therapies
    • De Palma M, Lewis CE. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell (2013) 23:277-86. doi: 10.1016/j.ccr.2013.02.013.
    • (2013) Cancer, Cell , vol.23 , pp. 277-286
    • De Palma, M.1    Lewis, C.E.2
  • 9
    • 85026758189 scopus 로고    scopus 로고
    • Exploiting tumor-Associated dendritic cell heterogeneity for novel cancer therapies
    • Keirsse J, Van Damme H, Van Ginderachter JA, Laoui D. Exploiting tumor-Associated dendritic cell heterogeneity for novel cancer therapies. J Leukoc Biol. (2017) 102:317-24. doi:10.1189/jlb.4MR1116-466R.
    • (2017) J Leukoc Biol , vol.102 , pp. 317-324
    • Keirsse, J.1    Van Damme, H.2    Van Ginderachter, J.A.3    Laoui, D.4
  • 10
    • 77955038532 scopus 로고    scopus 로고
    • Different tumor microenvironments contain functionally distinct subsets of macrophages derived from ly6c(high) monocytes
    • Movahedi K, Laoui D, Gysemans C, Baeten M, Stangé G, Van Bossche J Den, et al. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res. (2010) 70:5728-39. doi:10.1158/0008-5472.CAN-09-4672.
    • (2010) Cancer Res. , vol.70 , pp. 5728-5739
    • Movahedi, K.1    Laoui, D.2    Gysemans, C.3    Baeten, M.4    Stangé, G.5    Van Bossche, J.D.6
  • 11
    • 84964314847 scopus 로고    scopus 로고
    • Wucherpfennig kw, goldstein dr. The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells
    • Elpek KG, Cremasco V, Shen H, Harvey CJ, Wucherpfennig KW, Goldstein DR. The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells. Cancer Immunol Res. (2014) 2:655-67. doi:10.1158/2326-6066.CIR-13-0209.
    • (2014) Cancer Immunol Res , vol.2 , pp. 655-667
    • Elpek, K.G.1    Cremasco, V.2    Shen, H.3    Harvey, C.J.4
  • 12
    • 85042358343 scopus 로고    scopus 로고
    • Myeloid cell heterogeneity in cancer: Not a single cell alike
    • Kiss M, Van Gassen S, Movahedi K, Saeys Y, Laoui D. Myeloid cell heterogeneity in cancer: not a single cell alike. Cell Immunol. (2018) 330:188-201. doi:10.1016/j.cellimm.2018.02.008.
    • (2018) Cell Immunol , vol.330 , pp. 188-201
    • Kiss, M.1    Van Gassen, S.2    Movahedi, K.3    Saeys, Y.4    Laoui, D.5
  • 13
    • 85044272999 scopus 로고    scopus 로고
    • Emerging concepts for immune checkpoint blockade-based combination therapies
    • Zappasodi R, Merghoub T, Wolchok JD. Emerging concepts for immune checkpoint blockade-based combination therapies. Cancer Cell (2018) 33:581-98. doi:10.1016/j.ccell.2018.03.005.
    • (2018) Cancer Cell , vol.33 , pp. 581-598
    • Zappasodi, R.1    Merghoub, T.2    Wolchok, J.D.3
  • 15
    • 85043244810 scopus 로고    scopus 로고
    • Adoptive cancer immunotherapy using DNA-demethylated t helper cells as antigen-presenting cells
    • Kirkin AF, Dzhandzhugazyan KN, Guldberg P, Fang JJ, Andersen RS, Dahl C, et al. Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells. Nat Commun. (2018) 9:1-12doi:10.1038/s41467-018-03217-9.
    • (2018) Nat Commun. , vol.9 , pp. 1-12
    • Kirkin, A.F.1    Dzhandzhugazyan, K.N.2    Guldberg, P.3    Fang, J.J.4    Andersen, R.S.5    Dahl, C.6
  • 16
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • Sharma P, Allison JP. The future of immune checkpoint therapy. Science (2015) 348:56-61. doi: 10.1126/science.aaa8172.
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 17
    • 85035343267 scopus 로고    scopus 로고
    • De-novo and acquired resistance to immune checkpoint targeting
    • Syn NL, Teng MWL, Mok TSK, Soo RA. De-novo and acquired resistance to immune checkpoint targeting. Lancet Oncol. (2017) 18:e731-e41. doi: 10.1016/S1470-2045(17)30607-1.
    • (2017) Lancet Oncol , vol.18
    • Syn, N.L.1    Teng, M.W.L.2    Mok, T.S.K.3    Soo, R.A.4
  • 18
    • 84876800337 scopus 로고    scopus 로고
    • Origins and hallmarks of macrophages: Development, homeostasis, and disease
    • Wynn TA, Chawla A, Pollard JW. Origins and hallmarks of macrophages: development, homeostasis, and disease. Nature (2013) 496:445-55. doi:10.1038/nature12034.
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 19
    • 85018308665 scopus 로고    scopus 로고
    • Does niche competition determine the origin of tissue-resident macrophages?
    • Guilliams M, Scott CL. Does niche competition determine the origin of tissue-resident macrophages? Nat Rev Immunol. (2017) 17:451-60. doi:10.1038/nri.2017.42.
    • (2017) Nat Rev Immunol , vol.17 , pp. 451-460
    • Guilliams, M.1    Scott, C.L.2
  • 20
    • 84960354901 scopus 로고    scopus 로고
    • Tissue-resident macrophage ontogeny and homeostasis
    • Ginhoux F, Guilliams M. Tissue-resident macrophage ontogeny and homeostasis. Immunity (2016) 44:439-49. doi:10.1016/j.immuni.2016.02.024.
    • (2016) Immunity , vol.44 , pp. 439-449
    • Ginhoux, F.1    Guilliams, M.2
  • 21
    • 84928077532 scopus 로고    scopus 로고
    • Macrophages and therapeutic resistance in cancer
    • Ruffell B, Coussens LM. Macrophages and therapeutic resistance in cancer. Cancer Cell (2015) 27:462-72. doi:10.1016/j.ccell.2015.02.015.
    • (2015) Cancer Cell , vol.27 , pp. 462-472
    • Ruffell, B.1    Coussens, L.M.2
  • 22
    • 84992740400 scopus 로고    scopus 로고
    • Novel insights in the regulation and function of macrophages in the tumor microenvironment
    • Bolli E, Movahedi K, Laoui D, Van Ginderachter JA. Novel insights in the regulation and function of macrophages in the tumor microenvironment. Curr Opin Oncol. (2017) 29:55-61. doi:10.1097/CCO.0000000000000344.
    • (2017) Curr Opin Oncol , vol.29 , pp. 55-61
    • Bolli, E.1    Movahedi, K.2    Laoui, D.3    Van Ginderachter, J.A.4
  • 23
    • 84996790738 scopus 로고    scopus 로고
    • Macrophage ontogeny underlies differences in tumor-specific education in brain malignancies
    • Bowman RL, Klemm F, Akkari L, Pyonteck SM, Quail DF, Dhara S, et al. Macrophage ontogeny underlies differences in tumor-specific education in brain malignancies. Cell Rep. (2017) 17:2445-59. doi:10.1016/j.celrep.2016.10.052.
    • (2017) Cell Rep. , vol.17 , pp. 2445-2459
    • Bowman, R.L.1    Klemm, F.2    Akkari, L.3    Pyonteck, S.M.4    Quail, D.F.5    Dhara, S.6
  • 24
    • 85027340338 scopus 로고    scopus 로고
    • Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoiesis and promote tumor progression
    • Zhu Y, Herndon JM, Sojka DK, Kim KW, Knolhoff BL, Zuo C, et al. Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoiesis and promote tumor progression. Immunity (2017) 47:323-38. doi:10.1016/j.immuni.2017.07.014.
    • (2017) Immunity , vol.47 , pp. 323-338
    • Zhu, Y.1    Herndon, J.M.2    Sojka, D.K.3    Kim, K.W.4    Knolhoff, B.L.5    Zuo, C.6
  • 25
    • 84892747845 scopus 로고    scopus 로고
    • Tumor hypoxia does not drive differentiation of tumor-Associated macrophages but rather fine-Tunes the m2-like macrophage population
    • Laoui D, Van Overmeire E, Conza GD, Aldeni C, Keirsse J, Morias Y, et al. Tumor hypoxia does not drive differentiation of tumor-Associated macrophages but rather fine-Tunes the M2-like macrophage population. Cancer Res. (2014) 74:24-30. doi:10.1158/0008-5472.CAN-13-1196.
    • (2014) Cancer Res. , vol.74 , pp. 24-30
    • Laoui, D.1    Van Overmeire, E.2    Conza, G.D.3    Aldeni, C.4    Keirsse, J.5    Morias, Y.6
  • 26
    • 67651111095 scopus 로고    scopus 로고
    • A distinguishing gene signature shared by tumor-infiltrating tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships
    • Pucci F, Venneri MA, Biziato D, Nonis A, Moi D, Sica A, et al. A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships. Blood (2009) 114:901-14. doi:10.1182/blood-2009-01-200931.
    • (2009) Blood , vol.114 , pp. 901-914
    • Pucci, F.1    Venneri, M.A.2    Biziato, D.3    Nonis, A.4    Moi, D.5    Sica, A.6
  • 27
    • 85024396301 scopus 로고    scopus 로고
    • Redirecting tumor-Associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy
    • Zheng X, Turkowski K, Mora J, Brüne B, Seeger W, Weigert A, et al. Redirecting tumor-Associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy. Oncotarget (2015) 8:48436-52. doi:10.18632/oncotarget.17061.
    • (2015) Oncotarget , vol.8 , pp. 48436-48452
    • Zheng, X.1    Turkowski, K.2    Mora, J.3    Brüne, B.4    Seeger, W.5    Weigert, A.6
  • 28
    • 85014029818 scopus 로고    scopus 로고
    • Tumor-Associated macrophages: Implications in cancer immunotherapy
    • Petty AJ, Yang Y. Tumor-Associated macrophages: implications in cancer immunotherapy. Immunotherapy (2017) 9:289-302. doi:10.2217/imt-2016-0135.
    • (2017) Immunotherapy , vol.9 , pp. 289-302
    • Petty, A.J.1    Yang, Y.2
  • 29
    • 84979582060 scopus 로고    scopus 로고
    • Abandoning M1/M2 for a network model of macrophage function
    • Narhendorf M, Swirski FK. Abandoning M1/M2 for a network model of macrophage function. Circ Res. (2016) 119:414-7. doi:10.1161/CIRCRESAHA.116.309194.
    • (2016) Circ Res. , vol.119 , pp. 414-417
    • Narhendorf, M.1    Swirski, F.K.2
  • 30
    • 85055328869 scopus 로고    scopus 로고
    • Single-cell immune map of breast carcinoma reveals diverse phenotypic states driven by the tumor microenvironment
    • Azizi E, Carr AJ, Plitas G, Cornish AE, Konopacki C, Prabhakaran S, et al. Single-cell immune map of breast carcinoma reveals diverse phenotypic states driven by the tumor microenvironment. Cell (2017) 174:221994. doi:10.1016/j.cell.2018.05.060.
    • (2017) Cell , vol.174 , pp. 221994
    • Azizi, E.1    Carr, A.J.2    Plitas, G.3    Cornish, A.E.4    Konopacki, C.5    Prabhakaran, S.6
  • 32
    • 85049650563 scopus 로고    scopus 로고
    • Phenotype molding of stromal cells in the lung tumor microenvironment
    • Lambrechts D, Wauters E, Boeckx B, Aibar S, Nittner D, Burton O, et al. Phenotype molding of stromal cells in the lung tumor microenvironment. Nature (2018) 24:1277-89. doi:10.1038/s41591-018-0096-5.
    • (2018) Nature , vol.24 , pp. 1277-1289
    • Lambrechts, D.1    Wauters, E.2    Boeckx, B.3    Aibar, S.4    Nittner, D.5    Burton, O.6
  • 33
    • 84873597334 scopus 로고    scopus 로고
    • Role of macrophage targeting in the antitumor activity of trabectedin
    • Germano G, Frapolli R, Belgiovine C, Anselmo A, Pesce S, Liguori M, et al. Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell (2013) 23:249-62. doi:10.1016/j.ccr.2013.01.008.
    • (2013) Cancer Cell , vol.23 , pp. 249-262
    • Germano, G.1    Frapolli, R.2    Belgiovine, C.3    Anselmo, A.4    Pesce, S.5    Liguori, M.6
  • 34
    • 85033670024 scopus 로고    scopus 로고
    • Depletion of tumor-Associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-Tumor phenotype
    • Borgoni S, Iannello A, Cutrupi S, Allavena P, D'Incalci M, Novelli F, et al. Depletion of tumor-Associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-Tumor phenotype. Oncoimmunology (2018) 7:e1393596doi:10.1080/2162402X.2017.1393596.
    • (2018) Oncoimmunology , vol.7 , pp. e1393596
    • Borgoni, S.1    Iannello, A.2    Cutrupi, S.3    Allavena, P.4    D'Incalci, M.5    Novelli, F.6
  • 35
    • 85052729826 scopus 로고    scopus 로고
    • Therapeutic targeting of tumor-Associated macrophages in pancreatic neuroendocrine tumors
    • Krug S, Abbassi R, Griesmann H, Sipos B, Wiese D, Rexin P, et al. Therapeutic targeting of tumor-Associated macrophages in pancreatic neuroendocrine tumors. Int J Cancer (2018) 143:1806-16. doi:10.1002/ijc.31562.
    • (2018) Int J Cancer , vol.143 , pp. 1806-1816
    • Krug, S.1    Abbassi, R.2    Griesmann, H.3    Sipos, B.4    Wiese, D.5    Rexin, P.6
  • 36
    • 85046473174 scopus 로고    scopus 로고
    • Anti-pd-1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of os lung metastases
    • Dhupkar P, Gordon N, Stewart J, Kleinerman ES. Anti-PD-1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases. Cancer Med. (2018) 46:1141-2. doi:10.1002/cam4.1518.
    • (2018) Cancer Med , vol.46 , pp. 1141-1142
    • Dhupkar, P.1    Gordon, N.2    Stewart, J.3    Kleinerman, E.S.4
  • 37
    • 84973646350 scopus 로고    scopus 로고
    • Tumor-Associated macrophage-mediated targeted therapy of triple-negative breast cancer
    • Niu M, Valdes S, Naguib YW, Hursting SD, Cui Z. Tumor-Associated macrophage-mediated targeted therapy of triple-negative breast cancer. Mol Pharm. (2016) 13:1833-42. doi:10.1021/acs.molpharmaceut.5b00987.
    • (2016) Mol Pharm , vol.13 , pp. 1833-1842
    • Niu, M.1    Valdes, S.2    Naguib, Y.W.3    Hursting, S.D.4    Cui, Z.5
  • 38
    • 84865147481 scopus 로고    scopus 로고
    • Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-Associated macrophages
    • Movahedi K, Schoonooghe S, Laoui D, Houbracken I, Waelput W, Breckpot K, et al. Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-Associated macrophages. Cancer Res. (2012) 72:4165-77. doi:10.1158/0008-5472.CAN-11-2994.
    • (2012) Cancer Res , vol.72 , pp. 4165-4177
    • Movahedi, K.1    Schoonooghe, S.2    Laoui, D.3    Houbracken, I.4    Waelput, W.5    Breckpot, K.6
  • 39
    • 84938883713 scopus 로고    scopus 로고
    • Pet imaging of macrophage mannose receptor-expressing macrophages in tumor stroma using 18f-radiolabeled camelid single-domain antibody fragments
    • Blykers A, Schoonooghe S, Xavier C, D'hoe K, Laoui D, D'Huyvetter M, et al. PET imaging of macrophage mannose receptor-expressing macrophages in tumor stroma using 18F-radiolabeled camelid single-domain antibody fragments. J Nucl Med. (2015) 56:1265-71. doi:10.2967/jnumed.115.156828.
    • (2015) J Nucl Med , vol.56 , pp. 1265-1271
    • Blykers, A.1    Schoonooghe, S.2    Xavier, C.3    D'Hoe, K.4    Laoui, D.5    D'Huyvetter, M.6
  • 40
    • 85048466691 scopus 로고    scopus 로고
    • Targeting protumoral tumor-Associated macrophages with nanobody-functionalized nanogels through strain promoted azide alkyne cycloaddition ligation
    • Nuhn L, Bolli E, Massa S, Vandenberghe I, Movahedi K, Devreese B, et al. Targeting protumoral tumor-Associated macrophages with nanobody-functionalized nanogels through strain promoted azide alkyne cycloaddition ligation. Bioconjug Chem. (2018) 29:2394-405. doi:10.1021/acs.bioconjchem.8b00319.
    • (2018) Bioconjug Chem , vol.29 , pp. 2394-2405
    • Nuhn, L.1    Bolli, E.2    Massa, S.3    Vandenberghe, I.4    Movahedi, K.5    Devreese, B.6
  • 41
    • 84908540608 scopus 로고    scopus 로고
    • Enhancement of paclitaxel and carboplatin therapies by CCL2 blockade in ovarian cancers
    • Moisan F, Francisco EB, Brozovic A, Duran GE, Wang YC, Chaturvedi S, et al. Enhancement of paclitaxel and carboplatin therapies by CCL2 blockade in ovarian cancers. Mol Oncol. (2014) 8:1-9. doi:10.1016/j.molonc.2014.03.016.
    • (2014) Mol Oncol , vol.8 , pp. 1-9
    • Moisan, F.1    Francisco, E.B.2    Brozovic, A.3    Duran, G.E.4    Wang, Y.C.5    Chaturvedi, S.6
  • 42
    • 84863724938 scopus 로고    scopus 로고
    • Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models
    • Zollo M, Di Dato V, Spano D, De Martino D, Liguori L, Marino N, et al. Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models. Clin Exp Metastasis (2012) 29:585-601. doi:10.1007/s10585-012-9473-5.
    • (2012) Clin Exp Metastasis , vol.29 , pp. 585-601
    • Zollo, M.1    Di Dato, V.2    Spano, D.3    De Martino, D.4    Liguori, L.5    Marino, N.6
  • 43
    • 84902546715 scopus 로고    scopus 로고
    • Targeting tumor-Associated macrophages with anti-csf-1r antibody reveals a strategy for cancer therapy
    • Ries CH, Cannarile MA, Hoves S, Benz J, Wartha K, Runza V, et al. Targeting tumor-Associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell (2014) 25:846-59. doi:10.1016/j.ccr.2014.05.016.
    • (2014) Cancer Cell , vol.25 , pp. 846-859
    • Ries, C.H.1    Cannarile, M.A.2    Hoves, S.3    Benz, J.4    Wartha, K.5    Runza, V.6
  • 44
    • 84918831817 scopus 로고    scopus 로고
    • Functional relationship between tumor-Associated macrophages and macrophage colony-stimulating factor as contributors to cancer progression
    • Laoui D, van Overmeire E, de Baetselier P, van Ginderachter JA, Raes G. Functional relationship between tumor-Associated macrophages and macrophage colony-stimulating factor as contributors to cancer progression. Front Immunol. (2014) 5:1-15. doi:10.3389/fimmu.2014.00489.
    • (2014) Front Immunol , vol.5 , pp. 1-15
    • Laoui, D.1    Van Overmeire, E.2    De Baetselier, P.3    Van Ginderachter, J.A.4    Raes, G.5
  • 46
    • 84887481716 scopus 로고    scopus 로고
    • Csf-1r inhibition alters macrophage polarization and blocks glioma progression
    • Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. (2013) 19:1264-72. doi:10.1038/nm.3337.
    • (2013) Nat Med , vol.19 , pp. 1264-1272
    • Pyonteck, S.M.1    Akkari, L.2    Schuhmacher, A.J.3    Bowman, R.L.4    Sevenich, L.5    Quail, D.F.6
  • 47
    • 84958953467 scopus 로고    scopus 로고
    • M-csf and gm-csf receptor signaling differentially regulate monocyte maturation and macrophagepolarization in the tumor microenvironment
    • Van Overmeire E, Stijlemans B, Heymann F, Keirsse J, Morias Y, Elkrim Y, et al. M-CSF and GM-CSF receptor signaling differentially regulate monocyte maturation and macrophagepolarization in the tumor microenvironment. Cancer Res. (2016) 76:35-42. doi:10.1158/0008-5472.CAN-15-0869.
    • (2016) Cancer Res. , vol.76 , pp. 35-42
    • Van Overmeire, E.1    Stijlemans, B.2    Heymann, F.3    Keirsse, J.4    Morias, Y.5    Elkrim, Y.6
  • 48
    • 84873468174 scopus 로고    scopus 로고
    • Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression and improves chemotherapeutic responses
    • Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, et al. Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression and improves chemotherapeutic responses. Cancer Res. (2013) 73:1128-41. doi:10.1158/0008-5472.CAN-12-2731.
    • (2013) Cancer Res , vol.73 , pp. 1128-1141
    • Mitchem, J.B.1    Brennan, D.J.2    Knolhoff, B.L.3    Belt, B.A.4    Zhu, Y.5    Sanford, D.E.6
  • 49
    • 85010901048 scopus 로고    scopus 로고
    • Tumor-Associated macrophages as treatment targets in oncology
    • Mantovani A, Marchesi F, Malesci A, Laghi L. Tumor-Associated macrophages as treatment targets in oncology. Nat Rev Clin Oncol. (2018) 14:399-416. doi:10.1038/nrclinonc.2016.217.
    • (2018) Nat Rev Clin Oncol , vol.14 , pp. 399-416
    • Mantovani, A.1    Marchesi, F.2    Malesci, A.3    Laghi, L.4
  • 51
    • 84995948061 scopus 로고    scopus 로고
    • Overcoming resistance to checkpoint blockade therapy by targeting pi3k-? in myeloid cells
    • De Henau O, Rausch M, Winkler D, Campesato LF, Liu C, Cymerman DH, et al. Overcoming resistance to checkpoint blockade therapy by targeting PI3K-? in myeloid cells. Nature (2016) 539:443-7. doi:10.1038/nature20554.
    • (2016) Nature , vol.539 , pp. 443-447
    • De Henau, O.1    Rausch, M.2    Winkler, D.3    Campesato, L.F.4    Liu, C.5    Cymerman, D.H.6
  • 52
    • 85017396883 scopus 로고    scopus 로고
    • Inhibition of hematopoietic cell kinase activity suppresses myeloid cell-mediated colon cancer progression
    • Poh AR, Love CG, Masson F, Preaudet A, Tsui C, Whitehead L, et al. Inhibition of hematopoietic cell kinase activity suppresses myeloid cell-mediated colon cancer progression. Cancer Cell (2017) 31:563-75. doi:10.1016/j.ccell.2017.03.006.
    • (2017) Cancer Cell , vol.31 , pp. 563-575
    • Poh, A.R.1    Love, C.G.2    Masson, F.3    Preaudet, A.4    Tsui, C.5    Whitehead, L.6
  • 53
    • 85015368931 scopus 로고    scopus 로고
    • Class iia hdac inhibition reduces breast tumours and metastases through anti-Tumour macrophages
    • Guerriero JL, Sotayo A, Ponichtera HE, Castrillon JA, Pourzia AL, Schad S, et al. Class IIa HDAC inhibition reduces breast tumours and metastases through anti-Tumour macrophages. Nature (2017) 543:428-32. doi:10.1038/nature21409.
    • (2017) Nature , vol.543 , pp. 428-432
    • Guerriero, J.L.1    Sotayo, A.2    Ponichtera, H.E.3    Castrillon, J.A.4    Pourzia, A.L.5    Schad, S.6
  • 54
    • 84908147322 scopus 로고    scopus 로고
    • Effective innate and adaptive anti-melanoma immunity through localized tlr-7/8 activation
    • Singh M, Khong H, Dai Z, Huang X-F, Wargo JA, Cooper ZA, et al. Effective innate and adaptive anti-melanoma immunity through localized TLR-7/8 activation. J Immunol. (2014) 193:4722-31. doi:10.4049/jimmunol.1401160.
    • (2014) J Immunol , vol.193 , pp. 4722-4731
    • Singh, M.1    Khong, H.2    Dai, Z.3    Huang, X.-F.4    Wargo, J.A.5    Cooper, Z.A.6
  • 55
    • 84871230007 scopus 로고    scopus 로고
    • Synergy of topical toll-like receptor 7 agonist with radiation and low dose cyclophosphamide in a mouse model of cutaneous breast cancer
    • Dewan MZ, Vanpouille-Box C, Kawashima N, DiNapoli S, Babb JS, Formenti SC, et al. Synergy of topical Toll-Like Receptor 7 agonist with radiation and low dose cyclophosphamide in a mouse model of cutaneous breast cancer. Clin Cancer Res. (2012) 18:6668-78. doi:10.1158/1078-0432.CCR-12-0984.
    • (2012) Clin Cancer Res. , vol.18 , pp. 6668-6678
    • Dewan, M.Z.1    Vanpouille-Box, C.2    Kawashima, N.3    DiNapoli, S.4    Babb, J.S.5    Formenti, S.C.6
  • 56
    • 85047226785 scopus 로고    scopus 로고
    • Tlr7/8-Agonist-loaded nanoparticles promote the polarization of tumour-Associated macrophages to enhance cancer immunotherapy
    • Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, et al. TLR7/8-Agonist-loaded nanoparticles promote the polarization of tumour-Associated macrophages to enhance cancer immunotherapy. Nat Biomed Eng. (2018) 1:1-11. doi:10.1038/s41551-018-0236-8.
    • (2018) Nat Biomed Eng , vol.1 , pp. 1-11
    • Rodell, C.B.1    Arlauckas, S.P.2    Cuccarese, M.F.3    Garris, C.S.4    Li, R.5    Ahmed, M.S.6
  • 57
    • 84857136783 scopus 로고    scopus 로고
    • Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors
    • Shime H, Matsumoto M, Oshiumi H, Tanaka S, Nakane A, Iwakura Y, et al. Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors. Proc Natl Acad Sci USA. (2012) 109:2066-71. doi:10.1073/pnas.1113099109.
    • (2012) Proc Natl Acad Sci USA. , vol.109 , pp. 2066-2071
    • Shime, H.1    Matsumoto, M.2    Oshiumi, H.3    Tanaka, S.4    Nakane, A.5    Iwakura, Y.6
  • 58
    • 85019545270 scopus 로고    scopus 로고
    • Reversing the polarization of tumor-Associated macrophages inhibits tumor metastasis
    • Yuan R, Li S, Geng H, Wang X, Guan Q, Li X, et al. Reversing the polarization of tumor-Associated macrophages inhibits tumor metastasis. Int Immunopharmacol. (2017) 49:30-7. doi:10.1016/j.intimp.2017.05.014.
    • (2017) Int Immunopharmacol , vol.49 , pp. 30-37
    • Yuan, R.1    Li, S.2    Geng, H.3    Wang, X.4    Guan, Q.5    Li, X.6
  • 59
    • 85013103792 scopus 로고    scopus 로고
    • Adjuvant activity enhanced by cross-linked cpg-oligonucleotides in ß-glucan nanogel and its antitumor effect
    • Miyamoto N, Mochizuki S, Fujii S, Yoshida K, Sakurai K. Adjuvant activity enhanced by cross-linked CpG-Oligonucleotides in ß-Glucan nanogel and its antitumor effect. Bioconjug Chem. (2017) 28:565-73. doi:10.1021/acs.bioconjchem.6b00675.
    • (2017) Bioconjug Chem , vol.28 , pp. 565-573
    • Miyamoto, N.1    Mochizuki, S.2    Fujii, S.3    Yoshida, K.4    Sakurai, K.5
  • 60
    • 85036635837 scopus 로고    scopus 로고
    • Combination immunotherapy with tlr agonists and checkpoint inhibitors suppresses head and neck cancer
    • Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, et al. Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight (2017) 2:e93397. doi:10.1172/jci.insight.93397.
    • (2017) JCI Insight , vol.2 , pp. e93397
    • Sato-Kaneko, F.1    Yao, S.2    Ahmadi, A.3    Zhang, S.S.4    Hosoya, T.5    Kaneda, M.M.6
  • 61
    • 85032263944 scopus 로고    scopus 로고
    • Toll-like receptor ligands and interferon-? Synergize for induction of antitumor m1 macrophages
    • Müller E, Christopoulos PF, Halder S, Lunde A, Beraki K, Speth M, et al. Toll-like receptor ligands and interferon-? synergize for induction of antitumor M1 macrophages. Front Immunol. (2017) 8:1383. doi:10.3389/fimmu.2017.01383.
    • (2017) Front Immunol , vol.8 , pp. 1383
    • Müller, E.1    Christopoulos, P.F.2    Halder, S.3    Lunde, A.4    Beraki, K.5    Speth, M.6
  • 62
    • 84962003985 scopus 로고    scopus 로고
    • Bacteria in cancer therapy: Renaissance of an old concept
    • Felgner S, Kocijancic D, Frahm M, Weiss S. Bacteria in cancer therapy: Renaissance of an old concept. Int J Microbiol. (2016) 2016:1-14. doi:10.1155/2016/8451728.
    • (2016) Int J Microbiol , vol.2016 , pp. 1-14
    • Felgner, S.1    Kocijancic, D.2    Frahm, M.3    Weiss, S.4
  • 63
    • 85046671633 scopus 로고    scopus 로고
    • Attenuated bacteria as immunotherapeutic tools for cancer treatment
    • Kaimala S, Al-sbiei A, Cabral-marques O, Fernandez- MJ. Attenuated bacteria as immunotherapeutic tools for cancer treatment. Front Immunol. (2018) 8:136. doi:10.3389/fonc.2018.00136.
    • (2018) Front Immunol , vol.8 , pp. 136
    • Kaimala, S.1    Al-Sbiei, A.2    Cabral-Marques, O.3    Fernandez-, M.J.4
  • 64
    • 84867420120 scopus 로고    scopus 로고
    • Re-polarization of tumor-Associated macrophages to pro-inflammatory m 1 macrophages
    • Cai X, Yin Y, Li N, Zhu D, Zhang J, Zhang C-Y, et al. Re-polarization of tumor-Associated macrophages to pro-inflammatory M 1 macrophages. J Mol Cell Biol. (2012) 4:341-3. doi:10.1093/jmcb/mjs044.
    • (2012) J Mol Cell Biol , vol.4 , pp. 341-343
    • Cai, X.1    Yin, Y.2    Li, N.3    Zhu, D.4    Zhang, J.5    Zhang, C.-Y.6
  • 65
    • 85049346854 scopus 로고    scopus 로고
    • Microrna-155 inversely correlates with esophageal cancer progression through regulating tumor-Associated macrophage FGF2 expression
    • Wang P, Xu LJ, Qin JJ, Zhang L, Zhuang GH. MicroRNA-155 inversely correlates with esophageal cancer progression through regulating tumor-Associated macrophage FGF2 expression. Biochem Biophys Res Commun. 503:452-8. doi:10.1016/j.bbrc.2018.04.094.
    • Biochem Biophys Res Commun , vol.503 , pp. 452-458
    • Wang, P.1    Xu, L.J.2    Qin, J.J.3    Zhang, L.4    Zhuang, G.H.5
  • 67
    • 85046690976 scopus 로고    scopus 로고
    • Repolarization of tumor-Associated macrophages in a genetically engineered non-small cell lung cancer model by intraperitoneal administration of hyaluronic acid-based nanoparticles encapsulating microrna-125b
    • Parayath NN, Parikh A, Amiji MM. Repolarization of tumor-Associated macrophages in a genetically engineered non-small cell lung cancer model by intraperitoneal administration of hyaluronic acid-based nanoparticles encapsulating MicroRNA-125b. Nano Lett. 18:3571-9. doi:10.1021/acs.nanolett.8b00689.
    • Nano Lett. , vol.18 , pp. 3571-3579
    • Parayath, N.N.1    Parikh, A.2    Amiji, M.M.3
  • 68
    • 84861152312 scopus 로고    scopus 로고
    • Mir-511-3p modulates genetic programs of tumor-Associated macrophages
    • Squadrito ML, Pucci F, Magri L, Moi D, Gilfillan GD, Ranghetti A, et al. MiR-511-3p modulates genetic programs of tumor-Associated macrophages. Cell Rep. (2012) 1:141-54. doi:10.1016/j.celrep.2011.12.005.
    • (2012) Cell Rep , vol.1 , pp. 141-154
    • Squadrito, M.L.1    Pucci, F.2    Magri, L.3    Moi, D.4    Gilfillan, G.D.5    Ranghetti, A.6
  • 69
    • 84976516808 scopus 로고    scopus 로고
    • Suppression of microrna activity amplifies IFN-?-induced macrophage activation and promotes anti-Tumour immunity
    • Baer C, Squadrito ML, Laoui D, Thompson D, Hansen SK, Kiialainen A, et al. Suppression of microRNA activity amplifies IFN-?-induced macrophage activation and promotes anti-Tumour immunity. Nat Cell Biol. (2016) 18:790-802. doi:10.1038/ncb3371.
    • (2016) Nat Cell Biol , vol.18 , pp. 790-802
    • Baer, C.1    Squadrito, M.L.2    Laoui, D.3    Thompson, D.4    Hansen, S.K.5    Kiialainen, A.6
  • 70
    • 85029290103 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumour angiogenesis
    • De Palma M, Biziato D, Petrova TV. Microenvironmental regulation of tumour angiogenesis. Nat Rev Cancer (2017) 17:457-74. doi:10.1038/nrc.2017.51.
    • (2017) Nat Rev Cancer , vol.17 , pp. 457-474
    • De Palma, M.1    Biziato, D.2    Petrova, T.V.3
  • 71
    • 79957894276 scopus 로고    scopus 로고
    • Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    • Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov. (2011) 10:417-27. doi:10.1038/nrd3455.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 417-427
    • Carmeliet, P.1    Jain, R.K.2
  • 72
    • 84903390248 scopus 로고    scopus 로고
    • Dmxaa causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide sting agonist, 2'3'-CGAMP, induces M2 macrophage repolarization
    • Downey CM, Aghaei M, Schwendener RA, Jirik FR. DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS ONE (2014) 9:e99988. doi:10.1371/journal.pone.0099988.
    • (2014) PLoS ONE , vol.9 , pp. e99988
    • Downey, C.M.1    Aghaei, M.2    Schwendener, R.A.3    Jirik, F.R.4
  • 73
    • 85046889362 scopus 로고    scopus 로고
    • Combination of anti-vascular agent-dmxaa and hif-1a inhibitor-digoxin inhibits the growth of melanoma tumors
    • Smolarczyk R, Cichon T, Pilny E, Jarosz-Biej M, Poczkaj A, Kulach N, et al. Combination of anti-vascular agent-DMXAA and HIF-1a inhibitor-digoxin inhibits the growth of melanoma tumors. Sci Rep. (2018) 8:1-9. doi:10.1038/s41598-018-25688-y.
    • (2018) Sci Rep , vol.8 , pp. 1-9
    • Smolarczyk, R.1    Cichon, T.2    Pilny, E.3    Jarosz-Biej, M.4    Poczkaj, A.5    Kulach, N.6
  • 74
    • 85041314838 scopus 로고    scopus 로고
    • A vascular disrupting agent overcomes tumor multidrug resistance by skewing macrophage polarity toward the m1 phenotype
    • Lei X, Chen M, Li X, Huang M, Nie Q, Ma N, et al. A vascular disrupting agent overcomes tumor multidrug resistance by skewing macrophage polarity toward the M1 phenotype. Cancer Lett. (2018) 418:239-49. doi:10.1016/j.canlet.2018.01.016.
    • (2018) Cancer Lett. , vol.418 , pp. 239-249
    • Lei, X.1    Chen, M.2    Li, X.3    Huang, M.4    Nie, Q.5    Ma, N.6
  • 75
    • 84964402874 scopus 로고    scopus 로고
    • ANG-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-Tumor phenotype and prolongs glioblastoma survival
    • Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, et al. Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-Tumor phenotype and prolongs glioblastoma survival. Proc Natl Acad Sci USA. (2016) 113:4476-81. doi:10.1073/pnas.1525360113.
    • (2016) Proc Natl Acad Sci USA. , vol.113 , pp. 4476-4481
    • Kloepper, J.1    Riedemann, L.2    Amoozgar, Z.3    Seano, G.4    Susek, K.5    Yu, V.6
  • 76
    • 84964409623 scopus 로고    scopus 로고
    • Dual inhibition of ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival inglioblastoma by altering macrophages
    • Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, et al. Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival inglioblastoma by altering macrophages. Proc Natl Acad Sci USA. (2016) 113:4470-75. doi:10.1073/pnas.1525349113.
    • (2016) Proc Natl Acad Sci USA , vol.113 , pp. 4470-4475
    • Peterson, T.E.1    Kirkpatrick, N.D.2    Huang, Y.3    Farrar, C.T.4    Marijt, K.A.5    Kloepper, J.6
  • 77
    • 85038098619 scopus 로고    scopus 로고
    • The dual effects of a novel peptibody on angiogenesis inhibition and M2 macrophage polarization on sarcoma
    • Zhu X, Yang J, Gao Y, Wu C, Yi L, Li G, et al. The dual effects of a novel peptibody on angiogenesis inhibition and M2 macrophage polarization on sarcoma. Cancer Lett. (2018) 416:1-10. doi:10.1016/j.canlet.2017.10.043.
    • (2018) Cancer Lett , vol.416 , pp. 1-10
    • Zhu, X.1    Yang, J.2    Gao, Y.3    Wu, C.4    Yi, L.5    Li, G.6
  • 78
    • 85017547813 scopus 로고    scopus 로고
    • Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by pd-1 checkpoint blockade
    • Schmittnaegel M, Rigamonti N, Kadioglu E, Cassará A, Rmili CW, Kiialainen A, et al. Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade. Sci Transl Med. (2017) 9:eaak9670. doi:10.1126/scitranslmed.aak9670.
    • (2017) Sci Transl Med , vol.9 , pp. eaak9670
    • Schmittnaegel, M.1    Rigamonti, N.2    Kadioglu, E.3    Cassara, A.4    Rmili, C.W.5    Kiialainen, A.6
  • 79
    • 78651461701 scopus 로고    scopus 로고
    • Hrg inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of plgf
    • Rolny C, Mazzone M, Tugues S, Laoui D, Johansson I, Coulon C, et al. HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. Cancer Cell (2011) 19:31-44. doi:10.1016/j.ccr.2010.11.009.
    • (2011) Cancer Cell , vol.19 , pp. 31-44
    • Rolny, C.1    Mazzone, M.2    Tugues, S.3    Laoui, D.4    Johansson, I.5    Coulon, C.6
  • 80
    • 79953154967 scopus 로고    scopus 로고
    • Cd40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty GL, Chiorean EG, Fishman MP, Saboury B, Teitelbaum R, Sun W, et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science (2011) 331:1612-6. doi:10.1126/science.1198443.
    • (2011) Science , vol.331 , pp. 1612-1616
    • Beatty, G.L.1    Chiorean, E.G.2    Fishman, M.P.3    Saboury, B.4    Teitelbaum, R.5    Sun, W.6
  • 81
    • 85042861054 scopus 로고    scopus 로고
    • Rapid activation of tumor-Associated macrophages boosts preexisting tumor immunity
    • Hoves S, Ooi C-H, Wolter C, Sade H, Bissinger S, Schmittnaegel M, et al. Rapid activation of tumor-Associated macrophages boosts preexisting tumor immunity. J Exp Med. (2018) 215:859-76. doi:10.1084/jem.20171440.
    • (2018) J Exp Med , vol.215 , pp. 859-876
    • Hoves, S.1    Ooi, C.-H.2    Wolter, C.3    Sade, H.4    Bissinger, S.5    Schmittnaegel, M.6
  • 82
    • 85042854291 scopus 로고    scopus 로고
    • Myeloid-Targeted immunotherapies act in synergy to induce inflammation and antitumor immunity
    • Perry CJ, Muñoz-Rojas AR, Meeth KM, Kellman LN, Amezquita RA, Thakral D, et al. Myeloid-Targeted immunotherapies act in synergy to induce inflammation and antitumor immunity. J Exp Med. (2018) 215:877-93. doi:10.1084/jem.20171435.
    • (2018) J Exp Med. , vol.215 , pp. 877-893
    • Perry, C.J.1    Muñoz-Rojas, A.R.2    Meeth, K.M.3    Kellman, L.N.4    Amezquita, R.A.5    Thakral, D.6
  • 83
    • 84971220837 scopus 로고    scopus 로고
    • Reprogramming tumor-Associated macrophages by antibody targeting inhibits cancer progression and metastasis
    • Georgoudaki AM, Prokopec KE, Boura VF, Hellqvist E, Sohn S, Östling J, et al. Reprogramming tumor-Associated macrophages by antibody targeting inhibits cancer progression and metastasis. Cell Rep. (2016) 15:2000-11. doi:10.1016/j.celrep.2016.04.084.
    • (2016) Cell Rep , vol.15 , pp. 2000-2011
    • Georgoudaki, A.M.1    Prokopec, K.E.2    Boura, V.F.3    Hellqvist, E.4    Sohn, S.5    Östling, J.6
  • 85
    • 84891930215 scopus 로고    scopus 로고
    • Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity
    • Casazza A, Laoui D, Wenes M, Rizzolio S, Bassani N, Mambretti M, et al. Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. Cancer Cell (2013) 24:695-709. doi:10.1016/j.ccr.2013.11.007.
    • (2013) Cancer Cell , vol.24 , pp. 695-709
    • Casazza, A.1    Laoui, D.2    Wenes, M.3    Rizzolio, S.4    Bassani, N.5    Mambretti, M.6
  • 86
  • 87
    • 85014060474 scopus 로고    scopus 로고
    • A first-in-human, first-in-class phase i trial of the ANTI-CD47 antibody HU5F9-g4 in patients with advanced cancers
    • Sikic BI, Narayanan S, Colevas D, Padda SK, Fisher GA, Supan D, et al. A first-in-human, first-in-class phase I trial of the anti-CD47 antibody Hu5F9-G4 in patients with advanced cancers. J Clin Oncol. (2017) 34:3019. doi:10.1200/JCO.2016.34.15-suppl.3019.
    • (2017) J Clin Oncol. , vol.34 , pp. 3019
    • Sikic, B.I.1    Narayanan, S.2    Colevas, D.3    Padda, S.K.4    Fisher, G.A.5    Supan, D.6
  • 88
    • 84879797224 scopus 로고    scopus 로고
    • Engineered SIRPA variants as immunotherapeutic adjuvants to anticancer antibodies
    • Weiskopf K, Ring AM, Ho CCM, Volkmer J, Levin A, van de Rijn M., Volkmer A. K., et al. Engineered SIRPa variants as immunotherapeutic adjuvants to anticancer antibodies. Science (2013) 341:88-91. doi:10.1126/science.1238856.
    • (2013) Science , vol.341 , pp. 88-91
    • Weiskopf, K.1    Ring, A.M.2    Ho, C.C.M.3    Volkmer, J.4    Levin, A.5    Van De Rijn, M.6    Volkmer, A.K.7
  • 89
    • 85042772739 scopus 로고    scopus 로고
    • Chloroquine modulates antitumor immune response by resetting tumor-Associated macrophages toward m1 phenotype
    • Chen D, Xie J, Fiskesund R, Dong W, Liang X, Lv J, et al. Chloroquine modulates antitumor immune response by resetting tumor-Associated macrophages toward M1 phenotype. Nat Commun. (2018) 8:1-15. doi:10.1038/s41467-018-03225-9.
    • (2018) Nat Commun , vol.8 , pp. 1-15
    • Chen, D.1    Xie, J.2    Fiskesund, R.3    Dong, W.4    Liang, X.5    Lv, J.6
  • 90
    • 84860844691 scopus 로고    scopus 로고
    • Reprogramming of tam toward proimmunogenic type through regulation of map kinases using a redox-Active copper chelate
    • Chakraborty P, Chatterjee S, Ganguly A, Saha P, Adhikary A, Das T, et al. Reprogramming of TAM toward proimmunogenic type through regulation of MAP kinases using a redox-Active copper chelate. J Leukoc Biol. (2012) 91:1-11. doi:10.1189/jlb.0611287.
    • (2012) J Leukoc Biol , vol.91 , pp. 1-11
    • Chakraborty, P.1    Chatterjee, S.2    Ganguly, A.3    Saha, P.4    Adhikary, A.5    Das, T.6
  • 91
    • 84990961171 scopus 로고    scopus 로고
    • Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species
    • Guilliams M, Dutertre CA, Scott CL, McGovern N, Sichien D, Chakarov S, et al. Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species. Immunity (2016) 45:669-84. doi:10.1016/j.immuni.2016.08.015.
    • (2016) Immunity , vol.45 , pp. 669-684
    • Guilliams, M.1    Dutertre, C.A.2    Scott, C.L.3    McGovern, N.4    Sichien, D.5    Chakarov, S.6
  • 92
    • 84875528275 scopus 로고    scopus 로고
    • The dendritic cell lineage: Ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
    • Merad M, Sathe P, Helft J, Miller J, Mortha A. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol. (2013) 31:1-16. doi: 10.1146/annurev-immunol-020711-074950.
    • (2013) Annu Rev Immunol , vol.31 , pp. 1-16
    • Merad, M.1    Sathe, P.2    Helft, J.3    Miller, J.4    Mortha, A.5
  • 93
    • 84901358607 scopus 로고    scopus 로고
    • Monocytes and macrophages: Developmental pathways and tissue homeostasis
    • Ginhoux F, Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol. (2014) 14:392-404. doi:10.1038/nri3671.
    • (2014) Nat Rev Immunol , vol.14 , pp. 392-404
    • Ginhoux, F.1    Jung, S.2
  • 94
    • 85007174655 scopus 로고    scopus 로고
    • The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity
    • Laoui D, Keirsse J, Morias Y, Van Overmeire E, Geeraerts X, Elkrim Y, et al. The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity. Nat Commun. (2016) 7:1-17. doi:10.1038/ncomms13720.
    • (2016) Nat Commun , Issue.7 , pp. 1-17
    • Laoui, D.1    Keirsse, J.2    Morias, Y.3    Van, O.E.4    Geeraerts, X.5    Elkrim, Y.6
  • 95
    • 85018582872 scopus 로고    scopus 로고
    • Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes and progenitors
    • Villani A, Satija R, Reynolds G, Sarkizova S, Shekhar K, Fletcher J, et al. Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes and progenitors. Science (2017) 356:1-31. doi:10.1126/science.aah4573.
    • (2017) Science , vol.356 , pp. 1-31
    • Villani, A.1    Satija, R.2    Reynolds, G.3    Sarkizova, S.4    Shekhar, K.5    Fletcher, J.6
  • 96
    • 84874234535 scopus 로고    scopus 로고
    • Human inflammatory dendritic cells induce TH17 cell differentiation
    • Segura E, Touzot M, Bohineust A, Cappuccio A, Chiocchia G, Hosmalin A, et al. Human inflammatory dendritic cells induce Th17 cell differentiation. Immunity (2013) 38:336-48. doi:10.1016/j.immuni.2012.10.01.
    • (2013) Immunity , vol.38 , pp. 336-348
    • Segura, E.1    Touzot, M.2    Bohineust, A.3    Cappuccio, A.4    Chiocchia, G.5    Hosmalin, A.6
  • 97
    • 84937967684 scopus 로고    scopus 로고
    • The multifaceted biology of plasmacytoid dendritic cells
    • Swiecki M, Colonna M. The multifaceted biology of plasmacytoid dendritic cells. Nat Rev Immunol. (2015) 15:471-85. doi:10.1038/nri3865.
    • (2015) Nat Rev Immunol. , vol.15 , pp. 471-485
    • Swiecki, M.1    Colonna, M.2
  • 98
    • 84982732283 scopus 로고    scopus 로고
    • Expansion of a BDCA1+CD14+ myeloid cell population in melanoma patients may attenuate the efficacy of dendritic cell vaccines
    • Bakdash G, Buschow SI, Gorris MAJ, Halilovic A, Hato SV, Sko ld AE, et al. Expansion of a BDCA1+CD14+ myeloid cell population in melanoma patients may attenuate the efficacy of dendritic cell vaccines. Cancer Res. (2016) 76:4332-46. doi:10.1158/0008-5472.CAN-15-1695.
    • (2016) Cancer Res. , vol.76 , pp. 4332-4346
    • Bakdash, G.1    Buschow, S.I.2    Gorris, M.A.J.3    Halilovic, A.4    Hato, S.V.5    Sko, L.A.E.6
  • 100
    • 84975775438 scopus 로고    scopus 로고
    • State-of-The-Art of regulatory dendritic cells in cancer
    • Conejo-Garcia JR, Rutkowski MR, Cubillos-Ruiz JR. State-of-The-Art of regulatory dendritic cells in cancer. Pharmacol Ther. (2016) 164:97-104. doi:10.1016/j.pharmthera.2016.04.003.
    • (2016) Pharmacol Ther , vol.164 , pp. 97-104
    • Conejo-Garcia, J.R.1    Rutkowski, M.R.2    Cubillos-Ruiz, J.R.3
  • 101
    • 84911937777 scopus 로고    scopus 로고
    • Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity
    • Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, et al. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell (2014) 26:638-52. doi:10.1016/j.ccell.2014.09.007.
    • (2014) Cancer Cell , vol.26 , pp. 638-652
    • Broz, M.L.1    Binnewies, M.2    Boldajipour, B.3    Nelson, A.E.4    Pollack, J.L.5    Erle, D.J.6
  • 102
    • 85018766073 scopus 로고    scopus 로고
    • Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses
    • Lavin Y, Kobayashi S, Leader A, Amir E-AD, Elefant N, Bigenwald C, et al. Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses. Cell (2017) 169:750-65. doi:10.1016/j.cell.2017.04.014.
    • (2017) Cell , vol.169 , pp. 750-765
    • Lavin, Y.1    Kobayashi, S.2    Leader, A.3    Amir, E.-A.D.4    Elefant, N.5    Bigenwald, C.6
  • 103
    • 85020379791 scopus 로고    scopus 로고
    • Integrating next-generation dendritic cell vaccines into the current cancer immunotherapy landscape
    • Garg AD, Coulie PG, Van Den Eynde BJ, Agostinis P. Integrating next-generation dendritic cell vaccines into the current cancer immunotherapy landscape. Trends Immunol. (2017) 38:577-93. doi:10.1016/j.it.2017.05.006.
    • (2017) Trends Immunol , vol.38 , pp. 577-593
    • Garg, A.D.1    Coulie, P.G.2    Van Den Eynde, J.3    Agostinis, P.4
  • 105
    • 84935123210 scopus 로고    scopus 로고
    • Dendritic cell-based therapeutic cancer vaccines: Past, present and future
    • Ahmed S, Bae Y-S. Dendritic cell-based therapeutic cancer vaccines: Past, present and future. Clin Exp Vaccine Res. (2014) 3:113-6. doi:10.7774/cevr.2014.3.2.113.
    • (2014) Clin Exp Vaccine Res , vol.3 , pp. 113-116
    • Ahmed, S.1    Bae, Y.-S.2
  • 106
  • 107
    • 79957879852 scopus 로고    scopus 로고
    • Provenge (sipuleucel-T) in prostate cancer: The first fda-Approved therapeutic cancer vaccine
    • Cheever MA, Higano CS. PROVENGE (sipuleucel-T) in prostate cancer: The first FDA-Approved therapeutic cancer vaccine. Clin Cancer Res. (2011) 17:3520-6. doi: 10.1158/1078-0432.CCR-10-3126.
    • (2011) Clin Cancer Res , vol.17 , pp. 3520-3526
    • Cheever, M.A.1    Higano, C.S.2
  • 108
    • 84992585706 scopus 로고    scopus 로고
    • Gene-modified dendritic cell vaccines for cancer
    • Abraham RS, Mitchell DA. Gene-modified dendritic cell vaccines for cancer. Cytotherapy (2016) 18:1446-55. doi:10.1016/j.jcyt.2016.09.009.
    • (2016) Cytotherapy , vol.18 , pp. 1446-1455
    • Abraham, R.S.1    Mitchell, D.A.2
  • 110
    • 84959452716 scopus 로고    scopus 로고
    • Dendritic cell vaccines based on immunogenic cell death elicit danger signals and t cell-driven rejection of high-grade glioma dendritic cell vaccines based on immunogenic cell death elicit danger signals and t cell-driven rejection of high-grade glio
    • Garg AD, Vandenberk L, Koks C, Verschuere T, Boon L. Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glio. Immunotherapy (2016) 8:1-16. doi:10.1126/scitranslmed.aae0105.
    • (2016) Immunotherapy , vol.8 , pp. 1-16
    • Garg, A.D.1    Vandenberk, L.2    Koks, C.3    Verschuere, T.4    Boon, L.5
  • 111
    • 84857997683 scopus 로고    scopus 로고
    • A novel pathway combining calreticulin exposure and atp secretion in immunogenic cancer cell death
    • Garg AD, Krysko DV, Verfaillie T, Kaczmarek A, Ferreira GB, Marysael T, et al. A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death. EMBO J. (2012) 31:1062-79. doi:10.1038/emboj.2011.497.
    • (2012) EMBO J. , vol.31 , pp. 1062-1079
    • Garg, A.D.1    Krysko, D.V.2    Verfaillie, T.3    Kaczmarek, A.4    Ferreira, G.B.5    Marysael, T.6
  • 112
    • 85012123599 scopus 로고    scopus 로고
    • Generation of dendritic cell-based vaccine using high hydrostatic pressure for non-small cell lung cancer immunotherapy
    • Hradilova N, Sadilkova L, Palata O, Mysikova D, Mrazkova H, Lischke R, et al. Generation of dendritic cell-based vaccine using high hydrostatic pressure for non-small cell lung cancer immunotherapy. PLoS ONE (2017) 12: E0171539. doi:10.1371/journal.pone.0171539.
    • (2017) PLoS ONE , vol.12 , pp. e0171539
    • Hradilova, N.1    Sadilkova, L.2    Palata, O.3    Mysikova, D.4    Mrazkova, H.5    Lischke, R.6
  • 113
    • 84962019868 scopus 로고    scopus 로고
    • Intratumoral delivery of trimix mRNA results in t-cell activation by cross-presenting dendritic cells
    • Van Lint S, Renmans D, Broos K, Goethals L, Maenhout S, Benteyn D, et al. Intratumoral delivery of TriMix mRNA results in T-cell activation by cross-presenting dendritic cells. Cancer Immunol Res. (2016) 4:146-56. doi10.1158/2326-6066.CIR-15-0163.
    • (2016) Cancer Immunol Res. , vol.4 , pp. 146-156
    • Van Lint, S.1    Renmans, D.2    Broos, K.3    Goethals, L.4    Maenhout, S.5    Benteyn, D.6
  • 114
    • 84980318110 scopus 로고    scopus 로고
    • Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients
    • Seremet T, Koch A, Jansen Y, Schreuer M, Wilgenhof S, Marmol V, et al. Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients. J Transl Med. (2016) 14:1-14. doi:10.1186/s12967-016-0990-x.
    • (2016) J Transl Med , vol.14 , pp. 1-14
    • Seremet, T.1    Koch, A.2    Jansen, Y.3    Schreuer, M.4    Wilgenhof, S.5    Marmol, V.6
  • 115
    • 84963629041 scopus 로고    scopus 로고
    • Phase II study of autologous monocyte-derived mRNA electroporated dendritic cells (trimixdc-mel) plus ipilimumab in patientswith pretreated advanced melanoma
    • Wilgenhof S, Corthals J, Heirman C, Van Baren N, Lucas S, Kvistborg P, et al. Phase II study of autologous monocyte-derived mRNA electroporated dendritic cells (TriMixDC-MEL) plus ipilimumab in patientswith pretreated advanced melanoma. J Clin Oncol. (2016) 34:1330-8. doi:10.1200/JCO.2015.63.4121.
    • (2016) J Clin Oncol , vol.34 , pp. 1330-1338
    • Wilgenhof, S.1    Corthals, J.2    Heirman, C.3    Van Baren, N.4    Lucas, S.5    Kvistborg, P.6
  • 116
    • 70349136587 scopus 로고    scopus 로고
    • The role of CD40 and CD40L in dendritic cells
    • Ma DY, Clark EA. The role of CD40 and CD40L in dendritic cells. Semin Immunol. (2009) 21:265-72.
    • (2009) Semin Immunol. , vol.21 , pp. 265-272
    • Ma, D.Y.1    Clark, E.A.2
  • 117
    • 35948999237 scopus 로고    scopus 로고
    • Enhanced activation of human dendritic cells by inducible cd40 and toll-like receptor-4 ligation.
    • Lapteva N, Seethammagari MR, Hanks BA, Jiang H, Levitt JM, Slawin KM, et al. Enhanced activation of human dendritic cells by inducible CD40 and toll-like receptor-4 ligation. Cancer Res. (2007) 67:10528-37. doi:10.1158/0008-5472.CAN-07-0833.
    • (2007) Cancer Res , vol.67 , pp. 10528-10537
    • Lapteva, N.1    Seethammagari, M.R.2    Hanks, B.A.3    Jiang, H.4    Levitt, J.M.5    Slawin, K.M.6
  • 118
    • 70350225364 scopus 로고    scopus 로고
    • Nanoparticle-delivered multimeric soluble cd40l DNA combined with toll-like receptor agonists as a treatment for melanoma
    • Stone GW, Barzee S, Snarsky V, Santucci C, Tran B, Langer R, et al. Nanoparticle-delivered multimeric soluble CD40L DNA combined with toll-like receptor agonists as a treatment for melanoma. PLoS ONE (2009) 4:e7334. doi:10.1371/journal.pone.0007334.
    • (2009) PLoS ONE , vol.4 , pp. e7334
    • Stone, G.W.1    Barzee, S.2    Snarsky, V.3    Santucci, C.4    Tran, B.5    Langer, R.6
  • 119
    • 35548970740 scopus 로고    scopus 로고
    • Identification of clonogenic common FLT3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow
    • Onai N, Obata-Onai A, Schmid MA, Ohteki T, Jarrossay D, Manz MG. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol. (2007) 8:1207-16. doi:10.1038/ni1518.
    • (2007) Nat Immunol , vol.8 , pp. 1207-1216
    • Onai, N.1    Obata-Onai, A.2    Schmid, M.A.3    Ohteki, T.4    Jarrossay, D.5    Manz, M.G.6
  • 120
    • 84888414871 scopus 로고    scopus 로고
    • Fms-like tyrosine kinase 3 receptor ligand (FLT3L)-based vaccination administered with an adenoviral vector prevents tumor growth of colorectal cancer in a balb/c mouse model
    • Riediger C, Wingender G, Knolle P, Aulmann S, Stremmel W, Encke J. Fms-like tyrosine kinase 3 receptor ligand (Flt3L)-based vaccination administered with an adenoviral vector prevents tumor growth of colorectal cancer in a BALB/c mouse model. J Cancer Res Clin Oncol. (2013) 139:2097-110. doi:10.1007/s00432-013-1532-z.
    • (2013) J Cancer Res Clin Oncol , vol.139 , pp. 2097-2110
    • Riediger, C.1    Wingender, G.2    Knolle, P.3    Aulmann, S.4    Stremmel, W.5    Encke, J.6
  • 121
    • 84873460701 scopus 로고    scopus 로고
    • Natural human plasmacytoid dendritic cells induce antigen-specific t-cell responses in melanoma patients
    • Tel J, Aarntzen EHJG, Baba T, Schreibelt G, Schulte BM, Benitez-Ribas D, et al. Natural human plasmacytoid dendritic cells induce antigen-specific T-Cell responses in melanoma patients. Cancer Res. (2013) 73:1063-75. doi:10.1158/0008-5472.CAN-12-2583.
    • (2013) Cancer Res , vol.73 , pp. 1063-1075
    • Tel, J.1    Aarntzen, E.H.J.G.2    Baba, T.3    Schreibelt, G.4    Schulte, B.M.5    Benitez-Ribas, D.6
  • 122
    • 84969194975 scopus 로고    scopus 로고
    • Effective clinical responses in metastatic melanoma patients after vaccination with primary myeloid dendritic cells
    • Schreibelt G, Bol KF, Westdorp H, Wimmers F, Aarntzen EHJG, Duiveman-De Boer T, et al. Effective clinical responses in metastatic melanoma patients after vaccination with primary myeloid dendritic cells. Clin Cancer Res. (2016) 22:2155-66. doi:10.1158/1078-0432.CCR-15-2205.
    • (2016) Clin Cancer Res , vol.22 , pp. 2155-2166
    • Schreibelt, G.1    Bol, K.F.2    Westdorp, H.3    Wimmers, F.4    Aarntzen, E.H.J.G.5    Duiveman-De, B.T.6
  • 123
    • 79959255984 scopus 로고    scopus 로고
    • Intratumoral administration of tlr4 agonist absorbed into a cellular vector improves antitumor responses
    • Davis MB, Vasquez-Dunddel D, Fu J, Albesiano E, Pardoll D, Kim YJ. Intratumoral administration of TLR4 agonist absorbed into a cellular vector improves antitumor responses. Clin Cancer Res. (2011) 17:3984-92. doi:10.1158/1078-0432.CCR-10-3262.
    • (2011) Clin Cancer Res , vol.17 , pp. 3984-3992
    • Davis, M.B.1    Vasquez-Dunddel, D.2    Fu, J.3    Albesiano, E.4    Pardoll, D.5    Kim, Y.J.6
  • 124
    • 84964344569 scopus 로고    scopus 로고
    • Expansion and activation of cd103+ dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic pd-l1 and braf inhibition
    • Salmon H, Idoyaga J, Rahman A, Leboeuf M, Remark R, Jordan S, et al. Expansion and activation of CD103+ dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition. Immunity (2016) 44:924-38. doi:10.1016/j.immuni.2016.03.012.
    • (2016) Immunity , vol.44 , pp. 924-938
    • Salmon, H.1    Idoyaga, J.2    Rahman, A.3    Leboeuf, M.4    Remark, R.5    Jordan, S.6
  • 125
    • 84912079521 scopus 로고    scopus 로고
    • Nanovaccine loaded with poly I: C and STAT3 sirna robustly elicits anti-Tumor immune responses through modulating tumor-Associated dendritic cells in vivo
    • Luo Z, Wang C, Yi H, Li P, Pan H, Liu L, Cai L, Ma Y. Nanovaccine loaded with poly I: C and STAT3 siRNA robustly elicits anti-Tumor immune responses through modulating tumor-Associated dendritic cells in vivo. Biomaterials (2015) 38:50-60. doi:10.1016/j.biomaterials.2014.10.050.
    • (2015) Biomaterials , vol.38 , pp. 50-60
    • Luo, Z.1    Wang, C.2    Yi, H.3    Li, P.4    Pan, H.5    Liu, L.6    Cai, L.7    Ma, Y.8
  • 126
    • 84919667582 scopus 로고    scopus 로고
    • Cd40-Targeted dendritic cell delivery of plga-nanoparticle vaccines induce potent anti-Tumor responses
    • Rosalia RA, Cruz LJ, van Duikeren S, Tromp AT, Silva AL, Jiskoot W, et al. CD40-Targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-Tumor responses. Biomaterials (2015) 40:88-97. doi:10.1016/j.biomaterials.2014.10.053.
    • (2015) Biomaterials , vol.40 , pp. 88-97
    • Rosalia, R.A.1    Cruz, L.J.2    Van Duikeren, S.3    Tromp, A.T.4    Silva, A.L.5    Jiskoot, W.6
  • 127
    • 0034979375 scopus 로고    scopus 로고
    • Sentinel lymph nodes show profound downregulation of antigen-presenting cells of the paracortex: Implications for tumor biology and treatment
    • Cochran AJ, Morton DL, Stern S, Lana AM, Essner R, Wen DR. Sentinel lymph nodes show profound downregulation of antigen-presenting cells of the paracortex: implications for tumor biology and treatment. Mod Pathol. (2001) 14:604-8. doi:10.1038/modpathol.3880358.
    • (2001) Mod Pathol , vol.14 , pp. 604-608
    • Cochran, A.J.1    Morton, D.L.2    Stern, S.3    Lana, A.M.4    Essner, R.5    Wen, D.R.6
  • 128
    • 84962216970 scopus 로고    scopus 로고
    • Arming the melanoma sentinel lymph node through local administration of cpg-b and gm-csf: Recruitment and activation of bdca3/cd141+ dendritic cells and enhanced cross-presentation
    • Sluijter BJR, van den Hout MFCM, Koster BD, van Leeuwen PAM, Schneiders FL, van de Ven R, et al. Arming the melanoma sentinel lymph node through local administration of CpG-B and GM-CSF: Recruitment and activation of BDCA3/CD141+ dendritic cells and enhanced cross-presentation. Cancer Immunol Res. (2015) 3:495-505. doi:10.1158/2326-6066.CIR-14-0165.
    • (2015) Cancer Immunol Res , vol.3 , pp. 495-505
    • Sluijter, B.J.R.1    Van Den Hout, M.2    Koster, B.D.3    Van Leeuwen, M.4    Schneiders, F.L.5    Van De Ven, R.6
  • 131
    • 84975832642 scopus 로고    scopus 로고
    • Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
    • Kranz LM, Diken M, Haas H, Kreiter S, Loquai C, Reuter KC, et al. Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy. Nature (2016) 534:396-401. doi:10.1038/nature18300.
    • (2016) Nature , vol.534 , pp. 396-401
    • Kranz, L.M.1    Diken, M.2    Haas, H.3    Kreiter, S.4    Loquai, C.5    Reuter, K.C.6
  • 132
    • 85041637908 scopus 로고    scopus 로고
    • Nk cells stimulate recruitment of cdc1 into the tumor microenvironment promoting cancer immune control
    • e14
    • Böttcher JP, Bonavita E, Chakravarty P, Blees H, Cabeza-Cabrerizo M, Sammicheli S, et al. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control. Cell (2018) 172:1022-8.e14. doi:10.1016/j.cell.2018.01.004.
    • (2018) Cell , vol.172 , pp. 1022-1028
    • Böttcher, J.P.1    Bonavita, E.2    Chakravarty, P.3    Blees, H.4    Cabeza-Cabrerizo, M.5    Sammicheli, S.6
  • 134
    • 85047939782 scopus 로고    scopus 로고
    • New insights into the biological impacts of immune cell-derived exosomes within the tumor environment
    • Shen M, Ren X. New insights into the biological impacts of immune cell-derived exosomes within the tumor environment. Cancer Lett. (2018) 431:115-22. doi:10.1016/j.canlet.2018.05.040.
    • (2018) Cancer Lett , vol.431 , pp. 115-122
    • Shen, M.1    Ren, X.2
  • 135
    • 85023186415 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models
    • Lu Z, Zuo B, Jing R, Gao X, Rao Q, Liu Z, et al. Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models. J Hepatol. (2017) 67:739-48. doi:10.1016/j.jhep.2017.05.019.
    • (2017) J Hepatol , vol.67 , pp. 739-748
    • Lu, Z.1    Zuo, B.2    Jing, R.3    Gao, X.4    Rao, Q.5    Liu, Z.6
  • 136
    • 84874108466 scopus 로고    scopus 로고
    • Chemoimmunotherapy:reengineering tumor immunity
    • Chen Gang EL. Chemoimmunotherapy:reengineering tumor immunity. Cancer Immunol Immunother. (2013) 33:203-16. doi:10.1007/s00262-012-1388-0.
    • (2013) Cancer Immunol Immunother , vol.33 , pp. 203-216
    • Chen, G.E.L.1
  • 137
    • 85040721940 scopus 로고    scopus 로고
    • Establishment of synergistic chemoimmunotherapy for head and neck cancer using peritumoral immature dendritic cell injections and low-dose chemotherapies
    • Ishii H, Chikamatsu K, Igarashi S, Takahashi H, Sakamoto K, Higuchi H, et al. Establishment of synergistic chemoimmunotherapy for head and neck cancer using peritumoral immature dendritic cell injections and low-dose chemotherapies. Transl Oncol. (2018) 11:18-23. doi:10.1016/j.tranon.2017.11.006.
    • (2018) Transl Oncol , vol.11 , pp. 18-23
    • Ishii, H.1    Chikamatsu, K.2    Igarashi, S.3    Takahashi, H.4    Sakamoto, K.5    Higuchi, H.6
  • 138
    • 84988915207 scopus 로고    scopus 로고
    • Extended tumor control after dendritic cell vaccination with low-dose cyclophosphamide as adjuvant treatment in patients with malignant pleural mesothelioma
    • Cornelissen R, Hegmans JPJJ, Maat APWM, Kaijen-Lambers MEH, Bezemer K, Hendriks RW, et al. Extended tumor control after dendritic cell vaccination with low-dose cyclophosphamide as adjuvant treatment in patients with malignant pleural mesothelioma. Am J Respir Crit Care Med. (2016) 193:1023-31. doi:10.1164/rccm.201508-1573OC.
    • (2016) Am J Respir Crit Care Med. , vol.193 , pp. 1023-1031
    • Cornelissen, R.1    Hegmans, J.P.J.J.2    Maat, A.P.W.M.3    Kaijen-Lambers, M.E.H.4    Bezemer, K.5    Hendriks, R.W.6
  • 140
    • 84865974140 scopus 로고    scopus 로고
    • Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis
    • Jamieson T, Clarke M, Steele CW, Samuel MS, Neumann J, Jung A, et al. Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. J Clin Invest. (2012) 122:3127-44. doi:10.1172/JCI61067.
    • (2012) J Clin Invest , vol.122 , pp. 3127-3144
    • Jamieson, T.1    Clarke, M.2    Steele, C.W.3    Samuel, M.S.4    Neumann, J.5    Jung, A.6
  • 141
    • 85042498257 scopus 로고    scopus 로고
    • Neutrophils, g-CSF and their contribution to breast cancer metastasis
    • Mouchemore KA, Anderson RL, Hamilton JA. Neutrophils, G-CSF and their contribution to breast cancer metastasis. FEBS J. (2018) 285:665-79. doi:10.1111/febs.14206.
    • (2018) FEBS J , vol.285 , pp. 665-679
    • Mouchemore, K.A.1    Anderson, R.L.2    Hamilton, J.A.3
  • 142
    • 84989948632 scopus 로고    scopus 로고
    • Key role for neutrophils in radiation-induced antitumor immune responses: Potentiation with G-CSF
    • Takeshima T, Pop LM, Laine A, Iyengar P, Vitetta ES, Hannan R. Key role for neutrophils in radiation-induced antitumor immune responses: Potentiation with G-CSF. Proc Natl Acad Sci USA. (2016) 113:11300-5. doi:10.1073/pnas.1613187113.
    • (2016) Proc Natl Acad Sci USA , vol.113 , pp. 11300-11305
    • Takeshima, T.1    Pop, L.M.2    Laine, A.3    Iyengar, P.4    Vitetta, E.S.5    Hannan, R.6
  • 143
    • 85027531032 scopus 로고    scopus 로고
    • Neutrophils in cancer: Prognostic role and therapeutic strategies
    • Ocana A, Nieto-Jiménez C, Pandiella A, Templeton AJ. Neutrophils in cancer: Prognostic role and therapeutic strategies. Mol Cancer (2017) 16:1-7. doi:10.1186/s12943-017-0707-7.
    • (2017) Mol Cancer , vol.16 , pp. 1-7
    • Ocana, A.1    Nieto-Jiménez, C.2    Pandiella, A.3    Templeton, A.J.4
  • 144
    • 84962762345 scopus 로고    scopus 로고
    • Human neutrophils: Their role in cancer and relation to myeloid-derived suppressor cells
    • Moses K, Brandau S. Human neutrophils: Their role in cancer and relation to myeloid-derived suppressor cells. Semin Immunol. (2016) 28:187-96. doi:10.1016/j.smim.2016.03.018.
    • (2016) Semin Immunol , vol.28 , pp. 187-196
    • Moses, K.1    Brandau, S.2
  • 145
    • 84948963323 scopus 로고    scopus 로고
    • Transcriptional regulation of myeloid-derived suppressor cells
    • Condamine T, Mastio J, Gabrilovich DI. Transcriptional regulation of myeloid-derived suppressor cells. J Leukoc Biol. (2015) 98:913-22. doi:10.1189/jlb.4RI0515-204R.
    • (2015) J Leukoc Biol , vol.98 , pp. 913-922
    • Condamine, T.1    Mastio, J.2    Gabrilovich, D.I.3
  • 146
    • 84946050055 scopus 로고    scopus 로고
    • Breast cancer associated A2 isoform vacuolar atpase immunomodulates neutrophils: Potential role in tumor progression
    • Ibrahim SA, Katara GK, Kulshrestha A, Jaiswal MK, Amin MA, Beaman KD. Breast cancer associated A2 isoform vacuolar ATPase immunomodulates neutrophils: Potential role in tumor progression. Oncotarget (2015) 6:33033-45. doi:10.18632/oncotarget.5439.
    • (2015) Oncotarget , vol.6 , pp. 33033-33045
    • Ibrahim, S.A.1    Katara, G.K.2    Kulshrestha, A.3    Jaiswal, M.K.4    Amin, M.A.5    Beaman, K.D.6
  • 149
    • 84946071949 scopus 로고    scopus 로고
    • Increased neutrophil-lymphocyte ratio is a poor prognostic factor in patients with esophageal cancer in a high incidence area in China
    • Yutong H, Xiaoli X, Shumei L, Shan S, Di L, Baoen S. Increased neutrophil-lymphocyte ratio is a poor prognostic factor in patients with esophageal cancer in a high incidence area in China. Arch Med Res. (2015) 46:557-63. doi:10.1016/j.arcmed.2015.09.003.
    • (2015) Arch Med Res. , vol.46 , pp. 557-563
    • Yutong, H.1    Xiaoli, X.2    Shumei, L.3    Shan, S.4    Di, L.5    Baoen, S.6
  • 150
    • 85047202441 scopus 로고    scopus 로고
    • Pretreatment neutrophil-lymphocyte ratio: Useful prognostic biomarker in hepatocellular carcinoma
    • Najjar M, Agrawal S, Emond JC, Halazun KJ. Pretreatment neutrophil-lymphocyte ratio: useful prognostic biomarker in hepatocellular carcinoma. J Hepatocell Carcinoma (2018) 5:17-28. doi: 10.2147/JHC.S86792.
    • (2018) J Hepatocell Carcinoma , vol.5 , pp. 17-28
    • Najjar, M.1    Agrawal, S.2    Emond, J.C.3    Halazun, K.J.4
  • 151
    • 84866762166 scopus 로고    scopus 로고
    • The pros and cons of chemokines in tumor immunology
    • Viola A, Sarukhan A, Bronte V, Molon B. The pros and cons of chemokines in tumor immunology. Trends Immunol. (2012) 33:496-504. doi:10.1016/j.it.2012.05.007.
    • (2012) Trends Immunol , vol.33 , pp. 496-504
    • Viola, A.1    Sarukhan, A.2    Bronte, V.3    Molon, B.4
  • 152
    • 85036536357 scopus 로고    scopus 로고
    • Osteoblasts remotely supply lung tumors with cancer-promoting siglecfhighneutrophils
    • Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, et al. Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhighneutrophils. Science (2017) 358:eaal5081. doi:10.1126/science.aal5081.
    • (2017) Science , vol.358 , pp. eaal5081
    • Engblom, C.1    Pfirschke, C.2    Zilionis, R.3    Da Silva Martins, J.4    Bos, S.A.5    Courties, G.6
  • 153
    • 84902546905 scopus 로고    scopus 로고
    • Neutrophils recruit regulatory T-cells into tumors via secretion of CCL17-A new mechanism of impaired antitumor immunity
    • Mishalian I, Bayuh R, Eruslanov E, Michaeli J, Levy L, Zolotarov L, et al. Neutrophils recruit regulatory T-cells into tumors via secretion of CCL17-A new mechanism of impaired antitumor immunity. Int J Cancer (2014) 135:1178-86. doi: 10.1002/ijc.28770.
    • (2014) Int J Cancer , vol.135 , pp. 1178-1186
    • Mishalian, I.1    Bayuh, R.2    Eruslanov, E.3    Michaeli, J.4    Levy, L.5    Zolotarov, L.6
  • 154
    • 84952868028 scopus 로고    scopus 로고
    • Human polymorphonuclear neutrophils specifically recognize and kill cancerous cells
    • Yan J, Kloecker G, Fleming C, Bousamra M, Hansen R, Hu X, et al. Human polymorphonuclear neutrophils specifically recognize and kill cancerous cells. Oncoimmunology (2014) 3:e950163. doi:10.4161/15384101.2014.950163.
    • (2014) Oncoimmunology , vol.3 , pp. e950163
    • Yan, J.1    Kloecker, G.2    Fleming, C.3    Bousamra, M.4    Hansen, R.5    Hu, X.6
  • 155
    • 84950299450 scopus 로고    scopus 로고
    • Neutrophils support lung colonization of metastasis-initiating breast cancer cells
    • Wculek SK, Malanchi I. Neutrophils support lung colonization of metastasis-initiating breast cancer cells. Nature (2015) 528:413-7. doi:10.1038/nature16140.
    • (2015) Nature , vol.528 , pp. 413-417
    • Wculek, S.K.1    Malanchi, I.2
  • 156
    • 80052869906 scopus 로고    scopus 로고
    • Tumor-recruited neutrophils and neutrophil timp-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation
    • Bekes EM, Schweighofer B, Kupriyanova TA, Zajac E, Ardi VC, Quigley JP, et al. Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation. Am J Pathol. (2011) 179:1455-70. doi:10.1016/j.ajpath.2011.05.031.
    • (2011) Am J Pathol , vol.179 , pp. 1455-1470
    • Bekes, E.M.1    Schweighofer, B.2    Kupriyanova, T.A.3    Zajac, E.4    Ardi, V.C.5    Quigley, J.P.6
  • 157
    • 77951187779 scopus 로고    scopus 로고
    • Neutrophils responsive to endogenous IFN-b regulate tumor angiogenesis and growth in a mouse tumor model
    • Jablonska J, Leschner S, Westphal K, Lienenklaus S, Weiss S. Neutrophils responsive to endogenous IFN-b regulate tumor angiogenesis and growth in a mouse tumor model. J Clin Invest. (2010) 120:1151-64. doi:10.1172/JCI37223.
    • (2010) J Clin Invest , vol.120 , pp. 1151-1164
    • Jablonska, J.1    Leschner, S.2    Westphal, K.3    Lienenklaus, S.4    Weiss, S.5
  • 158
    • 84942932323 scopus 로고    scopus 로고
    • Il17 promotes mammary tumor progression by changing the behavior of tumor cells and eliciting tumorigenic neutrophils recruitment
    • Benevides L, Da Fonseca DM, Donate PB, Tiezzi DG, De Carvalho DD, De Andrade JM, et al. IL17 promotes mammary tumor progression by changing the behavior of tumor cells and eliciting tumorigenic neutrophils recruitment. Cancer Res (2015) 75:3788-99. doi:10.1158/0008-5472.CAN-15-0054.
    • (2015) Cancer Res , vol.75 , pp. 3788-3799
    • Benevides, L.1    Da Fonseca, D.M.2    Donate, P.B.3    Tiezzi, D.G.4    De Carvalho, D.D.5    De Andrade, M.6
  • 159
    • 69249222379 scopus 로고    scopus 로고
    • Polarization of tumor-Associated neutrophil (TAN) phenotype by TGF-ß: "N1" versus "n2" TAN
    • Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G, Worthen GS, et al. Polarization of tumor-Associated neutrophil (TAN) phenotype by TGF-ß: "N1" versus "N2" TAN. Cancer Cell (2009) 16:183-94. doi:10.1016/j.ccr.2009.06.017.
    • (2009) Cancer Cell , vol.16 , pp. 183-194
    • Fridlender, Z.G.1    Sun, J.2    Kim, S.3    Kapoor, V.4    Cheng, G.5    Worthen, G.S.6
  • 160
    • 84958925156 scopus 로고    scopus 로고
    • Type i ifns induce anti-Tumor polarization of tumor associated neutrophils in mice and human
    • Andzinski L, Kasnitz N, Stahnke S, Wu CF, Gereke M, Von Köckritz-Blickwede M, et al. Type i IFNs induce anti-Tumor polarization of tumor associated neutrophils in mice and human. Int J Cancer (2016) 138:1982-93doi:10.1002/ijc.29945.
    • (2016) Int J Cancer , vol.138 , pp. 1982-1993
    • Andzinski, L.1    Kasnitz, N.2    Stahnke, S.3    Wu, C.F.4    Gereke, M.5    Von, K.-B.M.6
  • 161
    • 85009347639 scopus 로고    scopus 로고
    • The essential role of type i interferons in differentiation and activation of tumor-Associated neutrophils
    • Pylaeva E, Lang S, Jablonska J. The essential role of type I interferons in differentiation and activation of tumor-Associated neutrophils. Front Immunol. (2016) 7:629. doi:10.3389/fimmu.2016.00629.
    • (2016) Front Immunol , vol.7 , pp. 629
    • Pylaeva, E.1    Lang, S.2    Jablonska, J.3
  • 162
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal
    • Similarities between tumor stroma generation and wound healing
    • Dvorak HF. Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med. (1986) 315:1650-9.
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 163
    • 79953672266 scopus 로고    scopus 로고
    • Polymorphonuclear neutrophils and cancer: Intense and sustained neutrophilia as a treatment against solid tumors
    • Souto JC, Vila L, Bru A. Polymorphonuclear neutrophils and cancer: intense and sustained neutrophilia as a treatment against solid tumors. Med Res Rev. (2009) 31:311-63. doi:10.1002/med.20185.
    • (2009) Med Res Rev , vol.31 , pp. 311-363
    • Souto, J.C.1    Vila, L.2    Bru, A.3
  • 164
    • 84869506980 scopus 로고    scopus 로고
    • G-csf rescues tumor growth and neo-Angiogenesis during liver metastasis under host angiopoietin-2 deficiency
    • Im JH, Tapmeier T, Balathasan L, Gal A, Yameen S, Hill S, et al. G-CSF rescues tumor growth and neo-Angiogenesis during liver metastasis under host angiopoietin-2 deficiency. Int J Cancer (2013) 132:315-26. doi:10.1002/ijc.27677.
    • (2013) Int J Cancer , vol.132 , pp. 315-326
    • Im, J.H.1    Tapmeier, T.2    Balathasan, L.3    Gal, A.4    Yameen, S.5    Hill, S.6
  • 165
    • 85028566036 scopus 로고    scopus 로고
    • Development of aggressive pancreatic ductal adenocarcinomas depends on granulocyte-colony stimulating factor secretion in carcinoma cells
    • Pickup MW, Owens P, Gorska AE, Chytil A, Ye F, Shi C, et al. Development of aggressive pancreatic ductal adenocarcinomas depends on granulocyte-colony stimulating factor secretion in carcinoma cells. Cancer Immunol Res. (2017) 5:718-29. doi: 10.1158/2326-6066.CIR-16-0311.
    • (2017) Cancer Immunol Res , vol.5 , pp. 718-729
    • Pickup, M.W.1    Owens, P.2    Gorska, A.E.3    Chytil, A.4    Ye, F.5    Shi, C.6
  • 166
    • 84957432656 scopus 로고    scopus 로고
    • G-csf is a key modulator of MDSC and could be a potential therapeutic target in colitis-Associated colorectal cancers
    • Li W, Zhang X, Chen Y, Xie Y, Liu J, Feng Q, et al. G-CSF is a key modulator of MDSC and could be a potential therapeutic target in colitis-Associated colorectal cancers. Protein Cell (2016) 7:130-40. doi:10.1007/s13238-015-0237-2.
    • (2016) Protein Cell , vol.7 , pp. 130-140
    • Li, W.1    Zhang, X.2    Chen, Y.3    Xie, Y.4    Liu, J.5    Feng, Q.6
  • 167
    • 85020217578 scopus 로고    scopus 로고
    • Glioblastoma-synthesized g-csf and gm-csf contribute to growth and immunosuppression: Potential therapeutic benefit from dapsone, fenofibrate, and ribavirin
    • 1010428317699797
    • Kast RE, Hill QA, Wion D, Mellstedt H, Focosi D, Karpel-Massler G, et al. Glioblastoma-synthesized G-CSF and GM-CSF contribute to growth and immunosuppression: Potential therapeutic benefit from dapsone, fenofibrate, and ribavirin. Tumor Biol. (2017) 39:1010428317699797. doi:10.1177/1010428317699797.
    • (2017) Tumor Biol , vol.39
    • Kast, R.E.1    Hill, Q.A.2    Wion, D.3    Mellstedt, H.4    Focosi, D.5    Karpel-Massler, G.6
  • 168
    • 80052566377 scopus 로고    scopus 로고
    • Tumor entrained neutrophils inhibit seeding in the premetastatic lung
    • Granot Z, Henke E, Comen E, King T, Norton L, Benezra R. Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell (2011) 20:300-14. doi:10.1016/j.ccr.2011.08.012.
    • (2011) Cancer Cell , vol.20 , pp. 300-314
    • Granot, Z.1    Henke, E.2    Comen, E.3    King, T.4    Norton, L.5    Benezra, R.6
  • 169
    • 85016266410 scopus 로고    scopus 로고
    • G-csf maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling
    • Bajrami B, Zhu H, Kwak H-J, Mondal S, Hou Q, Geng G, et al. G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling. J Exp Med. (2016) 213:1999-2018. doi:10.1084/jem.20160393.
    • (2016) J Exp Med , vol.213 , pp. 1999-2018
    • Bajrami, B.1    Zhu, H.2    Kwak, H.-J.3    Mondal, S.4    Hou, Q.5    Geng, G.6
  • 170
    • 84929519381 scopus 로고    scopus 로고
    • Nfat1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer
    • Kaunisto A, Henry WS, Montaser-Kouhsari L, Jaminet SC, Oh EY, Zhao L, et al. NFAT1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer. Mol Oncol. (2015) 9:1140-54. doi:10.1016/j.molonc.2015.02.004.
    • (2015) Mol Oncol , vol.9 , pp. 1140-1154
    • Kaunisto, A.1    Henry, W.S.2    Montaser-Kouhsari, L.3    Jaminet, S.C.4    Oh, E.Y.5    Zhao, L.6
  • 171
    • 84876156177 scopus 로고    scopus 로고
    • Neutrophil chemokines secreted by tumor cells mount a lung antimetastatic response during renal cell carcinoma progression
    • López-Lago MA, Posner S, Thodima VJ, Molina AM, Motzer RJ, Chaganti R. Neutrophil chemokines secreted by tumor cells mount a lung antimetastatic response during renal cell carcinoma progression. Oncogene (2013) 32:1752-60. doi:10.1038/onc.2012.201.
    • (2013) Oncogene , vol.32 , pp. 1752-1760
    • López-Lago, M.A.1    Posner, S.2    Thodima, V.J.3    Molina, A.M.4    Motzer, R.J.5    Chaganti, R.6
  • 172
    • 85022060715 scopus 로고    scopus 로고
    • Cabozantinib eradicates advanced murine prostate cancer by activating antitumor innate immunity
    • Patnaik A, Swanson KD, Csizmadia E, Solanki A, Landon-Brace N, Gehring MP, et al. Cabozantinib eradicates advanced murine prostate cancer by activating antitumor innate immunity. Cancer Discov. (2017) 7:750-65. doi10.1158/2159-8290.CD-16-0778.
    • (2017) Cancer, Discov , vol.7 , pp. 750-765
    • Patnaik, A.1    Swanson, K.D.2    Csizmadia, E.3    Solanki, A.4    Landon-Brace, N.5    Gehring, M.P.6
  • 173
    • 85018869328 scopus 로고    scopus 로고
    • Effective combinatorial immunotherapy for castration resistant prostate cancer
    • Lu X, Horner JW, Paul E, Shang X, Troncoso P, Deng P, et al. Effective combinatorial immunotherapy for castration resistant prostate cancer. Nature (2017) 344:1173-8. doi:10.1038/nature21676.
    • (2017) Nature , vol.344 , pp. 1173-1178
    • Lu, X.1    Horner, J.W.2    Paul, E.3    Shang, X.4    Troncoso, P.5    Deng, P.6
  • 174
    • 84946925389 scopus 로고    scopus 로고
    • CXCR2 inhibition combined with sorafenib improved antitumor and antiangiogenic response in preclinical models of ovarian cancer
    • Devapatla B, Sharma A, Woo S. CXCR2 inhibition combined with sorafenib improved antitumor and antiangiogenic response in preclinical models of ovarian cancer. PLoS ONE (2015) 10:e0139237. doi:10.1371/journal.pone.0139237.
    • (2015) PLoS ONE , vol.10 , pp. e0139237
    • Devapatla, B.1    Sharma, A.2    Woo, S.3
  • 175
    • 85032788807 scopus 로고    scopus 로고
    • Reactive neutrophil responses dependent on the receptor tyrosine kinase c-MET limit cancer immunotherapy
    • e9
    • Glodde N, Bald T, van den Boorn-Konijnenberg D, Nakamura K, O'Donnell JS, Szczepanski S, et al. Reactive neutrophil responses dependent on the receptor tyrosine kinase c-MET limit cancer immunotherapy. Immunity (2017) 47:789-802.e9. doi:10.1016/j.immuni.2017.09.012.
    • (2017) Immunity , vol.47 , pp. 789-802
    • Glodde, N.1    Bald, T.2    Van Den Boorn-Konijnenberg, D.3    Nakamura, K.4    O'Donnell, J.S.5    Szczepanski, S.6
  • 177
    • 84952861791 scopus 로고    scopus 로고
    • Neutrophils in the tumor microenvironment
    • Powell DR, Huttenlocher A. Neutrophils in the tumor microenvironment. Trends Immunol. (2016) 37:41-52. doi:10.1016/j.it.2015.11.008.
    • (2016) Trends Immunol , vol.37 , pp. 41-52
    • Powell, D.R.1    Huttenlocher, A.2
  • 178
    • 84978371387 scopus 로고    scopus 로고
    • Origin and role of a subset of tumor-Associated neutrophils with antigen presenting cell features (hybrid tans) in early- stage human lung cancer
    • Singhal S, Bhojnagarwala PS, O'Brien S, Moon EK, Garfall AL, Rao A, et al. Origin and role of a subset of tumor-Associated neutrophils with antigen presenting cell features (hybrid TANs) in early- stage human lung cancer. Cancer Cell (2016) 30:120-35. doi:10.1016/j.ccell.2016.06.001.
    • (2016) Cancer Cell , vol.30 , pp. 120-135
    • Singhal, S.1    Bhojnagarwala, P.S.2    O'Brien, S.3    Moon, E.K.4    Garfall, A.L.5    Rao, A.6
  • 179
    • 84896382045 scopus 로고    scopus 로고
    • A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism
    • Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, et al. A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med. (2014) 6:225-9. doi:10.1126/scitranslmed.3007672.
    • (2014) Sci Transl Med , vol.6 , pp. 225-229
    • Robertson, A.L.1    Holmes, G.R.2    Bojarczuk, A.N.3    Burgon, J.4    Loynes, C.A.5    Chimen, M.6
  • 180
    • 84920019093 scopus 로고    scopus 로고
    • Redox and src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration
    • Tauzin S, Starnes TW, Becker FB, Lam P Ying, Huttenlocher A. Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. J Cell Biol. (2014) 207:589-98. doi:10.1083/jcb.201408090.
    • (2014) J Cell Biol , vol.207 , pp. 589-598
    • Tauzin, S.1    Starnes, T.W.2    Becker, F.B.3    Lam, P.Y.4    Huttenlocher, A.5
  • 181
    • 84937634493 scopus 로고    scopus 로고
    • Neutrophil elastase axis drives neutrophil reverse transendothelial cell migration in vivo
    • Colom B, Bodkin JV, Beyrau M, Woodfin A, Ody C, Rourke C, et al. Neutrophil elastase axis drives neutrophil reverse transendothelial cell migration in vivo. Immunity (2015) 42:1075-86. doi:10.1016/j.immuni.2015.05.010.
    • (2015) Immunity , vol.42 , pp. 1075-1086
    • Colom, B.1    Bodkin, J.V.2    Beyrau, M.3    Woodfin, A.4    Ody, C.5    Rourke, C.6
  • 182
    • 85037720074 scopus 로고    scopus 로고
    • Neutrophil elastase in the tumor microenvironment
    • Lerman I, Hammes SR. Neutrophil elastase in the tumor microenvironment. Steroids (2018) 133:96-101. doi:10.1016/j.steroids.2017.11.006.
    • (2018) Steroids , vol.133 , pp. 96-101
    • Lerman, I.1    Hammes, S.R.2
  • 183
    • 84926647283 scopus 로고    scopus 로고
    • Angels and demons: Th17 cells represent a beneficial response, while neutrophil IL-17 is associated with poor prognosis in squamous cervical cancer
    • Punt S, Fleuren GJ, Kritikou E, Lubberts E, Trimbos JB, Jordanova ES, et al. Angels and demons: Th17 cells represent a beneficial response, while neutrophil IL-17 is associated with poor prognosis in squamous cervical cancer. Oncoimmunology (2015) 4:984539. doi: 10.4161/2162402X.2014.984539.
    • (2015) Oncoimmunology , vol.4 , pp. 984539
    • Punt, S.1    Fleuren, G.J.2    Kritikou, E.3    Lubberts, E.4    Trimbos, J.B.5    Jordanova, E.S.6
  • 184
    • 84977632889 scopus 로고    scopus 로고
    • Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
    • Bronte V, Brandau S, Chen SH, Colombo MP, Frey AB, Greten TF, et al. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat Commun. (2016) 7:12150. doi:10.1038/ncomms12150.
    • (2006) Nat Commun , vol.7 , pp. 12150
    • Bronte, V.1    Brandau, S.2    Chen, S.H.3    Colombo, M.P.4    Frey, A.B.5    Greten, T.F.6
  • 185
    • 43249130187 scopus 로고    scopus 로고
    • Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct t cell-suppressive activity
    • Movahedi K, Guilliams M, Van Den Bossche J, Van Den Bergh R, Beschin A, De Baetselier P, et al. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood (2008) 111:4233-44. doi:10.1182/blood-2007-07-099226.
    • (2008) Blood , vol.111 , pp. 4233-4244
    • Movahedi, K.1    Guilliams, M.2    Van Den Bossche, J.3    Van Den Bergh, R.4    Beschin, A.5    De Baetselier, P.6
  • 186
    • 84885696103 scopus 로고    scopus 로고
    • Tumor-induced myeloid-derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct cd8+ t-cell activation events
    • Schouppe E, Mommer C, Movahedi K, Laoui D, Morias Y, Gysemans C, et al. Tumor-induced myeloid-derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+ T-cell activation events. Eur J Immunol. (2013) 43:2930-42. doi:10.1002/eji.201343349.
    • (2013) Eur J Immunol , vol.43 , pp. 2930-2942
    • Schouppe, E.1    Mommer, C.2    Movahedi, K.3    Laoui, D.4    Morias, Y.5    Gysemans, C.6
  • 187
    • 85040054110 scopus 로고    scopus 로고
    • Monocytic myeloid-derived suppressor cells in chronic infections
    • Dorhoi A, Du Plessis N. Monocytic myeloid-derived suppressor cells in chronic infections. Front Immunol. (2018) 8:1895. doi:10.3389/fimmu.2017.01895.
    • (2018) Front Immunol. , vol.8 , pp. 1895
    • Dorhoi, A.1    Du, P.N.2
  • 188
    • 85045706502 scopus 로고    scopus 로고
    • Phenotypic and functional alterations of myeloid-derived suppressor cells during the disease course of multiple sclerosis
    • Iacobaeus E, Douagi I, Jitschin R, Marcusson-Ståhl M, Törnqvist Andrén A, Gavin C, et al. Phenotypic and functional alterations of myeloid-derived suppressor cells during the disease course of multiple sclerosis. Immunol Cell Biol. (2018) 96:820-30. doi:10.1111/imcb.12042.
    • (2018) Immunol Cell Biol , vol.96 , pp. 820-830
    • Iacobaeus, E.1    Douagi, I.2    Jitschin, R.3    Marcusson-Ståhl, M.4    Törnqvist, A.A.5    Gavin, C.6
  • 189
    • 85047109289 scopus 로고    scopus 로고
    • The potential importance of myeloid-derived suppressor cells (mdscs) in the pathogenesis of Alzheimer's disease
    • Salminen A, Kaarniranta K, Kauppinen A. The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of Alzheimer's disease. Cell Mol Life Sci. (2018) 75:3099-120. doi:10.1007/s00018-018-2844-6.
    • (2018) Cell Mol Life Sci , vol.75 , pp. 3099-3120
    • Salminen, A.1    Kaarniranta, K.2    Kauppinen, A.3
  • 192
    • 84866920497 scopus 로고    scopus 로고
    • Immune tolerance to tumor antigens occurs in a specialized environment of the spleen
    • Ugel S, Peranzoni E, Desantis G, Chioda M, Walter S, Weinschenk T, et al. Immune tolerance to tumor antigens occurs in a specialized environment of the spleen. Cell Rep. (2012) 2:628-39. doi: 10.1016/j.celrep.2012.08.006.
    • (2012) Cell Rep , vol.2 , pp. 628-639
    • Ugel, S.1    Peranzoni, E.2    Desantis, G.3    Chioda, M.4    Walter, S.5    Weinschenk, T.6
  • 193
    • 77953914366 scopus 로고    scopus 로고
    • Tumor-induced tolerance and immune suppression depend on the c/ebpß transcription factor
    • Marigo I, Bosio E, Solito S, Mesa C, Fernandez A, Dolcetti L, et al. Tumor-induced tolerance and immune suppression depend on the C/EBPß transcription factor. Immunity (2010) 32:790-802. doi: 10.1016/j.immuni.2010.05.010.
    • (2010) Immunity , vol.32 , pp. 790-802
    • Marigo, I.1    Bosio, E.2    Solito, S.3    Mesa, C.4    Fernandez, A.5    Dolcetti, L.6
  • 194
    • 84890560741 scopus 로고    scopus 로고
    • Enhanced suppressive capacity of tumor-infiltrating myeloid-derived suppressor cells compared with their peripheral counterparts
    • Maenhout SK, Van Lint S, Emeagi PU, Thielemans K, Aerts JL. Enhanced suppressive capacity of tumor-infiltrating myeloid-derived suppressor cells compared with their peripheral counterparts. Int J Cancer (2014) 134:1077-90. doi: 10.1002/ijc.28449.
    • (2014) Int J Cancer , vol.134 , pp. 1077-1090
    • Maenhout, S.K.1    Van, L.S.2    Emeagi, P.U.3    Thielemans, K.4    Aerts, J.L.5
  • 195
    • 84992723893 scopus 로고    scopus 로고
    • The role of myeloid-derived suppressor cells in patients with solid tumors: A meta-Analysis
    • Zhang S, Ma X, Zhu C, Liu L, Wang G, Yuan X. The role of myeloid-derived suppressor cells in patients with solid tumors: A meta-Analysis. PLoS ONE (2016) 11:e0164514. doi:10.1371/journal.pone.0164514.
    • (2016) PLoS ONE , vol.11 , pp. e0164514
    • Zhang, S.1    Ma, X.2    Zhu, C.3    Liu, L.4    Wang, G.5    Yuan, X.6
  • 196
    • 5444225991 scopus 로고    scopus 로고
    • Expansion of myeloid immune suppressor gr+cd11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
    • Yang L, DeBusk LM, Fukuda K, Fingleton B, Green-Jarvis B, Shyr Y, et al. Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell (2004) 6:409-21. doi:10.1016/j.ccr.2004.08.031.
    • (2004) Cancer Cell , vol.6 , pp. 409-421
    • Yang, L.1    DeBusk, L.M.2    Fukuda, K.3    Fingleton, B.4    Green-Jarvis, B.5    Shyr, Y.6
  • 197
    • 77955384579 scopus 로고    scopus 로고
    • GR-1+CD11B+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung
    • Yan HH, Pickup M, Pang Y, Gorska AE, Li Z, Chytil A, et al. Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung. Cancer Res. (2010) 70:6139-49. doi:10.1158/0008-5472.CAN-10-0706.
    • (2010) Cancer Res , vol.70 , pp. 6139-6149
    • Yan, H.H.1    Pickup, M.2    Pang, Y.3    Gorska, A.E.4    Li, Z.5    Chytil, A.6
  • 198
    • 84912561603 scopus 로고    scopus 로고
    • Tumour-infiltrating gr-1 + myeloid cells antagonize senescence in cancer
    • Di Mitri D, Toso A, Chen JJ, Sarti M, Pinton S, Jost TR, et al. Tumour-infiltrating Gr-1 + myeloid cells antagonize senescence in cancer. Nature (2014) 515:134-37. doi:10.1038/nature13638.
    • (2014) Nature , vol.515 , pp. 134-137
    • Di, M.D.1    Toso, A.2    Chen, J.J.3    Sarti, M.4    Pinton, S.5    Jost, T.R.6
  • 199
    • 74249101123 scopus 로고    scopus 로고
    • Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF
    • Dolcetti L, Peranzoni E, Ugel S, Marigo I, Gomez AF, Mesa C, et al. Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF. Eur J Immunol. (2010) 40:22-35. doi:10.1002/eji.200939903.
    • (2010) Eur J Immunol. , vol.40 , pp. 22-35
    • Dolcetti, L.1    Peranzoni, E.2    Ugel, S.3    Marigo, I.4    Gomez, A.F.5    Mesa, C.6
  • 200
    • 80054694464 scopus 로고    scopus 로고
    • Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
    • Molon B, Ugel S, Del Pozzo F, Soldani C, Zilio S, Avella D, et al. Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J Exp Med. (2011) 208:1949-62. doi:10.1084/jem.20101956.
    • (2011) J Exp Med , vol.208 , pp. 1949-1962
    • Molon, B.1    Ugel, S.2    Del Pozzo, F.3    Soldani, C.4    Zilio, S.5    Avella, D.6
  • 201
    • 84951768535 scopus 로고    scopus 로고
    • Bone marrow PMN-MDSCS and neutrophils are functionally similar in protection of multiple myeloma from chemotherapy
    • Ramachandran IR, Condamine T, Lin C, Herlihy SE, Garfall A, Vogl DT, et al. Bone marrow PMN-MDSCs and neutrophils are functionally similar in protection of multiple myeloma from chemotherapy. Cancer Lett. (2016) 371:117-24. doi: 10.1016/j.canlet.2015.10.040.
    • (2016) Cancer Lett , vol.371 , pp. 117-124
    • Ramachandran, I.R.1    Condamine, T.2    Lin, C.3    Herlihy, S.E.4    Garfall, A.5    Vogl, D.T.6
  • 202
    • 84912081252 scopus 로고    scopus 로고
    • A circulating subpopulation of monocytic myeloid-derived suppressor cells as an independent prognostic/predictive factor in untreated non-small lung cancer patients
    • Vetsika EK, Koinis F, Gioulbasani M, Aggouraki D, Koutoulaki A, Skalidaki E, et al. A circulating subpopulation of monocytic myeloid-derived suppressor cells as an independent prognostic/predictive factor in untreated non-small lung cancer patients. J Immunol Res. (2014) 2014:659294. doi:10.1155/2014/659294.
    • (2014) J Immunol Res , vol.2014 , pp. 659294
    • Vetsika, E.K.1    Koinis, F.2    Gioulbasani, M.3    Aggouraki, D.4    Koutoulaki, A.5    Skalidaki, E.6
  • 203
    • 84894501478 scopus 로고    scopus 로고
    • Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab
    • Meyer C, Cagnon L, Costa-Nunes CM, Baumgaertner P, Montandon N, Leyvraz L, et al. Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab. Cancer Immunol Immunother. (2014) 63:247-57. doi:10.1007/s00262-013-1508-5.
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 247-257
    • Meyer, C.1    Cagnon, L.2    Costa-Nunes, C.M.3    Baumgaertner, P.4    Montandon, N.5    Leyvraz, L.6
  • 204
    • 85024402294 scopus 로고    scopus 로고
    • Myeloid suppressor cells in cancer and autoimmunity
    • Sica A, Massarotti M. Myeloid suppressor cells in cancer and autoimmunity. J Autoimmun. (2017) 85:117-25. doi:10.1016/j.jaut.2017.07.010.
    • (2017) J Autoimmun , vol.85 , pp. 117-125
    • Sica, A.1    Massarotti, M.2
  • 205
    • 84959542771 scopus 로고    scopus 로고
    • The nature of myeloid-derived suppressor cells in the tumor microenvironment
    • Kumar V, Patel S, Tcyganov E, Gabrilovich DI. The nature of myeloid-derived suppressor cells in the tumor microenvironment. Trends Immunol. (2016) 37:208-20. doi: 10.1016/j.it.2016.01.004.
    • (2016) Trends Immunol , vol.37 , pp. 208-220
    • Kumar, V.1    Patel, S.2    Tcyganov, E.3    Gabrilovich, D.I.4
  • 206
    • 84996598259 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells and proinflammatory cytokines as targets for cancer therapy
    • Atretkhany K-SN, Drutskaya MS. Myeloid-derived suppressor cells and proinflammatory cytokines as targets for cancer therapy. Biochemistry (2016) 81:1274-83. doi:10.1134/S0006297916110055.
    • (2016) Biochemistry , vol.81 , pp. 1274-1283
    • Atretkhany, K.-S.N.1    Drutskaya, M.S.2
  • 207
    • 84916908891 scopus 로고    scopus 로고
    • Human fibrocytic myeloid-derived suppressor cells express IDO and promote tolerance via treg-cell expansion
    • Zoso A, Mazza EMC, Bicciato S, Mandruzzato S, Bronte V, Serafini P, et al. Human fibrocytic myeloid-derived suppressor cells express IDO and promote tolerance via Treg-cell expansion. Eur J Immunol. (2014) 44:3307-19. doi:10.1002/eji.201444522.
    • (2014) Eur J Immunol. , vol.44 , pp. 3307-3319
    • Zoso, A.1    Mazza, E.M.C.2    Bicciato, S.3    Mandruzzato, S.4    Bronte, V.5    Serafini, P.6
  • 209
    • 59849126377 scopus 로고    scopus 로고
    • Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1
    • Li H, Han Y, Guo Q, Zhang M, Cao X. Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1. J Immunol. (2009) 182:240-9. doi:10.4049/jimmunol.182.1.240.
    • (2009) J Immunol. , vol.182 , pp. 240-249
    • Li, H.1    Han, Y.2    Guo, Q.3    Zhang, M.4    Cao, X.5
  • 210
    • 66949145484 scopus 로고    scopus 로고
    • Mechanisms regulating reactive oxygen species in tumor induced myeloid-derived suppressor cells: Mdsc and ros in cancer=
    • Corzo CA, Cotter MJ, Cheng P, Cheng F, Kusmartsev S, Sotomayor E, et al. Mechanisms regulating reactive oxygen species in tumor induced myeloid-derived suppressor cells: MDSC and ROS in cancer. J Immunol. (2009) 182:5693-701. doi:10.4049/jimmunol.0900092.
    • (2009) J Immunol. , vol.182 , pp. 5693-5701
    • Corzo, C.A.1    Cotter, M.J.2    Cheng, P.3    Cheng, F.4    Kusmartsev, S.5    Sotomayor, E.6
  • 211
    • 34447118098 scopus 로고    scopus 로고
    • Altered recognition of antigen is a novel mechanism of cd8+ t cell tolerance in cancer
    • Nagaraj S, Gupta K, Pisarev V, Kinarsky L, Sherman S, Kang L, et al. Altered recognition of antigen is a novel mechanism of CD8+ T cell tolerance in cancer. Nat Med. (2007) 13:828-35. doi:10.1038/nm1609.
    • (2007) Nat Med , vol.13 , pp. 828-835
    • Nagaraj, S.1    Gupta, K.2    Pisarev, V.3    Kinarsky, L.4    Sherman, S.5    Kang, L.6
  • 212
    • 84878030003 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells suppress antitumor immune responses through ido expression and correlate with lymph node metastasis in patients with breast cancer
    • Yu J, Du W, Yan F, Wang Y, Li H, Cao S, et al. Myeloid-derived suppressor cells suppress antitumor immune responses through ido expression and correlate with lymph node metastasis in patients with breast cancer. J Immunol. (2013) 190:3783-97. doi:10.4049/jimmunol.1390024.
    • (2013) J Immunol. , vol.190 , pp. 3783-3797
    • Yu, J.1    Du, W.2    Yan, F.3    Wang, Y.4    Li, H.5    Cao, S.6
  • 213
    • 84985982543 scopus 로고    scopus 로고
    • Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express s100a8/9 and arginase and suppress t cell function
    • Gielen PR, Schulte BM, Kers-Rebel ED, Verrijp K, Bossman SAJFH, Ter Laan M, et al. Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function. Neuro Oncol. (2016) 18:1253-64. doi:10.1093/neuonc/now034.
    • (2016) Neuro Oncol. , vol.18 , pp. 1253-1264
    • Gielen, P.R.1    Schulte, B.M.2    Kers-Rebel, E.D.3    Verrijp, K.4    Bossman, S.A.J.F.H.5    Ter, L.M.6
  • 214
    • 53349099219 scopus 로고    scopus 로고
    • Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by s100a9 protein
    • Cheng P, Corzo CA, Luetteke N, Yu B, Nagaraj S, Bui MM, et al. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med. (2008) 205:2235-49. doi:10.1084/jem.20080132.
    • (2008) J Exp Med , vol.205 , pp. 2235-2249
    • Cheng, P.1    Corzo, C.A.2    Luetteke, N.3    Yu, B.4    Nagaraj, S.5    Bui, M.M.6
  • 215
    • 53349125963 scopus 로고    scopus 로고
    • Proinflammatory s100 proteins regulate the accumulation of myeloid-derived suppressor cells
    • Sinha P, Okoro C, Foell D, Freeze HH, Ostrand-Rosenberg S, Srikrishna G. Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells. J Immunol. (2008) 181:4666-75. doi:10.4049/jimmunol.181.7.4666.
    • (2008) J Immunol , vol.181 , pp. 4666-4675
    • Sinha, P.1    Okoro, C.2    Foell, D.3    Freeze, H.H.4    Ostrand-Rosenberg, S.5    Srikrishna, G.6
  • 216
    • 84964490751 scopus 로고    scopus 로고
    • Low dose gemcitabine-loaded lipid nanocapsules target monocytic myeloid-derived suppressor cells and potentiate cancer immunotherapy
    • Sasso MS, Lollo G, Pitorre M, Solito S, Pinton L, Valpione S, et al. Low dose gemcitabine-loaded lipid nanocapsules target monocytic myeloid-derived suppressor cells and potentiate cancer immunotherapy. Biomaterials (2016) 96:47-62. doi:10.1016/j.biomaterials.2016.04.010.
    • (2016) Biomaterials , vol.96 , pp. 47-62
    • Sasso, M.S.1    Lollo, G.2    Pitorre, M.3    Solito, S.4    Pinton, L.5    Valpione, S.6
  • 217
    • 77951086882 scopus 로고    scopus 로고
    • 5-Fluorouracil selectively kills tumor-Associated myeloid-derived suppressor cells resulting in enhanced t cell-dependent antitumor immunity
    • Vincent J, Mignot G, Chalmin F, Ladoire S, Bruchard M, Chevriaux A, et al. 5-Fluorouracil selectively kills tumor-Associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity. Cancer Res. (2010) 70:3052-61. doi:10.1158/0008-5472.CAN-09-3690.
    • (2010) Cancer Res , vol.70 , pp. 3052-3061
    • Vincent, J.1    Mignot, G.2    Chalmin, F.3    Ladoire, S.4    Bruchard, M.5    Chevriaux, A.6
  • 218
    • 84955716519 scopus 로고    scopus 로고
    • Cisplatin selectively downregulated the frequency and immunoinhibitory function of myeloid-derived suppressor cells in a murine b16 melanoma model
    • Huang X, Cui S, Shu Y. Cisplatin selectively downregulated the frequency and immunoinhibitory function of myeloid-derived suppressor cells in a murine B16 melanoma model. Immunol Res. (2016) 64:160-70. doi:10.1007/s12026-015-8734-1.
    • (2016) Immunol Res. , vol.64 , pp. 160-170
    • Huang, X.1    Cui, S.2    Shu, Y.3
  • 219
    • 84902129552 scopus 로고    scopus 로고
    • Generation of a novel therapeutic peptide that depletes MDSC in tumor-bearing mice
    • Qin H, Lerman B, Sakamaki I, Wei G, Cha S, Rao SS, et al. Generation of a novel therapeutic peptide that depletes MDSC in tumor-bearing mice. Nat Med. (2014) 20:676-81. doi:10.1038/nm.3560.
    • (2014) Nat Med , vol.20 , pp. 676-681
    • Qin, H.1    Lerman, B.2    Sakamaki, I.3    Wei, G.4    Cha, S.5    Rao, S.S.6
  • 220
    • 84903368492 scopus 로고    scopus 로고
    • Specific inhibition of the vegfr-3 tyrosine kinase by SAR131675 reduces peripheral and tumor associated immunosuppressive myeloid cells
    • Espagnolle N, Barron P, Mandron M, Blanc I, Bonnin J, Agnel M, et al. Specific inhibition of the VEGFR-3 tyrosine kinase by SAR131675 reduces peripheral and tumor associated immunosuppressive myeloid cells. Cancers (2014) 6:472-90. doi:10.3390/cancers6010472.
    • (2014) Cancers , vol.6 , pp. 472-490
    • Espagnolle, N.1    Barron, P.2    Mandron, M.3    Blanc, I.4    Bonnin, J.5    Agnel, M.6
  • 221
    • 84971009622 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells express bruton's tyrosine kinase and can be depleted in tumor bearing hosts by ibrutinib treatment hhs public access
    • Stiff A, Trikha P, Wesolowski R, Kendra K, Hsu V, Uppati S, et al. Myeloid-derived suppressor cells express Bruton's tyrosine kinase and can be depleted in tumor bearing hosts by ibrutinib treatment HHS Public Access. Cancer Res. (2016) 15:2125-36. doi:10.1158/0008-5472.CAN-15-1490.
    • (2016) Cancer Res , vol.15 , pp. 2125-2136
    • Stiff, A.1    Trikha, P.2    Wesolowski, R.3    Kendra, K.4    Hsu, V.5    Uppati, S.6
  • 222
    • 84982850702 scopus 로고    scopus 로고
    • Interleukin-10 attenuates tumour growth by inhibiting interleukin-6/signal transducer and activator of transcription 3 signalling in myeloid-derived suppressor cells
    • Lee BR, Kwon BE, Hong EH, Shim A, Song JH, Kim HM, et al. Interleukin-10 attenuates tumour growth by inhibiting interleukin-6/signal transducer and activator of transcription 3 signalling in myeloid-derived suppressor cells. Cancer Lett. (2016) 381:156-64. doi: 10.1016/j.canlet.2016.07.012.
    • (2016) Cancer Lett. , vol.381 , pp. 156-164
    • Lee, B.R.1    Kwon, B.E.2    Hong, E.H.3    Shim, A.4    Song, J.H.5    Kim, H.M.6
  • 223
    • 85033366107 scopus 로고    scopus 로고
    • Pi3k? Activates integrin a 4 and promotes immune suppressive myeloid cell polarization during tumor progression
    • Foubert P, Kaneda MM, Varner JA. PI3K? activates integrin a 4 and promotes immune suppressive myeloid cell polarization during tumor progression. Cancer Immunol Res. (2017) 5:957-68. doi:10.1158/2326-6066.CIR-17-0143.
    • (2017) Cancer Immunol Res. , vol.5 , pp. 957-968
    • Foubert, P.1    Kaneda, M.M.2    Varner, J.A.3
  • 224
    • 85020802570 scopus 로고    scopus 로고
    • Selective targeting of myeloid-derived suppressor cells in cancer patients using ds-8273a, an agonistic trail-r2 antibody
    • Dominguez GA, Condamine T, Mony S, Hashimoto A, Wang F, Liu Q, et al. Selective targeting of myeloid-derived suppressor cells in cancer patients using DS-8273a, an agonistic TRAIL-R2 antibody. Clin Cancer Res. (2017) 23:2942-50. doi:10.1158/1078-0432.CCR-16-1784.
    • (2017) Clin Cancer Res. , vol.23 , pp. 2942-2950
    • Dominguez, G.A.1    Condamine, T.2    Mony, S.3    Hashimoto, A.4    Wang, F.5    Liu, Q.6
  • 225
    • 84940720838 scopus 로고    scopus 로고
    • Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma
    • Guislain A, Gadiot J, Kaiser A, Jordanova ES, Broeks A, Sanders J, et al. Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma. Cancer Immunol Immunother. (2015) 64:1241-50. doi: 10.1007/s00262-015-1735-z.
    • (2015) Cancer Immunol Immunother , vol.64 , pp. 1241-1250
    • Guislain, A.1    Gadiot, J.2    Kaiser, A.3    Jordanova, E.S.4    Broeks, A.5    Sanders, J.6
  • 226
    • 85024881255 scopus 로고    scopus 로고
    • Phenformin inhibits myeloid-derived suppressor cells and enhances the anti-Tumor activity of pd-1 blockade in melanoma
    • Kim SH, Li M, Trousil S, Zhang Y, Pasca di Magliano M, Swanson KD, et al. Phenformin inhibits myeloid-derived suppressor cells and enhances the anti-Tumor activity of PD-1 blockade in melanoma. J Invest Dermatol. (2017) 137:1740-8. doi:10.1016/j.jid.2017.03.033.
    • (2017) J Invest Dermatol , vol.137 , pp. 1740-1748
    • Kim, S.H.1    Li, M.2    Trousil, S.3    Zhang, Y.4    Pasca, D.M.M.5    Swanson, K.D.6
  • 227
    • 84907484156 scopus 로고    scopus 로고
    • Csf1/csf1r blockade reprograms tumor-infiltrating macrophages and improves response to t cell checkpoint immunotherapy in pancreatic cancer models
    • Zhu Y, Knolhoff BL, Meyer MA, Nywening TM, Brian L, Luo J, et al. CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T cell checkpoint immunotherapy in pancreatic cancer models. Cancer Res. (2014) 74:5057-69. doi:10.1158/0008-5472.CAN-13-3723.
    • (2014) Cancer Res. , vol.74 , pp. 5057-5069
    • Zhu, Y.1    Knolhoff, B.L.2    Meyer, M.A.3    Nywening, T.M.4    Brian, L.5    Luo, J.6
  • 228
    • 84946781007 scopus 로고    scopus 로고
    • Cd11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment
    • Zhang QQ, Hu XW, Liu YL, Ye ZJ, Gui YH, Zhou DL, et al. CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment. Sci Rep. (2015) 5:1-12. doi:10.1038/srep15948.
    • (2015) Sci Rep , vol.5 , pp. 1-12
    • Zhang, Q.Q.1    Hu, X.W.2    Liu, Y.L.3    Ye, Z.J.4    Gui, Y.H.5    Zhou, D.L.6
  • 229
    • 84905994658 scopus 로고    scopus 로고
    • Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells
    • Kim K, Skora AD, Li Z, Liu Q, Tam AJ, Blosser RL, et al. Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells. Proc Natl Acad Sci USA. (2014) 111:11774-9. doi:10.1073/pnas.1410626111.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 11774-11779
    • Kim, K.1    Skora, A.D.2    Li, Z.3    Liu, Q.4    Tam, A.J.5    Blosser, R.L.6
  • 230
    • 84920531874 scopus 로고    scopus 로고
    • Tadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma
    • Califano JA, Khan Z, Noonan KA, Rudraraju L, Wang H, Goodman S, et al. Tadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma. Clin Cancer Res. (2015) 21:30-8. doi:10.1158/1078-0432.CCR-14-1716.
    • (2015) Clin Cancer Res , vol.21 , pp. 30-38
    • Califano, J.A.1    Khan, Z.2    Noonan, K.A.3    Rudraraju, L.4    Wang, H.5    Goodman, S.6
  • 231
    • 84902162433 scopus 로고    scopus 로고
    • Er stress regulates myeloid-derived suppressor cell fate through trail-r - mediated apoptosis
    • Condamine T, Kumar V, Ramachandran IR, Youn J, Celis E, Finnberg N, et al. ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R - mediated apoptosis. J Clin Invest. (2014) 124:2626-39. doi:10.1172/JCI74056.
    • (2014) J Clin Invest , vol.124 , pp. 2626-2639
    • Condamine, T.1    Kumar, V.2    Ramachandran, I.R.3    Youn, J.4    Celis, E.5    Finnberg, N.6
  • 233
    • 77749239707 scopus 로고    scopus 로고
    • MasT cells mobilize myeloid-derived suppressor cells and treg cells in tumor microenvironment via il-17 pathway in murine hepatocarcinoma model
    • Yang Z, Zhang B, Li D, Lv M, Huang C, Shen GX, et al. MasT cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model. PLoS ONE (2010) 5:e8922. doi:10.1371/journal.pone.0008922.
    • (2010) PLoS ONE , vol.5 , pp. e8922
    • Yang, Z.1    Zhang, B.2    Li, D.3    Lv, M.4    Huang, C.5    Shen, G.X.6
  • 234
    • 84906933858 scopus 로고    scopus 로고
    • Resiquimod, a tlr7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells
    • Lee M, Park C-S, Lee Y-R, Im S-A, Song S, Lee C-K. Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells. Arch Pharm Res. (2014) 37:1234-40. doi:10.1007/s12272-014-0379-4.
    • (2014) Arch Pharm Res , vol.37 , pp. 1234-1240
    • Lee, M.1    Park, C.-S.2    Lee, Y.-R.3    Im, S.-A.4    Song, S.5    Lee, C.-K.6
  • 235
    • 84994115593 scopus 로고    scopus 로고
    • Tlr7-based cancer immunotherapy decreases intratumoral myeloid-derived suppressor cells and blocks their immunosuppressive function
    • Spinetti T, Spagnuolo L, Mottas I, Secondini C, Treinies M, Rüegg C, et al. TLR7-based cancer immunotherapy decreases intratumoral myeloid-derived suppressor cells and blocks their immunosuppressive function. Oncoimmunology (2016) 5:e1230578. doi:10.1080/2162402X.2016.1230578.
    • (2016) Oncoimmunology , vol.5 , pp. e1230578
    • Spinetti, T.1    Spagnuolo, L.2    Mottas, I.3    Secondini, C.4    Treinies, M.5    Rüegg, C.6
  • 236
    • 85040046312 scopus 로고    scopus 로고
    • Phase ib study of immune biomarker modulation with neoadjuvant cetuximab and tlr8 stimulation in head and neck cancer to overcome suppressive myeloid signals
    • Shayan G, Kansy BA, Gibson SP, Srivastava RM, Bryan JK, Bauman JE, et al. Phase Ib study of immune biomarker modulation with neoadjuvant cetuximab and TLR8 stimulation in head and neck cancer to overcome suppressive myeloid signals. Clin Cancer Res. (2018) 24:62-72. doi:10.1158/1078-0432.CCR-17-0357.
    • (2018) Clin Cancer Res , vol.24 , pp. 62-72
    • Shayan, G.1    Kansy, B.A.2    Gibson, S.P.3    Srivastava, R.M.4    Bryan, J.K.5    Bauman, J.E.6
  • 237
    • 84928482103 scopus 로고    scopus 로고
    • Effect of tlr agonists on the differentiation and function of human monocytic myeloid-derived suppressor cells
    • Wang J, Shirota Y, Bayik D, Shirota H, Tross D, Gulley JL, et al. Effect of TLR agonists on the differentiation and function of human monocytic myeloid-derived suppressor cells. J Immunol. (2015) 194:4215-21. doi:10.4049/jimmunol.1402004.
    • (2015) J Immunol , vol.194 , pp. 4215-4221
    • Wang, J.1    Shirota, Y.2    Bayik, D.3    Shirota, H.4    Tross, D.5    Gulley, J.L.6
  • 238
    • 84964391958 scopus 로고    scopus 로고
    • Tlr9 ligation in pancreatic stellate cells promotes tumorigenesis
    • Zambirinis CP, Levie E, Nguy S, Avanzi A, Barilla R, Xu Y, et al. TLR9 ligation in pancreatic stellate cells promotes tumorigenesis. J Exp Med. (2015) 212:2077-94. doi:10.1084/jem.20142162.
    • (2015) J Exp Med , vol.212 , pp. 2077-2094
    • Zambirinis, C.P.1    Levie, E.2    Nguy, S.3    Avanzi, A.4    Barilla, R.5    Xu, Y.6
  • 239
    • 85029697694 scopus 로고    scopus 로고
    • Toll-like receptor 2 ligand and interferon-? Suppress anti-Tumor t cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells
    • Shime H, Maruyama A, Yoshida S, Takeda Y, Matsumoto M, Seya T. Toll-like receptor 2 ligand and interferon-? suppress anti-Tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells. Oncoimmunology (2018) 7:1-13. doi:10.1080/2162402X.2017.1373231.
    • (2018) Oncoimmunology , vol.7 , pp. 1-13
    • Shime, H.1    Maruyama, A.2    Yoshida, S.3    Takeda, Y.4    Matsumoto, M.5    Seya, T.6
  • 240
    • 76649097628 scopus 로고    scopus 로고
    • Membrane associated HSP72 from tumor derived exosomes mediates stat3 depedent immunosuppressive function of mouse and human myeloid derived suppressor cells
    • Chalmin F, Ladoire S, Mignot G, Vincent J, Bruchard M, Boireau W, et al. Membrane associated Hsp72 from tumor derived exosomes mediates STAT3 depedent immunosuppressive function of mouse and human myeloid derived suppressor cells. J Clin Invest. (2010) 120:467-71. doi: 10.1172/JCI40483.
    • (2010) J Clin Invest , vol.120 , pp. 467-471
    • Chalmin, F.1    Ladoire, S.2    Mignot, G.3    Vincent, J.4    Bruchard, M.5    Boireau, W.6
  • 241
    • 85042360191 scopus 로고    scopus 로고
    • Inhibiting HSP90 prevents the induction of myeloid-derived suppressor cells by melanoma cells
    • Janssen N, Speigl L, Pawelec G, Niessner H, Shipp C. Inhibiting HSP90 prevents the induction of myeloid-derived suppressor cells by melanoma cells. Cell Immunol. (2018) 327:68-76. doi:10.1016/j.cellimm.2018.02.012.
    • (2018) Cell Immunol , vol.327 , pp. 68-76
    • Janssen, N.1    Speigl, L.2    Pawelec, G.3    Niessner, H.4    Shipp, C.5
  • 242
    • 84962026544 scopus 로고    scopus 로고
    • Yeast-derived particulate ß-glucan treatment subverts the suppression of myeloid-derived suppressor cells by inducing pmn-mdsc apoptosis and m-mdsc differentiation to apc in cancer
    • Albeituni SH, Ding C, Liu M, Hu X, Luo F, Kloecker G, et al. Yeast-derived particulate ß-glucan treatment subverts the suppression of myeloid-derived suppressor cells by inducing PMN-MDSC apoptosis and M-MDSC differentiation to APC in cancer. J Immunol. (2016) 196:2167-80. doi: 10.1016/j.cogdev.2010.08.003.
    • (2016) J Immunol , vol.196 , pp. 2167-2180
    • Albeituni, S.H.1    Ding, C.2    Liu, M.3    Hu, X.4    Luo, F.5    Kloecker, G.6
  • 243
    • 84890933692 scopus 로고    scopus 로고
    • Phosphatidylserine-Targeting antibody induces m1 macrophage polarization and promotes myeloid-derived suppressor cell differentiation
    • Yin Y, Huang X, Lynn KD, Thorpe PE. Phosphatidylserine-Targeting antibody induces M1 macrophage polarization and promotes myeloid-derived suppressor cell differentiation. Cancer Immunol Res. (2013) 1:256-68. doi:10.1158/2326-6066.CIR-13-0073.
    • (2013) Cancer Immunol Res , vol.1 , pp. 256-268
    • Yin, Y.1    Huang, X.2    Lynn, K.D.3    Thorpe, P.E.4
  • 244
    • 84978393053 scopus 로고    scopus 로고
    • Therapeutic targeting of myeloid-derived suppressor cells involves a novel mechanism mediated by clusterin
    • Zhou J, Donatelli SS, Gilvary DL, Tejera MM, Eksioglu EA, Chen X, et al. Therapeutic targeting of myeloid-derived suppressor cells involves a novel mechanism mediated by clusterin. Sci Rep. (2016) 6:29521. doi:10.1038/srep29521.
    • (2016) Sci Rep. , vol.6 , pp. 29521
    • Zhou, J.1    Donatelli, S.S.2    Gilvary, D.L.3    Tejera, M.M.4    Eksioglu, E.A.5    Chen, X.6
  • 245
    • 84962020072 scopus 로고    scopus 로고
    • Mif is necessary for late-stage melanoma patient MDSC immune suppression and differentiation
    • Yaddanapudi K, Rendon BE, Lamont G, Kim EJ, Al Rayyan N, Richie J, et al. MIF is necessary for late-stage melanoma patient MDSC immune suppression and differentiation. Cancer Immunol Res. (2016) 4:101-12. doi:10.1158/2326-6066.CIR-15-0070-T.
    • (2016) Cancer Immunol Res , vol.4 , pp. 101-112
    • Yaddanapudi, K.1    Rendon, B.E.2    Lamont, G.3    Kim, E.J.4    Al Rayyan, N.5    Richie, J.6
  • 246
    • 84962290319 scopus 로고    scopus 로고
    • Tasquinimod modulates suppressive myeloid cells and enhances cancer immunotherapies in murine models
    • Shen L, Sundstedt A, Ciesielski M, Miles KM, Celander M, Adelaiye R, et al. Tasquinimod modulates suppressive myeloid cells and enhances cancer immunotherapies in murine models. Cancer Immunol Res. (2015) 3:136-48. doi:10.1158/2326-6066.CIR-14-0036.
    • (2015) Cancer Immunol Res. , vol.3 , pp. 136-148
    • Shen, L.1    Sundstedt, A.2    Ciesielski, M.3    Miles, K.M.4    Celander, M.5    Adelaiye, R.6
  • 247
    • 84954357305 scopus 로고    scopus 로고
    • Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic mdscs in an intracranial mouse melanoma model
    • Du Four S, Maenhout SK, De Pierre K, Renmans D, Niclou SP, Thielemans K, et al. Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model. Oncoimmunology (2015) 4:e998107. doi:10.1080/2162402X.2014.998107.
    • (2015) Oncoimmunology , vol.4 , pp. e998107
    • Du Four, S.1    Maenhout, S.K.2    De Pierre, K.3    Renmans, D.4    Niclou, S.P.5    Thielemans, K.6
  • 248
    • 84938984463 scopus 로고    scopus 로고
    • The prognostic landscape of genes and infiltrating immune cells across human cancers
    • Gentles AJ, Newman AM, Liu CL, Bratman SV, Diehn M, West RB, et al. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat Med. (2015) 21:938-45. doi: 10.1038/nm.3909.
    • (2015) Nat Med , vol.21 , pp. 938-945
    • Gentles, A.J.1    Newman, A.M.2    Liu, C.L.3    Bratman, S.V.4    Diehn, M.5    West, R.B.6
  • 249
    • 85009106590 scopus 로고    scopus 로고
    • Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade
    • Charoentong P, Finotello F, Angelova M, Mayer C, Efremova M, Rieder D, et al. Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade. Cell Rep. (2017) 18:248-62. doi:10.1016/j.celrep.2016.12.019.
    • (2017) Cell Rep. , vol.18 , pp. 248-262
    • Charoentong, P.1    Finotello, F.2    Angelova, M.3    Mayer, C.4    Efremova, M.5    Rieder, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.