Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils

Science

Volumn 358, Issue 6367, 2017, Pages

  Engblom, Camilla ^a,b   Pfirschke, Christina ^a   Zilionis, Rapolas ^b,c   Da Silva Martins, Janaina ^a   Bos, Stijn A ^a   Courties, Gabriel ^a   Rickelt, Steffen ^d   Severe, Nicolas ^e   Baryawno, Ninib ^e   Faget, Julien ^f   Savova, Virginia ^b   Zemmour, David ^b   Kline, Jaclyn ^a   Siwicki, Marie ^a,b   Garris, Christopher ^a,b   Pucci, Ferdinando ^a   Liao, Hsin Wei ^a   Lin, Yi Jang ^a   Newton, Andita ^a   Yaghi, Omar K ^a,b   Iwamoto, Yoshiko ^a   Tricot, Benoit ^a   Wojtkiewicz, Gregory R ^a   Nahrendorf, Matthias ^a   Cortez Retamozo, Virna ^a   Meylan, Etienne ^f   Hynes, Richard O ^d   Demay, Marie ^a   Klein, Allon ^b   Bredella, Miriam A ^a   Scadden, David T ^e   Weissleder, Ralph ^a,b   Pittet, Mikael J ^a   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c VILNIUS UNIVERSITY   (Lithuania)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^f EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOCALCIN; ADVANCED GLYCATION END PRODUCT RECEPTOR; DIFFERENTIATION ANTIGEN; LECTIN; LEUKOCYTE ANTIGEN; SIGLEC5 PROTEIN, HUMAN; SRAGE PROTEIN, HUMAN;

BONE; CANCER; CELLS AND CELL COMPONENTS; EXPERIMENTAL STUDY; GROWTH; PHENOTYPE; TUMOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE METASTASIS; CANCER PATIENT; CELL COUNT; HUMAN; LUNG ADENOCARCINOMA; MAJOR CLINICAL STUDY; MOUSE; NEUTROPHIL; NONHUMAN; OSTEOBLAST; PHENOTYPE; PRIORITY JOURNAL; TUMOR GROWTH; ADENOCARCINOMA; ANIMAL; BONE; BONE DENSITY; BONE MARROW CELL; C57BL MOUSE; EXPERIMENTAL NEOPLASM; LUNG TUMOR; METABOLISM; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; TUMOR CELL LINE;

ANIMALIA; MUS;

ADENOCARCINOMA; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BONE AND BONES; BONE DENSITY; BONE MARROW CELLS; CELL LINE, TUMOR; HUMANS; LECTINS; LUNG NEOPLASMS; MICE; MICE, INBRED C57BL; MYELOID CELLS; NEOPLASMS, EXPERIMENTAL; NEUTROPHIL INFILTRATION; NEUTROPHILS; OSTEOBLASTS; OSTEOCALCIN; RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS;

EID: 85036536357     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aal5081     Document Type: Article

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