메뉴 건너뛰기




Volumn 124, Issue 6, 2014, Pages 2626-2639

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis

(19)  Condamine, Thomas a   Kumar, Vinit a   Ramachandran, Indu R a   Youn, Je In a   Celis, Esteban b,h   Finnberg, Niklas c   El Deiry, Wafik S c   Winograd, Rafael d   Vonderheide, Robert H d   English, Nickolas R e   Knight, Stella C e   Yagita, Hideo f   McCaffrey, Judith C b   Antonia, Scott b   Hockstein, Neil g   Witt, Robert g   Masters, Gregory g   Bauer, Thomas g   Gabrilovich, Dmitry I a  


Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

EID: 84902162433     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI74056     Document Type: Article
Times cited : (286)

References (53)
  • 2
    • 54049134747 scopus 로고    scopus 로고
    • Subsets of myeloid-derived suppressor cells in tumorbearing mice
    • Youn JI, Nagaraj S, Collazo M, Gabrilovich DI. Subsets of myeloid-derived suppressor cells in tumorbearing mice. J Immunol. 2008;181(8):5791-5802.
    • (2008) J Immunol. , vol.181 , Issue.8 , pp. 5791-5802
    • Youn, J.I.1    Nagaraj, S.2    Collazo, M.3    Gabrilovich, D.I.4
  • 3
    • 43249130187 scopus 로고    scopus 로고
    • Identification of discrete tumorinduced myeloid-derived suppressor cell subpopulations with distinct T-cell suppressive activity
    • Movahedi K, et al. Identification of discrete tumorinduced myeloid-derived suppressor cell subpopulations with distinct T-cell suppressive activity. Blood. 2008;111(8):4233-4244.
    • (2008) Blood , vol.111 , Issue.8 , pp. 4233-4244
    • Movahedi, K.1
  • 4
    • 84855301911 scopus 로고    scopus 로고
    • Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice
    • Youn JI, Collazo M, Shalova IN, Biswas SK, Gabrilovich DI. Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. J Leukoc Biol. 2012;91(1):167-181.
    • (2012) J Leukoc Biol. , vol.91 , Issue.1 , pp. 167-181
    • Youn, J.I.1    Collazo, M.2    Shalova, I.N.3    Biswas, S.K.4    Gabrilovich, D.I.5
  • 5
    • 77951258918 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cell heterogeneity and subset definition
    • Peranzoni E, et al. Myeloid-derived suppressor cell heterogeneity and subset definition. Curr Opin Immunol. 2010;22(2):238-244.
    • (2010) Curr Opin Immunol. , vol.22 , Issue.2 , pp. 238-244
    • Peranzoni, E.1
  • 6
    • 78650756969 scopus 로고    scopus 로고
    • Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function
    • Condamine T, Gabrilovich DI. Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function. Trends Immunol. 2011;32(1):19-25.
    • (2011) Trends Immunol. , vol.32 , Issue.1 , pp. 19-25
    • Condamine, T.1    Gabrilovich, D.I.2
  • 7
    • 79953113052 scopus 로고    scopus 로고
    • Transcription factors in myeloid-derived suppressor cell generation
    • Sonda N, Chioda M, Zilio S, Simonato F, Bronte V. Transcription factors in myeloid-derived suppressor cell generation. Curr Opin Immunol. 2011;23(2):279-285.
    • (2011) Curr Opin Immunol. , vol.23 , Issue.2 , pp. 279-285
    • Sonda, N.1    Chioda, M.2    Zilio, S.3    Simonato, F.4    Bronte, V.5
  • 8
    • 84868629269 scopus 로고    scopus 로고
    • TNF signaling drives myeloid-derived suppressor cell accumulation
    • Zhao X, et al. TNF signaling drives myeloid-derived suppressor cell accumulation. J Clin Invest. 2012;122(11):4094-4104.
    • (2012) J Clin Invest. , vol.122 , Issue.11 , pp. 4094-4104
    • Zhao, X.1
  • 9
    • 84858202940 scopus 로고    scopus 로고
    • Aptamer-mediated blockade of IL4Rα triggers apoptosis of MDSCs and limits tumor progression
    • Roth F, De La Fuente AC, Vella JL, Zoso A, Inverardi L, Serafini P. Aptamer-mediated blockade of IL4Rα triggers apoptosis of MDSCs and limits tumor progression. Cancer Res. 2012;72(6):1373-1383.
    • (2012) Cancer Res. , vol.72 , Issue.6 , pp. 1373-1383
    • Roth, F.1    De La Fuente, A.C.2    Vella, J.L.3    Zoso, A.4    Inverardi, L.5    Serafini, P.6
  • 10
    • 84879592535 scopus 로고    scopus 로고
    • Deregulation of apoptotic factors Bcl-xL and Bax confers apoptotic resistance to myeloid-derived suppressor cells and contributes to their persistence in cancer
    • Hu X, et al. Deregulation of apoptotic factors Bcl-xL and Bax confers apoptotic resistance to myeloid-derived suppressor cells and contributes to their persistence in cancer. J Biol Chem. 2013;288(26):19103-19115.
    • (2013) J Biol Chem. , vol.288 , Issue.26 , pp. 19103-19115
    • Hu, X.1
  • 12
    • 79956348160 scopus 로고    scopus 로고
    • Myeloidderived suppressor cells express the death receptor Fas and apoptose in response to T cell-expressed FasL
    • Sinha P, Chornoguz O, Clements VK, Artemenko KA, Zubarev RA, Ostrand-Rosenberg S. Myeloidderived suppressor cells express the death receptor Fas and apoptose in response to T cell-expressed FasL. Blood. 2011;117(20):5381-5390.
    • (2011) Blood , vol.117 , Issue.20 , pp. 5381-5390
    • Sinha, P.1    Chornoguz, O.2    Clements, V.K.3    Artemenko, K.A.4    Zubarev, R.A.5    Ostrand-Rosenberg, S.6
  • 13
    • 85027923251 scopus 로고    scopus 로고
    • Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer
    • Youn JI, et al. Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer. Nat Immunol. 2013;14(3):211-220.
    • (2013) Nat Immunol. , vol.14 , Issue.3 , pp. 211-220
    • Youn, J.I.1
  • 14
    • 0033017328 scopus 로고    scopus 로고
    • Caspase inhibitors in prevention of apoptosis
    • Rudel T. Caspase inhibitors in prevention of apoptosis. Herz. 1999;24(3):236-241.
    • (1999) Herz. , vol.24 , Issue.3 , pp. 236-241
    • Rudel, T.1
  • 15
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: Critical control points
    • Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell. 2004;116(2):205-219.
    • (2004) Cell , vol.116 , Issue.2 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 16
    • 52649109068 scopus 로고    scopus 로고
    • The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nature reviews
    • Johnstone RW, Frew AJ, Smyth MJ. The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nature reviews. Cancer. 2008;8(10):782-798.
    • (2008) Cancer , vol.8 , Issue.10 , pp. 782-798
    • Johnstone, R.W.1    Frew, A.J.2    Smyth, M.J.3
  • 17
    • 77957045066 scopus 로고    scopus 로고
    • TRAIL receptor signaling and therapeutics
    • Abdulghani J, El-Deiry WS. TRAIL receptor signaling and therapeutics. Expert Opin Ther Targets. 2010;14(10):1091-1108.
    • (2010) Expert Opin Ther Targets. , vol.14 , Issue.10 , pp. 1091-1108
    • Abdulghani, J.1    El-Deiry, W.S.2
  • 18
    • 7344233085 scopus 로고    scopus 로고
    • Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL
    • Emery JG, et al. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem. 1998;273(23):14363-14367.
    • (1998) J Biol Chem. , vol.273 , Issue.23 , pp. 14363-14367
    • Emery, J.G.1
  • 19
    • 20044391426 scopus 로고    scopus 로고
    • DR5 knockout mice are compromised in radiation-induced apoptosis
    • Finnberg N, et al. DR5 knockout mice are compromised in radiation-induced apoptosis. Mol Cell Biol. 2005;25(5):2000-2013.
    • (2005) Mol Cell Biol. , vol.25 , Issue.5 , pp. 2000-2013
    • Finnberg, N.1
  • 20
    • 38149139518 scopus 로고    scopus 로고
    • TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis
    • Finnberg N, Klein-Szanto AJ, El-Deiry WS. TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis. J Clin Invest. 2008;118(1):111-123.
    • (2008) J Clin Invest. , vol.118 , Issue.1 , pp. 111-123
    • Finnberg, N.1    Klein-Szanto, A.J.2    El-Deiry, W.S.3
  • 21
    • 14544288632 scopus 로고    scopus 로고
    • CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activationinduced cell death
    • Janssen EM, et al. CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activationinduced cell death. Nature. 2005;434(7029):88-93.
    • (2005) Nature , vol.434 , Issue.7029 , pp. 88-93
    • Janssen, E.M.1
  • 22
    • 9144232224 scopus 로고    scopus 로고
    • The role of activation-induced cell death in the differentiation of T-helper-cell subsets
    • Roberts AI, et al. The role of activation-induced cell death in the differentiation of T-helper-cell subsets. Immunol Res. 2003;28(3):285-293.
    • (2003) Immunol Res. , vol.28 , Issue.3 , pp. 285-293
    • Roberts, A.I.1
  • 23
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12(4):252-264.
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 24
    • 80655149472 scopus 로고    scopus 로고
    • Death receptor 5 signaling promotes hepatocyte lipoapoptosis
    • Cazanave SC, et al. Death receptor 5 signaling promotes hepatocyte lipoapoptosis. J Biol Chem. 2011;286(45):39336-39348.
    • (2011) J Biol Chem. , vol.286 , Issue.45 , pp. 39336-39348
    • Cazanave, S.C.1
  • 26
    • 80051686709 scopus 로고    scopus 로고
    • Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    • Tian X, Ye J, Alonso-Basanta M, Hahn SM, Koumenis C, Dorsey JF. Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Biol Chem. 2011;286(33):29408-29416.
    • (2011) J Biol Chem. , vol.286 , Issue.33 , pp. 29408-29416
    • Tian, X.1    Ye, J.2    Alonso-Basanta, M.3    Hahn, S.M.4    Koumenis, C.5    Dorsey, J.F.6
  • 27
    • 84862502203 scopus 로고    scopus 로고
    • ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2
    • Martin-Perez R, Niwa M, Lopez-Rivas A. ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2. Apoptosis. 2012;17(4):349-363.
    • (2012) Apoptosis. , vol.17 , Issue.4 , pp. 349-363
    • Martin-Perez, R.1    Niwa, M.2    Lopez-Rivas, A.3
  • 28
    • 77955643939 scopus 로고    scopus 로고
    • Role of endoplasmic reticulum stress in α-TEA mediated TRAIL/DR5 death receptor dependent apoptosis
    • Tiwary R, Yu W, Li J, Park SK, Sanders BG, Kline K. Role of endoplasmic reticulum stress in α-TEA mediated TRAIL/DR5 death receptor dependent apoptosis. PLoS One. 2010;5(7):e11865.
    • (2010) PLoS One. , vol.5 , Issue.7
    • Tiwary, R.1    Yu, W.2    Li, J.3    Park, S.K.4    Sanders, B.G.5    Kline, K.6
  • 29
    • 84863103122 scopus 로고    scopus 로고
    • Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells
    • Liu G, et al. Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells. J Cell Mol Med. 2012;16(7):1618-1628.
    • (2012) J Cell Mol Med. , vol.16 , Issue.7 , pp. 1618-1628
    • Liu, G.1
  • 30
    • 84856111924 scopus 로고    scopus 로고
    • The unfolded protein response: Controlling cell fate decisions under ER stress and beyond
    • Hetz C. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol. 2012;13(2):89-102.
    • (2012) Nat Rev Mol Cell Biol. , vol.13 , Issue.2 , pp. 89-102
    • Hetz, C.1
  • 31
    • 79955723632 scopus 로고    scopus 로고
    • Myeloid derived suppressor cells in human diseases
    • Greten TF, Manns MP, Korangy F. Myeloid derived suppressor cells in human diseases. Int Immunopharmacol. 2011;11(7):802-807.
    • (2011) Int Immunopharmacol. , vol.11 , Issue.7 , pp. 802-807
    • Greten, T.F.1    Manns, M.P.2    Korangy, F.3
  • 33
    • 63549105681 scopus 로고    scopus 로고
    • Sunitinib mediates reversal of myeloidderived suppressor cell accumulation in renal cell carcinoma patients
    • Ko JS, et al. Sunitinib mediates reversal of myeloidderived suppressor cell accumulation in renal cell carcinoma patients. Clin Cancer Res. 2009;15(6):2148-2157.
    • (2009) Clin Cancer Res. , vol.15 , Issue.6 , pp. 2148-2157
    • Ko, J.S.1
  • 34
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • Ozcan U, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. 2006;313(5790):1137- 1140.
    • (2006) Science , vol.313 , Issue.5790 , pp. 1137-1140
    • Ozcan, U.1
  • 35
    • 67650422616 scopus 로고    scopus 로고
    • The liver is a site for tumorinduced myeloid-derived suppressor cell accumulation and immunosuppression
    • Ilkovitch D, Lopez DM. The liver is a site for tumorinduced myeloid-derived suppressor cell accumulation and immunosuppression. Cancer Res. 2009;69(13):5514-5521.
    • (2009) Cancer Res. , vol.69 , Issue.13 , pp. 5514-5521
    • Ilkovitch, D.1    Lopez, D.M.2
  • 36
    • 80052646150 scopus 로고    scopus 로고
    • Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus
    • Chen S, Akbar SM, Abe M, Hiasa Y, Onji M. Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus. Clin Exp Immunol. 2011;166(1):134-142.
    • (2011) Clin Exp Immunol. , vol.166 , Issue.1 , pp. 134-142
    • Chen, S.1    Akbar, S.M.2    Abe, M.3    Hiasa, Y.4    Onji, M.5
  • 37
    • 68149119072 scopus 로고    scopus 로고
    • Identification of splenic reservoir monocytes and their deployment to inflammatory sites
    • Swirski FK, et al. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009;325(5940):612-616.
    • (2009) Science , vol.325 , Issue.5940 , pp. 612-616
    • Swirski, F.K.1
  • 38
    • 84863151366 scopus 로고    scopus 로고
    • Origins of tumor-associated macrophages and neutrophils
    • Cortez-Retamozo V, et al. Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci U S A. 2012;109(7):2491-2496.
    • (2012) Proc Natl Acad Sci U S A. , vol.109 , Issue.7 , pp. 2491-2496
    • Cortez-Retamozo, V.1
  • 39
    • 73249125588 scopus 로고    scopus 로고
    • Gr-1 antibody induces STAT signaling, macrophage marker expression and abrogation of myeloid-derived suppressor cell activity in BM cells
    • Ribechini E, Leenen PJ, Lutz MB. Gr-1 antibody induces STAT signaling, macrophage marker expression and abrogation of myeloid-derived suppressor cell activity in BM cells. Eur J Immunol. 2009;39(12):3538-3551.
    • (2009) Eur J Immunol. , vol.39 , Issue.12 , pp. 3538-3551
    • Ribechini, E.1    Leenen, P.J.2    Lutz, M.B.3
  • 40
    • 0032929520 scopus 로고    scopus 로고
    • Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    • Walczak H, et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nature medicine. 1999;5(2):157-163.
    • (1999) Nature medicine. , vol.5 , Issue.2 , pp. 157-163
    • Walczak, H.1
  • 41
    • 77956202076 scopus 로고    scopus 로고
    • CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors
    • Haynes NM, et al. CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors. J Immunol. 2010;185(1):532-541.
    • (2010) J Immunol. , vol.185 , Issue.1 , pp. 532-541
    • Haynes, N.M.1
  • 42
    • 10744220151 scopus 로고    scopus 로고
    • Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy
    • Takeda K, et al. Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy. J Exp Med. 2004;199(4):437-448.
    • (2004) J Exp Med. , vol.199 , Issue.4 , pp. 437-448
    • Takeda, K.1
  • 43
    • 29144496895 scopus 로고    scopus 로고
    • Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis
    • Clancy L, et al. Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc Natl Acad Sci U S A. 2005;102(50):18099-18104.
    • (2005) Proc Natl Acad Sci U S A. , vol.102 , Issue.50 , pp. 18099-18104
    • Clancy, L.1
  • 44
    • 33749164762 scopus 로고    scopus 로고
    • Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2
    • Merino D, Lalaoui N, Morizot A, Schneider P, Solary E, Micheau O. Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol. 2006;26(19):7046-7055.
    • (2006) Mol Cell Biol. , vol.26 , Issue.19 , pp. 7046-7055
    • Merino, D.1    Lalaoui, N.2    Morizot, A.3    Schneider, P.4    Solary, E.5    Micheau, O.6
  • 45
    • 20744433491 scopus 로고    scopus 로고
    • Transcription factor NF-κB differentially regulates death receptor 5 expression involving histone deacetylase 1
    • Shetty S, et al. Transcription factor NF-κB differentially regulates death receptor 5 expression involving histone deacetylase 1. Mol Cell Biol. 2005;25(13):5404-5416.
    • (2005) Mol Cell Biol. , vol.25 , Issue.13 , pp. 5404-5416
    • Shetty, S.1
  • 46
    • 22244472001 scopus 로고    scopus 로고
    • Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligandinduced apoptosis in human prostate cancer cells
    • Shiraishi T, et al. Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligandinduced apoptosis in human prostate cancer cells. Cancer Res. 2005;65(14):6364-6370.
    • (2005) Cancer Res. , vol.65 , Issue.14 , pp. 6364-6370
    • Shiraishi, T.1
  • 47
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: From stress pathway to homeostatic regulation
    • Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science. 2011;334(6059):1081-1086.
    • (2011) Science , vol.334 , Issue.6059 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 48
    • 2942534749 scopus 로고    scopus 로고
    • Thapsigargin potentiates TRAIL-induced apoptosis in giant cell tumor of bone
    • Huang L, Xu J, Li K, Zheng MH, Kumta SM. Thapsigargin potentiates TRAIL-induced apoptosis in giant cell tumor of bone. Bone. 2004;34(6):971-981.
    • (2004) Bone , vol.34 , Issue.6 , pp. 971-981
    • Huang, L.1    Xu, J.2    Li, K.3    Zheng, M.H.4    Kumta, S.M.5
  • 49
    • 70349352744 scopus 로고    scopus 로고
    • Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: Roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase
    • Santos CX, Tanaka LY, Wosniak J, Laurindo FR. Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase. Antioxid Redox Signal. 2009;11(10):2409-2427.
    • (2009) Antioxid Redox Signal. , vol.11 , Issue.10 , pp. 2409-2427
    • Santos, C.X.1    Tanaka, L.Y.2    Wosniak, J.3    Laurindo, F.R.4
  • 50
    • 84860483727 scopus 로고    scopus 로고
    • The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling
    • Fu S, Watkins SM, Hotamisligil GS. The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling. Cell Metab. 2012;15(5):623-634.
    • (2012) Cell Metab. , vol.15 , Issue.5 , pp. 623-634
    • Fu, S.1    Watkins, S.M.2    Hotamisligil, G.S.3
  • 51
    • 77955344402 scopus 로고    scopus 로고
    • Lipid accumulation and dendritic cell dysfunction in cancer
    • Herber DL, et al. Lipid accumulation and dendritic cell dysfunction in cancer. Nat Med. 2010;16(8):880-886.
    • (2010) Nat Med. , vol.16 , Issue.8 , pp. 880-886
    • Herber, D.L.1
  • 52
    • 84862150896 scopus 로고    scopus 로고
    • Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
    • Bayne LJ, et al. Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell. 2012;21(6):822-835.
    • (2012) Cancer Cell , vol.21 , Issue.6 , pp. 822-835
    • Bayne, L.J.1
  • 53
    • 84857205712 scopus 로고    scopus 로고
    • Antigen-specific CD4 (+) T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling
    • Nagaraj S, Nelson A, Youn JI, Cheng P, Quiceno D, Gabrilovich DI. Antigen-specific CD4 (+) T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling. Cancer Res. 2012;72(4):928-938.
    • (2012) Cancer Res. , vol.72 , Issue.4 , pp. 928-938
    • Nagaraj, S.1    Nelson, A.2    Youn, J.I.3    Cheng, P.4    Quiceno, D.5    Gabrilovich, D.I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.