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Volumn 7, Issue , 2016, Pages

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(15)  Bronte, Vincenzo a   Brandau, Sven b   Chen, Shu Hsia c   Colombo, Mario P d   Frey, Alan B e   Greten, Tim F f   Mandruzzato, Susanna g,h   Murray, Peter J i   Ochoa, Augusto j   Ostrand Rosenberg, Suzanne k   Rodriguez, Paulo C l   Sica, Antonio m,n   Umansky, Viktor o,p   Vonderheide, Robert H q   Gabrilovich, Dmitry I r  


Author keywords

[No Author keywords available]

Indexed keywords

CANCER; CELLS AND CELL COMPONENTS; HETEROGENEITY; IMMUNE RESPONSE; MORPHOLOGY; PHENOTYPE; RESEARCH WORK; TUMOR;

EID: 84977632889     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12150     Document Type: Review
Times cited : (2067)

References (81)
  • 1
    • 84884979960 scopus 로고    scopus 로고
    • Circulating immunosuppressive cells of prostate cancer patients before and after radical prostatectomy: Profile comparison
    • Brusa, D. et al. Circulating immunosuppressive cells of prostate cancer patients before and after radical prostatectomy: profile comparison. Int. J. Urol. 20, 971-978 (2013).
    • (2013) Int. J. Urol. , vol.20 , pp. 971-978
    • Brusa, D.1
  • 2
    • 0032533478 scopus 로고    scopus 로고
    • Apoptotic death of CD8 T lymphocytes after immunization: Induction of a suppressive population of Mac-1/Gr-1 cells
    • Bronte, V. et al. Apoptotic death of CD8 T lymphocytes after immunization: induction of a suppressive population of Mac-1/Gr-1 cells. J. Immunol. 161, 5313-5320 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 5313-5320
    • Bronte, V.1
  • 3
    • 0032400862 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo
    • Gabrilovich, D. et al. Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 92, 4150-4166 (1998).
    • (1998) Blood , vol.92 , pp. 4150-4166
    • Gabrilovich, D.1
  • 4
    • 0028928899 scopus 로고
    • Inhibition of tumor growth by elimination of granulocytes
    • Pekarek, L. A., Starr, B. A., Toledano, A. Y. & Schreiber, H. Inhibition of tumor growth by elimination of granulocytes. J. Exp. Med. 181, 435-440 (1995).
    • (1995) J. Exp. Med. , vol.181 , pp. 435-440
    • Pekarek, L.A.1    Starr, B.A.2    Toledano, A.Y.3    Schreiber, H.4
  • 5
    • 84884556145 scopus 로고    scopus 로고
    • History of myeloid-derived suppressor cells
    • Talmadge, J. E. & Gabrilovich, D. I. History of myeloid-derived suppressor cells. Nat. Rev. Cancer 13, 739-752 (2013).
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 739-752
    • Talmadge, J.E.1    Gabrilovich, D.I.2
  • 6
    • 33846434093 scopus 로고    scopus 로고
    • The terminology issue for myeloid-derived suppressor cells
    • Gabrilovich, D. I. et al. The terminology issue for myeloid-derived suppressor cells. Cancer Res. 67, 425 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 425
    • Gabrilovich, D.I.1
  • 7
    • 43249130187 scopus 로고    scopus 로고
    • Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity
    • Movahedi, K. et al. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood 111, 4233-4244 (2008).
    • (2008) Blood , vol.111 , pp. 4233-4244
    • Movahedi, K.1
  • 8
    • 54049134747 scopus 로고    scopus 로고
    • Subsets of myeloidderived suppressor cells in tumor-bearing mice
    • Youn, J. I., Nagaraj, S., Collazo, M. & Gabrilovich, D. I. Subsets of myeloidderived suppressor cells in tumor-bearing mice. J. Immunol. 181, 5791-5802 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 5791-5802
    • Youn, J.I.1    Nagaraj, S.2    Collazo, M.3    Gabrilovich, D.I.4
  • 9
    • 84855301911 scopus 로고    scopus 로고
    • Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice
    • Youn, J. I., Collazo, M., Shalova, I. N., Biswas, S. K. & Gabrilovich, D. I. Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. J. Leukoc. Biol. 91, 167-181 (2012).
    • (2012) J. Leukoc. Biol. , vol.91 , pp. 167-181
    • Youn, J.I.1    Collazo, M.2    Shalova, I.N.3    Biswas, S.K.4    Gabrilovich, D.I.5
  • 10
    • 60549088732 scopus 로고    scopus 로고
    • Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
    • Rodriguez, P. C. et al. Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res. 69, 1553-1560 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 1553-1560
    • Rodriguez, P.C.1
  • 11
    • 84902959977 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cell heterogeneity in human cancers
    • Solito, S. et al. Myeloid-derived suppressor cell heterogeneity in human cancers. Ann. NY Acad. Sci. 1319, 47-65 (2014).
    • (2014) Ann. NY Acad. Sci. , vol.1319 , pp. 47-65
    • Solito, S.1
  • 12
    • 84941695057 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in the tumor microenvironment: Expect the unexpected
    • Marvel, D. & Gabrilovich, D. I. Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. J. Clin. Invest. 125, 3356-3364 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 3356-3364
    • Marvel, D.1    Gabrilovich, D.I.2
  • 14
    • 77951258918 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cell heterogeneity and subset definition
    • Peranzoni, E. et al. Myeloid-derived suppressor cell heterogeneity and subset definition. Curr. Opin. Immunol. 22, 238-244 (2010).
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 238-244
    • Peranzoni, E.1
  • 15
    • 84865715288 scopus 로고    scopus 로고
    • Neutrophils and granulocytic myeloid-derived suppressor cells: Immunophenotyping, cell biology and clinical relevance in human oncology
    • Dumitru, C. A., Moses, K., Trellakis, S., Lang, S. & Brandau, S. Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology. Cancer Immunol. Immunother. 61, 1155-1167 (2012).
    • (2012) Cancer Immunol. Immunother. , vol.61 , pp. 1155-1167
    • Dumitru, C.A.1    Moses, K.2    Trellakis, S.3    Lang, S.4    Brandau, S.5
  • 16
    • 84955654158 scopus 로고    scopus 로고
    • Toward harmonized phenotyping of human myeloidderived suppressor cells by flow cytometry: Results from an interim study
    • Mandruzzato, S. et al. Toward harmonized phenotyping of human myeloidderived suppressor cells by flow cytometry: results from an interim study. Cancer Immunol. Immunother. 65, 161-169 (2016).
    • (2016) Cancer Immunol. Immunother. , vol.65 , pp. 161-169
    • Mandruzzato, S.1
  • 17
    • 84867840534 scopus 로고    scopus 로고
    • Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential
    • Liu, T., Daniels, C. K. & Cao, S. Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential. Pharmacol. Ther. 136, 354-374 (2012).
    • (2012) Pharmacol. Ther. , vol.136 , pp. 354-374
    • Liu, T.1    Daniels, C.K.2    Cao, S.3
  • 18
    • 33745225494 scopus 로고    scopus 로고
    • C/EBP[beta] is required for 'emergency' granulopoiesis
    • Hirai, H. et al. C/EBP[beta] is required for 'emergency' granulopoiesis. Nat. Immunol. 7, 732-739 (2006).
    • (2006) Nat. Immunol. , vol.7 , pp. 732-739
    • Hirai, H.1
  • 19
    • 84877766429 scopus 로고    scopus 로고
    • Granulocytic myeloid-derived suppressor cells are cryosensitive and their frequency does not correlate with serum concentrations of colony-stimulating factors in head and neck cancer
    • Trellakis, S. et al. Granulocytic myeloid-derived suppressor cells are cryosensitive and their frequency does not correlate with serum concentrations of colony-stimulating factors in head and neck cancer. Innate. Immun. 19, 328-336 (2013).
    • (2013) Innate. Immun. , vol.19 , pp. 328-336
    • Trellakis, S.1
  • 20
    • 84911861458 scopus 로고    scopus 로고
    • Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
    • Viale, A. et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature 514, 628-632 (2014).
    • (2014) Nature , vol.514 , pp. 628-632
    • Viale, A.1
  • 21
    • 74249101123 scopus 로고    scopus 로고
    • Hierarchy of immunosuppressive strength among myeloidderived suppressor cell subsets is determined by GM-CSF
    • Dolcetti, L. et al. Hierarchy of immunosuppressive strength among myeloidderived suppressor cell subsets is determined by GM-CSF. Eur. J. Immunol. 40, 22-35 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , pp. 22-35
    • Dolcetti, L.1
  • 22
    • 78649610261 scopus 로고    scopus 로고
    • IL-1beta regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function
    • Elkabets, M. et al. IL-1beta regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function. Eur. J. Immunol. 40, 3347-3357 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , pp. 3347-3357
    • Elkabets, M.1
  • 23
    • 84901589082 scopus 로고    scopus 로고
    • Requirement for interactions of natural killer T cells and myeloid-derived suppressor cells for transplantation tolerance
    • Hongo, D., Tang, X., Baker, J., Engleman, E. G. & Strober, S. Requirement for interactions of natural killer T cells and myeloid-derived suppressor cells for transplantation tolerance. Am. J. Transplant. 14, 2467-2477 (2014).
    • (2014) Am. J. Transplant. , vol.14 , pp. 2467-2477
    • Hongo, D.1    Tang, X.2    Baker, J.3    Engleman, E.G.4    Strober, S.5
  • 24
    • 84907031164 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as a potential therapy for experimental autoimmune myasthenia gravis
    • Li, Y. et al. Myeloid-derived suppressor cells as a potential therapy for experimental autoimmune myasthenia gravis. J. Immunol. 193, 2127-2134 (2014).
    • (2014) J. Immunol. , vol.193 , pp. 2127-2134
    • Li, Y.1
  • 25
    • 84942333071 scopus 로고    scopus 로고
    • GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells
    • Koehn, B. H. et al. GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells. Blood 126, 1621-1628 (2015).
    • (2015) Blood , vol.126 , pp. 1621-1628
    • Koehn, B.H.1
  • 26
    • 77953914366 scopus 로고    scopus 로고
    • Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor
    • Marigo, I. et al. Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. Immunity 32, 790-802 (2010).
    • (2010) Immunity , vol.32 , pp. 790-802
    • Marigo, I.1
  • 27
    • 77949718839 scopus 로고    scopus 로고
    • Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer
    • Nagaraj, S. et al. Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer. Clin. Cancer Res. 16, 1812-1823 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 1812-1823
    • Nagaraj, S.1
  • 28
    • 85027923251 scopus 로고    scopus 로고
    • Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer
    • Youn, J. I. et al. Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer. Nat. Immunol. 14, 211-220 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 211-220
    • Youn, J.I.1
  • 29
    • 80052469556 scopus 로고    scopus 로고
    • Slow disease progression in a C57BL/6 pten-deficient mouse model of prostate cancer
    • Svensson, R. U. et al. Slow disease progression in a C57BL/6 pten-deficient mouse model of prostate cancer. Am. J. Pathol. 179, 502-512 (2011).
    • (2011) Am. J. Pathol. , vol.179 , pp. 502-512
    • Svensson, R.U.1
  • 30
    • 84920724791 scopus 로고    scopus 로고
    • Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
    • Lavin, Y. et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 159, 1312-1326 (2014).
    • (2014) Cell , vol.159 , pp. 1312-1326
    • Lavin, Y.1
  • 31
    • 84879569764 scopus 로고    scopus 로고
    • MIR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis
    • Sonda, N. et al. miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis. Immunity 38, 1236-1249 (2013).
    • (2013) Immunity , vol.38 , pp. 1236-1249
    • Sonda, N.1
  • 32
    • 79952258755 scopus 로고    scopus 로고
    • Modulators of arginine metabolism do not impact on peripheral T-cell tolerance and disease progression in a model of spontaneous prostate cancer
    • Rigamonti, N. et al. Modulators of arginine metabolism do not impact on peripheral T-cell tolerance and disease progression in a model of spontaneous prostate cancer. Clin. Cancer. Res. 17, 1012-1023 (2011).
    • (2011) Clin. Cancer. Res. , vol.17 , pp. 1012-1023
    • Rigamonti, N.1
  • 33
    • 84883863501 scopus 로고    scopus 로고
    • Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8() T cells
    • Spranger, S. et al. Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8() T cells. Sci. Transl. Med. 5, 200ra116 (2013).
    • (2013) Sci. Transl. Med. , vol.5 , pp. 200ra116
    • Spranger, S.1
  • 34
    • 84866784798 scopus 로고    scopus 로고
    • Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy
    • DeNardo, D. G. et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 1, 54-67 (2011).
    • (2011) Cancer Discov. , vol.1 , pp. 54-67
    • DeNardo, D.G.1
  • 35
    • 84938984463 scopus 로고    scopus 로고
    • The prognostic landscape of genes and infiltrating immune cells across human cancers
    • Gentles, A. J. et al. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat. Med. 21, 938-945 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 938-945
    • Gentles, A.J.1
  • 36
    • 84941622047 scopus 로고    scopus 로고
    • Tumor-induced myeloid deviation: When myeloid-derived suppressor cells meet tumor-associated macrophages
    • Ugel, S., De Sanctis, F., Mandruzzato, S. & Bronte, V. Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages. J. Clin. Invest. 125, 3365-3376 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 3365-3376
    • Ugel, S.1    De Sanctis, F.2    Mandruzzato, S.3    Bronte, V.4
  • 37
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: From mechanisms to therapy
    • Noy, R. & Pollard, J. W. Tumor-associated macrophages: from mechanisms to therapy. Immunity 41, 49-61 (2014).
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 38
    • 69249222379 scopus 로고    scopus 로고
    • Polarization of tumor-associated neutrophil phenotype by TGF-beta: N1 versus N2 TAN
    • Fridlender, Z. G. et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta: N1 versus N2 TAN. Cancer Cell 16, 183-194 (2009).
    • (2009) Cancer Cell , vol.16 , pp. 183-194
    • Fridlender, Z.G.1
  • 39
    • 84904394690 scopus 로고    scopus 로고
    • Macrophage activation and polarization: Nomenclature and experimental guidelines
    • Murray, P. J. et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41, 14-20 (2014).
    • (2014) Immunity , vol.41 , pp. 14-20
    • Murray, P.J.1
  • 40
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: In vivo veritas
    • Sica, A. & Mantovani, A. Macrophage plasticity and polarization: in vivo veritas. J. Clin. Invest. 122, 787-795 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 41
    • 84942833116 scopus 로고    scopus 로고
    • TNF counterbalances the emergence of M2 tumor macrophages
    • Kratochvill, F. et al. TNF counterbalances the emergence of M2 tumor macrophages. Cell Rep. 12, 1902-1914 (2015).
    • (2015) Cell Rep. , vol.12 , pp. 1902-1914
    • Kratochvill, F.1
  • 42
    • 77955038532 scopus 로고    scopus 로고
    • Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes
    • Movahedi, K. et al. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res. 70, 5728-5739 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 5728-5739
    • Movahedi, K.1
  • 43
    • 84918555897 scopus 로고    scopus 로고
    • Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways
    • Haverkamp, J. M. et al. Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways. Immunity 41, 947-959 (2014).
    • (2014) Immunity , vol.41 , pp. 947-959
    • Haverkamp, J.M.1
  • 44
    • 84939420392 scopus 로고    scopus 로고
    • RORC1 regulates tumor-promoting Emergency granulo-monocytopoiesis
    • Strauss, L. et al. RORC1 regulates tumor-promoting Emergency granulo-monocytopoiesis. Cancer Cell 28, 253-269 (2015).
    • (2015) Cancer Cell , vol.28 , pp. 253-269
    • Strauss, L.1
  • 45
    • 84959542771 scopus 로고    scopus 로고
    • The nature of myeloidderived suppressor cells in the tumor microenvironment
    • Kumar, V., Patel, S., Tcyganov, E. & Gabrilovich, D. I. The nature of myeloidderived suppressor cells in the tumor microenvironment. Trends Immunol. 37, 208-220 (2016).
    • (2016) Trends Immunol. , vol.37 , pp. 208-220
    • Kumar, V.1    Patel, S.2    Tcyganov, E.3    Gabrilovich, D.I.4
  • 46
    • 84908003234 scopus 로고    scopus 로고
    • The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors
    • Thevenot, P. T. et al. The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors. Immunity 41, 389-401 (2014).
    • (2014) Immunity , vol.41 , pp. 389-401
    • Thevenot, P.T.1
  • 47
    • 84902162433 scopus 로고    scopus 로고
    • ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis
    • Condamine, T. et al. ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis. J. Clin. Invest. 124, 2626-2639 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 2626-2639
    • Condamine, T.1
  • 48
    • 84863116466 scopus 로고    scopus 로고
    • Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils
    • Fridlender, Z. G. et al. Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils. PLoS ONE 7, e31524 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e31524
    • Fridlender, Z.G.1
  • 49
    • 84915748819 scopus 로고    scopus 로고
    • Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer
    • Eruslanov, E. B. et al. Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. J. Clin. Invest. 124, 5466-5480 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 5466-5480
    • Eruslanov, E.B.1
  • 51
    • 84948845737 scopus 로고    scopus 로고
    • Expression of cationic amino acid transporter 2 is required for myeloid-derived suppressor cell-mediated control of T cell immunity
    • Cimen Bozkus, C., Elzey, B. D., Crist, S. A., Ellies, L. G. & Ratliff, T. L. Expression of cationic amino acid transporter 2 is required for myeloid-derived suppressor cell-mediated control of T cell immunity. J. Immunol. 195, 5237-5250 (2015).
    • (2015) J. Immunol. , vol.195 , pp. 5237-5250
    • Cimen Bozkus, C.1    Elzey, B.D.2    Crist, S.A.3    Ellies, L.G.4    Ratliff, T.L.5
  • 52
    • 84947026838 scopus 로고    scopus 로고
    • Impaired gp100-Specific CD8() T-cell responses in the presence of myeloid-derived suppressor cells in a spontaneous mouse melanoma model
    • Mairhofer, D. G. et al. Impaired gp100-Specific CD8() T-cell responses in the presence of myeloid-derived suppressor cells in a spontaneous mouse melanoma model. J. Invest. Dermatol. 135, 2785-2793 (2015).
    • (2015) J. Invest. Dermatol. , vol.135 , pp. 2785-2793
    • Mairhofer, D.G.1
  • 53
    • 84897992390 scopus 로고    scopus 로고
    • Subpopulations of myeloid-derived suppressor cells impair T cell responses through independent nitric oxide-related pathways
    • Raber, P. L. et al. Subpopulations of myeloid-derived suppressor cells impair T cell responses through independent nitric oxide-related pathways. Int. J. Cancer 134, 2853-2864 (2014).
    • (2014) Int. J. Cancer , vol.134 , pp. 2853-2864
    • Raber, P.L.1
  • 54
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: Balance, tolerance, and diversity
    • Mantovani, A. & Sica, A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr. Opin. Immunol. 22, 231-237 (2010).
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 56
    • 84885029080 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis
    • Waight, J. D. et al. Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis. J. Clin. Invest. 123, 4464-4478 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 4464-4478
    • Waight, J.D.1
  • 57
    • 76649097628 scopus 로고    scopus 로고
    • Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
    • Chalmin, F. et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J. Clin. Invest. 120, 457-471 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 457-471
    • Chalmin, F.1
  • 58
    • 0347364683 scopus 로고    scopus 로고
    • Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer
    • Nefedova, Y. et al. Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer. J. Immunol. 172, 464-474 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 464-474
    • Nefedova, Y.1
  • 59
    • 66949145484 scopus 로고    scopus 로고
    • Mechanism regulating reactive oxygen species in tumorinduced myeloid-derived suppressor cells
    • Corzo, C. A. et al. Mechanism regulating reactive oxygen species in tumorinduced myeloid-derived suppressor cells. J. Immunol. 182, 5693-5701 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 5693-5701
    • Corzo, C.A.1
  • 60
    • 53349125963 scopus 로고    scopus 로고
    • Proinflammatory s100 proteins regulate the accumulation of myeloid-derived suppressor cells
    • Sinha, P. et al. Proinflammatory s100 proteins regulate the accumulation of myeloid-derived suppressor cells. J. Immunol. 181, 4666-4675 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 4666-4675
    • Sinha, P.1
  • 61
    • 53349099219 scopus 로고    scopus 로고
    • Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
    • Cheng, P. et al. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J. Exp. Med. 205, 2235-2249 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 2235-2249
    • Cheng, P.1
  • 62
    • 79958052123 scopus 로고    scopus 로고
    • MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy
    • Finke, J. et al. MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy. Int. Immunopharmacol. 11, 856-861 (2011).
    • (2011) Int. Immunopharmacol. , vol.11 , pp. 856-861
    • Finke, J.1
  • 63
    • 33749425534 scopus 로고    scopus 로고
    • Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8 T cells
    • Gallina, G. et al. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8 T cells. J. Clin. Invest. 116, 2777-2790 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 2777-2790
    • Gallina, G.1
  • 64
    • 0037223170 scopus 로고    scopus 로고
    • IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice
    • Bronte, V. et al. IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice. J. Immunol. 170, 270-278 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 270-278
    • Bronte, V.1
  • 65
    • 80054694464 scopus 로고    scopus 로고
    • Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
    • Molon, B. et al. Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J. Exp. Med. 208, 1949-1962 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1949-1962
    • Molon, B.1
  • 66
    • 46949094641 scopus 로고    scopus 로고
    • Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1-and M2-type characteristics
    • Umemura, N. et al. Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1-and M2-type characteristics. J. Leukoc. Biol. 83, 1136-1144 (2008).
    • (2008) J. Leukoc. Biol. , vol.83 , pp. 1136-1144
    • Umemura, N.1
  • 67
    • 77950829023 scopus 로고    scopus 로고
    • Mechanism of T cell tolerance induced by myeloid-derived suppressor cells
    • Nagaraj, S., Schrum, A. G., Cho, H. I., Celis, E. & Gabrilovich, D. I. Mechanism of T cell tolerance induced by myeloid-derived suppressor cells. J. Immunol. 184, 3106-3116 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 3106-3116
    • Nagaraj, S.1    Schrum, A.G.2    Cho, H.I.3    Celis, E.4    Gabrilovich, D.I.5
  • 68
    • 80053421470 scopus 로고    scopus 로고
    • Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice
    • Lu, T. et al. Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice. J. Clin. Invest. 121, 4015-4029 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 4015-4029
    • Lu, T.1
  • 69
    • 34547820876 scopus 로고    scopus 로고
    • Tumor refractoriness to anti-VEGF treatment is mediated by CD11b()Gr1() myeloid cells
    • Shojaei, F. et al. Tumor refractoriness to anti-VEGF treatment is mediated by CD11b()Gr1() myeloid cells. Nat. Biotechnol. 25, 911-920 (2007).
    • (2007) Nat. Biotechnol. , vol.25 , pp. 911-920
    • Shojaei, F.1
  • 70
    • 5444225991 scopus 로고    scopus 로고
    • Expansion of myeloid immune suppressor GrCD11b cells in tumor-bearing host directly promotes tumor angiogenesis
    • Yang, L. et al. Expansion of myeloid immune suppressor GrCD11b cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 6, 409-421 (2004).
    • (2004) Cancer Cell , vol.6 , pp. 409-421
    • Yang, L.1
  • 71
    • 34249300128 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
    • Sinha, P., Clements, V. K., Fulton, A. M. & Ostrand-Rosenberg, S. Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells. Cancer. Res. 67, 4507-4513 (2007).
    • (2007) Cancer. Res. , vol.67 , pp. 4507-4513
    • Sinha, P.1    Clements, V.K.2    Fulton, A.M.3    Ostrand-Rosenberg, S.4
  • 72
    • 84905455438 scopus 로고    scopus 로고
    • Inhibition of tumor-derived prostaglandin-e2 blocks the induction of myeloid-derived suppressor cells and recovers natural killer cell activity
    • Mao, Y. et al. Inhibition of tumor-derived prostaglandin-e2 blocks the induction of myeloid-derived suppressor cells and recovers natural killer cell activity. Clin. Cancer. Res. 20, 4096-4106 (2014).
    • (2014) Clin. Cancer. Res. , vol.20 , pp. 4096-4106
    • Mao, Y.1
  • 73
    • 84899753178 scopus 로고    scopus 로고
    • PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
    • Noman, M. Z. et al. PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J. Exp. Med. 211, 781-790 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 781-790
    • Noman, M.Z.1
  • 74
    • 84914096079 scopus 로고    scopus 로고
    • Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors
    • Beury, D. W. et al. Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors. J. Leukoc. Biol. 96, 1109-1118 (2014).
    • (2014) J. Leukoc. Biol. , vol.96 , pp. 1109-1118
    • Beury, D.W.1
  • 75
    • 34548805636 scopus 로고    scopus 로고
    • Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response
    • Sinha, P., Clements, V. K., Bunt, S. K., Albelda, S. M. & Ostrand-Rosenberg, S. Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J. Immunol. 179, 977-983 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 977-983
    • Sinha, P.1    Clements, V.K.2    Bunt, S.K.3    Albelda, S.M.4    Ostrand-Rosenberg, S.5
  • 76
    • 84864746109 scopus 로고    scopus 로고
    • Anti-IL-6 receptor mAb eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T-cell responses
    • Sumida, K. et al. Anti-IL-6 receptor mAb eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T-cell responses. Eur. J. Immunol. 42, 2060-2072 (2012).
    • (2012) Eur. J. Immunol. , vol.42 , pp. 2060-2072
    • Sumida, K.1
  • 77
    • 84858202940 scopus 로고    scopus 로고
    • Aptamer-mediated blockade of IL4Ralpha triggers apoptosis of MDSCs and limits tumor progression
    • Roth, F. et al. Aptamer-mediated blockade of IL4Ralpha triggers apoptosis of MDSCs and limits tumor progression. Cancer Res. 72, 1373-1383 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 1373-1383
    • Roth, F.1
  • 78
    • 4344590947 scopus 로고    scopus 로고
    • High-dose GM-CSF-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells
    • Serafini, P. et al. High-dose GM-CSF-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells. Cancer Res. 64, 6337-6343 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 6337-6343
    • Serafini, P.1
  • 79
    • 70350111154 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in mammary tumor progression in FVB Neu transgenic mice
    • Abe, F. et al. Myeloid-derived suppressor cells in mammary tumor progression in FVB Neu transgenic mice. Cancer Immunol. Immunother. 59, 47-62 (2010).
    • (2010) Cancer Immunol. Immunother. , vol.59 , pp. 47-62
    • Abe, F.1
  • 80
    • 78650722060 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6GLy6C granulocytes
    • Kowanetz, M. et al. Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6GLy6C granulocytes. Proc. Natl Acad. Sci. USA 107, 21248-21255 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 21248-21255
    • Kowanetz, M.1
  • 81
    • 78650474985 scopus 로고    scopus 로고
    • Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13
    • Highfill, S. L. et al. Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13. Blood 116, 5738-5747 (2010).
    • (2010) Blood , vol.116 , pp. 5738-5747
    • Highfill, S.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.