Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155

Journal of Molecular Cell Biology

Volumn 4, Issue 5, 2012, Pages 341-343

  Cai, Xing ^a   Yin, Yuan ^a   Li, Ningzhu ^a   Zhu, Dihan ^a   Zhang, Junfeng ^a   Zhang, Chen Yu ^a   Zen, Ke ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BIOLOGICAL MARKER; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; MICRORNA 155;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; CELL INVASION; CELL SURVIVAL; GENE OVEREXPRESSION; INFLAMMATION; LETTER; M1 MACROPHAGE; METASTASIS; NONHUMAN; POLARIZATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR CELL; TUMOR GROWTH; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; UPREGULATION;

ANIMALS; APOPTOSIS; INFLAMMATION; MACROPHAGES; MICE; MICE, INBRED BALB C; MICRORNAS; NEOPLASMS;

EID: 84867420120     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mjs044     Document Type: Letter

References (10)

1. Hagemann, T., Wilson, J., Burke, F., et al. (2006). Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype. J. Immunol. 176, 5023-5032.
2. He, M., Xu, Z., Ding, T., et al. (2009). MicroRNA-155 regulates inflammatory cytokine production in tumor-associated macrophages via targeting C/EBPbeta. Cell. Mol. Immunol. 6, 343-352.
3. Lodish, H.F., Zhou, B., Liu, G., et al. (2008). Micromanagement of the immune system by microRNAs. Nat. Rev. Immunol. 8, 120-130.
4. Martinez-Nunez, R.T., Louafi, F., and Sanchez- Elsner, T. (2011). The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1). J. Biol. Chem. 286, 1786-1794.
5. Mills, C.D., Kincaid, K., Alt, J.M., et al. (2000). M-1/ M-2 macrophages and the Th1/Th2 paradigm. J. Immunol. 164, 6166-6173.
6. Mosser, D.M. (2003). The many faces of macrophage activation. J. Leukoc. Biol. 73, 209-212.
7. O'Connell, R.M., Chaudhuri, A.A., Rao, D.S., et al. (2009). Inositol phosphatase SHIP1 is a primary target of miR-155. Proc. Natl Acad. Sci. USA 106, 7113-7118.
8. Pelegrin, P., and Surprenant, A. (2009). Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates. EMBO J. 28, 2114-2127.
9. Sica, A., Larghi, P., Mancino, A., et al. (2008). Macrophage polarization in tumour progression. Semin. Cancer Biol. 18, 349-355.
10. Sierra-Filardi, E., Puig-Kroger, A., Blanco, F.J., et al. (2011). Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers. Blood 117, 5092-5101.