Novel insights in the regulation and function of macrophages in the tumor microenvironment

Current Opinion in Oncology

Volumn 29, Issue 1, 2017, Pages 55-61

  Bolli, Evangelia ^a,b   Movahedi, Kiavash ^a,b   Laoui, Damya ^a,b   Ginderachter, Jo A Van ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Immune checkpoint blockade; metastatic niche; therapy resistance; tumor microenvironment; tumor associated macrophage

Indexed keywords

CANCER PROGNOSIS; CANCER RECURRENCE; CANCER RESISTANCE; CANCER SURVIVAL; CELL HETEROGENEITY; HEALTH CARE QUALITY; HUMAN; HUMAN CELL; IMMUNOREGULATION; MACROPHAGE FUNCTION; METASTASIS; MOUSE; NONHUMAN; ONTOGENY; OVERALL SURVIVAL; PHENOTYPE; PRIORITY JOURNAL; REPOLARIZATION; REVIEW; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; TUMOR MICROENVIRONMENT; ANIMAL; CELL TRANSFORMATION; DISEASE COURSE; MACROPHAGE; NEOPLASM; PATHOLOGY;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; HUMANS; MACROPHAGES; NEOPLASMS; TUMOR MICROENVIRONMENT;

EID: 84992740400     PISSN: 10408746     EISSN: 1531703X     Source Type: Journal    
DOI: 10.1097/CCO.0000000000000344     Document Type: Review

References (45)

1. Gentles AJ, Newman AM, Liu CL, et al. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat Med 2015; 21:938-945.
2. Lahmar Q, Keirsse J, Laoui D, et al. Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment. Biochim Biophys Acta 2016; 1865:23-34.
3. Gomez Perdiguero E, Klapproth K, Schulz C, et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 2014; 518:547-551.
4. Van Overmeire E, Stijlemans B, Heymann F, et al. M-CSF and GM-CSF receptor signaling differentially regulate monocyte maturation and macrophage polarization in the tumor microenvironment. Cancer Res 2016; 76:35-42.
5. Shand FHW, Ueha S, Otsuji M, et al. Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes. Proc Natl Acad Sci USA 2014; 111:7771-7776.
6. Strauss L, Sangaletti S, Consonni FM, et al. RORC1 regulates tumorpromoting 'emergency' granulo-monocytopoiesis. Cancer Cell 2015; 28:253-269.
7. Laoui D, Van Overmeire E, Di Conza G, et al. Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population. Cancer Res 2014; 74:24-30.
8. Poczobutt JM, De S, Yadav VK, et al. Expression profiling of macrophages reveals multiple populations with distinct biological roles in an immunocompetent orthotopic model of lung cancer. J Immunol 2016; 196:2847-2859.
9. Hughes R, Qian B-Z, Rowan C, et al. Perivascular M2 macrophages stimulate tumor relapse after chemotherapy. Cancer Res 2015; 75:3479-3491.
10. Wyckoff J, Wang W, Lin EY, et al. A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res 2004; 64:7022-7029.
11. Harney AS, Arwert EN, Entenberg D, et al. Real-time imaging reveals local, transient vascular permeability, and tumor cell intravasation stimulated by TIE2hi macrophage-derived VEGFA. Cancer Discov 2015; 5:932-943.
12. Rohan TE, Xue X, Lin H-M, et al. Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer. J Natl Cancer Inst 2014; 106:dju136-dju1136.
13. Su S, Liu Q, Chen J, et al. A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer Cell 2014; 25:605-620.
14. Meng F, Li W, Li C, et al. CCL18 promotes epithelial-mesenchymal transition, invasion and migration of pancreatic cancer cells in pancreatic ductal adenocarcinoma. Int J Oncol 2015; 46:1109-1120.
15. Kitamura T, Qian B-Z, Soong D, et al. CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasisassociated macrophages. J Exp Med 2015; 212:1043-1059.
16. Srivastava K, Hu J, Korn C, et al. Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Cancer Cell 2014; 26:880-895.
17. Headley MB, Bins A, Nip A, et al. Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature 2016; 531:513-517.
18. Qian B-Z, Zhang H, Li J, et al. FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis. J Exp Med 2015; 212:1433-1448.
19. Hanna RN, Cekic C, Sag D, et al. Patrolling monocytes control tumor metastasis to the lung. Science 2015; 350:985-990.
20. Hamm A, Prenen H, Van Delm W, et al. Tumour-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer. Gut 2016; 65:990-1000.
21. Chittezhath M, Dhillon MK, Lim JY, et al. Molecular profiling reveals a tumorpromoting phenotype of monocytes and macrophages in human cancer progression. Immunity 2014; 41:815-829.
22. Pucci F, Garris C, Lai CP, et al. SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science 2016; 352:242-246.
23. Bonavita E, Gentile S, Rubino M, et al. PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer. Cell 2015; 160:700-714.
24. Yamada K, Uchiyama A, Uehara A, et al. MFG-E8 drives melanoma growth by stimulating mesenchymal stromal cell-induced angiogenesis and M2 polarization of tumor-associated macrophages. Cancer Res 2016; 76: 4283-4292.
25. Zhou W, Ke SQ, Huang Z, et al. Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. Nat Cell Biol 2015; 17:170-182.
26. Frankenberger C, Rabe D, Bainer R, et al. Metastasis suppressors regulate the tumor microenvironment by blocking recruitment of prometastatic tumor-associated macrophages. Cancer Res 2015; 75:4063-4073.
27. Ries CH, Cannarile MA, Hoves S, et al. Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell 2014; 25:846-859.
28. Pyonteck SM, Akkari L, Schuhmacher AJ, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med 2013; 19:1264-1272.
29. Kratochvill F, Neale G, Haverkamp JM, et al. TNF counterbalances the emergence of M2 tumor macrophages. Cell Rep 2015; 12:1902-1914.
30. Kratochvill F, Gratz N, Qualls JE, et al. Tristetraprolin limits inflammatory cytokine production in tumor-associated macrophages in an mRNA decayindependent manner. Cancer Res 2015; 75:3054-3064.
31. Baer C, Squadrito ML, Laoui D, et al. Suppression of microRNA activity amplifies IFN-g-induced macrophage activation and promotes antitumour immunity. Nat Cell Biol 2016; 18:790-802.
32. Zhou S-L, Hu Z-Q, Zhou Z-J, et al. miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis. Hepatology 2016; 63:1560-1575.
33. Zhao J-L, Huang F, He F, et al. Forced activation of notch in macrophages represses tumor growth by upregulating miR-125a and disabling tumorassociated macrophages. Cancer Res 2016; 76:1403-1415.
34. Seifert L, Werba G, Tiwari S, et al. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature 2016; 532:245-249.
35. Casazza A, Laoui D, Wenes M, et al. Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. Cancer Cell 2013; 24:695-709.
36. Kumar V, Cheng P, Condamine T, et al. CD45 phosphatase inhibits STAT3 transcription factor activity in myeloid cells and promotes tumor-associated macrophage differentiation. Immunity 2016; 44:303-315.
37. Colegio OR, Chu N-Q, Szabo AL, et al. Functional polarization of tumourassociated macrophages by tumour-derived lactic acid. Nature 2014; 513:559-563.
38. Rivera LB, Meyronet D, Hervieu V, et al. Intratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy. Cell Rep 2015; 11:577-591.
39. Quail DF, Bowman RL, Akkari L, et al. The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science 2016; 352:aad3018. The first article to analyze in detail the mechanisms behind tumor resistance against anti-CSF-1R therapy.
40. Kaneda MM, Cappello P, Nguyen AV, et al. Macrophage PI3Kg drives pancreatic ductal adenocarcinoma progression. Cancer Discov 2016; 6:870-885.
41. Zhu Y, Knolhoff BL, Meyer MA, et al. CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. Cancer Res 2014; 74:5057-5069.
42. Gunderson AJ, Kaneda MM, Tsujikawa T, et al. Bruton tyrosine kinasedependent immune cell cross-talk drives pancreas cancer. Cancer Discov 2016; 6:270-285.
43. Kloepper J, Riedemann L, Amoozgar Z, et al. Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to antitumor phenotype and prolongs glioblastoma survival. Proc Natl Acad Sci USA 2016; 113:4476-4481.
44. Peterson TE, Kirkpatrick ND, Huang Y, et al. Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages. Proc Natl Acad Sci USA 2016; 113:4470-4475.
45. Georgoudaki A-M, Prokopec KE, Boura VF, et al. Reprogramming tumorassociated macrophages by antibody targeting inhibits cancer progression and metastasis. Cell Rep 2016; 15:2000-2011.