메뉴 건너뛰기




Volumn 9, Issue 3, 2017, Pages 289-302

Tumor-associated macrophages: Implications in cancer immunotherapy

Author keywords

immunotherapy; tumor microenvironment; tumor associated macrophages (TAM)

Indexed keywords

AMG 820; BLZ 945; CARLUMAB; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; COLONY STIMULATING FACTOR 1; COLONY STIMULATING FACTOR RECEPTOR; DACARBAZINE; DNA VACCINE; DOXORUBICIN; EMACTUZUMAB; ERIBULIN; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; IMC CS4; IMIQUIMOD; IRINOTECAN; LEGUMAIN; MONOCLONAL ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 1; NANOPARTICLE; OXALIPLATIN; PACLITAXEL; PDR 001; PF 04136309; PLX 3397; TRABECTEDIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 85014029818     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt-2016-0135     Document Type: Review
Times cited : (294)

References (98)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell. 144(5), 646-674 (2011).
    • (2011) Cell. , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat. Med. 19(11), 1423-1437 (2013).
    • (2013) Nat. Med. , vol.19 , Issue.11 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 3
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm
    • Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat. Immunol. 11(10), 889-896 (2010).
    • (2010) Nat. Immunol. , vol.11 , Issue.10 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 4
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell. 141(1), 39-51 (2010).
    • (2010) Cell. , vol.141 , Issue.1 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 5
    • 84901358607 scopus 로고    scopus 로고
    • Monocytes and macrophages: Developmental pathways and tissue homeostasis
    • Ginhoux F, Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat. Rev. Immunol. 14(6), 392-404 (2014).
    • (2014) Nat. Rev. Immunol. , vol.14 , Issue.6 , pp. 392-404
    • Ginhoux, F.1    Jung, S.2
  • 6
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: In vivo veritas
    • Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J. Clin. Invest. 122(3), 787-795 (2012).
    • (2012) J. Clin. Invest. , vol.122 , Issue.3 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 7
    • 84894102230 scopus 로고    scopus 로고
    • Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
    • Xue J, Schmidt SV, Sander J et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 40(2), 274-288 (2014).
    • (2014) Immunity , vol.40 , Issue.2 , pp. 274-288
    • Xue, J.1    Schmidt, S.V.2    Sander, J.3
  • 8
    • 84871076444 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization in tissue repair and remodelling
    • Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M. Macrophage plasticity and polarization in tissue repair and remodelling. J. Pathol. 229(2), 176-185 (2013).
    • (2013) J. Pathol. , vol.229 , Issue.2 , pp. 176-185
    • Mantovani, A.1    Biswas, S.K.2    Galdiero, M.R.3    Sica, A.4    Locati, M.5
  • 9
    • 33344460032 scopus 로고    scopus 로고
    • A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/ STAT1 activation)
    • Biswas SK, Gangi L, Paul S et al. A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/ STAT1 activation). Blood 107(5), 2112-2122 (2006).
    • (2006) Blood , vol.107 , Issue.5 , pp. 2112-2122
    • Biswas, S.K.1    Gangi, L.2    Paul, S.3
  • 10
    • 84876775203 scopus 로고    scopus 로고
    • Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
    • Hashimoto D, Chow A, Noizat C et al. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38(4), 792-804 (2013).
    • (2013) Immunity , vol.38 , Issue.4 , pp. 792-804
    • Hashimoto, D.1    Chow, A.2    Noizat, C.3
  • 11
    • 84920514940 scopus 로고    scopus 로고
    • The origin and function of tumor-associated macrophages
    • Liu Y, Cao X. The origin and function of tumor-associated macrophages. Cell. Mol. Immunol. 12(1), 1-4 (2015).
    • (2015) Cell. Mol. Immunol. , vol.12 , Issue.1 , pp. 1-4
    • Liu, Y.1    Cao, X.2
  • 12
    • 85026641366 scopus 로고    scopus 로고
    • Tumor-associated macrophages: Unwitting accomplices in breast cancer malignancy
    • Williams CB, Yeh ES, Soloff AC. Tumor-associated macrophages: unwitting accomplices in breast cancer malignancy. NPJ Breast Cancer 2, 15025 (2016).
    • (2016) NPJ Breast Cancer , vol.2 , pp. 15025
    • Williams, C.B.1    Yeh, E.S.2    Soloff, A.C.3
  • 13
    • 85009115863 scopus 로고    scopus 로고
    • Ontogeny of tumor-associated macrophages and its implication in cancer regulation
    • Franklin RA, Li MO. Ontogeny of tumor-associated macrophages and its implication in cancer regulation. Trends. Cancer. 2(1), 20-34 (2016).
    • (2016) Trends. Cancer. , vol.2 , Issue.1 , pp. 20-34
    • Franklin, R.A.1    Li, M.O.2
  • 14
    • 77955038532 scopus 로고    scopus 로고
    • Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes
    • Movahedi K, Laoui D, Gysemans C et al. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res. 70(14), 5728-5739 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.14 , pp. 5728-5739
    • Movahedi, K.1    Laoui, D.2    Gysemans, C.3
  • 15
    • 84901215262 scopus 로고    scopus 로고
    • The cellular and molecular origin of tumor-associated macrophages
    • Franklin RA, Liao W, Sarkar A et al. The cellular and molecular origin of tumor-associated macrophages. Science 344(6186), 921-925 (2014).
    • (2014) Science , vol.344 , Issue.6186 , pp. 921-925
    • Franklin, R.A.1    Liao, W.2    Sarkar, A.3
  • 16
    • 84901675728 scopus 로고    scopus 로고
    • Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes
    • Shand FHW, Ueha S, Otsuji M et al. Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes. PNAS 111(21), 7771-7776 (2014).
    • (2014) PNAS , vol.111 , Issue.21 , pp. 7771-7776
    • Shand, F.H.W.1    Ueha, S.2    Otsuji, M.3
  • 17
    • 84859643154 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages
    • Linde N, Lederle W, Depner S, Van Rooijen N, Gutschalk CM, Mueller MM. Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages. J. Pathol. 227(1), 17-28 (2012).
    • (2012) J. Pathol. , vol.227 , Issue.1 , pp. 17-28
    • Linde, N.1    Lederle, W.2    Depner, S.3    Van Rooijen, N.4    Gutschalk, C.M.5    Mueller, M.M.6
  • 18
    • 79960411324 scopus 로고    scopus 로고
    • CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    • Qian B-Z, Li J, Zhang H et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature. 475(7355), 222-225 (2011).
    • (2011) Nature. , vol.475 , Issue.7355 , pp. 222-225
    • Qian, B.-Z.1    Li, J.2    Zhang, H.3
  • 19
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: From mechanisms to therapy
    • Noy R, Pollard JW. Tumor-associated macrophages: from mechanisms to therapy. Immunity 41(1), 49-61 (2014).
    • (2014) Immunity , vol.41 , Issue.1 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 20
    • 80355146399 scopus 로고    scopus 로고
    • Transcriptional regulation of macrophage polarization; Enabling diversity with identity
    • Lawrence T, Natoli G. Transcriptional regulation of macrophage polarization; enabling diversity with identity. Nat. Rev. Immunol. 11(11), 750-761 (2011).
    • (2011) Nat. Rev. Immunol. , vol.11 , Issue.11 , pp. 750-761
    • Lawrence, T.1    Natoli, G.2
  • 21
    • 84907223092 scopus 로고    scopus 로고
    • Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
    • Colegio OR, Chu N-Q, Szabo AL et al. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 513(7519), 559-563 (2014).
    • (2014) Nature , vol.513 , Issue.7519 , pp. 559-563
    • Colegio, O.R.1    Chu, N.-Q.2    Szabo, A.L.3
  • 22
    • 83455203338 scopus 로고    scopus 로고
    • Identification and manipulation of tumor associated macrophages in human cancers
    • Heusinkveld M, Van Der Burg SH. Identification and manipulation of tumor associated macrophages in human cancers. J. Transl. Med. 9, 216 (2011).
    • (2011) J. Transl. Med. , vol.9 , pp. 216
    • Heusinkveld, M.1    Van Der Burg, S.H.2
  • 23
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Regulators of the tumor microenvironment
    • Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell. 141(1), 52-67 (2010).
    • (2010) Cell. , vol.141 , Issue.1 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 24
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • Murdoch C, Muthana M, Coffelt SB, Lewis CE. The role of myeloid cells in the promotion of tumour angiogenesis. Nat. Rev. Cancer 8(8), 618-631 (2008).
    • (2008) Nat. Rev. Cancer , vol.8 , Issue.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 25
    • 0036329210 scopus 로고    scopus 로고
    • Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma
    • Valkovic T, Dobrila F, Melato M, Sasso F, Rizzardi C, Jonjic N. Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma. Virchows Arch. 440(6), 583-588 (2002).
    • (2002) Virchows Arch. , vol.440 , Issue.6 , pp. 583-588
    • Valkovic, T.1    Dobrila, F.2    Melato, M.3    Sasso, F.4    Rizzardi, C.5    Jonjic, N.6
  • 26
    • 34347226359 scopus 로고    scopus 로고
    • Tumor-associated macrophages press the angiogenic switch in breast cancer
    • Lin EY, Pollard JW. Tumor-associated macrophages press the angiogenic switch in breast cancer. Cancer Res. 67(11), 5064-5066 (2007).
    • (2007) Cancer Res. , vol.67 , Issue.11 , pp. 5064-5066
    • Lin, E.Y.1    Pollard, J.W.2
  • 27
    • 84902456985 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor augments tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer
    • Forget MA, Voorhees JL, Cole SL et al. Macrophage colony-stimulating factor augments tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer. PLoS ONE. 9(6), e98623 (2014).
    • (2014) PLoS ONE. , vol.9 , Issue.6 , pp. e98623
    • Forget, M.A.1    Voorhees, J.L.2    Cole, S.L.3
  • 28
    • 84902208605 scopus 로고    scopus 로고
    • Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer
    • Yeo EJ, Cassetta L, Qian BZ et al. Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer. Cancer Res. 74(11), 2962-2973 (2014).
    • (2014) Cancer Res. , vol.74 , Issue.11 , pp. 2962-2973
    • Yeo, E.J.1    Cassetta, L.2    Qian, B.Z.3
  • 29
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124(2), 263-266 (2006).
    • (2006) Cell , vol.124 , Issue.2 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 30
    • 84862823626 scopus 로고    scopus 로고
    • Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors
    • Bonde AK, Tischler V, Kumar S, Soltermann A, Schwendener RA. Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors. BMC Cancer 12, 35 (2012).
    • (2012) BMC Cancer , vol.12 , pp. 35
    • Bonde, A.K.1    Tischler, V.2    Kumar, S.3    Soltermann, A.4    Schwendener, R.A.5
  • 31
    • 34047246527 scopus 로고    scopus 로고
    • Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors
    • Wyckoff JB, Wang Y, Lin EY et al. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res. 67(6), 2649-2656 (2007).
    • (2007) Cancer Res. , vol.67 , Issue.6 , pp. 2649-2656
    • Wyckoff, J.B.1    Wang, Y.2    Lin, E.Y.3
  • 32
    • 55349145218 scopus 로고    scopus 로고
    • Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis
    • Sangaletti S, Di Carlo E, Gariboldi S et al. Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis. Cancer Res. 68(21), 9050-9059 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.21 , pp. 9050-9059
    • Sangaletti, S.1    Di Carlo, E.2    Gariboldi, S.3
  • 33
    • 84920943285 scopus 로고    scopus 로고
    • Tumor-associated macrophages as major players in the tumor microenvironment
    • Chanmee T, Ontong P, Konno K, Itano N. Tumor-associated macrophages as major players in the tumor microenvironment. Cancers 6(3), 1670-1690 (2014).
    • (2014) Cancers , vol.6 , Issue.3 , pp. 1670-1690
    • Chanmee, T.1    Ontong, P.2    Konno, K.3    Itano, N.4
  • 34
    • 79953747613 scopus 로고    scopus 로고
    • CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3
    • Chen J, Yao Y, Gong C et al. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell. 19(4), 541-555 (2011).
    • (2011) Cancer Cell. , vol.19 , Issue.4 , pp. 541-555
    • Chen, J.1    Yao, Y.2    Gong, C.3
  • 35
    • 68749109536 scopus 로고    scopus 로고
    • A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    • Qian B, Deng Y, Im JH et al. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS ONE 4(8), e6562 (2009).
    • (2009) PLoS ONE , vol.4 , Issue.8 , pp. e6562
    • Qian, B.1    Deng, Y.2    Im, J.H.3
  • 36
    • 84896125494 scopus 로고    scopus 로고
    • Evolution of the cancer stem cell model
    • Kreso A, Dick JE. Evolution of the cancer stem cell model. Cell Stem Cell 14(3), 275-291 (2014).
    • (2014) Cell Stem Cell , vol.14 , Issue.3 , pp. 275-291
    • Kreso, A.1    Dick, J.E.2
  • 37
    • 80053531658 scopus 로고    scopus 로고
    • Regulation of cancer stem cells by cytokine networks: Attacking cancer's inflammatory roots
    • Korkaya H, Liu S, Wicha MS. Regulation of cancer stem cells by cytokine networks: Attacking cancer's inflammatory roots. Clin. Cancer Res. 17(19), 6125-6129 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.19 , pp. 6125-6129
    • Korkaya, H.1    Liu, S.2    Wicha, M.S.3
  • 38
    • 84872600554 scopus 로고    scopus 로고
    • Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
    • Schwitalla S, Fingerle AA, Cammareri P et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell 152(1-2), 25-38 (2013).
    • (2013) Cell , vol.152 , Issue.1-2 , pp. 25-38
    • Schwitalla, S.1    Fingerle, A.A.2    Cammareri, P.3
  • 39
    • 84913580379 scopus 로고    scopus 로고
    • Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells
    • Wan S, Zhao E, Kryczek I et al. Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. Gastroenterology 147(6), 1393-1404 (2014).
    • (2014) Gastroenterology , vol.147 , Issue.6 , pp. 1393-1404
    • Wan, S.1    Zhao, E.2    Kryczek, I.3
  • 40
    • 84978680807 scopus 로고    scopus 로고
    • Infiltrating macrophages increase RCC epithelial mesenchymal transition (EMT) and stem cell-like populations via AKT and mTOR signaling
    • Yang Z, Xie H, He D, Li L. Infiltrating macrophages increase RCC epithelial mesenchymal transition (EMT) and stem cell-like populations via AKT and mTOR signaling. Oncotarget 7(28), 44478-44491 (2016).
    • (2016) Oncotarget , vol.7 , Issue.28 , pp. 44478-44491
    • Yang, Z.1    Xie, H.2    He, D.3    Li, L.4
  • 41
    • 84908485098 scopus 로고    scopus 로고
    • A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages
    • Lu H, Clauser KR, Tam WL et al. A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat. Cell Biol. 16(11), 1105-1117 (2014).
    • (2014) Nat. Cell Biol. , vol.16 , Issue.11 , pp. 1105-1117
    • Lu, H.1    Clauser, K.R.2    Tam, W.L.3
  • 42
    • 84874291853 scopus 로고    scopus 로고
    • Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway
    • Yang J, Liao D, Chen C et al. Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway. Stem Cells 31(2), 248-258 (2013).
    • (2013) Stem Cells , vol.31 , Issue.2 , pp. 248-258
    • Yang, J.1    Liao, D.2    Chen, C.3
  • 43
    • 79961074770 scopus 로고    scopus 로고
    • Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells
    • Jinushi M, Chiba S, Yoshiyama H et al. Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells. PNAS 108(30), 12425-12430 (2011).
    • (2011) PNAS , vol.108 , Issue.30 , pp. 12425-12430
    • Jinushi, M.1    Chiba, S.2    Yoshiyama, H.3
  • 44
    • 84873468174 scopus 로고    scopus 로고
    • Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses
    • Mitchem JB, Brennan DJ, Knolhoff BL et al. Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses. Cancer Res. 73(3), 1128-1141 (2013).
    • (2013) Cancer Res. , vol.73 , Issue.3 , pp. 1128-1141
    • Mitchem, J.B.1    Brennan, D.J.2    Knolhoff, B.L.3
  • 45
    • 84928226005 scopus 로고    scopus 로고
    • The interaction of anticancer therapies with tumor-associated macrophages
    • Mantovani A, Allavena P. The interaction of anticancer therapies with tumor-associated macrophages. J. Exp. Med. 212, 435-445 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 435-445
    • Mantovani, A.1    Allavena, P.2
  • 46
    • 84868030361 scopus 로고    scopus 로고
    • Tumor-associated macrophages: Function, phenotype, and link to prognosis in human lung cancer
    • Quatromoni JG, Eruslanov E. Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer. Am. J. Transl. Res. 4(4), 376-389 (2012).
    • (2012) Am. J. Transl. Res. , vol.4 , Issue.4 , pp. 376-389
    • Quatromoni, J.G.1    Eruslanov, E.2
  • 47
    • 36849010167 scopus 로고    scopus 로고
    • Adaptive immunity maintains occult cancer in an equilibrium state
    • Koebel CM, Vermi W, Swann JB et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 450(7171), 903-907 (2007).
    • (2007) Nature , vol.450 , Issue.7171 , pp. 903-907
    • Koebel, C.M.1    Vermi, W.2    Swann, J.B.3
  • 48
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • Gajewski TF, Schreiber H, Fu Y-X. Innate and adaptive immune cells in the tumor microenvironment. Nat. Immunol. 14(10), 1014-1022 (2013).
    • (2013) Nat. Immunol. , vol.14 , Issue.10 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.-X.3
  • 49
    • 0038181111 scopus 로고    scopus 로고
    • Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma
    • Mortarini R, Piris A, Maurichi A et al. Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma. Cancer Res. 63(10), 2535-2545 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.10 , pp. 2535-2545
    • Mortarini, R.1    Piris, A.2    Maurichi, A.3
  • 50
    • 19344377474 scopus 로고    scopus 로고
    • GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2, 3-dioxygenase
    • Munn DH, Sharma MD, Baban B et al. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2, 3-dioxygenase. Immunity 22(5), 633-642 (2005).
    • (2005) Immunity , vol.22 , Issue.5 , pp. 633-642
    • Munn, D.H.1    Sharma, M.D.2    Baban, B.3
  • 51
    • 33846933459 scopus 로고    scopus 로고
    • L-arginine availability regulates T-lymphocyte cell-cycle progression
    • Rodriguez PC, Quiceno DG, Ochoa AC. L-arginine availability regulates T-lymphocyte cell-cycle progression. Blood 109(4), 1568-1573 (2007).
    • (2007) Blood , vol.109 , Issue.4 , pp. 1568-1573
    • Rodriguez, P.C.1    Quiceno, D.G.2    Ochoa, A.C.3
  • 52
    • 0041845173 scopus 로고    scopus 로고
    • L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes
    • Rodriguez PC, Zea AH, Desalvo J et al. L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes. J. Immunol. 171(3), 1232-1239 (2003).
    • (2003) J. Immunol. , vol.171 , Issue.3 , pp. 1232-1239
    • Rodriguez, P.C.1    Zea, A.H.2    Desalvo, J.3
  • 53
    • 0037080021 scopus 로고    scopus 로고
    • Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism
    • Mazzoni A, Bronte V, Visintin A et al. Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism. J. Immunol. 168(2), 689-695 (2002).
    • (2002) J. Immunol. , vol.168 , Issue.2 , pp. 689-695
    • Mazzoni, A.1    Bronte, V.2    Visintin, A.3
  • 54
    • 84855361145 scopus 로고    scopus 로고
    • Regulation of immune responses by prostaglandin E2
    • Kalinski P. Regulation of immune responses by prostaglandin E2. J. Immunol. 188(1), 21-28 (2012).
    • (2012) J. Immunol. , vol.188 , Issue.1 , pp. 21-28
    • Kalinski, P.1
  • 55
    • 84885457151 scopus 로고    scopus 로고
    • TGF-beta: Guardian of T cell function
    • Oh SA, Li MO. TGF-beta: guardian of T cell function. J. Immunol. 191(8), 3973-3979 (2013).
    • (2013) J. Immunol. , vol.191 , Issue.8 , pp. 3973-3979
    • Oh, S.A.1    Li, M.O.2
  • 56
    • 84912089439 scopus 로고    scopus 로고
    • Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells
    • Ruffell B, Chang-Strachan D, Chan V et al. Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells. Cancer Cell 26(5), 623-637 (2014).
    • (2014) Cancer Cell , vol.26 , Issue.5 , pp. 623-637
    • Ruffell, B.1    Chang-Strachan, D.2    Chan, V.3
  • 57
    • 67449110979 scopus 로고    scopus 로고
    • Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    • Kuang DM, Zhao Q, Peng C et al. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J. Exp. Med. 206(6), 1327-1337 (2009).
    • (2009) J. Exp. Med. , vol.206 , Issue.6 , pp. 1327-1337
    • Kuang, D.M.1    Zhao, Q.2    Peng, C.3
  • 58
    • 62549109923 scopus 로고    scopus 로고
    • High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors
    • Ojalvo LS, King W, Cox D, Pollard JW. High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors. Am. J. Pathol. 174(3), 1048-1064 (2009).
    • (2009) Am. J. Pathol. , vol.174 , Issue.3 , pp. 1048-1064
    • Ojalvo, L.S.1    King, W.2    Cox, D.3    Pollard, J.W.4
  • 59
    • 84899753178 scopus 로고    scopus 로고
    • PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T-cell activation
    • Noman MZ, Desantis G, Janji B et al. PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T-cell activation. J. Exp. Med. 211(5), 781-790 (2014).
    • (2014) J. Exp. Med. , vol.211 , Issue.5 , pp. 781-790
    • Noman, M.Z.1    Desantis, G.2    Janji, B.3
  • 60
    • 84873534154 scopus 로고    scopus 로고
    • The role of B7 family molecules in hematologic malignancy
    • Greaves P, Gribben JG. The role of B7 family molecules in hematologic malignancy. Blood 121(5), 734-744 (2013).
    • (2013) Blood , vol.121 , Issue.5 , pp. 734-744
    • Greaves, P.1    Gribben, J.G.2
  • 61
    • 0034650833 scopus 로고    scopus 로고
    • Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages
    • Sica A, Saccani A, Bottazzi B et al. Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages. J. Immunol. 164(2), 762-767 (2000).
    • (2000) J. Immunol. , vol.164 , Issue.2 , pp. 762-767
    • Sica, A.1    Saccani, A.2    Bottazzi, B.3
  • 62
    • 85008426058 scopus 로고    scopus 로고
    • M2-polarized and tumor-associated macrophages alter NK cell phenotype and function in a contact-dependent manner
    • Epub ahead of print
    • Krneta T, Gillgrass A, Poznanski S et al. M2-polarized and tumor-associated macrophages alter NK cell phenotype and function in a contact-dependent manner. J. Leukoc. Biol. doi:10. 1189/jlb. 3A1215-552R (2016) (Epub ahead of print).
    • (2016) J. Leukoc. Biol.
    • Krneta, T.1    Gillgrass, A.2    Poznanski, S.3
  • 63
    • 84861801527 scopus 로고    scopus 로고
    • IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity
    • Liu D, Song L, Wei J et al. IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity. J. Clin. Invest. 122(6), 2221-2233 (2012).
    • (2012) J. Clin. Invest. , vol.122 , Issue.6 , pp. 2221-2233
    • Liu, D.1    Song, L.2    Wei, J.3
  • 64
    • 84883681998 scopus 로고    scopus 로고
    • Natural and induced T regulatory cells in cancer
    • Adeegbe DO, Nishikawa H. Natural and induced T regulatory cells in cancer. Front. Immunol. 4, 190 (2013).
    • (2013) Front. Immunol. , vol.4 , pp. 190
    • Adeegbe, D.O.1    Nishikawa, H.2
  • 65
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 10(9), 942-949 (2004).
    • (2004) Nat. Med. , vol.10 , Issue.9 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3
  • 66
    • 79955774902 scopus 로고    scopus 로고
    • Tumor-associated macrophages recruit ccr6+ regulatory t cells and promote the development of colorectal cancer via enhancing ccl20 production in mice
    • Liu J, Zhang N, Li Q et al. Tumor-associated macrophages recruit ccr6+ regulatory t cells and promote the development of colorectal cancer via enhancing ccl20 production in mice. PLoS ONE 6(4), e19495 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.4 , pp. e19495
    • Liu, J.1    Zhang, N.2    Li, Q.3
  • 67
    • 34548764423 scopus 로고    scopus 로고
    • Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
    • Denning TL, Wang YC, Patel SR, Williams IR, Pulendran B. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nature Immunol. 8(10), 1086-1094 (2007).
    • (2007) Nature Immunol. , vol.8 , Issue.10 , pp. 1086-1094
    • Denning, T.L.1    Wang, Y.C.2    Patel, S.R.3    Williams, I.R.4    Pulendran, B.5
  • 68
    • 49649093608 scopus 로고    scopus 로고
    • Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1
    • Savage ND, De Boer T, Walburg KV et al. Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1. J. Immunol. 181(3), 2220-2226 (2008).
    • (2008) J. Immunol. , vol.181 , Issue.3 , pp. 2220-2226
    • Savage, N.D.1    De Boer, T.2    Walburg, K.V.3
  • 69
    • 80054017653 scopus 로고    scopus 로고
    • Tumor-associated macrophages mediate immunosuppression in the renal cancer microenvironment by activating the 15-lipoxygenase-2 pathway
    • Daurkin I, Eruslanov E, Stoffs T et al. Tumor-associated macrophages mediate immunosuppression in the renal cancer microenvironment by activating the 15-lipoxygenase-2 pathway. Cancer Res. 71(20), 6400-6409 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.20 , pp. 6400-6409
    • Daurkin, I.1    Eruslanov, E.2    Stoffs, T.3
  • 70
    • 67651111095 scopus 로고    scopus 로고
    • A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood 'resident' monocytes, and embryonic macrophages suggests common functions and developmental relationships
    • Pucci F, Venneri MA, Biziato D et al. A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood 'resident' monocytes, and embryonic macrophages suggests common functions and developmental relationships. Blood. 114(4), 901-914 (2009).
    • (2009) Blood. , vol.114 , Issue.4 , pp. 901-914
    • Pucci, F.1    Venneri, M.A.2    Biziato, D.3
  • 71
    • 84941622047 scopus 로고    scopus 로고
    • Tumor-induced myeloid deviation: When myeloid-derived suppressor cells meet tumor-associated macrophages
    • Ugel S, De Sanctis F, Mandruzzato S, Bronte V. Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages. J. Clin. Invest. 125(9), 3365-3376 (2015).
    • (2015) J. Clin. Invest. , vol.125 , Issue.9 , pp. 3365-3376
    • Ugel, S.1    De Sanctis, F.2    Mandruzzato, S.3    Bronte, V.4
  • 72
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • Corzo CA, Condamine T, Lu L et al. HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J. Exp. Med. 207(11), 2439-2453 (2010).
    • (2010) J. Exp. Med. , vol.207 , Issue.11 , pp. 2439-2453
    • Corzo, C.A.1    Condamine, T.2    Lu, L.3
  • 73
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature 496(7446), 445-455 (2013).
    • (2013) Nature , vol.496 , Issue.7446 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 74
    • 84857219446 scopus 로고    scopus 로고
    • Monocytic CCR2+ myeloid derived suppressor cells promote immune escape by limiting activated CD8 T cell infiltration into the tumor microenvironment
    • Lesokhin AM, Hohl TM, Kitano S et al. Monocytic CCR2+ myeloid derived suppressor cells promote immune escape by limiting activated CD8 T cell infiltration into the tumor microenvironment. Cancer Res. 72(4), 876-886 (2012).
    • (2012) Cancer Res. , vol.72 , Issue.4 , pp. 876-886
    • Lesokhin, A.M.1    Hohl, T.M.2    Kitano, S.3
  • 75
    • 84989941652 scopus 로고    scopus 로고
    • CCL2 produced by the glioma microenvironment is essential for the recruitment of regulatory T cells and myeloid-derived suppressor cells
    • Chang AL, Miska J, Wainwright DA et al. CCL2 produced by the glioma microenvironment is essential for the recruitment of regulatory T cells and myeloid-derived suppressor cells. Cancer Res. 76(19), 5671-5682 (2016).
    • (2016) Cancer Res. , vol.76 , Issue.19 , pp. 5671-5682
    • Chang, A.L.1    Miska, J.2    Wainwright, D.A.3
  • 76
    • 84879850236 scopus 로고    scopus 로고
    • Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: A role for targeting the CCL2/CCR2 axis
    • Sanford DE, Belt BA, Panni RZ et al. Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: A role for targeting the CCL2/CCR2 axis. Clin. Cancer Res. 19(13), 3404-3415 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , Issue.13 , pp. 3404-3415
    • Sanford, D.E.1    Belt, B.A.2    Panni, R.Z.3
  • 77
    • 70350381008 scopus 로고    scopus 로고
    • Chemokine (C-C Motif) ligand 2 engages CCR2(+) stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone
    • Lu X, Kang Y. Chemokine (C-C Motif) ligand 2 engages CCR2(+) stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J. Biol. Chem. 284(42), 29087-29096 (2009).
    • (2009) J. Biol. Chem. , vol.284 , Issue.42 , pp. 29087-29096
    • Lu, X.1    Kang, Y.2
  • 78
    • 84962367349 scopus 로고    scopus 로고
    • Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resec and locally advanced pancreatic cancer: A single-centre, open-label, dose-finding, non-randomised, Phase 1b trial
    • Nywening TM, Wang-Gillam A, Sanford DE et al. Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resec and locally advanced pancreatic cancer: A single-centre, open-label, dose-finding, non-randomised, Phase 1b trial. Lancet Oncol. 17(5), 651-662 (2016).
    • (2016) Lancet Oncol. , vol.17 , Issue.5 , pp. 651-662
    • Nywening, T.M.1    Wang-Gillam, A.2    Sanford, D.E.3
  • 79
    • 84939873437 scopus 로고    scopus 로고
    • Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: An open-label, multicenter Phase 1b study
    • Brana I, Calles A, Lorusso PM et al. Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: An open-label, multicenter Phase 1b study. Targeted Oncol. 10(1), 111-123 (2015).
    • (2015) Targeted Oncol. , vol.10 , Issue.1 , pp. 111-123
    • Brana, I.1    Calles, A.2    Lorusso, P.M.3
  • 80
    • 84878849941 scopus 로고    scopus 로고
    • A first-in-human, first-in-class, phase i study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors
    • Sandhu SK, Papadopoulos K, Fong PC et al. A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors. Cancer Chemother. Pharmacol. 71(4), 1041-1050 (2013).
    • (2013) Cancer Chemother. Pharmacol. , vol.71 , Issue.4 , pp. 1041-1050
    • Sandhu, S.K.1    Papadopoulos, K.2    Fong, P.C.3
  • 81
    • 84866784798 scopus 로고    scopus 로고
    • Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy
    • DeNardo DG, Brennan DJ, Rexhepaj E et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 1(1), 54-67 (2011).
    • (2011) Cancer Discov. , vol.1 , Issue.1 , pp. 54-67
    • DeNardo, D.G.1    Brennan, D.J.2    Rexhepaj, E.3
  • 82
    • 84887481716 scopus 로고    scopus 로고
    • CSF-1R inhibition alters macrophage polarization and blocks glioma progression
    • Pyonteck SM, Akkari L, Schuhmacher AJ et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat. Med. 19(10), 1264-1272 (2013).
    • (2013) Nat. Med. , vol.19 , Issue.10 , pp. 1264-1272
    • Pyonteck, S.M.1    Akkari, L.2    Schuhmacher, A.J.3
  • 83
    • 84894520967 scopus 로고    scopus 로고
    • CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells
    • Strachan DC, Ruffell B, Oei Y et al. CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells. Oncoimmunology 2(12), e26968 (2013).
    • (2013) Oncoimmunology , vol.2 , Issue.12 , pp. e26968
    • Strachan, D.C.1    Ruffell, B.2    Oei, Y.3
  • 84
    • 84875862910 scopus 로고    scopus 로고
    • Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor
    • Zhang C, Ibrahim PN, Zhang J et al. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. PNAS 110(14), 5689-5694 (2013).
    • (2013) PNAS , vol.110 , Issue.14 , pp. 5689-5694
    • Zhang, C.1    Ibrahim, P.N.2    Zhang, J.3
  • 85
    • 84892738557 scopus 로고    scopus 로고
    • Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy
    • Mok S, Koya RC, Tsui C et al. Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy. Cancer Res. 74(1), 153-161 (2014).
    • (2014) Cancer Res. , vol.74 , Issue.1 , pp. 153-161
    • Mok, S.1    Koya, R.C.2    Tsui, C.3
  • 86
    • 84975154682 scopus 로고    scopus 로고
    • Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization
    • Stafford JH, Hirai T, Deng L et al. Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization. Neuro-oncology 18(6), 797-806 (2016).
    • (2016) Neuro-oncology , vol.18 , Issue.6 , pp. 797-806
    • Stafford, J.H.1    Hirai, T.2    Deng, L.3
  • 87
    • 84938369565 scopus 로고    scopus 로고
    • Structure-guided blockade of csf1r kinase in tenosynovial giant-cell tumor
    • Tap WD, Wainberg ZA, Anthony SP et al. Structure-guided blockade of csf1r kinase in tenosynovial giant-cell tumor. N. Engl. J. Med. 373(5), 428-437 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , Issue.5 , pp. 428-437
    • Tap, W.D.1    Wainberg, Z.A.2    Anthony, S.P.3
  • 88
    • 84902546715 scopus 로고    scopus 로고
    • Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy
    • Ries CH, Cannarile MA, Hoves S et al. Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell 25(6), 846-859 (2014).
    • (2014) Cancer Cell , vol.25 , Issue.6 , pp. 846-859
    • Ries, C.H.1    Cannarile, M.A.2    Hoves, S.3
  • 89
    • 77950231708 scopus 로고    scopus 로고
    • Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells
    • Germano G, Frapolli R, Simone M et al. Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res. 70(6), 2235-2244 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.6 , pp. 2235-2244
    • Germano, G.1    Frapolli, R.2    Simone, M.3
  • 90
    • 84873597334 scopus 로고    scopus 로고
    • Role of macrophage targeting in the antitumor activity of trabectedin
    • Germano G, Frapolli R, Belgiovine C et al. Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell 23(2), 249-262 (2013).
    • (2013) Cancer Cell , vol.23 , Issue.2 , pp. 249-262
    • Germano, G.1    Frapolli, R.2    Belgiovine, C.3
  • 91
    • 84961127695 scopus 로고    scopus 로고
    • Efficacy and safety of trabectedin or dacarbazine for metastatic liposarcoma or leiomyosarcoma after failure of conventional chemotherapy: Results of a Phase III randomized multicenter clinical trial
    • Demetri GD, Von Mehren M, Jones RL et al. Efficacy and safety of trabectedin or dacarbazine for metastatic liposarcoma or leiomyosarcoma after failure of conventional chemotherapy: results of a Phase III randomized multicenter clinical trial. J. Clin. Oncol. 34(8), 786-793 (2016).
    • (2016) J. Clin. Oncol. , vol.34 , Issue.8 , pp. 786-793
    • Demetri, G.D.1    Von Mehren, M.2    Jones, R.L.3
  • 92
    • 77955491837 scopus 로고    scopus 로고
    • Trabectedin plus pegylated liposomal doxorubicin in recurrent ovarian cancer
    • Monk BJ, Herzog TJ, Kaye SB et al. Trabectedin plus pegylated liposomal doxorubicin in recurrent ovarian cancer. J. Clin. Oncol. 28(19), 3107-3114 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.19 , pp. 3107-3114
    • Monk, B.J.1    Herzog, T.J.2    Kaye, S.B.3
  • 93
    • 84919457872 scopus 로고    scopus 로고
    • Molecular mechanisms that influence the macrophage m1-m2 polarization balance
    • Wang N, Liang H, Zen K. Molecular mechanisms that influence the macrophage m1-m2 polarization balance. Front. Immunol. 5, 614 (2014).
    • (2014) Front. Immunol. , vol.5 , pp. 614
    • Wang, N.1    Liang, H.2    Zen, K.3
  • 94
    • 84871230007 scopus 로고    scopus 로고
    • Synergy of topical toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer
    • Dewan MZ, Vanpouille-Box C, Kawashima N et al. Synergy of topical toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer. Clin. Cancer Res. 18(24), 6668-6678 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , Issue.24 , pp. 6668-6678
    • Dewan, M.Z.1    Vanpouille-Box, C.2    Kawashima, N.3
  • 95
    • 84908147322 scopus 로고    scopus 로고
    • Effective innate and adaptive antimelanoma immunity through localized TLR7/8 activation
    • Singh M, Khong H, Dai Z et al. Effective innate and adaptive antimelanoma immunity through localized TLR7/8 activation. J. Immunol. 193(9), 4722-4731 (2014).
    • (2014) J. Immunol. , vol.193 , Issue.9 , pp. 4722-4731
    • Singh, M.1    Khong, H.2    Dai, Z.3
  • 96
    • 84973646350 scopus 로고    scopus 로고
    • Tumor-associated macrophage-mediated targeted therapy of triple-negative breast cancer
    • Niu M, Valdes S, Naguib YW, Hursting SD, Cui Z. Tumor-associated macrophage-mediated targeted therapy of triple-negative breast cancer. Mol. Pharm. 13(6), 1833-1842 (2016).
    • (2016) Mol. Pharm. , vol.13 , Issue.6 , pp. 1833-1842
    • Niu, M.1    Valdes, S.2    Naguib, Y.W.3    Hursting, S.D.4    Cui, Z.5
  • 97
    • 33746718151 scopus 로고    scopus 로고
    • Targeting tumor-associated macrophages as a novel strategy against breast cancer
    • Luo Y, Zhou H, Krueger J et al. Targeting tumor-associated macrophages as a novel strategy against breast cancer. J. Clin. Invest. 116(8), 2132-2141 (2006).
    • (2006) J. Clin. Invest. , vol.116 , Issue.8 , pp. 2132-2141
    • Luo, Y.1    Zhou, H.2    Krueger, J.3
  • 98
    • 84921753458 scopus 로고    scopus 로고
    • Depletion of tumor-associated macrophages enhances the anti-tumor immunity induced by a Toll-like receptor agonist-conjugated peptide
    • Shen K-Y, Song Y-C, Chen IH, Chong P, Liu S-J. Depletion of tumor-associated macrophages enhances the anti-tumor immunity induced by a Toll-like receptor agonist-conjugated peptide. Hum. Vaccin. Immunother. 10(11), 3241-3250 (2014).
    • (2014) Hum. Vaccin. Immunother. , vol.10 , Issue.11 , pp. 3241-3250
    • Shen, K.-Y.1    Song, Y.-C.2    Chen, I.H.3    Chong, P.4    Liu, S.-J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.