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Volumn 18, Issue 24, 2012, Pages 6668-6678

Synergy of topical toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYCLOPHOSPHAMIDE; GLYCOPROTEIN P 15095; IMIQUIMOD; PLACEBO; TOLL LIKE RECEPTOR 7;

EID: 84871230007     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-0984     Document Type: Article
Times cited : (132)

References (40)
  • 1
    • 0027296991 scopus 로고
    • Cutaneous metastases in patients with metastatic carcinoma: A retrospective study of 4020 patients
    • Lookingbill DP, Spangler N, Helm KF. Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol 1993;29:228-36. (Pubitemid 23221903)
    • (1993) Journal of the American Academy of Dermatology , vol.29 , Issue.2 I , pp. 228-236
    • Lookingbill, D.P.1    Spangler, N.2    Helm, K.F.3
  • 2
    • 0037330518 scopus 로고    scopus 로고
    • Cutaneous metastasis: A metaanalysis of data
    • Krathen RA, Orengo IF, Rosen T. Cutaneous metastasis: a metaanalysis of data. South Med J 2003;96:164-7.
    • (2003) South Med J , vol.96 , pp. 164-167
    • Krathen, R.A.1    Orengo, I.F.2    Rosen, T.3
  • 3
    • 41149132993 scopus 로고    scopus 로고
    • Twelve immunotherapy drugs that could cure cancers
    • DOI 10.1111/j.1600-065X.2008.00604.x
    • Cheever MA. Twelve immunotherapy drugs that could cure cancers. Immunol Rev 2008;222:357-68. (Pubitemid 351430366)
    • (2008) Immunological Reviews , vol.222 , Issue.1 , pp. 357-368
    • Mac, C.M.A.1
  • 4
    • 77953469710 scopus 로고    scopus 로고
    • Toll-like receptor agonists in cancer therapy
    • Adams S. Toll-like receptor agonists in cancer therapy. Immunotherapy 2009;1:949-64.
    • (2009) Immunotherapy , vol.1 , pp. 949-964
    • Adams, S.1
  • 5
    • 2342473348 scopus 로고    scopus 로고
    • Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: Results from two phase III, randomized, vehicle-controlled studies
    • DOI 10.1016/j.jaad.2003.11.066
    • Geisse J, Caro I, Lindholm J, Golitz L, Stampone P, Owens M. Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies. J Am Acad Dermatol 2004;50:722-33. (Pubitemid 38580549)
    • (2004) Journal of the American Academy of Dermatology , vol.50 , Issue.5 , pp. 722-733
    • Geisse, J.1    Caro, I.2    Lindholm, J.3    Golitz, L.4    Stampone, P.5    Owens, M.6
  • 6
    • 33847646901 scopus 로고    scopus 로고
    • Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection
    • Panelli MC, Stashower ME, Slade HB, Smith K, Norwood C, Abati A, et al. Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection. Genome Biol 2007;8:R8.
    • (2007) Genome Biol , vol.8
    • Panelli, M.C.1    Stashower, M.E.2    Slade, H.B.3    Smith, K.4    Norwood, C.5    Abati, A.6
  • 7
    • 77957982756 scopus 로고    scopus 로고
    • Toll-like receptor agonists: Are they good adjuvants?
    • Gnjatic S, Sawhney NB, Bhardwaj N. Toll-like receptor agonists: are they good adjuvants? Cancer J 2010;16:382-91.
    • (2010) Cancer J , vol.16 , pp. 382-391
    • Gnjatic, S.1    Sawhney, N.B.2    Bhardwaj, N.3
  • 8
    • 47949129948 scopus 로고    scopus 로고
    • Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant
    • Adams S, O'Neill DW, Nonaka D, Hardin E, Chiriboga L, Siu K, et al. Immunization of malignant melanoma patients with full-length NY-ESO-1 protein using TLR7 agonist imiquimod as vaccine adjuvant. J Immunol 2008;181:776-84.
    • (2008) J Immunol , vol.181 , pp. 776-784
    • Adams, S.1    O'Neill, D.W.2    Nonaka, D.3    Hardin, E.4    Chiriboga, L.5    Siu, K.6
  • 9
    • 37848999304 scopus 로고    scopus 로고
    • TLR7 and TLR8 as targets in cancer therapy
    • Schon MP, Schon M. TLR7 and TLR8 as targets in cancer therapy. Oncogene 2008;27:190-9.
    • (2008) Oncogene , vol.27 , pp. 190-199
    • Schon, M.P.1    Schon, M.2
  • 10
    • 0041920772 scopus 로고    scopus 로고
    • Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod
    • Schön M,BongAB, Drewniok C,Herz J,GeilenCC, Reifenberger J, et al. Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod. J Natl Cancer Inst 2003;95:1138-49.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1138-1149
    • Schön, M.1    Bong, A.B.2    Drewniok, C.3    Herz, J.4    Geilen, C.C.5    Reifenberger, J.6
  • 12
    • 84861823282 scopus 로고    scopus 로고
    • Melanoma in situ treated successfully using imiquimod after nonclearance with surgery: Review of the literature
    • Ellis LZ, Cohen JL, High W, Stewart L. Melanoma in situ treated successfully using imiquimod after nonclearance with surgery: review of the literature. Dermatol Surg 2012;38:937-46.
    • (2012) Dermatol Surg , vol.38 , pp. 937-946
    • Ellis, L.Z.1    Cohen, J.L.2    High, W.3    Stewart, L.4
  • 16
    • 78049420571 scopus 로고    scopus 로고
    • In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: A phase I/II study
    • Brody JD, Ai WZ, Czerwinski DK, Torchia JA, Levy M, Advani RH, et al. In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study. J Clin Oncol 2010;28:4324-32.
    • (2010) J Clin Oncol , vol.28 , pp. 4324-4332
    • Brody, J.D.1    Ai, W.Z.2    Czerwinski, D.K.3    Torchia, J.A.4    Levy, M.5    Advani, R.H.6
  • 17
    • 0042024964 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides potentiate the antitumor effects of chemotherapy or tumor resection in an orthotopic murine model of rhabdomyosarcoma
    • Weigel BJ, Rodeberg DA, Krieg AM, Blazar BR. CpG oligodeoxynucleotides potentiate the antitumor effects of chemotherapy or tumor resection in an orthotopic murine model of rhabdomyosarcoma. Clin Cancer Res 2003;9:3105-14. (Pubitemid 36993273)
    • (2003) Clinical Cancer Research , vol.9 , Issue.8 , pp. 3105-3114
    • Weigel, B.J.1    Rodeberg, D.A.2    Krieg, A.M.3    Blazar, B.R.4
  • 18
    • 77955433721 scopus 로고    scopus 로고
    • Potentiation of the anti-tumor effects of imidazoquinoline immune response modifiers by cyclophosphamide
    • Dumitru CD, Antonysamy MA, Tomai MA, Lipson KE. Potentiation of the anti-tumor effects of imidazoquinoline immune response modifiers by cyclophosphamide. Cancer Biol Ther 2010;10:155-65.
    • (2010) Cancer Biol Ther , vol.10 , pp. 155-165
    • Dumitru, C.D.1    Antonysamy, M.A.2    Tomai, M.A.3    Lipson, K.E.4
  • 19
    • 0035328683 scopus 로고    scopus 로고
    • Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice
    • Machiels JP, Reilly RT, Emens LA, Ercolini AM, Lei RY, Weintraub D, et al. Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice. Cancer Res 2001;61:3689-97. (Pubitemid 32694981)
    • (2001) Cancer Research , vol.61 , Issue.9 , pp. 3689-3697
    • Machiels, J.-P.H.1    Todd, R.R.2    Emens, L.A.3    Ercolini, A.M.4    Lei, R.Y.5    Weintraub, D.6    Okoye, F.I.7    Jaffee, E.M.8
  • 20
    • 66249095192 scopus 로고    scopus 로고
    • Cyclophosphamide augments antitumor immunity: Studies in an autochthonous prostate cancer model
    • Wada S, Yoshimura K, Hipkiss EL, Harris TJ, Yen HR, Goldberg MV, et al. Cyclophosphamide augments antitumor immunity: studies in an autochthonous prostate cancer model. Cancer Res 2009;69:4309-18.
    • (2009) Cancer Res , vol.69 , pp. 4309-4318
    • Wada, S.1    Yoshimura, K.2    Hipkiss, E.L.3    Harris, T.J.4    Yen, H.R.5    Goldberg, M.V.6
  • 22
    • 0037728812 scopus 로고    scopus 로고
    • The cytotoxic T-lymphocyte response against a poorly immunogenic mammary adenocarcinoma is focused on a single immunodominant class I epitope derived from the gp70 Env product of an endogenous retrovirus
    • Rosato A, Santa SD, Zoso A, Giacomelli S, Milan G, Macino B, et al. The cytotoxic T-lymphocyte response against a poorly immunogenic mammary adenocarcinoma is focused on a single immunodominant class I epitope derived from the gp70 Env product of an endogenous retrovirus. Cancer Res 2003;63:2158-63. (Pubitemid 36538621)
    • (2003) Cancer Research , vol.63 , Issue.9 , pp. 2158-2163
    • Rosato, A.1    Dalla, S.S.2    Zoso, A.3    Giacomelli, S.4    Milan, G.5    Macino, B.6    Tosello, V.7    Dellabona, P.8    Lollini, P.-L.9    De Giovanni, C.10    Zanovello, P.11
  • 23
    • 37048998555 scopus 로고    scopus 로고
    • Matrix protein mediated shutdown of host cell metabolism limits vesicular stomatitis virus-induced interferon-alpha responses to plasmacytoid dendritic cells
    • DOI 10.1016/j.imbio.2007.09.003, PII S0171298507001040, Macrophage and Dendritic Cells
    • Waibler Z, Detje CN, Bell JC, Kalinke U. Matrix protein mediated shutdown of host cell metabolism limits vesicular stomatitis virus-induced interferon-alpha responses to plasmacytoid dendritic cells. Immunobiology 2007;212:887-94. (Pubitemid 350246253)
    • (2008) Immunobiology , vol.212 , Issue.9-10 , pp. 887-894
    • Waibler, Z.1    Detje, C.N.2    Bell, J.C.3    Kalinke, U.4
  • 24
    • 69949085196 scopus 로고    scopus 로고
    • Fractionated but not single dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
    • Dewan MZ, Galloway AE, Kawashima N, Dewyngaert JK, Babb JS, Formenti SC, et al. Fractionated but not single dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res 2009;15:5379-88.
    • (2009) Clin Cancer Res , vol.15 , pp. 5379-5388
    • Dewan, M.Z.1    Galloway, A.E.2    Kawashima, N.3    Dewyngaert, J.K.4    Babb, J.S.5    Formenti, S.C.6
  • 25
    • 12244252335 scopus 로고    scopus 로고
    • Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
    • Demaria S, Kawashima N, Yang AM, Devitt M-L, Babb JS, Allison JP, et al. Immune-mediated inhibition of metastases following treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res 2005;11:728-34. (Pubitemid 40116901)
    • (2005) Clinical Cancer Research , vol.11 , Issue.2 I , pp. 728-734
    • Demaria, S.1    Kawashima, N.2    Yang, A.M.3    Devitt, M.L.4    Babb, J.S.5    Allison, J.P.6    Formenti, S.C.7
  • 26
    • 51549088023 scopus 로고    scopus 로고
    • Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells
    • Matsumura S, Wang B, Kawashima N, Braunstein S, Badura M, Cameron TO, et al. Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol 2008;181:3099-107.
    • (2008) J Immunol , vol.181 , pp. 3099-3107
    • Matsumura, S.1    Wang, B.2    Kawashima, N.3    Braunstein, S.4    Badura, M.5    Cameron, T.O.6
  • 27
    • 45849130522 scopus 로고    scopus 로고
    • Toll-like receptors expressed in tumor cells: Targets for therapy
    • Yu L, Chen S. Toll-like receptors expressed in tumor cells: targets for therapy. Cancer Immunol Immunother 2008;57:1271-8.
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 1271-1278
    • Yu, L.1    Chen, S.2
  • 28
    • 34247239745 scopus 로고    scopus 로고
    • Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines
    • DOI 10.1016/j.molimm.2007.02.007, PII S0161589007000727
    • Uehara A, Fujimoto Y, Fukase K, Takada H. Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines. Mol Immunol 2007;44:3100-11. (Pubitemid 46610510)
    • (2007) Molecular Immunology , vol.44 , Issue.12 , pp. 3100-3111
    • Uehara, A.1    Fujimoto, Y.2    Fukase, K.3    Takada, H.4
  • 29
    • 84856521363 scopus 로고    scopus 로고
    • Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells
    • Drobits B, Holcmann M, Amberg N, Swiecki M, Grundtner R, Hammer M, et al. Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. J Clin Invest 2012;122:575-85.
    • (2012) J Clin Invest , vol.122 , pp. 575-585
    • Drobits, B.1    Holcmann, M.2    Amberg, N.3    Swiecki, M.4    Grundtner, R.5    Hammer, M.6
  • 30
    • 77954514970 scopus 로고    scopus 로고
    • Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade
    • Lu H, Wagner WM, Gad E, Yang Y, Duan H, Amon LM, et al. Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade. J Immunol 2010;184:5360-7.
    • (2010) J Immunol , vol.184 , pp. 5360-5367
    • Lu, H.1    Wagner, W.M.2    Gad, E.3    Yang, Y.4    Duan, H.5    Amon, L.M.6
  • 32
    • 15944410592 scopus 로고    scopus 로고
    • + T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
    • DOI 10.1182/blood-2004-06-2410
    • Lutsiak MEC, Semnani RT, De Pascalis R, Kashmiri SVS, Schlom J, Sabzevari H. Inhibition of CD4(+)25 +T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 2005;105:2862-8. (Pubitemid 40446280)
    • (2005) Blood , vol.105 , Issue.7 , pp. 2862-2868
    • Lutsiak, M.E.C.1    Semnani, R.T.2    De Pascalis, R.3    Kashmiri, S.V.S.4    Schlom, J.5    Sabzevari, H.6
  • 33
    • 77953730756 scopus 로고    scopus 로고
    • Selective depletion of CD4+CD25+Foxp3 +regulatory T cells by low-dose cyclophosphamide is explained by reduced intracellular ATP levels
    • Zhao J, Cao Y, Lei Z, Yang Z, Zhang B, Huang B. Selective depletion of CD4+CD25+Foxp3 +regulatory T cells by low-dose cyclophosphamide is explained by reduced intracellular ATP levels. Cancer Res 2010;70:4850-8.
    • (2010) Cancer Res , vol.70 , pp. 4850-4858
    • Zhao, J.1    Cao, Y.2    Lei, Z.3    Yang, Z.4    Zhang, B.5    Huang, B.6
  • 35
    • 67649359533 scopus 로고    scopus 로고
    • Systemic effects of local radiotherapy
    • Formenti SC, Demaria S. Systemic effects of local radiotherapy. Lancet Oncol 2009;10:718-26.
    • (2009) Lancet Oncol , vol.10 , pp. 718-726
    • Formenti, S.C.1    Demaria, S.2
  • 36
    • 79551523389 scopus 로고    scopus 로고
    • Cyclophosphamide synergizes with type i interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis
    • Schiavoni G, Sistigu A, Valentini M, Mattei F, Sestili P, Spadaro F, et al. Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis. Cancer Res 2011;71:768-78.
    • (2011) Cancer Res , vol.71 , pp. 768-778
    • Schiavoni, G.1    Sistigu, A.2    Valentini, M.3    Mattei, F.4    Sestili, P.5    Spadaro, F.6
  • 39
    • 70350068545 scopus 로고    scopus 로고
    • Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin
    • Huang SJ, Hijnen D, Murphy GF, Kupper TS, Calarese AW, Mollet IG, et al. Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J Invest Dermatol 2009;129:2676-85.
    • (2009) J Invest Dermatol , vol.129 , pp. 2676-2685
    • Huang, S.J.1    Hijnen, D.2    Murphy, G.F.3    Kupper, T.S.4    Calarese, A.W.5    Mollet, I.G.6
  • 40
    • 84871217036 scopus 로고    scopus 로고
    • Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer
    • Adams S, Kozhaya L, Martiniuk F, Meng TC, Chiriboga L, Liebes L, et al. Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer. Clin Cancer Res 2012;18:6748-57.
    • (2012) Clin Cancer Res , vol.18 , pp. 6748-6757
    • Adams, S.1    Kozhaya, L.2    Martiniuk, F.3    Meng, T.C.4    Chiriboga, L.5    Liebes, L.6


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