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Volumn 5, Issue OCT, 2014, Pages

Functional relationship between tumor-associated macrophages and macrophage colony-stimulating factor as contributors to cancer progression

Author keywords

Cancer progression; CSF 1; CSF 1R; M CSF; M CSFR; M1; M2; Tumor associated macrophages

Indexed keywords

ARGINASE; COLONY STIMULATING FACTOR 1; ENDOCRINE GLAND DERIVED VASCULAR ENDOTHELIAL GROWTH FACTOR; GAMMA INTERFERON; GELATINASE B; GEMCITABINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMATINIB; MANNOSE RECEPTOR; PACLITAXEL; PROTEIN TYROSINE KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; SCAVENGER RECEPTOR A; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

EID: 84918831817     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00489     Document Type: Review
Times cited : (164)

References (135)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell (2000) 100(1):57-70. doi: 10.1016/S0092-8674(00)81683-9
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell (2011) 144(5):646-74. doi:10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill F, Charles KA, Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell (2005) 7(3):211-7. doi:10.1016/j.ccr.2005.02.013
    • (2005) Cancer Cell , vol.7 , Issue.3 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 4
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
    • Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis (2009) 30(7):1073-81. doi:10.1093/carcin/bgp127
    • (2009) Carcinogenesis , vol.30 , Issue.7 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3    Garlanda, C.4    Mantovani, A.5
  • 5
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature (2008) 454(7203):436-44. doi:10.1038/nature07205
    • (2008) Nature , vol.454 , Issue.7203 , pp. 436-444
    • Mantovani, A.1    Allavena, P.2    Sica, A.3    Balkwill, F.4
  • 7
    • 80053224897 scopus 로고    scopus 로고
    • Mononuclear phagocyte heterogeneity in cancer: different subsets and activation states reaching out at the tumor site
    • Laoui D, Van Overmeire E, Movahedi K, Van den Bossche J, Schouppe E, Mommer C, et al. Mononuclear phagocyte heterogeneity in cancer: different subsets and activation states reaching out at the tumor site. Immunobiology (2011) 216(11):1192-202. doi:10.1016/j.imbio.2011.06.007
    • (2011) Immunobiology , vol.216 , Issue.11 , pp. 1192-1202
    • Laoui, D.1    Van Overmeire, E.2    Movahedi, K.3    Van den Bossche, J.4    Schouppe, E.5    Mommer, C.6
  • 8
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies
    • Bingle L, Brown NJ, Lewis CE. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J Pathol (2002) 196(3):254-65. doi:10.1002/path.1027
    • (2002) J Pathol , vol.196 , Issue.3 , pp. 254-265
    • Bingle, L.1    Brown, N.J.2    Lewis, C.E.3
  • 9
    • 84871694284 scopus 로고    scopus 로고
    • Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature
    • Zhang QW, Liu L, Gong CY, Shi HS, Zeng YH, Wang XZ, et al. Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature. PLoS One (2012) 7(12):e50946. doi:10.1371/journal.pone.0050946
    • (2012) PLoS One , vol.7 , Issue.12
    • Zhang, Q.W.1    Liu, L.2    Gong, C.Y.3    Shi, H.S.4    Zeng, Y.H.5    Wang, X.Z.6
  • 10
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvironments. Cancer Res (2006) 66(2):605-12. doi:10.1158/0008-5472.CAN-05-4005
    • (2006) Cancer Res , vol.66 , Issue.2 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 11
    • 67650646082 scopus 로고    scopus 로고
    • CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
    • Jaiswal S, Jamieson CH, Pang WW, Park CY, Chao MP, Majeti R, et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell (2009) 138(2):271-85. doi:10.1016/j.cell.2009.05.046
    • (2009) Cell , vol.138 , Issue.2 , pp. 271-285
    • Jaiswal, S.1    Jamieson, C.H.2    Pang, W.W.3    Park, C.Y.4    Chao, M.P.5    Majeti, R.6
  • 12
    • 78650664067 scopus 로고    scopus 로고
    • Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47
    • Chao MP, Jaiswal S, Weissman-Tsukamoto R, Alizadeh AA, Gentles AJ, Volkmer J, et al. Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. Sci Transl Med (2010) 2(63):63ra94. doi:10.1126/scitranslmed.3001375
    • (2010) Sci Transl Med , vol.2 , Issue.63 , pp. 63-94
    • Chao, M.P.1    Jaiswal, S.2    Weissman-Tsukamoto, R.3    Alizadeh, A.A.4    Gentles, A.J.5    Volkmer, J.6
  • 13
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty GL, Chiorean EG, Fishman MP, Saboury B, Teitelbaum UR, Sun W, et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science (2011) 331(6024):1612-6. doi:10.1126/science.1198443
    • (2011) Science , vol.331 , Issue.6024 , pp. 1612-1616
    • Beatty, G.L.1    Chiorean, E.G.2    Fishman, M.P.3    Saboury, B.4    Teitelbaum, U.R.5    Sun, W.6
  • 14
    • 67449138564 scopus 로고    scopus 로고
    • Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia
    • Wu QL, Buhtoiarov IN, Sondel PM, Rakhmilevich AL, Ranheim EA. Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia. J Immunol (2009) 182(11):6771-8. doi:10.4049/jimmunol.0801847
    • (2009) J Immunol , vol.182 , Issue.11 , pp. 6771-6778
    • Wu, Q.L.1    Buhtoiarov, I.N.2    Sondel, P.M.3    Rakhmilevich, A.L.4    Ranheim, E.A.5
  • 15
    • 78650648668 scopus 로고    scopus 로고
    • CTL induction of tumoricidal nitric oxide production by intratumoral macrophages is critical for tumor elimination
    • Vicetti Miguel RD, Cherpes TL, Watson LJ, McKenna KC. CTL induction of tumoricidal nitric oxide production by intratumoral macrophages is critical for tumor elimination. J Immunol (2010) 185(11):6706-18. doi:10.4049/jimmunol.0903411
    • (2010) J Immunol , vol.185 , Issue.11 , pp. 6706-6718
    • Vicetti Miguel, R.D.1    Cherpes, T.L.2    Watson, L.J.3    McKenna, K.C.4
  • 16
    • 17144398046 scopus 로고    scopus 로고
    • Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection
    • Guiducci C, Vicari AP, Sangaletti S, Trinchieri G, Colombo MP. Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection. Cancer Res (2005) 65(8):3437-46.
    • (2005) Cancer Res , vol.65 , Issue.8 , pp. 3437-3446
    • Guiducci, C.1    Vicari, A.P.2    Sangaletti, S.3    Trinchieri, G.4    Colombo, M.P.5
  • 17
    • 15244338630 scopus 로고    scopus 로고
    • Primary antitumor immune response mediated by CD4+ T cells
    • Corthay A, Skovseth DK, Lundin KU, Rosjo E, Omholt H, Hofgaard PO, et al. Primary antitumor immune response mediated by CD4+ T cells. Immunity (2005) 22(3):371-83. doi:10.1016/j.immuni.2005.02.003
    • (2005) Immunity , vol.22 , Issue.3 , pp. 371-383
    • Corthay, A.1    Skovseth, D.K.2    Lundin, K.U.3    Rosjo, E.4    Omholt, H.5    Hofgaard, P.O.6
  • 18
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell (2010) 141(1):39-51. doi:10.1016/j.cell.2010.03.014
    • (2010) Cell , vol.141 , Issue.1 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 19
    • 84857692141 scopus 로고    scopus 로고
    • Differential macrophage programming in the tumor microenvironment
    • Ruffell B, Affara NI, Coussens LM. Differential macrophage programming in the tumor microenvironment. Trends Immunol (2012) 33(3):119-26. doi:10.1016/j.it.2011.12.001
    • (2012) Trends Immunol , vol.33 , Issue.3 , pp. 119-126
    • Ruffell, B.1    Affara, N.I.2    Coussens, L.M.3
  • 20
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell (2006) 124(2):263-6. doi:10.1016/j.cell.2006.01.007
    • (2006) Cell , vol.124 , Issue.2 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 21
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • Murdoch C, Muthana M, Coffelt SB, Lewis CE. The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer (2008) 8(8):618-31. doi:10.1038/nrc2444
    • (2008) Nat Rev Cancer , vol.8 , Issue.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 22
    • 63149088164 scopus 로고    scopus 로고
    • Trophic macrophages in development and disease
    • Pollard JW. Trophic macrophages in development and disease. Nat Rev Immunol (2009) 9(4):259-70. doi:10.1038/nri2528
    • (2009) Nat Rev Immunol , vol.9 , Issue.4 , pp. 259-270
    • Pollard, J.W.1
  • 23
    • 84876424760 scopus 로고    scopus 로고
    • Macrophage regulation of tumor responses to anticancer therapies
    • De Palma M, Lewis CE. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell (2013) 23(3):277-86. doi:10.1016/j.ccr.2013.02.013
    • (2013) Cancer Cell , vol.23 , Issue.3 , pp. 277-286
    • De Palma, M.1    Lewis, C.E.2
  • 24
    • 77955928161 scopus 로고    scopus 로고
    • Tumors as organs: complex tissues that interface with the entire organism
    • Egeblad M, Nakasone ES, Werb Z. Tumors as organs: complex tissues that interface with the entire organism. Dev Cell (2010) 18(6):884-901. doi:10.1016/j.devcel.2010.05.012
    • (2010) Dev Cell , vol.18 , Issue.6 , pp. 884-901
    • Egeblad, M.1    Nakasone, E.S.2    Werb, Z.3
  • 25
    • 77955038532 scopus 로고    scopus 로고
    • Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes
    • Movahedi K, Laoui D, Gysemans C, Baeten M, Stange G, Van den Bossche J, et al. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res (2010) 70(14):5728-39. doi:10.1158/0008-5472.CAN-09-4672
    • (2010) Cancer Res , vol.70 , Issue.14 , pp. 5728-5739
    • Movahedi, K.1    Laoui, D.2    Gysemans, C.3    Baeten, M.4    Stange, G.5    Van den Bossche, J.6
  • 26
    • 84865147481 scopus 로고    scopus 로고
    • Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages
    • Movahedi K, Schoonooghe S, Laoui D, Houbracken I, Waelput W, Breckpot K, et al. Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages. Cancer Res (2012) 72(16):4165-77. doi:10.1158/0008-5472.CAN-11-2994
    • (2012) Cancer Res , vol.72 , Issue.16 , pp. 4165-4177
    • Movahedi, K.1    Schoonooghe, S.2    Laoui, D.3    Houbracken, I.4    Waelput, W.5    Breckpot, K.6
  • 27
    • 84892747845 scopus 로고    scopus 로고
    • Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population
    • Laoui D, Van Overmeire E, Di Conza G, Aldeni C, Keirsse J, Morias Y, et al. Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population. Cancer Res (2014) 74(1):24-30. doi:10.1158/0008-5472.CAN-13-1196
    • (2014) Cancer Res , vol.74 , Issue.1 , pp. 24-30
    • Laoui, D.1    Van Overmeire, E.2    Di Conza, G.3    Aldeni, C.4    Keirsse, J.5    Morias, Y.6
  • 28
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
    • Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol (2010) 11(10):889-96. doi:10.1038/ni.1937
    • (2010) Nat Immunol , vol.11 , Issue.10 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 29
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature (2013) 496(7446):445-55. doi:10.1038/nature12034
    • (2013) Nature , vol.496 , Issue.7446 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 30
    • 33747345981 scopus 로고    scopus 로고
    • Classical and alternative activation of mononuclear phagocytes: picking the best of both worlds for tumor promotion
    • Van Ginderachter JA, Movahedi K, Hassanzadeh Ghassabeh G, Meerschaut S, Beschin A, Raes G, et al. Classical and alternative activation of mononuclear phagocytes: picking the best of both worlds for tumor promotion. Immunobiology (2006) 211(6-8):487-501. doi:10.1016/j.imbio.2006.06.002
    • (2006) Immunobiology , vol.211 , Issue.6-8 , pp. 487-501
    • Van Ginderachter, J.A.1    Movahedi, K.2    Hassanzadeh Ghassabeh, G.3    Meerschaut, S.4    Beschin, A.5    Raes, G.6
  • 31
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat Rev Immunol (2003) 3(1):23-35. doi:10.1038/nri978
    • (2003) Nat Rev Immunol , vol.3 , Issue.1 , pp. 23-35
    • Gordon, S.1
  • 32
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: mechanism and functions
    • Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity (2010) 32(5):593-604. doi:10.1016/j.immuni.2010.05.007
    • (2010) Immunity , vol.32 , Issue.5 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 33
    • 84873743410 scopus 로고    scopus 로고
    • M1 and M2 Macrophages: oracles of health and disease
    • Mills CD. M1 and M2 Macrophages: oracles of health and disease. Crit Rev Immunol (2012) 32(6):463-88. doi:10.1615/CritRevImmunol.v32.i6.10
    • (2012) Crit Rev Immunol , vol.32 , Issue.6 , pp. 463-488
    • Mills, C.D.1
  • 34
    • 0034659784 scopus 로고    scopus 로고
    • M-1/M-2 macrophages and the Th1/Th2 paradigm
    • Mills CD, Kincaid K, Alt JM, Heilman MJ, Hill AM. M-1/M-2 macrophages and the Th1/Th2 paradigm. J Immunol (2000) 164(12):6166-73. doi:10.4049/jimmunol.164.12.6166
    • (2000) J Immunol , vol.164 , Issue.12 , pp. 6166-6173
    • Mills, C.D.1    Kincaid, K.2    Alt, J.M.3    Heilman, M.J.4    Hill, A.M.5
  • 35
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol (2004) 25(12):677-86. doi:10.1016/j.it.2004.09.015
    • (2004) Trends Immunol , vol.25 , Issue.12 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 36
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: an immunologic functional perspective
    • Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol (2009) 27:451-83. doi:10.1146/annurev.immunol.021908.132532
    • (2009) Annu Rev Immunol , vol.27 , pp. 451-483
    • Martinez, F.O.1    Helming, L.2    Gordon, S.3
  • 37
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: in vivo veritas
    • Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest (2012) 122(3):787-95. doi:10.1172/JCI59643
    • (2012) J Clin Invest , vol.122 , Issue.3 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 38
    • 33745938947 scopus 로고    scopus 로고
    • Identification of a common gene signature for type II cytokine-associated myeloid cells elicited in vivo in different pathologic conditions
    • Hassanzadeh Ghassabeh G, De Baetselier P, Brys L, Noel W, Van Ginderachter JA, Meerschaut S, et al. Identification of a common gene signature for type II cytokine-associated myeloid cells elicited in vivo in different pathologic conditions. Blood (2006) 108(2):575-83. doi:10.1182/blood-2005-04-1485
    • (2006) Blood , vol.108 , Issue.2 , pp. 575-583
    • Hassanzadeh Ghassabeh, G.1    De Baetselier, P.2    Brys, L.3    Noel, W.4    Van Ginderachter, J.A.5    Meerschaut, S.6
  • 39
    • 77949571347 scopus 로고    scopus 로고
    • Expression of the inhibitory CD200 receptor is associated with alternative macrophage activation
    • Koning N, van Eijk M, Pouwels W, Brouwer MS, Voehringer D, Huitinga I, et al. Expression of the inhibitory CD200 receptor is associated with alternative macrophage activation. J Innate Immun (2010) 2(2):195-200. doi:10.1159/000252803
    • (2010) J Innate Immun , vol.2 , Issue.2 , pp. 195-200
    • Koning, N.1    van Eijk, M.2    Pouwels, W.3    Brouwer, M.S.4    Voehringer, D.5    Huitinga, I.6
  • 40
    • 34548013962 scopus 로고    scopus 로고
    • Alternatively activated macrophages in protozoan infections
    • Raes G, Beschin A, Ghassabeh GH, De Baetselier P. Alternatively activated macrophages in protozoan infections. Curr Opin Immunol (2007) 19(4):454-9. doi:10.1016/j.coi.2007.05.007
    • (2007) Curr Opin Immunol , vol.19 , Issue.4 , pp. 454-459
    • Raes, G.1    Beschin, A.2    Ghassabeh, G.H.3    De Baetselier, P.4
  • 41
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol (2008) 8(12):958-69. doi:10.1038/nri2448
    • (2008) Nat Rev Immunol , vol.8 , Issue.12 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 42
    • 84867740805 scopus 로고    scopus 로고
    • Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
    • Gautier EL, Shay T, Miller J, Greter M, Jakubzick C, Ivanov S, et al. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat Immunol (2012) 13(11):1118-28. doi:10.1038/ni.2419
    • (2012) Nat Immunol , vol.13 , Issue.11 , pp. 1118-1128
    • Gautier, E.L.1    Shay, T.2    Miller, J.3    Greter, M.4    Jakubzick, C.5    Ivanov, S.6
  • 43
    • 84904394690 scopus 로고    scopus 로고
    • Macrophage activation and polarization: nomenclature and experimental guidelines
    • Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity (2014) 41(1):14-20. doi:10.1016/j.immuni.2014.06.008
    • (2014) Immunity , vol.41 , Issue.1 , pp. 14-20
    • Murray, P.J.1    Allen, J.E.2    Biswas, S.K.3    Fisher, E.A.4    Gilroy, D.W.5    Goerdt, S.6
  • 44
    • 84873103649 scopus 로고    scopus 로고
    • Colony stimulating factors and myeloid cell biology in health and disease
    • Hamilton JA, Achuthan A. Colony stimulating factors and myeloid cell biology in health and disease. Trends Immunol (2013) 34(2):81-9. doi:10.1016/j.it.2012.08.006
    • (2013) Trends Immunol , vol.34 , Issue.2 , pp. 81-89
    • Hamilton, J.A.1    Achuthan, A.2
  • 45
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell (2010) 141(7):1117-34. doi:10.1016/j.cell.2010.06.011
    • (2010) Cell , vol.141 , Issue.7 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 46
    • 0028839045 scopus 로고
    • Transcriptional regulation of the c-fms (CSF-1R) proto-oncogene in human breast carcinoma cells by glucocorticoids
    • Sapi E, Flick MB, Gilmore-Hebert M, Rodov S, Kacinski BM. Transcriptional regulation of the c-fms (CSF-1R) proto-oncogene in human breast carcinoma cells by glucocorticoids. Oncogene (1995) 10(3):529-42.
    • (1995) Oncogene , vol.10 , Issue.3 , pp. 529-542
    • Sapi, E.1    Flick, M.B.2    Gilmore-Hebert, M.3    Rodov, S.4    Kacinski, B.M.5
  • 47
    • 0024215674 scopus 로고
    • The role of the CSF-1 receptor gene (C-fms) in cell transformation
    • Sherr CJ. The role of the CSF-1 receptor gene (C-fms) in cell transformation. Leukemia (1988) 2(12 Suppl):132S-42S.
    • (1988) Leukemia , vol.2 , Issue.12 SUPPL , pp. 132S-142S
    • Sherr, C.J.1
  • 48
    • 0037307026 scopus 로고    scopus 로고
    • A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse
    • Sasmono RT, Oceandy D, Pollard JW, Tong W, Pavli P, Wainwright BJ, et al. A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood (2003) 101(3):1155-63. doi:10.1182/blood-2002-02-0569
    • (2003) Blood , vol.101 , Issue.3 , pp. 1155-1163
    • Sasmono, R.T.1    Oceandy, D.2    Pollard, J.W.3    Tong, W.4    Pavli, P.5    Wainwright, B.J.6
  • 49
    • 84877787762 scopus 로고    scopus 로고
    • M-CSF instructs myeloid lineage fate in single haematopoietic stem cells
    • Mossadegh-Keller N, Sarrazin S, Kandalla PK, Espinosa L, Stanley ER, Nutt SL, et al. M-CSF instructs myeloid lineage fate in single haematopoietic stem cells. Nature (2013) 497(7448):239-43. doi:10.1038/nature12026
    • (2013) Nature , vol.497 , Issue.7448 , pp. 239-243
    • Mossadegh-Keller, N.1    Sarrazin, S.2    Kandalla, P.K.3    Espinosa, L.4    Stanley, E.R.5    Nutt, S.L.6
  • 52
    • 84857618521 scopus 로고    scopus 로고
    • Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling
    • Hume DA, MacDonald KP. Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. Blood (2012) 119(8):1810-20. doi:10.1182/blood-2011-09-379214
    • (2012) Blood , vol.119 , Issue.8 , pp. 1810-1820
    • Hume, D.A.1    MacDonald, K.P.2
  • 53
    • 84878738380 scopus 로고    scopus 로고
    • Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation
    • Davies LC, Rosas M, Jenkins SJ, Liao CT, Scurr MJ, Brombacher F, et al. Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nat Commun (2013) 4:1886. doi:10.1038/ncomms2877
    • (2013) Nat Commun , vol.4 , pp. 1886
    • Davies, L.C.1    Rosas, M.2    Jenkins, S.J.3    Liao, C.T.4    Scurr, M.J.5    Brombacher, F.6
  • 54
    • 84870907320 scopus 로고    scopus 로고
    • Stroma-derived interleukin-34 controls the development and maintenance of Langerhans cells and the maintenance of microglia
    • Greter M, Lelios I, Pelczar P, Hoeffel G, Price J, Leboeuf M, et al. Stroma-derived interleukin-34 controls the development and maintenance of Langerhans cells and the maintenance of microglia. Immunity (2012) 37(6):1050-60. doi:10.1016/j.immuni.2012.11.001
    • (2012) Immunity , vol.37 , Issue.6 , pp. 1050-1060
    • Greter, M.1    Lelios, I.2    Pelczar, P.3    Hoeffel, G.4    Price, J.5    Leboeuf, M.6
  • 55
    • 84864152036 scopus 로고    scopus 로고
    • IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
    • Wang Y, Szretter KJ, Vermi W, Gilfillan S, Rossini C, Cella M, et al. IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol (2012) 13(8):753-60. doi:10.1038/ni.2360
    • (2012) Nat Immunol , vol.13 , Issue.8 , pp. 753-760
    • Wang, Y.1    Szretter, K.J.2    Vermi, W.3    Gilfillan, S.4    Rossini, C.5    Cella, M.6
  • 56
    • 33750813483 scopus 로고    scopus 로고
    • Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression
    • Martinez FO, Gordon S, Locati M, Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol (2006) 177(10):7303-11. doi:10.4049/jimmunol.177.10.7303
    • (2006) J Immunol , vol.177 , Issue.10 , pp. 7303-7311
    • Martinez, F.O.1    Gordon, S.2    Locati, M.3    Mantovani, A.4
  • 57
    • 34247124840 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation
    • Fleetwood AJ, Lawrence T, Hamilton JA, Cook AD. Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation. J Immunol (2007) 178(8):5245-52. doi:10.4049/jimmunol.178.8.5245
    • (2007) J Immunol , vol.178 , Issue.8 , pp. 5245-5252
    • Fleetwood, A.J.1    Lawrence, T.2    Hamilton, J.A.3    Cook, A.D.4
  • 58
    • 69449085100 scopus 로고    scopus 로고
    • GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling
    • Fleetwood AJ, Dinh H, Cook AD, Hertzog PJ, Hamilton JA. GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling. J Leukoc Biol (2009) 86(2):411-21. doi:10.1189/jlb.1108702
    • (2009) J Leukoc Biol , vol.86 , Issue.2 , pp. 411-4121
    • Fleetwood, A.J.1    Dinh, H.2    Cook, A.D.3    Hertzog, P.J.4    Hamilton, J.A.5
  • 59
    • 80052621954 scopus 로고    scopus 로고
    • Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1
    • Tagliani E, Shi C, Nancy P, Tay CS, Pamer EG, Erlebacher A. Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1. J Exp Med (2011) 208(9):1901-16. doi:10.1084/jem.20110866
    • (2011) J Exp Med , vol.208 , Issue.9 , pp. 1901-1916
    • Tagliani, E.1    Shi, C.2    Nancy, P.3    Tay, C.S.4    Pamer, E.G.5    Erlebacher, A.6
  • 60
    • 0028057251 scopus 로고
    • Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis
    • Scholl SM, Pallud C, Beuvon F, Hacene K, Stanley ER, Rohrschneider L, et al. Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis. J Natl Cancer Inst (1994) 86(2):120-6. doi:10.1093/jnci/86.2.120
    • (1994) J Natl Cancer Inst , vol.86 , Issue.2 , pp. 120-126
    • Scholl, S.M.1    Pallud, C.2    Beuvon, F.3    Hacene, K.4    Stanley, E.R.5    Rohrschneider, L.6
  • 61
    • 65349163532 scopus 로고    scopus 로고
    • Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors
    • Kawamura K, Komohara Y, Takaishi K, Katabuchi H, Takeya M. Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors. Pathol Int (2009) 59(5):300-5. doi:10.1111/j.1440-1827.2009.02369.x
    • (2009) Pathol Int , vol.59 , Issue.5 , pp. 300-305
    • Kawamura, K.1    Komohara, Y.2    Takaishi, K.3    Katabuchi, H.4    Takeya, M.5
  • 63
    • 84896731937 scopus 로고    scopus 로고
    • Tumor-associated macrophages are involved in tumor progression in papillary renal cell carcinoma
    • Behnes CL, Bremmer F, Hemmerlein B, Strauss A, Strobel P, Radzun HJ. Tumor-associated macrophages are involved in tumor progression in papillary renal cell carcinoma. Virchows Arch (2014) 464(2):191-6. doi:10.1007/s00428-013-1523-0
    • (2014) Virchows Arch , vol.464 , Issue.2 , pp. 191-196
    • Behnes, C.L.1    Bremmer, F.2    Hemmerlein, B.3    Strauss, A.4    Strobel, P.5    Radzun, H.J.6
  • 64
    • 67049109263 scopus 로고    scopus 로고
    • Coordinate expression of colony-stimulating factor-1 and colony-stimulating factor-1-related proteins is associated with poor prognosis in gynecological and nongynecological leiomyosarcoma
    • Espinosa I, Beck AH, Lee CH, Zhu S, Montgomery KD, Marinelli RJ, et al. Coordinate expression of colony-stimulating factor-1 and colony-stimulating factor-1-related proteins is associated with poor prognosis in gynecological and nongynecological leiomyosarcoma. Am J Pathol (2009) 174(6):2347-56. doi:10.2353/ajpath.2009.081037
    • (2009) Am J Pathol , vol.174 , Issue.6 , pp. 2347-2356
    • Espinosa, I.1    Beck, A.H.2    Lee, C.H.3    Zhu, S.4    Montgomery, K.D.5    Marinelli, R.J.6
  • 65
    • 1642576136 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor-1 receptor expression is associated with poor outcome in breast cancer by large cohort tissue microarray analysis
    • Kluger HM, Dolled-Filhart M, Rodov S, Kacinski BM, Camp RL, Rimm DL. Macrophage colony-stimulating factor-1 receptor expression is associated with poor outcome in breast cancer by large cohort tissue microarray analysis. Clin Cancer Res (2004) 10(1 Pt 1):173-7. doi:10.1158/1078-0432.CCR-0699-3
    • (2004) Clin Cancer Res , vol.10 , Issue.1 , pp. 173-177
    • Kluger, H.M.1    Dolled-Filhart, M.2    Rodov, S.3    Kacinski, B.M.4    Camp, R.L.5    Rimm, D.L.6
  • 66
    • 84918813152 scopus 로고    scopus 로고
    • The promotion of breast cancer metastasis caused by inhibition of CSF-1R/CSF-1 signaling is blocked by targeting the G-CSF receptor
    • Swierczak A, Cook AD, Lenzo JC, Restall CM, Doherty JP, Anderson RL, et al. The promotion of breast cancer metastasis caused by inhibition of CSF-1R/CSF-1 signaling is blocked by targeting the G-CSF receptor. Cancer Immunol Res (2014) 2:765-76. doi:10.1158/2326-6066.CIR-13-0190
    • (2014) Cancer Immunol Res , vol.2 , pp. 765-776
    • Swierczak, A.1    Cook, A.D.2    Lenzo, J.C.3    Restall, C.M.4    Doherty, J.P.5    Anderson, R.L.6
  • 67
    • 84899491428 scopus 로고    scopus 로고
    • CSF-1R expression in tumor-associated macrophages is associated with worse prognosis in classical Hodgkin lymphoma
    • Koh YW, Park C, Yoon DH, Suh C, Huh J. CSF-1R expression in tumor-associated macrophages is associated with worse prognosis in classical Hodgkin lymphoma. Am J Clin Pathol (2014) 141(4):573-83. doi:10.1309/AJCPR92TDDFARISU
    • (2014) Am J Clin Pathol , vol.141 , Issue.4 , pp. 573-583
    • Koh, Y.W.1    Park, C.2    Yoon, D.H.3    Suh, C.4    Huh, J.5
  • 68
    • 61349148145 scopus 로고    scopus 로고
    • The macrophage colony-stimulating factor 1 response signature in breast carcinoma
    • Beck AH, Espinosa I, Edris B, Li R, Montgomery K, Zhu S, et al. The macrophage colony-stimulating factor 1 response signature in breast carcinoma. Clin Cancer Res (2009) 15(3):778-87. doi:10.1158/1078-0432.CCR-08-1283
    • (2009) Clin Cancer Res , vol.15 , Issue.3 , pp. 778-787
    • Beck, A.H.1    Espinosa, I.2    Edris, B.3    Li, R.4    Montgomery, K.5    Zhu, S.6
  • 69
    • 77956184046 scopus 로고    scopus 로고
    • Analysis of stromal signatures in the tumor microenvironment of ductal carcinoma in situ
    • Sharma M, Beck AH, Webster JA, Espinosa I, Montgomery K, Varma S, et al. Analysis of stromal signatures in the tumor microenvironment of ductal carcinoma in situ. Breast Cancer Res Treat (2010) 123(2):397-404. doi:10.1007/s10549-009-0654-0
    • (2010) Breast Cancer Res Treat , vol.123 , Issue.2 , pp. 397-404
    • Sharma, M.1    Beck, A.H.2    Webster, J.A.3    Espinosa, I.4    Montgomery, K.5    Varma, S.6
  • 71
    • 84891402027 scopus 로고    scopus 로고
    • Elevated CSF1 serum concentration predicts poor overall survival in women with early breast cancer
    • Aharinejad S, Salama M, Paulus P, Zins K, Berger A, Singer CF. Elevated CSF1 serum concentration predicts poor overall survival in women with early breast cancer. Endocr Relat Cancer (2013) 20(6):777-83. doi:10.1530/ERC-13-0198
    • (2013) Endocr Relat Cancer , vol.20 , Issue.6 , pp. 777-783
    • Aharinejad, S.1    Salama, M.2    Paulus, P.3    Zins, K.4    Berger, A.5    Singer, C.F.6
  • 73
    • 33344460032 scopus 로고    scopus 로고
    • A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation)
    • Biswas SK, Gangi L, Paul S, Schioppa T, Saccani A, Sironi M, et al. A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation). Blood (2006) 107(5):2112-22. doi:10.1182/blood-2005-01-0428
    • (2006) Blood , vol.107 , Issue.5 , pp. 2112-2122
    • Biswas, S.K.1    Gangi, L.2    Paul, S.3    Schioppa, T.4    Saccani, A.5    Sironi, M.6
  • 74
    • 34248172324 scopus 로고    scopus 로고
    • Altered macrophage differentiation and immune dysfunction in tumor development
    • Sica A, Bronte V. Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest (2007) 117(5):1155-66. doi:10.1172/JCI31422
    • (2007) J Clin Invest , vol.117 , Issue.5 , pp. 1155-1166
    • Sica, A.1    Bronte, V.2
  • 75
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol (2002) 23(11):549-55. doi:10.1016/S1471-4906(02)02302-5
    • (2002) Trends Immunol , vol.23 , Issue.11 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 76
    • 33645760428 scopus 로고    scopus 로고
    • Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype
    • Hagemann T, Wilson J, Burke F, Kulbe H, Li NF, Pluddemann A, et al. Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype. J Immunol (2006) 176(8):5023-32. doi:10.4049/jimmunol.176.8.5023
    • (2006) J Immunol , vol.176 , Issue.8 , pp. 5023-5032
    • Hagemann, T.1    Wilson, J.2    Burke, F.3    Kulbe, H.4    Li, N.F.5    Pluddemann, A.6
  • 77
    • 66349099293 scopus 로고    scopus 로고
    • Identification of a subpopulation of macrophages in mammary tumor-bearing mice that are neither M1 nor M2 and are less differentiated
    • Torroella-Kouri M, Silvera R, Rodriguez D, Caso R, Shatry A, Opiela S, et al. Identification of a subpopulation of macrophages in mammary tumor-bearing mice that are neither M1 nor M2 and are less differentiated. Cancer Res (2009) 69(11):4800-9. doi:10.1158/0008-5472.CAN-08-3427
    • (2009) Cancer Res , vol.69 , Issue.11 , pp. 4800-4809
    • Torroella-Kouri, M.1    Silvera, R.2    Rodriguez, D.3    Caso, R.4    Shatry, A.5    Opiela, S.6
  • 78
    • 84882637084 scopus 로고    scopus 로고
    • Tumor-associated macrophages: functional diversity, clinical significance, and open questions
    • Biswas SK, Allavena P, Mantovani A. Tumor-associated macrophages: functional diversity, clinical significance, and open questions. Semin Immunopathol (2013) 35(5):585-600. doi:10.1007/s00281-013-0367-7
    • (2013) Semin Immunopathol , vol.35 , Issue.5 , pp. 585-600
    • Biswas, S.K.1    Allavena, P.2    Mantovani, A.3
  • 79
    • 46949094641 scopus 로고    scopus 로고
    • Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics
    • Umemura N, Saio M, Suwa T, Kitoh Y, Bai J, Nonaka K, et al. Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics. J Leukoc Biol (2008) 83(5):1136-44. doi:10.1189/jlb.0907611
    • (2008) J Leukoc Biol , vol.83 , Issue.5 , pp. 1136-1144
    • Umemura, N.1    Saio, M.2    Suwa, T.3    Kitoh, Y.4    Bai, J.5    Nonaka, K.6
  • 80
    • 0026722310 scopus 로고
    • Macrophage arginine metabolism and the inhibition or stimulation of cancer
    • Mills CD, Shearer J, Evans R, Caldwell MD. Macrophage arginine metabolism and the inhibition or stimulation of cancer. J Immunol (1992) 149(8):2709-14.
    • (1992) J Immunol , vol.149 , Issue.8 , pp. 2709-2714
    • Mills, C.D.1    Shearer, J.2    Evans, R.3    Caldwell, M.D.4
  • 81
    • 82755192210 scopus 로고    scopus 로고
    • A critical role for macrophages in promotion of urethane-induced lung carcinogenesis
    • Zaynagetdinov R, Sherrill TP, Polosukhin VV, Han W, Ausborn JA, McLoed AG, et al. A critical role for macrophages in promotion of urethane-induced lung carcinogenesis. J Immunol (2011) 187(11):5703-11. doi:10.4049/jimmunol.1100558
    • (2011) J Immunol , vol.187 , Issue.11 , pp. 5703-5711
    • Zaynagetdinov, R.1    Sherrill, T.P.2    Polosukhin, V.V.3    Han, W.4    Ausborn, J.A.5    McLoed, A.G.6
  • 82
    • 80855130756 scopus 로고    scopus 로고
    • Prognostic implication of types of tumor-associated macrophages in Hodgkin lymphoma
    • Zaki MA, Wada N, Ikeda J, Shibayama H, Hashimoto K, Yamagami T, et al. Prognostic implication of types of tumor-associated macrophages in Hodgkin lymphoma. Virchows Arch (2011) 459(4):361-6. doi:10.1007/s00428-011-1140-8
    • (2011) Virchows Arch , vol.459 , Issue.4 , pp. 361-366
    • Zaki, M.A.1    Wada, N.2    Ikeda, J.3    Shibayama, H.4    Hashimoto, K.5    Yamagami, T.6
  • 83
    • 79961102700 scopus 로고    scopus 로고
    • Transition of tumor-associated macrophages from MHC class II(hi) to MHC class II(low) mediates tumor progression in mice
    • Wang B, Li Q, Qin L, Zhao S, Wang J, Chen X. Transition of tumor-associated macrophages from MHC class II(hi) to MHC class II(low) mediates tumor progression in mice. BMC Immunol (2011) 12:43. doi:10.1186/1471-2172-12-43
    • (2011) BMC Immunol , vol.12 , pp. 43
    • Wang, B.1    Li, Q.2    Qin, L.3    Zhao, S.4    Wang, J.5    Chen, X.6
  • 84
    • 84893655060 scopus 로고    scopus 로고
    • A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients
    • Zhang M, He Y, Sun X, Li Q, Wang W, Zhao A, et al. A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients. J Ovarian Res (2014) 7(1):19. doi:10.1186/1757-2215-7-19
    • (2014) J Ovarian Res , vol.7 , Issue.1 , pp. 19
    • Zhang, M.1    He, Y.2    Sun, X.3    Li, Q.4    Wang, W.5    Zhao, A.6
  • 85
    • 45149134605 scopus 로고    scopus 로고
    • "Re-educating" tumor-associated macrophages by targeting NF-kappaB
    • Hagemann T, Lawrence T, McNeish I, Charles KA, Kulbe H, Thompson RG, et al. "Re-educating" tumor-associated macrophages by targeting NF-kappaB. J Exp Med (2008) 205(6):1261-8. doi:10.1084/jem.20080108
    • (2008) J Exp Med , vol.205 , Issue.6 , pp. 1261-1268
    • Hagemann, T.1    Lawrence, T.2    McNeish, I.3    Charles, K.A.4    Kulbe, H.5    Thompson, R.G.6
  • 86
    • 84897933309 scopus 로고    scopus 로고
    • Mechanisms driving macrophage diversity and specialization in distinct tumor microenvironments and parallelisms with other tissues
    • Van Overmeire E, Laoui D, Keirsse J, Van Ginderachter JA, Sarukhan A. Mechanisms driving macrophage diversity and specialization in distinct tumor microenvironments and parallelisms with other tissues. Front Immunol (2014) 5:127. doi:10.3389/fimmu.2014.00127
    • (2014) Front Immunol , vol.5 , pp. 127
    • Van Overmeire, E.1    Laoui, D.2    Keirsse, J.3    Van Ginderachter, J.A.4    Sarukhan, A.5
  • 87
    • 84899080460 scopus 로고    scopus 로고
    • Hypoxia and tumor-associated macrophages: a deadly alliance in support of tumor progression
    • Van Overmeire E, Laoui D, Keirsse J, Van Ginderachter JA. Hypoxia and tumor-associated macrophages: a deadly alliance in support of tumor progression. Oncoimmunology (2014) 3(1):e27561. doi:10.4161/onci.27561
    • (2014) Oncoimmunology , vol.3 , Issue.1
    • Van Overmeire, E.1    Laoui, D.2    Keirsse, J.3    Van Ginderachter, J.A.4
  • 88
    • 82555181278 scopus 로고    scopus 로고
    • Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions
    • Laoui D, Movahedi K, Van Overmeire E, Van den Bossche J, Schouppe E, Mommer C, et al. Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions. Int J Dev Biol (2011) 55(7-9):861-7. doi:10.1387/ijdb.113371dl
    • (2011) Int J Dev Biol , vol.55 , Issue.7-9 , pp. 861-867
    • Laoui, D.1    Movahedi, K.2    Van Overmeire, E.3    Van den Bossche, J.4    Schouppe, E.5    Mommer, C.6
  • 89
    • 84876186488 scopus 로고    scopus 로고
    • Instruction of myeloid cells by the tumor microenvironment: open questions on the dynamics and plasticity of different tumor-associated myeloid cell populations
    • Schouppe E, De Baetselier P, Van Ginderachter JA, Sarukhan A. Instruction of myeloid cells by the tumor microenvironment: open questions on the dynamics and plasticity of different tumor-associated myeloid cell populations. Oncoimmunology (2012) 1(7):1135-45. doi:10.4161/onci.21566
    • (2012) Oncoimmunology , vol.1 , Issue.7 , pp. 1135-1145
    • Schouppe, E.1    De Baetselier, P.2    Van Ginderachter, J.A.3    Sarukhan, A.4
  • 90
    • 34047246527 scopus 로고    scopus 로고
    • Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors
    • Wyckoff JB, Wang Y, Lin EY, Li JF, Goswami S, Stanley ER, et al. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res (2007) 67(6):2649-56. doi:10.1158/0008-5472.CAN-06-1823
    • (2007) Cancer Res , vol.67 , Issue.6 , pp. 2649-2656
    • Wyckoff, J.B.1    Wang, Y.2    Lin, E.Y.3    Li, J.F.4    Goswami, S.5    Stanley, E.R.6
  • 91
    • 20444436815 scopus 로고    scopus 로고
    • Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop
    • Goswami S, Sahai E, Wyckoff JB, Cammer M, Cox D, Pixley FJ, et al. Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res (2005) 65(12):5278-83. doi:10.1158/0008-5472.CAN-04-1853
    • (2005) Cancer Res , vol.65 , Issue.12 , pp. 5278-5283
    • Goswami, S.1    Sahai, E.2    Wyckoff, J.B.3    Cammer, M.4    Cox, D.5    Pixley, F.J.6
  • 92
  • 93
    • 64249152007 scopus 로고    scopus 로고
    • Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy
    • Egeblad M, Ewald AJ, Askautrud HA, Truitt ML, Welm BE, Bainbridge E, et al. Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis Model Mech (2008) 1(2-3):155-67. doi:10.1242/dmm.000596
    • (2008) Dis Model Mech , vol.1 , Issue.2-3 , pp. 155-167
    • Egeblad, M.1    Ewald, A.J.2    Askautrud, H.A.3    Truitt, M.L.4    Welm, B.E.5    Bainbridge, E.6
  • 94
    • 76249106734 scopus 로고    scopus 로고
    • Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors
    • Ojalvo LS, Whittaker CA, Condeelis JS, Pollard JW. Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. J Immunol (2010) 184(2):702-12. doi:10.4049/jimmunol.0902360
    • (2010) J Immunol , vol.184 , Issue.2 , pp. 702-712
    • Ojalvo, L.S.1    Whittaker, C.A.2    Condeelis, J.S.3    Pollard, J.W.4
  • 95
    • 84906097515 scopus 로고    scopus 로고
    • In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors
    • Tymoszuk P, Evens H, Marzola V, Wachowicz K, Wasmer MH, Datta S, et al. In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors. Eur J Immunol (2014) 44:2247-62. doi:10.1002/eji.201344304
    • (2014) Eur J Immunol , vol.44 , pp. 2247-2262
    • Tymoszuk, P.1    Evens, H.2    Marzola, V.3    Wachowicz, K.4    Wasmer, M.H.5    Datta, S.6
  • 96
    • 84891930215 scopus 로고    scopus 로고
    • Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity
    • Casazza A, Laoui D, Wenes M, Rizzolio S, Bassani N, Mambretti M, et al. Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity. Cancer Cell (2013) 24(6):695-709. doi:10.1016/j.ccr.2013.11.007
    • (2013) Cancer Cell , vol.24 , Issue.6 , pp. 695-709
    • Casazza, A.1    Laoui, D.2    Wenes, M.3    Rizzolio, S.4    Bassani, N.5    Mambretti, M.6
  • 97
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • Lin EY, Nguyen AV, Russell RG, Pollard JW. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med (2001) 193(6):727-40. doi:10.1084/jem.193.6.727
    • (2001) J Exp Med , vol.193 , Issue.6 , pp. 727-740
    • Lin, E.Y.1    Nguyen, A.V.2    Russell, R.G.3    Pollard, J.W.4
  • 98
    • 84858339905 scopus 로고    scopus 로고
    • Deficiency of the macrophage growth factor CSF-1 disrupts pancreatic neuroendocrine tumor development
    • Pyonteck SM, Gadea BB, Wang HW, Gocheva V, Hunter KE, Tang LH, et al. Deficiency of the macrophage growth factor CSF-1 disrupts pancreatic neuroendocrine tumor development. Oncogene (2012) 31(11):1459-67. doi:10.1038/onc.2011.337
    • (2012) Oncogene , vol.31 , Issue.11 , pp. 1459-1467
    • Pyonteck, S.M.1    Gadea, B.B.2    Wang, H.W.3    Gocheva, V.4    Hunter, K.E.5    Tang, L.H.6
  • 99
    • 33646243569 scopus 로고    scopus 로고
    • Colony-stimulating factor-1 antibody reverses chemoresistance in human MCF-7 breast cancer xenografts
    • Paulus P, Stanley ER, Schafer R, Abraham D, Aharinejad S. Colony-stimulating factor-1 antibody reverses chemoresistance in human MCF-7 breast cancer xenografts. Cancer Res (2006) 66(8):4349-56. doi:10.1158/0008-5472.CAN-05-3523
    • (2006) Cancer Res , vol.66 , Issue.8 , pp. 4349-4356
    • Paulus, P.1    Stanley, E.R.2    Schafer, R.3    Abraham, D.4    Aharinejad, S.5
  • 100
    • 78149462163 scopus 로고    scopus 로고
    • An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation
    • MacDonald KP, Palmer JS, Cronau S, Seppanen E, Olver S, Raffelt NC, et al. An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation. Blood (2010) 116(19):3955-63. doi:10.1182/blood-2010-02-266296
    • (2010) Blood , vol.116 , Issue.19 , pp. 3955-3963
    • MacDonald, K.P.1    Palmer, J.S.2    Cronau, S.3    Seppanen, E.4    Olver, S.5    Raffelt, N.C.6
  • 101
    • 84883362872 scopus 로고    scopus 로고
    • Therapeutic effects of anti-CD115 monoclonal antibody in mouse cancer models through dual inhibition of tumor-associated macrophages and osteoclasts
    • Fend L, Accart N, Kintz J, Cochin S, Reymann C, Le Pogam F, et al. Therapeutic effects of anti-CD115 monoclonal antibody in mouse cancer models through dual inhibition of tumor-associated macrophages and osteoclasts. PLoS One (2013) 8(9):e73310. doi:10.1371/journal.pone.0073310
    • (2013) PLoS One , vol.8 , Issue.9
    • Fend, L.1    Accart, N.2    Kintz, J.3    Cochin, S.4    Reymann, C.5    Le Pogam, F.6
  • 102
    • 66049154097 scopus 로고    scopus 로고
    • M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis
    • Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, et al. M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med (2009) 206(5):1089-102. doi:10.1084/jem.20081605
    • (2009) J Exp Med , vol.206 , Issue.5 , pp. 1089-1102
    • Kubota, Y.1    Takubo, K.2    Shimizu, T.3    Ohno, H.4    Kishi, K.5    Shibuya, M.6
  • 103
    • 84872806275 scopus 로고    scopus 로고
    • Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression
    • Ryder M, Gild M, Hohl TM, Pamer E, Knauf J, Ghossein R, et al. Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression. PLoS One (2013) 8(1):e54302. doi:10.1371/journal.pone.0054302
    • (2013) PLoS One , vol.8 , Issue.1
    • Ryder, M.1    Gild, M.2    Hohl, T.M.3    Pamer, E.4    Knauf, J.5    Ghossein, R.6
  • 104
    • 84894520967 scopus 로고    scopus 로고
    • CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8 T cells
    • Strachan DC, Ruffell B, Oei Y, Bissell MJ, Coussens LM, Pryer N, et al. CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8 T cells. Oncoimmunology (2013) 2(12):e26968. doi:10.4161/onci.26968
    • (2013) Oncoimmunology , vol.2 , Issue.12
    • Strachan, D.C.1    Ruffell, B.2    Oei, Y.3    Bissell, M.J.4    Coussens, L.M.5    Pryer, N.6
  • 105
    • 84873468174 scopus 로고    scopus 로고
    • Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses
    • Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, et al. Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses. Cancer Res (2013) 73(3):1128-41. doi:10.1158/0008-5472.CAN-12-2731
    • (2013) Cancer Res , vol.73 , Issue.3 , pp. 1128-1141
    • Mitchem, J.B.1    Brennan, D.J.2    Knolhoff, B.L.3    Belt, B.A.4    Zhu, Y.5    Sanford, D.E.6
  • 106
    • 84902546715 scopus 로고    scopus 로고
    • Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy
    • Ries CH, Cannarile MA, Hoves S, Benz J, Wartha K, Runza V, et al. Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell (2014) 25(6):846-59. doi:10.1016/j.ccr.2014.05.016
    • (2014) Cancer Cell , vol.25 , Issue.6 , pp. 846-859
    • Ries, C.H.1    Cannarile, M.A.2    Hoves, S.3    Benz, J.4    Wartha, K.5    Runza, V.6
  • 107
    • 84918799498 scopus 로고    scopus 로고
    • Phase 1 study of IMC-CS4, a monoclonal antibody targeted to the CSF-1 receptor (CSF-1R), in subjects with advanced solid tumors refractory to standard therapy or for which no standard therapy is available [Internet]. Eli Lilly and Company. [Cited 2014 July 11]
    • Phase 1 study of IMC-CS4, a monoclonal antibody targeted to the CSF-1 receptor (CSF-1R), in subjects with advanced solid tumors refractory to standard therapy or for which no standard therapy is available [Internet]. Eli Lilly and Company. (2011) [Cited 2014 July 11]. Available from: http://clinicaltrials.gov/show/NCT01346358.
    • (2011)
  • 108
    • 84887481716 scopus 로고    scopus 로고
    • CSF-1R inhibition alters macrophage polarization and blocks glioma progression
    • Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med (2013) 19(10):1264-72. doi:10.1038/nm.3337
    • (2013) Nat Med , vol.19 , Issue.10 , pp. 1264-1272
    • Pyonteck, S.M.1    Akkari, L.2    Schuhmacher, A.J.3    Bowman, R.L.4    Sevenich, L.5    Quail, D.F.6
  • 109
    • 33845214085 scopus 로고    scopus 로고
    • A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model
    • Ohno H, Kubo K, Murooka H, Kobayashi Y, Nishitoba T, Shibuya M, et al. A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther (2006) 5(11):2634-43. doi:10.1158/1535-7163.MCT-05-0313
    • (2006) Mol Cancer Ther , vol.5 , Issue.11 , pp. 2634-2643
    • Ohno, H.1    Kubo, K.2    Murooka, H.3    Kobayashi, Y.4    Nishitoba, T.5    Shibuya, M.6
  • 110
    • 27644436741 scopus 로고    scopus 로고
    • Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580
    • Conway JG, McDonald B, Parham J, Keith B, Rusnak DW, Shaw E, et al. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A (2005) 102(44):16078-83. doi:10.1073/pnas.0502000102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.44 , pp. 16078-16083
    • Conway, J.G.1    McDonald, B.2    Parham, J.3    Keith, B.4    Rusnak, D.W.5    Shaw, E.6
  • 111
    • 84899708388 scopus 로고    scopus 로고
    • Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor
    • Kim TS, Cavnar MJ, Cohen NA, Sorenson EC, Greer JB, Seifert AM, et al. Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor. Clin Cancer Res (2014) 20(9):2350-62. doi:10.1158/1078-0432.CCR-13-3033
    • (2014) Clin Cancer Res , vol.20 , Issue.9 , pp. 2350-2362
    • Kim, T.S.1    Cavnar, M.J.2    Cohen, N.A.3    Sorenson, E.C.4    Greer, J.B.5    Seifert, A.M.6
  • 112
    • 79955003754 scopus 로고    scopus 로고
    • Combined GM-CSF treatment and M-CSF inhibition of tumor-associated macrophages induces dendritic cell-like signaling in vitro
    • Kitoh Y, Saio M, Gotoh N, Umemura N, Nonaka K, Bai J, et al. Combined GM-CSF treatment and M-CSF inhibition of tumor-associated macrophages induces dendritic cell-like signaling in vitro. Int J Oncol (2011) 38(5):1409-19. doi:10.3892/ijo.2011.960
    • (2011) Int J Oncol , vol.38 , Issue.5 , pp. 1409-1419
    • Kitoh, Y.1    Saio, M.2    Gotoh, N.3    Umemura, N.4    Nonaka, K.5    Bai, J.6
  • 113
    • 84892738557 scopus 로고    scopus 로고
    • Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy
    • Mok S, Koya RC, Tsui C, Xu J, Robert L, Wu L, et al. Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy. Cancer Res (2014) 74(1):153-61. doi:10.1158/0008-5472.CAN-13-1816
    • (2014) Cancer Res , vol.74 , Issue.1 , pp. 153-161
    • Mok, S.1    Koya, R.C.2    Tsui, C.3    Xu, J.4    Robert, L.5    Wu, L.6
  • 114
    • 84907484156 scopus 로고    scopus 로고
    • CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T Cell checkpoint immunotherapy in pancreatic cancer models
    • Zhu Y, Knolhoff BL, Meyer MA, Nywening TM, West BL, Luo J, et al. CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T Cell checkpoint immunotherapy in pancreatic cancer models. Cancer Res (2014) 74:5057-69. doi:10.1158/0008-5472.CAN-13-3723
    • (2014) Cancer Res , vol.74 , pp. 5057-5069
    • Zhu, Y.1    Knolhoff, B.L.2    Meyer, M.A.3    Nywening, T.M.4    West, B.L.5    Luo, J.6
  • 115
    • 77949900433 scopus 로고    scopus 로고
    • Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy
    • Priceman SJ, Sung JL, Shaposhnik Z, Burton JB, Torres-Collado AX, Moughon DL, et al. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood (2010) 115(7):1461-71. doi:10.1182/blood-2009-08-237412
    • (2010) Blood , vol.115 , Issue.7 , pp. 1461-1471
    • Priceman, S.J.1    Sung, J.L.2    Shaposhnik, Z.3    Burton, J.B.4    Torres-Collado, A.X.5    Moughon, D.L.6
  • 116
    • 84877738839 scopus 로고    scopus 로고
    • CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer
    • Xu J, Escamilla J, Mok S, David J, Priceman S, West B, et al. CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer. Cancer Res (2013) 73(9):2782-94. doi:10.1158/0008-5472.CAN-12-3981
    • (2013) Cancer Res , vol.73 , Issue.9 , pp. 2782-2794
    • Xu, J.1    Escamilla, J.2    Mok, S.3    David, J.4    Priceman, S.5    West, B.6
  • 117
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • Corzo CA, Condamine T, Lu L, Cotter MJ, Youn JI, Cheng P, et al. HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med (2010) 207(11):2439-53. doi:10.1084/jem.20100587
    • (2010) J Exp Med , vol.207 , Issue.11 , pp. 2439-2453
    • Corzo, C.A.1    Condamine, T.2    Lu, L.3    Cotter, M.J.4    Youn, J.I.5    Cheng, P.6
  • 118
    • 3442901908 scopus 로고    scopus 로고
    • Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice
    • Aharinejad S, Paulus P, Sioud M, Hofmann M, Zins K, Schafer R, et al. Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice. Cancer Res (2004) 64(15):5378-84. doi:10.1158/0008-5472.CAN-04-0961
    • (2004) Cancer Res , vol.64 , Issue.15 , pp. 5378-5384
    • Aharinejad, S.1    Paulus, P.2    Sioud, M.3    Hofmann, M.4    Zins, K.5    Schafer, R.6
  • 119
    • 33845767868 scopus 로고    scopus 로고
    • Macrophages regulate the angiogenic switch in a mouse model of breast cancer
    • Lin EY, Li JF, Gnatovskiy L, Deng Y, Zhu L, Grzesik DA, et al. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res (2006) 66(23):11238-46. doi:10.1158/0008-5472.CAN-06-1278
    • (2006) Cancer Res , vol.66 , Issue.23 , pp. 11238-11246
    • Lin, E.Y.1    Li, J.F.2    Gnatovskiy, L.3    Deng, Y.4    Zhu, L.5    Grzesik, D.A.6
  • 120
    • 54449085397 scopus 로고    scopus 로고
    • M-CSF signals through the MAPK/ERK pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo
    • Curry JM, Eubank TD, Roberts RD, Wang Y, Pore N, Maity A, et al. M-CSF signals through the MAPK/ERK pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo. PLoS One (2008) 3(10):e3405. doi:10.1371/journal.pone.0003405
    • (2008) PLoS One , vol.3 , Issue.10
    • Curry, J.M.1    Eubank, T.D.2    Roberts, R.D.3    Wang, Y.4    Pore, N.5    Maity, A.6
  • 121
    • 84902456985 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor augments tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer
    • Forget MA, Voorhees JL, Cole SL, Dakhlallah D, Patterson IL, Gross AC, et al. Macrophage colony-stimulating factor augments tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer. PLoS One (2014) 9(6):e98623. doi:10.1371/journal.pone.0098623
    • (2014) PLoS One , vol.9 , Issue.6
    • Forget, M.A.1    Voorhees, J.L.2    Cole, S.L.3    Dakhlallah, D.4    Patterson, I.L.5    Gross, A.C.6
  • 122
    • 78651461701 scopus 로고    scopus 로고
    • HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF
    • Rolny C, Mazzone M, Tugues S, Laoui D, Johansson I, Coulon C, et al. HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. Cancer Cell (2011) 19(1):31-44. doi:10.1016/j.ccr.2010.11.009
    • (2011) Cancer Cell , vol.19 , Issue.1 , pp. 31-44
    • Rolny, C.1    Mazzone, M.2    Tugues, S.3    Laoui, D.4    Johansson, I.5    Coulon, C.6
  • 123
    • 4944229701 scopus 로고    scopus 로고
    • A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors
    • Wyckoff J, Wang W, Lin EY, Wang Y, Pixley F, Stanley ER, et al. A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res (2004) 64(19):7022-9. doi:10.1158/0008-5472.CAN-04-1449
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7022-7029
    • Wyckoff, J.1    Wang, W.2    Lin, E.Y.3    Wang, Y.4    Pixley, F.5    Stanley, E.R.6
  • 124
    • 73649122504 scopus 로고    scopus 로고
    • Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor
    • Patsialou A, Wyckoff J, Wang Y, Goswami S, Stanley ER, Condeelis JS. Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. Cancer Res (2009) 69(24):9498-506. doi:10.1158/0008-5472.CAN-09-1868
    • (2009) Cancer Res , vol.69 , Issue.24 , pp. 9498-9506
    • Patsialou, A.1    Wyckoff, J.2    Wang, Y.3    Goswami, S.4    Stanley, E.R.5    Condeelis, J.S.6
  • 125
    • 33947629475 scopus 로고    scopus 로고
    • Effects of GM-CSF and M-CSF on tumor progression of lung cancer: roles of MEK1/ERK and AKT/PKB pathways
    • Uemura Y, Kobayashi M, Nakata H, Kubota T, Bandobashi K, Saito T, et al. Effects of GM-CSF and M-CSF on tumor progression of lung cancer: roles of MEK1/ERK and AKT/PKB pathways. Int J Mol Med (2006) 18(2):365-73.
    • (2006) Int J Mol Med , vol.18 , Issue.2 , pp. 365-373
    • Uemura, Y.1    Kobayashi, M.2    Nakata, H.3    Kubota, T.4    Bandobashi, K.5    Saito, T.6
  • 126
    • 68749109536 scopus 로고    scopus 로고
    • A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    • Qian B, Deng Y, Im JH, Muschel RJ, Zou Y, Li J, et al. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One (2009) 4(8):e6562. doi:10.1371/journal.pone.0006562
    • (2009) PLoS One , vol.4 , Issue.8
    • Qian, B.1    Deng, Y.2    Im, J.H.3    Muschel, R.J.4    Zou, Y.5    Li, J.6
  • 127
    • 65249126907 scopus 로고    scopus 로고
    • Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination
    • Robinson BD, Sica GL, Liu YF, Rohan TE, Gertler FB, Condeelis JS, et al. Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clin Cancer Res (2009) 15(7):2433-41. doi:10.1158/1078-0432.CCR-08-2179
    • (2009) Clin Cancer Res , vol.15 , Issue.7 , pp. 2433-2441
    • Robinson, B.D.1    Sica, G.L.2    Liu, Y.F.3    Rohan, T.E.4    Gertler, F.B.5    Condeelis, J.S.6
  • 128
    • 84918840478 scopus 로고    scopus 로고
    • A Phase 1 study to assess safety, pharmacokinetics, and pharmacodynamics of PLX3397 in patients with advanced, incurable, solid tumors in which the target kinases are linked to disease pathophysiology [Internet].
    • A Phase 1 study to assess safety, pharmacokinetics, and pharmacodynamics of PLX3397 in patients with advanced, incurable, solid tumors in which the target kinases are linked to disease pathophysiology [Internet]. Plexxikon. (2009). Available from: http://clinicaltrials.gov/show/NCT01004861.
    • (2009) Plexxikon
  • 129
    • 84918829181 scopus 로고    scopus 로고
    • A phase 1/2 safety and efficacy study of orally administered PLX3397 in adults with relapsed or refractory acute myeloid Leukemia (AML) [Internet].
    • A phase 1/2 safety and efficacy study of orally administered PLX3397 in adults with relapsed or refractory acute myeloid Leukemia (AML) [Internet]. Plexxikon. (2011). Available from: http://clinicaltrials.gov/show/NCT01349049.
    • (2011) Plexxikon.
  • 130
    • 84918829181 scopus 로고    scopus 로고
    • A phase 2 study of orally administered PLX3397 in patients with recurrent glioblastoma [Internet].
    • A phase 2 study of orally administered PLX3397 in patients with recurrent glioblastoma [Internet]. Plexxikon. (2011). Available from: http://clinicaltrials.gov/show/NCT01349036.
    • (2011) Plexxikon.
  • 131
    • 84918805055 scopus 로고    scopus 로고
    • A phase 1b study to assess the safety of PLX3397 and paclitaxel in patients with advanced solid tumors [Internet].
    • A phase 1b study to assess the safety of PLX3397 and paclitaxel in patients with advanced solid tumors [Internet]. Plexxikon. (2012). Available from: http://clinicaltrials.gov/show/NCT01525602.
    • (2012) Plexxikon.
  • 132
    • 84918805055 scopus 로고    scopus 로고
    • Enhancing efficacy of chemotherapy in triple negative/basal-like breast cancer by targeting macrophages: a multicenter phase Ib/II study of PLX 3397 and eribulin in patients with metastatic breast cancer [Internet].
    • Enhancing efficacy of chemotherapy in triple negative/basal-like breast cancer by targeting macrophages: a multicenter phase Ib/II study of PLX 3397 and eribulin in patients with metastatic breast cancer [Internet]. Plexxikon. (2012). Available from: http://clinicaltrials.gov/show/NCT01596751.
    • (2012) Plexxikon.
  • 133
    • 84918770683 scopus 로고    scopus 로고
    • An open label phase 1b/2 study of orally administered PLX3397 in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma [Internet].
    • An open label phase 1b/2 study of orally administered PLX3397 in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma [Internet]. Plexxikon. (2013). Available from: http://clinicaltrials.gov/show/NCT01790503.
    • (2013) Plexxikon.
  • 134
    • 84918770683 scopus 로고    scopus 로고
    • A phase 1b open label, dose escalation study to assess safety, pharmacokinetics, pharmacodynamics, and antitumor activity of PLX3397 in combination with vemurafenib in V600-mutated BRAF unresectable or metastatic melanoma [Internet].
    • A phase 1b open label, dose escalation study to assess safety, pharmacokinetics, pharmacodynamics, and antitumor activity of PLX3397 in combination with vemurafenib in V600-mutated BRAF unresectable or metastatic melanoma [Internet]. Plexxikon. (2013). Available from: http://clinicaltrials.gov/show/NCT01826448.
    • (2013) Plexxikon.
  • 135
    • 84911937055 scopus 로고    scopus 로고
    • Open-label, multicenter, dose escalation phase Ia/Ib study with expansion phase to evaluate safety, pharmacokinetics and activity of RO5509554, administered as an intravenous infusion as monotherapy and in combination with paclitaxel in patients with advanced solid tumors [Internet].
    • Open-label, multicenter, dose escalation phase Ia/Ib study with expansion phase to evaluate safety, pharmacokinetics and activity of RO5509554, administered as an intravenous infusion as monotherapy and in combination with paclitaxel in patients with advanced solid tumors [Internet]. Hoffmann-La Roche. (2011). Available from: http://clinicaltrials.gov/show/NCT01494688.
    • (2011) Hoffmann-La Roche.


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