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Volumn 31, Issue 2, 2018, Pages

Emerging technologies for molecular diagnosis of sepsis

Author keywords

Biomedical engineering; Diagnostic; DNA sequencing; Infectious disease; Microbiology techniques

Indexed keywords

ANTIBIOTIC RESISTANCE; BACTERIAL ENDOCARDITIS; BACTERIAL GROWTH; BACTERIAL STRAIN; BIOMEDICAL ENGINEERING; BLOOD CULTURE; CLINICAL DECISION MAKING; CLINICAL EVALUATION; COMMUNICABLE DISEASE; DISEASE CONTROL; DNA SEQUENCE; ELECTRONIC MEDICAL RECORD; GENE AMPLIFICATION; GOLD STANDARD; HOST CELL; HUMAN; MACHINE LEARNING; MICROBIAL IDENTIFICATION; MOLECULAR DIAGNOSIS; NONHUMAN; PREDICTIVE VALUE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SEPSIS; SEQUENCE ANALYSIS; STREPTOCOCCUS; UNITED STATES; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; STANDARDS; TRENDS;

EID: 85044174430     PISSN: 08938512     EISSN: 10986618     Source Type: Journal    
DOI: 10.1128/CMR.00089-17     Document Type: Review
Times cited : (246)

References (215)
  • 1
    • 0020667691 scopus 로고
    • The clinical significance of positive blood cultures: A comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. II. Clinical observations, with special reference to factors influencing prognosis
    • Weinstein, MP, Murphy JR, Reller LB, Lichtenstein KA. 1983. The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. II. Clinical observations, with special reference to factors influencing prognosis. Rev Infect Dis 5:54–70. https://doi.org/10.1093/clinids/5.1.54.
    • (1983) Rev Infect Dis , vol.5 , pp. 54-70
    • Weinstein, M.P.1    Murphy, J.R.2    Reller, L.B.3    Lichtenstein, K.A.4
  • 2
    • 34249027093 scopus 로고    scopus 로고
    • Comparison of clinical manifestations and outcome of community-acquired bloodstream infections among the oldest old, elderly, and adult patients
    • Lee, C-C, Chen S-Y, Chang I-J, Chen S-C, Wu S-C. 2007. Comparison of clinical manifestations and outcome of community-acquired bloodstream infections among the oldest old, elderly, and adult patients. Medicine (Baltimore) 86:138–144. https://doi.org/10.1097/MD.0b013e31806a754c.
    • (2007) Medicine (Baltimore) , vol.86 , pp. 138-144
    • Lee, C.-C.1    Chen, S.-Y.2    Chang, I.-J.3    Chen, S.-C.4    Wu, S.-C.5
  • 3
    • 0030945048 scopus 로고    scopus 로고
    • The clinical significance of positive blood cultures in the 1990s: A prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults
    • Weinstein, MP, Towns ML, Quartey SM, Mirrett S, Reimer LG, Parmigiani G, Reller LB. 1997. The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis 24:584–602. https://doi.org/10.1093/clind/24.4.584.
    • (1997) Clin Infect Dis , vol.24 , pp. 584-602
    • Weinstein, M.P.1    Towns, M.L.2    Quartey, S.M.3    Mirrett, S.4    Reimer, L.G.5    Parmigiani, G.6    Reller, L.B.7
  • 5
    • 84948186061 scopus 로고    scopus 로고
    • Effectiveness of practices to increase timeliness of providing targeted therapy for inpatients with bloodstream infections: A laboratory medicine best practices systematic review and meta-analysis
    • Buehler, SS, Madison B, Snyder SR, Derzon JH, Cornish NE, Saubolle MA, Weissfeld AS, Weinstein MP, Liebow EB, Wolk DM. 2016. Effectiveness of practices to increase timeliness of providing targeted therapy for inpatients with bloodstream infections: a laboratory medicine best practices systematic review and meta-analysis. Clin Microbiol Rev 29: 59–103. https://doi.org/10.1128/CMR.00053-14.
    • (2016) Clin Microbiol Rev , vol.29 , pp. 59-103
    • Buehler, S.S.1    Madison, B.2    Snyder, S.R.3    Derzon, J.H.4    Cornish, N.E.5    Saubolle, M.A.6    Weissfeld, A.S.7    Weinstein, M.P.8    Liebow, E.B.9    Wolk, D.M.10
  • 8
    • 84962726082 scopus 로고    scopus 로고
    • Varying estimates of sepsis mortality using death certificates and administrative codes—United States, 1999-2014
    • Epstein, L, Dantes R, Magill S, Fiore A. 2016. Varying estimates of sepsis mortality using death certificates and administrative codes—United States, 1999-2014. MMWR Morb Mortal Wkly Rep 65:342–345. https://doi.org/10.15585/mmwr.mm6513a2.
    • (2016) MMWR Morb Mortal Wkly Rep , vol.65 , pp. 342-345
    • Epstein, L.1    Dantes, R.2    Magill, S.3    Fiore, A.4
  • 9
    • 52449132676 scopus 로고    scopus 로고
    • The impact of antimicrobialresistant, health care-associated infections on mortality in the United States
    • Klevens, RM, Edwards JR, Gaynes RP. 2008. The impact of antimicrobialresistant, health care-associated infections on mortality in the United States. Clin Infect Dis 47:927–930. https://doi.org/10.1086/591698.
    • (2008) Clin Infect Dis , vol.47 , pp. 927-930
    • Klevens, R.M.1    Edwards, J.R.2    Gaynes, R.P.3
  • 10
    • 84864518463 scopus 로고    scopus 로고
    • Does this adult patient with suspected bacteremia require blood cultures?
    • Coburn, B, Morris AM, Tomlinson G, Detsky AS. 2012. Does this adult patient with suspected bacteremia require blood cultures? JAMA 308: 502–511. https://doi.org/10.1001/jama.2012.8262.
    • (2012) JAMA , vol.308 , pp. 502-511
    • Coburn, B.1    Morris, A.M.2    Tomlinson, G.3    Detsky, A.S.4
  • 11
    • 84901847927 scopus 로고    scopus 로고
    • Role of guidelines on length of therapy in chorioamnionitis and neonatal sepsis
    • Kiser, C, Nawab U, McKenna K, Aghai ZH. 2014. Role of guidelines on length of therapy in chorioamnionitis and neonatal sepsis. Pediatrics 133:992–998. https://doi.org/10.1542/peds.2013-2927.
    • (2014) Pediatrics , vol.133 , pp. 992-998
    • Kiser, C.1    Nawab, U.2    McKenna, K.3    Aghai, Z.H.4
  • 12
    • 84870178758 scopus 로고    scopus 로고
    • Principles and strategies of antimicrobial stewardship in the neonatal intensive care unit
    • Patel, SJ, Saiman L. 2012. Principles and strategies of antimicrobial stewardship in the neonatal intensive care unit. Semin Perinatol 36: 431–436. https://doi.org/10.1053/j.semperi.2012.06.005.
    • (2012) Semin Perinatol , vol.36 , pp. 431-436
    • Patel, S.J.1    Saiman, L.2
  • 13
    • 84891418810 scopus 로고    scopus 로고
    • Deaths: Leading causes for 2010
    • Heron, M. 2013. Deaths: leading causes for 2010. Natl, Vital Stat Rep 62(6):1–97.
    • (2013) Natl, Vital Stat Rep , vol.62 , Issue.6 , pp. 1-97
    • Heron, M.1
  • 14
    • 84906089611 scopus 로고    scopus 로고
    • Preterm labor: One syndrome, many causes
    • Romero, R, Dey SK, Fisher SJ. 2014. Preterm labor: one syndrome, many causes. Science 345:760–765. https://doi.org/10.1126/science.1251816.
    • (2014) Science , vol.345 , pp. 760-765
    • Romero, R.1    Dey, S.K.2    Fisher, S.J.3
  • 15
    • 84919708457 scopus 로고    scopus 로고
    • Preterm birth, intrauterine infection, and fetal inflammation
    • Kemp, MW. 2014. Preterm birth, intrauterine infection, and fetal inflammation. Front Immunol 5:574. https://doi.org/10.3389/fimmu.2014.00574.
    • (2014) Front Immunol , vol.5 , pp. 574
    • Kemp, M.W.1
  • 16
    • 84919336798 scopus 로고    scopus 로고
    • Exploring preterm birth as a polymicrobial disease: An overview of the uterine microbiome
    • Payne, MS, Bayatibojakhi S. 2014. Exploring preterm birth as a polymicrobial disease: an overview of the uterine microbiome. Front Immunol 5:595. https://doi.org/10.3389/fimmu.2014.00595.
    • (2014) Front Immunol , vol.5 , pp. 595
    • Payne, M.S.1    Bayatibojakhi, S.2
  • 17
    • 84876911641 scopus 로고    scopus 로고
    • Diversity of intestinal microbiota in infancy and the risk of allergic disease in childhood
    • Storro, O, Avershina E, Rudi K. 2013. Diversity of intestinal microbiota in infancy and the risk of allergic disease in childhood. Curr Opin Allergy Clin Immunol 13:257–262. https://doi.org/10.1097/ACI.0b013e328360968b.
    • (2013) Curr Opin Allergy Clin Immunol , vol.13 , pp. 257-262
    • Storro, O.1    Avershina, E.2    Rudi, K.3
  • 18
    • 84927741191 scopus 로고    scopus 로고
    • Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life
    • Saari, A, Virta LJ, Sankilampi U, Dunkel L, Saxen H. 2015. Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life. Pediatrics 135:617–626. https://doi.org/10.1542/peds.2014-3407.
    • (2015) Pediatrics , vol.135 , pp. 617-626
    • Saari, A.1    Virta, L.J.2    Sankilampi, U.3    Dunkel, L.4    Saxen, H.5
  • 19
    • 84863406072 scopus 로고    scopus 로고
    • Antibiotic use and misuse in the neonatal intensive care unit
    • Tripathi, N, Cotten CM, Smith PB. 2012. Antibiotic use and misuse in the neonatal intensive care unit. Clin Perinatol 39:61–68. https://doi.org/10.1016/j.clp.2011.12.003.
    • (2012) Clin Perinatol , vol.39 , pp. 61-68
    • Tripathi, N.1    Cotten, C.M.2    Smith, P.B.3
  • 20
    • 74049160280 scopus 로고    scopus 로고
    • Antibiotic use in neonatal intensive care units and adherence with Centers for Disease Control and Prevention 12 Step Campaign To Prevent Antimicrobial Resistance
    • Patel, SJ, Oshodi A, Prasad P, Delamora P, Larson E, Zaoutis T, Paul DA, Saiman L. 2009. Antibiotic use in neonatal intensive care units and adherence with Centers for Disease Control and Prevention 12 Step Campaign To Prevent Antimicrobial Resistance. Pediatr Infect Dis J 28:1047–1051. https://doi.org/10.1097/INF.0b013e3181b12484.
    • (2009) Pediatr Infect Dis J , vol.28 , pp. 1047-1051
    • Patel, S.J.1    Oshodi, A.2    Prasad, P.3    Delamora, P.4    Larson, E.5    Zaoutis, T.6    Paul, D.A.7    Saiman, L.8
  • 21
    • 78649605964 scopus 로고    scopus 로고
    • Prevention of perinatal group B streptococcal disease—revised guidelines from CDC, 2010
    • Verani, JR, McGee L, Schrag SJ. 2010. Prevention of perinatal group B streptococcal disease—revised guidelines from CDC, 2010. MMWR Recommend Rep 59:1–36.
    • (2010) MMWR Recommend Rep , vol.59 , pp. 1-36
    • Verani, J.R.1    McGee, L.2    Schrag, S.J.3
  • 22
    • 84900345067 scopus 로고    scopus 로고
    • The perpetual challenge of antimicrobial resistance
    • Fauci, AS, Marston HD. 2014. The perpetual challenge of antimicrobial resistance. JAMA 311:1853–1854. https://doi.org/10.1001/jama.2014.2465.
    • (2014) JAMA , vol.311 , pp. 1853-1854
    • Fauci, A.S.1    Marston, H.D.2
  • 23
    • 84926291696 scopus 로고    scopus 로고
    • The antibiotic resistance crisis. Part 1: Causes and threats
    • Ventola, CL. 2015. The antibiotic resistance crisis. Part 1: causes and threats. P T 40:277–283.
    • (2015) P T , vol.40 , pp. 277-283
    • Ventola, C.L.1
  • 24
    • 84903383222 scopus 로고    scopus 로고
    • Early empiric antibiotic use in preterm infants is associated with lower bacterial diversity and higher relative abundance of Enterobacter
    • Greenwood, C, Morrow AL, Lagomarcino AJ, Altaye M, Taft DH, Yu Z, Newburg DS, Ward DV, Schibler KR. 2014. Early empiric antibiotic use in preterm infants is associated with lower bacterial diversity and higher relative abundance of Enterobacter. J Pediatr 165:23–29. https://doi.org/10.1016/j.jpeds.2014.01.010.
    • (2014) J Pediatr , vol.165 , pp. 23-29
    • Greenwood, C.1    Morrow, A.L.2    Lagomarcino, A.J.3    Altaye, M.4    Taft, D.H.5    Yu, Z.6    Newburg, D.S.7    Ward, D.V.8    Schibler, K.R.9
  • 25
    • 0025065285 scopus 로고
    • Predicting bacteremia in hospitalized patients. A prospectively validated model
    • Bates, DW, Cook EF, Goldman L, Lee TH. 1990. Predicting bacteremia in hospitalized patients. A prospectively validated model. Ann Intern Med 113:495–500. https://doi.org/10.7326/0003-4819-113-7-495.
    • (1990) Ann Intern Med , vol.113 , pp. 495-500
    • Bates, D.W.1    Cook, E.F.2    Goldman, L.3    Lee, T.H.4
  • 28
    • 84969640965 scopus 로고    scopus 로고
    • Early identification and treatment of pathogens in sepsis
    • Riedel, S, Carroll KC. 2016. Early identification and treatment of pathogens in sepsis. Clin Chest Med 37:191–207. https://doi.org/10.1016/j.ccm.2016.01.018.
    • (2016) Clin Chest Med , vol.37 , pp. 191-207
    • Riedel, S.1    Carroll, K.C.2
  • 29
    • 84881483939 scopus 로고    scopus 로고
    • Laboratory detection of sepsis
    • Riedel, S, Carroll KC. 2013. Laboratory detection of sepsis. Clin Lab Med 33:413–437. https://doi.org/10.1016/j.cll.2013.03.006.
    • (2013) Clin Lab Med , vol.33 , pp. 413-437
    • Riedel, S.1    Carroll, K.C.2
  • 31
    • 0037910174 scopus 로고    scopus 로고
    • Utility of complete blood count and blood culture screening to diagnose neonatal sepsis in the asymptomatic at risk newborn
    • Ottolini, MC, Lundgren K, Mirkinson LJ, Cason S, Ottolini MG. 2003. Utility of complete blood count and blood culture screening to diagnose neonatal sepsis in the asymptomatic at risk newborn. Pediatr Infect Dis J 22:430–434. https://doi.org/10.1097/00006454-200305000-00008.
    • (2003) Pediatr Infect Dis J , vol.22 , pp. 430-434
    • Ottolini, M.C.1    Lundgren, K.2    Mirkinson, L.J.3    Cason, S.4    Ottolini, M.G.5
  • 33
    • 77950663673 scopus 로고    scopus 로고
    • New approaches to preventing, diagnosing, and treating neonatal sepsis
    • Edmond, K, Zaidi A. 2010. New approaches to preventing, diagnosing, and treating neonatal sepsis. PLoS Med 7:e1000213. https://doi.org/10.1371/journal.pmed.1000213.
    • (2010) Plos Med , vol.7
    • Edmond, K.1    Zaidi, A.2
  • 34
    • 58949084204 scopus 로고    scopus 로고
    • Neonatal sepsis: A major global public health challenge
    • Qazi, SA, Stoll BJ. 2009. Neonatal sepsis: a major global public health challenge. Pediatr Infect Dis J 28:S1–S2. https://doi.org/10.1097/INF.0b013e31819587a9.
    • (2009) Pediatr Infect Dis J , vol.28 , pp. S1-S2
    • Qazi, S.A.1    Stoll, B.J.2
  • 36
    • 0032911760 scopus 로고    scopus 로고
    • Inadequate antimicrobial treatment of infections: A risk factor for hospital mortality among critically ill patients
    • Kollef, MH, Sherman G, Ward S, Fraser VJ. 1999. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest 115:462–474. https://doi.org/10.1378/chest.115.2.462.
    • (1999) Chest , vol.115 , pp. 462-474
    • Kollef, M.H.1    Sherman, G.2    Ward, S.3    Fraser, V.J.4
  • 38
    • 0038555339 scopus 로고    scopus 로고
    • Communityacquired bloodstream infection in critically ill adult patients: Impact of shock and inappropriate antibiotic therapy on survival
    • Valles, J, Rello J, Ochagavia A, Garnacho J, Alcala MA. 2003. Communityacquired bloodstream infection in critically ill adult patients: impact of shock and inappropriate antibiotic therapy on survival. Chest 123: 1615–1624. https://doi.org/10.1378/chest.123.5.1615.
    • (2003) Chest , vol.123 , pp. 1615-1624
    • Valles, J.1    Rello, J.2    Ochagavia, A.3    Garnacho, J.4    Alcala, M.A.5
  • 41
    • 85030698960 scopus 로고    scopus 로고
    • Antibiotics for sepsis: Does each hour really count, or is it incestuous amplification?
    • Singer, M. 2017. Antibiotics for sepsis: does each hour really count, or is it incestuous amplification? Am J Respir Crit Care Med 196:800–802. https://doi.org/10.1164/rccm.201703-0621ED.
    • (2017) Am J Respir Crit Care Med , vol.196 , pp. 800-802
    • Singer, M.1
  • 42
    • 77953492400 scopus 로고    scopus 로고
    • Adjunct laboratory tests in the diagnosis of earlyonset neonatal sepsis
    • Benitz, WE. 2010. Adjunct laboratory tests in the diagnosis of earlyonset neonatal sepsis. Clin Perinatol 37:421–438. https://doi.org/10.1016/j.clp.2009.12.001.
    • (2010) Clin Perinatol , vol.37 , pp. 421-438
    • Benitz, W.E.1
  • 44
    • 33845910922 scopus 로고    scopus 로고
    • Lab-on-a-chip devices for global health: Past studies and future opportunities
    • Chin, CD, Linder V, Sia SK. 2007. Lab-on-a-chip devices for global health: past studies and future opportunities. Lab Chip 7:41–57. https://doi.org/10.1039/B611455E.
    • (2007) Lab Chip , vol.7 , pp. 41-57
    • Chin, C.D.1    Linder, V.2    Sia, S.K.3
  • 45
    • 0020768386 scopus 로고
    • The importance of volume of blood cultured in the detection of bacteremia and fungemia
    • Ilstrup, DM, Washington JA, II. 1983. The importance of volume of blood cultured in the detection of bacteremia and fungemia. Diagn Microbiol Infect Dis 1:107–110. https://doi.org/10.1016/0732-8893(83)90039-1.
    • (1983) Diagn Microbiol Infect Dis , vol.1 , pp. 107-110
    • Ilstrup, D.M.1    Washington, J.A.2
  • 46
    • 34248229209 scopus 로고    scopus 로고
    • How reliable is a negative blood culture result? Volume of blood submitted for culture in routine practice in a children’s hospital
    • Connell, TG, Rele M, Cowley D, Buttery JP, Curtis N. 2007. How reliable is a negative blood culture result? Volume of blood submitted for culture in routine practice in a children’s hospital. Pediatrics 119: 891–896. https://doi.org/10.1542/peds.2006-0440.
    • (2007) Pediatrics , vol.119 , pp. 891-896
    • Connell, T.G.1    Rele, M.2    Cowley, D.3    Buttery, J.P.4    Curtis, N.5
  • 47
    • 0027381788 scopus 로고
    • Detection of bacteremia in adults: Consequences of culturing an inadequate volume of blood
    • Mermel, LA, Maki DG. 1993. Detection of bacteremia in adults: consequences of culturing an inadequate volume of blood. Ann Intern Med 119:270–272. https://doi.org/10.7326/0003-4819-119-4-199308150-00003.
    • (1993) Ann Intern Med , vol.119 , pp. 270-272
    • Mermel, L.A.1    Maki, D.G.2
  • 50
    • 77956615417 scopus 로고    scopus 로고
    • Robert, Koch and the “golden age” of bacteriology
    • Blevins, SM, Bronze MS. 2010. Robert, Koch and the “golden age” of bacteriology. Int J Infect Dis 14:e744–e751. https://doi.org/10.1016/j.ijid.2009.12.003.
    • (2010) Int J Infect Dis , vol.14 , pp. e744-e751
    • Blevins, S.M.1    Bronze, M.S.2
  • 51
    • 30744432674 scopus 로고    scopus 로고
    • Utility of extended blood culture incubation for isolation of Haemophilus, Actinobacillus, Cardiobacterium, Eikenella, and Kingella organisms: A retrospective multicenter evaluation
    • Petti, CA, Bhally HS, Weinstein MP, Joho K, Wakefield T, Reller LB, Carroll KC. 2006. Utility of extended blood culture incubation for isolation of Haemophilus, Actinobacillus, Cardiobacterium, Eikenella, and Kingella organisms: a retrospective multicenter evaluation. J Clin Microbiol 44:257–259. https://doi.org/10.1128/JCM.44.1.257-259.2006.
    • (2006) J Clin Microbiol , vol.44 , pp. 257-259
    • Petti, C.A.1    Bhally, H.S.2    Weinstein, M.P.3    Joho, K.4    Wakefield, T.5    Reller, L.B.6    Carroll, K.C.7
  • 52
    • 28044453500 scopus 로고    scopus 로고
    • Prolonged incubation and extensive subculturing do not increase recovery of clinically significant microorganisms from standard automated blood cultures
    • Baron, EJ, Scott JD, Tompkins LS. 2005. Prolonged incubation and extensive subculturing do not increase recovery of clinically significant microorganisms from standard automated blood cultures. Clin Infect Dis 41:1677–1680. https://doi.org/10.1086/497595.
    • (2005) Clin Infect Dis , vol.41 , pp. 1677-1680
    • Baron, E.J.1    Scott, J.D.2    Tompkins, L.S.3
  • 53
    • 0018899472 scopus 로고
    • Gram-negative bacteremia. III. Reassessment of etiology, epidemiology and ecology in 612 patients
    • Kreger, BE, Craven DE, Carling PC, McCabe WR. 1980. Gram-negative bacteremia. III. Reassessment of etiology, epidemiology and ecology in 612 patients. Am J Med 68:332–343. https://doi.org/10.1016/0002-9343(80)90101-1.
    • (1980) Am J Med , vol.68 , pp. 332-343
    • Kreger, B.E.1    Craven, D.E.2    Carling, P.C.3    McCabe, W.R.4
  • 55
    • 84928542891 scopus 로고    scopus 로고
    • Microbial diagnosis of bloodstream infection: Towards molecular diagnosis directly from blood
    • Opota, O, Jaton K, Greub G. 2015. Microbial diagnosis of bloodstream infection: towards molecular diagnosis directly from blood. Clin Microbiol Infect 21:323–331. https://doi.org/10.1016/j.cmi.2015.02.005.
    • (2015) Clin Microbiol Infect , vol.21 , pp. 323-331
    • Opota, O.1    Jaton, K.2    Greub, G.3
  • 61
    • 84946487215 scopus 로고    scopus 로고
    • Multidisciplinary team review of best practices for collection and handling of blood cultures to determine effective interventions for increasing the yield of true-positive bacteremias, reducing contamination, and eliminating false-positive central line-a
    • Garcia, RA, Spitzer ED, Beaudry J, Beck C, Diblasi R, Gilleeny-Blabac M, Haugaard C, Heuschneider S, Kranz BP, McLean K, Morales KL, Owens S, Paciella ME, Torregrosa E. 2015. Multidisciplinary team review of best practices for collection and handling of blood cultures to determine effective interventions for increasing the yield of true-positive bacteremias, reducing contamination, and eliminating false-positive central line-a. Am J Infect Control 43:1222–1237. https://doi.org/10.1016/j.ajic.2015.06.030.
    • (2015) Am J Infect Control , vol.43 , pp. 1222-1237
    • Garcia, R.A.1    Spitzer, E.D.2    Beaudry, J.3    Beck, C.4    Diblasi, R.5    Gilleeny-Blabac, M.6    Haugaard, C.7    Heuschneider, S.8    Kranz, B.P.9    McLean, K.10    Morales, K.L.11    Owens, S.12    Paciella, M.E.13    Torregrosa, E.14
  • 63
    • 0016159011 scopus 로고
    • Neonatal, Escherichia coli septicemia—bacterial counts in blood
    • Dietzman, DE, Fischer GW, Schoenknecht FD. 1974. Neonatal, Escherichia coli septicemia—bacterial counts in blood. J Pediatr 85:128–130. https://doi.org/10.1016/S0022-3476(74)80308-2.
    • (1974) J Pediatr , vol.85 , pp. 128-130
    • Dietzman, D.E.1    Fischer, G.W.2    Schoenknecht, F.D.3
  • 64
    • 34848832884 scopus 로고    scopus 로고
    • Molecular diagnosis of bloodstream infections caused by non-cultivable bacteria
    • Fenollar, F, Raoult D. 2007. Molecular diagnosis of bloodstream infections caused by non-cultivable bacteria. Int J Antimicrob Agents 30: 7–15. https://doi.org/10.1016/j.ijantimicag.2007.06.024.
    • (2007) Int J Antimicrob Agents , vol.30 , pp. 7-15
    • Fenollar, F.1    Raoult, D.2
  • 65
    • 78149410103 scopus 로고    scopus 로고
    • Blood cultures: Key elements for best practices and future directions
    • Riedel, S, Carroll KC. 2010. Blood cultures: key elements for best practices and future directions. J Infect Chemother 16:301–316. https://doi.org/10.1007/s10156-010-0069-1.
    • (2010) J Infect Chemother , vol.16 , pp. 301-316
    • Riedel, S.1    Carroll, K.C.2
  • 68
    • 59449084598 scopus 로고    scopus 로고
    • Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants
    • Cotten, CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, Sanchez PJ, Ambalavanan N, Benjamin DK, Jr. 2009. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics 123:58–66. https://doi.org/10.1542/peds.2007-3423.
    • (2009) Pediatrics , vol.123 , pp. 58-66
    • Cotten, C.M.1    Taylor, S.2    Stoll, B.3    Goldberg, R.N.4    Hansen, N.I.5    Sanchez, P.J.6    Ambalavanan, N.7    Benjamin, D.K.8
  • 69
    • 79952756960 scopus 로고    scopus 로고
    • Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
    • Dethlefsen, L, Relman DA. 2011. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc Natl Acad Sci U S A 108(Suppl):4554–4561. https://doi.org/10.1073/pnas.1000087107.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4554-4561
    • Dethlefsen, L.1    Relman, D.A.2
  • 70
    • 26044457657 scopus 로고    scopus 로고
    • Trends in blood culture contamination: A College of American Pathologists Q-Tracks study of 356 institutions
    • Bekeris, LG, Tworek JA, Walsh MK, Valenstein PN. 2005. Trends in blood culture contamination: a College of American Pathologists Q-Tracks study of 356 institutions. Arch Pathol Lab Med 129:1222–1225.
    • (2005) Arch Pathol Lab Med , vol.129 , pp. 1222-1225
    • Bekeris, L.G.1    Tworek, J.A.2    Walsh, M.K.3    Valenstein, P.N.4
  • 71
    • 33947501931 scopus 로고    scopus 로고
    • Analysis of strategies to improve cost effectiveness of blood cultures
    • Zwang, O, Albert RK. 2006. Analysis of strategies to improve cost effectiveness of blood cultures. J Hosp Med 1:272–276. https://doi.org/10.1002/jhm.115.
    • (2006) J Hosp Med , vol.1 , pp. 272-276
    • Zwang, O.1    Albert, R.K.2
  • 73
    • 0034023346 scopus 로고    scopus 로고
    • Resource utilization and contaminated blood cultures in children at risk for occult bacteremia
    • Segal, GS, Chamberlain JM. 2000. Resource utilization and contaminated blood cultures in children at risk for occult bacteremia. Arch Pediatr Adolesc Med 154:469–473. https://doi.org/10.1001/archpedi.154.5.469.
    • (2000) Arch Pediatr Adolesc Med , vol.154 , pp. 469-473
    • Segal, G.S.1    Chamberlain, J.M.2
  • 74
    • 0343742646 scopus 로고    scopus 로고
    • Impact of a false positive blood culture result on the management of febrile children
    • Thuler, LC, Jenicek M, Turgeon JP, Rivard M, Lebel P, Lebel MH. 1997. Impact of a false positive blood culture result on the management of febrile children. Pediatr Infect Dis J 16:846–851. https://doi.org/10.1097/00006454-199709000-00006.
    • (1997) Pediatr Infect Dis J , vol.16 , pp. 846-851
    • Thuler, L.C.1    Jenicek, M.2    Turgeon, J.P.3    Rivard, M.4    Lebel, P.5    Lebel, M.H.6
  • 75
    • 65249123059 scopus 로고    scopus 로고
    • Impact of blood cultures drawn by phlebotomy on contamination rates and health care costs in a hospital emergency department
    • Gander, RM, Byrd L, DeCrescenzo M, Hirany S, Bowen M, Baughman J. 2009. Impact of blood cultures drawn by phlebotomy on contamination rates and health care costs in a hospital emergency department. J Clin Microbiol 47:1021–1024. https://doi.org/10.1128/JCM.02162-08.
    • (2009) J Clin Microbiol , vol.47 , pp. 1021-1024
    • Gander, R.M.1    Byrd, L.2    Decrescenzo, M.3    Hirany, S.4    Bowen, M.5    Baughman, J.6
  • 79
    • 33748791771 scopus 로고    scopus 로고
    • Peptide nucleic acid fluorescence in situ hybridization-based identification of Candida albicans and its impact on mortality and antifungal therapy costs
    • Forrest, GN, Mankes K, Jabra-Rizk MA, Weekes E, Johnson JK, Lincalis DP, Venezia RA. 2006. Peptide nucleic acid fluorescence in situ hybridization-based identification of Candida albicans and its impact on mortality and antifungal therapy costs. J Clin Microbiol 44: 3381–3383. https://doi.org/10.1128/JCM.00751-06.
    • (2006) J Clin Microbiol , vol.44 , pp. 3381-3383
    • Forrest, G.N.1    Mankes, K.2    Jabra-Rizk, M.A.3    Weekes, E.4    Johnson, J.K.5    Lincalis, D.P.6    Venezia, R.A.7
  • 80
    • 0031468374 scopus 로고    scopus 로고
    • The impact of blood culture reporting and clinical liaison on the empiric treatment of bacteraemia
    • Cunney, RJ, McNamara EB, Alansari N, Loo B, Smyth EG. 1997. The impact of blood culture reporting and clinical liaison on the empiric treatment of bacteraemia. J Clin Pathol 50:1010–1012. https://doi.org/10.1136/jcp.50.12.1010.
    • (1997) J Clin Pathol , vol.50 , pp. 1010-1012
    • Cunney, R.J.1    McNamara, E.B.2    Alansari, N.3    Loo, B.4    Smyth, E.G.5
  • 81
    • 0141922804 scopus 로고    scopus 로고
    • Excess length of stay, charges, and mortality attributable to medical injuries during hospitalization
    • Zhan, C, Miller MR. 2003. Excess length of stay, charges, and mortality attributable to medical injuries during hospitalization. JAMA 290: 1868–1874. https://doi.org/10.1001/jama.290.14.1868.
    • (2003) JAMA , vol.290 , pp. 1868-1874
    • Zhan, C.1    Miller, M.R.2
  • 83
    • 33750054112 scopus 로고    scopus 로고
    • Updated review of blood culture contamination
    • Hall, KK, Lyman JA. 2006. Updated review of blood culture contamination. Clin Microbiol Rev 19:788–802. https://doi.org/10.1128/CMR.00062-05.
    • (2006) Clin Microbiol Rev , vol.19 , pp. 788-802
    • Hall, K.K.1    Lyman, J.A.2
  • 85
    • 0035209350 scopus 로고    scopus 로고
    • Evaluation of BacT/ALERT system for detection of Mycoplasma hominis in simulated blood cultures
    • Waites, KB, Canupp KC. 2001. Evaluation of BacT/ALERT system for detection of Mycoplasma hominis in simulated blood cultures. J Clin Microbiol 39:4328–4331. https://doi.org/10.1128/JCM.39.12.4328-4331.2001.
    • (2001) J Clin Microbiol , vol.39 , pp. 4328-4331
    • Waites, K.B.1    Canupp, K.C.2
  • 88
    • 84928566410 scopus 로고    scopus 로고
    • Blood culture-based diagnosis of bacteraemia: State of the art
    • Opota, O, Croxatto A, Prod’hom G, Greub G. 2015. Blood culture-based diagnosis of bacteraemia: state of the art. Clin Microbiol Infect 21: 313–322. https://doi.org/10.1016/j.cmi.2015.01.003.
    • (2015) Clin Microbiol Infect , vol.21 , pp. 313-322
    • Opota, O.1    Croxatto, A.2    Prod’Hom, G.3    Greub, G.4
  • 89
    • 84904010926 scopus 로고    scopus 로고
    • Emerging technologies for rapid identification of bloodstream pathogens
    • Kothari, A, Morgan M, Haake DA. 2014. Emerging technologies for rapid identification of bloodstream pathogens. Clin Infect Dis 59:272–278. https://doi.org/10.1093/cid/ciu292.
    • (2014) Clin Infect Dis , vol.59 , pp. 272-278
    • Kothari, A.1    Morgan, M.2    Haake, D.A.3
  • 90
    • 84861657004 scopus 로고    scopus 로고
    • Bench-to-bedside review: Rapid molecular diagnostics for bloodstream infection—a new frontier?
    • Afshari, A, Schrenzel J, Ieven M, Harbarth S. 2012. Bench-to-bedside review: rapid molecular diagnostics for bloodstream infection—a new frontier? Crit Care 16:222. https://doi.org/10.1186/cc11202.
    • (2012) Crit Care , vol.16 , pp. 222
    • Afshari, A.1    Schrenzel, J.2    Ieven, M.3    Harbarth, S.4
  • 94
    • 84991224772 scopus 로고    scopus 로고
    • Broad-range PCR coupled with electrospray ionization time of flight mass spectrometry for detection of bacteremia and fungemia in patients with neutropenic fever
    • Desmet, S, Maertens J, Bueselinck K, Lagrou K. 2016. Broad-range PCR coupled with electrospray ionization time of flight mass spectrometry for detection of bacteremia and fungemia in patients with neutropenic fever. J Clin Microbiol 54:2513–2520. https://doi.org/10.1128/JCM.01066-16.
    • (2016) J Clin Microbiol , vol.54 , pp. 2513-2520
    • Desmet, S.1    Maertens, J.2    Bueselinck, K.3    Lagrou, K.4
  • 96
    • 84970004033 scopus 로고    scopus 로고
    • Diagnosis of bloodstream infections in children
    • Dien, Bard J, McElvania TeKippe E. 2016. Diagnosis of bloodstream infections in children. J Clin Microbiol 54:e02919-15. https://doi.org/10.1128/JCM.02919-15.
    • (2016) J Clin Microbiol , vol.54 , pp. e02915-e02919
    • Dien, B.J.1    McElvania Tekippe, E.2
  • 97
    • 84976634202 scopus 로고    scopus 로고
    • Sepsis: The LightCycler SeptiFast Test MGRADE, SepsiTest and IRIDICA BAC BSI assay for rapidly identifying bloodstream bacteria and fungi—a systematic review and economic evaluation
    • Stevenson, M, Pandor A, James M-S, Rafia R, Uttley L, Stevens J, Sanderson J, Wong R, Perkins GD, McMullan R. 2016. Sepsis: the LightCycler SeptiFast Test MGRADE, SepsiTest and IRIDICA BAC BSI assay for rapidly identifying bloodstream bacteria and fungi—a systematic review and economic evaluation. Health Technol Assess 20:1–246. https://doi.org/10.3310/hta20460.
    • (2016) Health Technol Assess , vol.20 , pp. 1-246
    • Stevenson, M.1    Pandor, A.2    James, M.-S.3    Rafia, R.4    Uttley, L.5    Stevens, J.6    Sanderson, J.7    Wong, R.8    Perkins, G.D.9    McMullan, R.10
  • 99
    • 42249084460 scopus 로고    scopus 로고
    • A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples
    • Lehmann, LE, Hunfeld K-P, Emrich T, Haberhausen G, Wissing H, Hoeft A, Stüber F. 2008. A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples. Med Microbiol Immunol 197:313–324. https://doi.org/10.1007/s00430-007-0063-0.
    • (2008) Med Microbiol Immunol , vol.197 , pp. 313-324
    • Lehmann, L.E.1    Hunfeld, K.-P.2    Emrich, T.3    Haberhausen, G.4    Wissing, H.5    Hoeft, A.6    Stüber, F.7
  • 100
    • 79957533179 scopus 로고    scopus 로고
    • Multiplex, PCR allows rapid and accurate diagnosis of bloodstream infections in newborns and children with suspected sepsis
    • Lucignano, B, Ranno S, Liesenfeld O, Pizzorno B, Putignani L, Bernaschi P, Menichella D. 2011. Multiplex, PCR allows rapid and accurate diagnosis of bloodstream infections in newborns and children with suspected sepsis. J Clin Microbiol 49:2252–2258. https://doi.org/10.1128/JCM.02460-10.
    • (2011) J Clin Microbiol , vol.49 , pp. 2252-2258
    • Lucignano, B.1    Ranno, S.2    Liesenfeld, O.3    Pizzorno, B.4    Putignani, L.5    Bernaschi, P.6    Menichella, D.7
  • 101
    • 84918509755 scopus 로고    scopus 로고
    • Accuracy of LightCycler SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: A systematic review and meta-analysis
    • Dark, P, Blackwood B, Gates S, McAuley D, Perkins GD, McMullan R, Wilson C, Graham D, Timms K, Warhurst G. 2015. Accuracy of LightCycler SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis. Intensive Care Med 41:21–33. https://doi.org/10.1007/s00134-014-3553-8.
    • (2015) Intensive Care Med , vol.41 , pp. 21-33
    • Dark, P.1    Blackwood, B.2    Gates, S.3    McAuley, D.4    Perkins, G.D.5    McMullan, R.6    Wilson, C.7    Graham, D.8    Timms, K.9    Warhurst, G.10
  • 102
    • 84878434234 scopus 로고    scopus 로고
    • Multiplex, PCR system for rapid detection of pathogens in patients with presumed sepsis—a systemic review and meta-analysis
    • Chang, S-S, Hsieh W-H, Liu T-S, Lee S-H, Wang C-H, Chou H-C, Yeo YH, Tseng C-P, Lee C-C. 2013. Multiplex, PCR system for rapid detection of pathogens in patients with presumed sepsis—a systemic review and meta-analysis. PLoS One 8:e62323. https://doi.org/10.1371/journal.pone.0062323.
    • (2013) Plos One , vol.8
    • Chang, S.-S.1    Hsieh, W.-H.2    Liu, T.-S.3    Lee, S.-H.4    Wang, C.-H.5    Chou, H.-C.6    Yeo, Y.H.7    Tseng, C.-P.8    Lee, C.-C.9
  • 103
    • 42949089382 scopus 로고    scopus 로고
    • Multiplex polymerase chain reaction detection enhancement of bacteremia and fungemia
    • Louie, RF, Tang Z, Albertson TE, Cohen S, Tran NK, Kost GJ. 2008. Multiplex polymerase chain reaction detection enhancement of bacteremia and fungemia. Crit Care Med 36:1487–1492. https://doi.org/10.1097/CCM.0b013e31816f487c.
    • (2008) Crit Care Med , vol.36 , pp. 1487-1492
    • Louie, R.F.1    Tang, Z.2    Albertson, T.E.3    Cohen, S.4    Tran, N.K.5    Kost, G.J.6
  • 105
    • 53749097248 scopus 로고    scopus 로고
    • LightCycler SeptiFast assay as a tool for the rapid diagnosis of sepsis in patients during antimicrobial therapy
    • Vince, A, Lepej SŽ, Baršic´ B, Dušek D, Mitrovic´ Z, Serventi-Seiwerth R, Labar B. 2008. LightCycler SeptiFast assay as a tool for the rapid diagnosis of sepsis in patients during antimicrobial therapy. J Med Microbiol 57:1306–1307. https://doi.org/10.1099/jmm.0.47797-0.
    • (2008) J Med Microbiol , vol.57 , pp. 1306-1307
    • Vince, A.1    Lepej, S.Ž.2    Baršic´, B.3    Dušek, D.4    Mitrovic´, Z.5    Serventi-Seiwerth, R.6    Labar, B.7
  • 106
    • 70349779856 scopus 로고    scopus 로고
    • Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis
    • Dierkes, C, Ehrenstein B, Siebig S, Linde H-J, Reischl U, Salzberger B. 2009. Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis. BMC Infect Dis 9:126. https://doi.org/10.1186/1471-2334-9-126.
    • (2009) BMC Infect Dis , vol.9 , pp. 126
    • Dierkes, C.1    Ehrenstein, B.2    Siebig, S.3    Linde, H.-J.4    Reischl, U.5    Salzberger, B.6
  • 110
    • 77953889323 scopus 로고    scopus 로고
    • Molecular identification of bloodstream pathogens in patients presenting to the emergency department with suspected sepsis
    • Avolio, M, Diamante P, Zamparo S, Modolo ML, Grosso S, Zigante P, Tosoni N, De Rosa R, Stano P, Camporese A. 2010. Molecular identification of bloodstream pathogens in patients presenting to the emergency department with suspected sepsis. Shock 34:27–30. https://doi.org/10.1097/SHK.0b013e3181d49299.
    • (2010) Shock , vol.34 , pp. 27-30
    • Avolio, M.1    Diamante, P.2    Zamparo, S.3    Modolo, M.L.4    Grosso, S.5    Zigante, P.6    Tosoni, N.7    de Rosa, R.8    Stano, P.9    Camporese, A.10
  • 118
  • 119
    • 79954626811 scopus 로고    scopus 로고
    • Diagnostic accuracy and potential clinical value of the LightCycler SeptiFast assay in the management of bloodstream infections occurring in neutropenic and critically ill patients
    • Bravo, D, Blanquer J, Tormo M, Aguilar G, Borrás R, Solano C, Clari MA, Costa E, Muñoz-Cobo B, Argüeso M, Pineda JR, Navarro D. 2011. Diagnostic accuracy and potential clinical value of the LightCycler SeptiFast assay in the management of bloodstream infections occurring in neutropenic and critically ill patients. Int J Infect Dis 15: e326–e331. https://doi.org/10.1016/j.ijid.2011.01.003.
    • (2011) Int J Infect Dis , vol.15 , pp. e326-e331
    • Bravo, D.1    Blanquer, J.2    Tormo, M.3    Aguilar, G.4    Borrás, R.5    Solano, C.6    Clari, M.A.7    Costa, E.8    Muñoz-Cobo, B.9    Argüeso, M.10    Pineda, J.R.11    Navarro, D.12
  • 121
    • 84859821717 scopus 로고    scopus 로고
    • PCR-based rapid sepsis diagnosis effectively guides clinical treatment in patients with new onset of SIRS
    • Lodes, U, Bohmeier B, Lippert H, König B, Meyer F. 2012. PCR-based rapid sepsis diagnosis effectively guides clinical treatment in patients with new onset of SIRS. Langenbecks Arch Surg 397:447–455. https://doi.org/10.1007/s00423-011-0870-z.
    • (2012) Langenbecks Arch Surg , vol.397 , pp. 447-455
    • Lodes, U.1    Bohmeier, B.2    Lippert, H.3    König, B.4    Meyer, F.5
  • 125
    • 84863774641 scopus 로고    scopus 로고
    • Diagnostic utility of LightCycler SeptiFast and procalcitonin assays in the diagnosis of bloodstream infection in immunocompromised patients
    • Mauro, MV, Cavalcanti P, Perugini D, Noto A, Sperlì D, Giraldi C. 2012. Diagnostic utility of LightCycler SeptiFast and procalcitonin assays in the diagnosis of bloodstream infection in immunocompromised patients. Diagn Microbiol Infect Dis 73:308–311. https://doi.org/10.1016/j.diagmicrobio.2012.04.006.
    • (2012) Diagn Microbiol Infect Dis , vol.73 , pp. 308-311
    • Mauro, M.V.1    Cavalcanti, P.2    Perugini, D.3    Noto, A.4    Sperlì, D.5    Giraldi, C.6
  • 127
    • 84862082599 scopus 로고    scopus 로고
    • Multiplex, PCR for rapid and improved diagnosis of bloodstream infections in liver transplant recipients
    • Rath, P-M, Saner F, Paul A, Lehmann N, Steinmann E, Buer J, Steinmann J. 2012. Multiplex, PCR for rapid and improved diagnosis of bloodstream infections in liver transplant recipients. J Clin Microbiol 50:2069–2071. https://doi.org/10.1128/JCM.00745-12.
    • (2012) J Clin Microbiol , vol.50 , pp. 2069-2071
    • Rath, P.-M.1    Saner, F.2    Paul, A.3    Lehmann, N.4    Steinmann, E.5    Buer, J.6    Steinmann, J.7
  • 128
    • 84857034429 scopus 로고    scopus 로고
    • Results and relevance of molecular detection of pathogens by SeptiFast—a retrospective analysis in 75 critically ill children
    • Tschiedel, E, Steinmann J, Buer J, Onnebrink J, Felderhoff-Müser U, Rath P-M, Dohna-Schwake C. 2012. Results and relevance of molecular detection of pathogens by SeptiFast—a retrospective analysis in 75 critically ill children. Klin Padiatr 224:12–16. https://doi.org/10.1055/s-0031-1285878.
    • (2012) Klin Padiatr , vol.224 , pp. 12-16
    • Tschiedel, E.1    Steinmann, J.2    Buer, J.3    Onnebrink, J.4    Felderhoff-Müser, U.5    Rath, P.-M.6    Dohna-Schwake, C.7
  • 129
    • 84904013244 scopus 로고    scopus 로고
    • Diagnostic performance and therapeutic impact of LightCycler SeptiFast assay in patients with suspected sepsis
    • Herne, V, Nelovkov A, Kütt M, Ivanova M. 2013. Diagnostic performance and therapeutic impact of LightCycler SeptiFast assay in patients with suspected sepsis. Eur J Microbiol Immunol (Bp) 3:68–76. https://doi.org/10.1556/EuJMI.3.2013.1.10.
    • (2013) Eur J Microbiol Immunol (Bp) , vol.3 , pp. 68-76
    • Herne, V.1    Nelovkov, A.2    Kütt, M.3    Ivanova, M.4
  • 131
    • 84904674023 scopus 로고    scopus 로고
    • Direct molecular detection of pathogens in blood as specific rule-in diagnostic biomarker in patients with presumed sepsis
    • Avolio, M, Diamante P, Modolo ML, De Rosa R, Stano P, Camporese A. 2014. Direct molecular detection of pathogens in blood as specific rule-in diagnostic biomarker in patients with presumed sepsis. Shock 42:86–92. https://doi.org/10.1097/SHK.0000000000000191.
    • (2014) Shock , vol.42 , pp. 86-92
    • Avolio, M.1    Diamante, P.2    Modolo, M.L.3    de Rosa, R.4    Stano, P.5    Camporese, A.6
  • 134
    • 84938406941 scopus 로고    scopus 로고
    • Added value of multi-pathogen probe-based real-time PCR SeptiFast in the rapid diagnosis of bloodstream infections in patients with bacteraemia
    • Stefani, S, Mongelli G, Romeo MA, Denaro C, Gennaro M, Fraggetta F. 2015. Added value of multi-pathogen probe-based real-time PCR SeptiFast in the rapid diagnosis of bloodstream infections in patients with bacteraemia. J Med Microbiol 64:670–675. https://doi.org/10.1099/jmm.0.000074.
    • (2015) J Med Microbiol , vol.64 , pp. 670-675
    • Stefani, S.1    Mongelli, G.2    Romeo, M.A.3    Denaro, C.4    Gennaro, M.5    Fraggetta, F.6
  • 135
    • 84930402854 scopus 로고    scopus 로고
    • Randomized controlled clinical trial evaluating multiplex polymerase chain reaction for pathogen identification and therapy adaptation in critical care patients with pulmonary or abdominal sepsis
    • Tafelski, S, Nachtigall I, Adam T, Bereswill S, Faust J, Tamarkin A, Trefzer T, Deja M, Idelevich EA, Wernecke K-D, Becker K, Spies C. 2015. Randomized controlled clinical trial evaluating multiplex polymerase chain reaction for pathogen identification and therapy adaptation in critical care patients with pulmonary or abdominal sepsis. J Int Med Res 43:364–377. https://doi.org/10.1177/0300060514561135.
    • (2015) J Int Med Res , vol.43 , pp. 364-377
    • Tafelski, S.1    Nachtigall, I.2    Adam, T.3    Bereswill, S.4    Faust, J.5    Tamarkin, A.6    Trefzer, T.7    Deja, M.8    Idelevich, E.A.9    Wernecke, K.-D.10    Becker, K.11    Spies, C.12
  • 141
    • 84981203565 scopus 로고    scopus 로고
    • Prospective evaluation of SeptiFast multiplex PCR in children with systemic inflammatory response syndrome under antibiotic treatment
    • Gies, F, Tschiedel E, Felderhoff-Müser U, Rath P-M, Steinmann J, Dohna- Schwake C. 2016. Prospective evaluation of SeptiFast multiplex PCR in children with systemic inflammatory response syndrome under antibiotic treatment. BMC Infect Dis 16:378. https://doi.org/10.1186/s12879-016-1722-9.
    • (2016) BMC Infect Dis , vol.16 , pp. 378
    • Gies, F.1    Tschiedel, E.2    Felderhoff-Müser, U.3    Rath, P.-M.4    Steinmann, J.5    Dohna-Schwake, C.6
  • 142
    • 84867157650 scopus 로고    scopus 로고
    • New approaches to sepsis: Molecular diagnostics and biomarkers
    • Reinhart, K, Bauer M, Riedemann NC, Hartog CS. 2012. New approaches to sepsis: molecular diagnostics and biomarkers. Clin Microbiol Rev 25:609–634. https://doi.org/10.1128/CMR.00016-12.
    • (2012) Clin Microbiol Rev , vol.25 , pp. 609-634
    • Reinhart, K.1    Bauer, M.2    Riedemann, N.C.3    Hartog, C.S.4
  • 144
    • 84864080835 scopus 로고    scopus 로고
    • Molecular diagnosis of polymicrobial newborn sepsis by multiplex real-time PCR using a small volume of blood sample
    • Vrioni, G, Daniil I, Drogari-Apiranthitou M, Kimouli M, Papadopoulou M, Tsakris A. 2012. Molecular diagnosis of polymicrobial newborn sepsis by multiplex real-time PCR using a small volume of blood sample. J Med Microbiol 61:1177–1178. https://doi.org/10.1099/jmm.0.037127-0.
    • (2012) J Med Microbiol , vol.61 , pp. 1177-1178
    • Vrioni, G.1    Daniil, I.2    Drogari-Apiranthitou, M.3    Kimouli, M.4    Papadopoulou, M.5    Tsakris, A.6
  • 145
    • 84875823959 scopus 로고    scopus 로고
    • The value of combining blood culture and SeptiFast data for predicting complicated bloodstream infections caused by Gram-positive bacteria or Candida species
    • Fernandez-Cruz A, Marin M, Kestler M, Alcala L, Rodriguez-Creixems M, Bouza E. 2013. The value of combining blood culture and SeptiFast data for predicting complicated bloodstream infections caused by Gram-positive bacteria or Candida species. J Clin Microbiol 51: 1130–1136. https://doi.org/10.1128/JCM.02882-12.
    • (2013) J Clin Microbiol , vol.51 , pp. 1130-1136
    • Fernandez-Cruz, A.1    Marin, M.2    Kestler, M.3    Alcala, L.4    Rodriguez-Creixems, M.5    Bouza, E.6
  • 147
    • 77949275873 scopus 로고    scopus 로고
    • New methods for selective isolation of bacterial DNA from human clinical specimens
    • Horz, H-P, Scheer S, Vianna ME, Conrads G. 2010. New methods for selective isolation of bacterial DNA from human clinical specimens. Anaerobe 16:47–53. https://doi.org/10.1016/j.anaerobe.2009.04.009.
    • (2010) Anaerobe , vol.16 , pp. 47-53
    • Horz, H.-P.1    Scheer, S.2    Vianna, M.E.3    Conrads, G.4
  • 148
    • 71049160836 scopus 로고    scopus 로고
    • Activity and DNA contamination of commercial polymerase chain reaction reagents for the universal 16S rDNA real-time polymerase chain reaction detection of bacterial pathogens in blood
    • Mühl, H, Kochem A-J, Disqué C, Sakka SG. 2010. Activity and DNA contamination of commercial polymerase chain reaction reagents for the universal 16S rDNA real-time polymerase chain reaction detection of bacterial pathogens in blood. Diagn Microbiol Infect Dis 66:41–49. https://doi.org/10.1016/j.diagmicrobio.2008.07.011.
    • (2010) Diagn Microbiol Infect Dis , vol.66 , pp. 41-49
    • Mühl, H.1    Kochem, A.-J.2    Disqué, C.3    Sakka, S.G.4
  • 149
    • 70350706095 scopus 로고    scopus 로고
    • Blood infection diagnosis by 16S rDNA broad-spectrum polymerase chain reaction: The relationship between antibiotic treatment and bacterial DNA load
    • Sakka, SG, Kochem A-J, Disqué C, Wellinghausen N. 2009. Blood infection diagnosis by 16S rDNA broad-spectrum polymerase chain reaction: the relationship between antibiotic treatment and bacterial DNA load. Anesth Analg 109:1707–1708. https://doi.org/10.1213/ANE.0b013e3181b79904.
    • (2009) Anesth Analg , vol.109 , pp. 1707-1708
    • Sakka, S.G.1    Kochem, A.-J.2    Disqué, C.3    Wellinghausen, N.4
  • 150
    • 84899540195 scopus 로고    scopus 로고
    • Biomarkers and molecular analysis to improve bloodstream infection diagnostics in an emergency care unit
    • Loonen, AJM, de Jager CPC, Tosserams J, Kusters R, Hilbink M, Wever PC, van den Brule AJC. 2014. Biomarkers and molecular analysis to improve bloodstream infection diagnostics in an emergency care unit. PLoS One 9:e87315. https://doi.org/10.1371/journal.pone.0087315.
    • (2014) Plos One , vol.9
    • Loonen, A.1    de Jager, C.2    Tosserams, J.3    Kusters, R.4    Hilbink, M.5    Wever, P.C.6    van Den Brule, A.J.C.7
  • 151
    • 79960933948 scopus 로고    scopus 로고
    • Evaluation of commercial universal rRNA gene PCR plus sequencing tests for identification of bacteria and fungi associated with infectious endocarditis
    • Kühn, C, Disqué C, Mühl H, Orszag P, Stiesch M, Haverich A. 2011. Evaluation of commercial universal rRNA gene PCR plus sequencing tests for identification of bacteria and fungi associated with infectious endocarditis. J Clin Microbiol 49:2919–2923. https://doi.org/10.1128/JCM.00830-11.
    • (2011) J Clin Microbiol , vol.49 , pp. 2919-2923
    • Kühn, C.1    Disqué, C.2    Mühl, H.3    Orszag, P.4    Stiesch, M.5    Haverich, A.6
  • 152
    • 69949087599 scopus 로고    scopus 로고
    • Diagnosis of bacteremia in whole-blood samples by use of a commercial universal 16S rRNA gene-based PCR and sequence analysis
    • Wellinghausen, N, Kochem A-J, Disqué C, Mühl H, Gebert S, Winter J, Matten J, Sakka SG. 2009. Diagnosis of bacteremia in whole-blood samples by use of a commercial universal 16S rRNA gene-based PCR and sequence analysis. J Clin Microbiol 47:2759–2765. https://doi.org/10.1128/JCM.00567-09.
    • (2009) J Clin Microbiol , vol.47 , pp. 2759-2765
    • Wellinghausen, N.1    Kochem, A.-J.2    Disqué, C.3    Mühl, H.4    Gebert, S.5    Winter, J.6    Matten, J.7    Sakka, S.G.8
  • 154
    • 84891537167 scopus 로고    scopus 로고
    • Monitoring of patients supported by extracorporeal membrane oxygenation for systemic infections by broadrange rRNA gene PCR amplification and sequence analysis
    • Orszag, P, Disque C, Keim S, Lorenz MG, Wiesner O, Hadem J, Stiesch M, Haverich A, Kuhn C. 2014. Monitoring of patients supported by extracorporeal membrane oxygenation for systemic infections by broadrange rRNA gene PCR amplification and sequence analysis. J Clin Microbiol 52:307–311. https://doi.org/10.1128/JCM.02493-13.
    • (2014) J Clin Microbiol , vol.52 , pp. 307-311
    • Orszag, P.1    Disque, C.2    Keim, S.3    Lorenz, M.G.4    Wiesner, O.5    Hadem, J.6    Stiesch, M.7    Haverich, A.8    Kuhn, C.9
  • 155
    • 84917738306 scopus 로고    scopus 로고
    • The evolution of nanopore sequencing
    • Wang, Y, Yang Q, Wang Z. 2015. The evolution of nanopore sequencing. Front Genet 5:449. https://doi.org/10.3389/fgene.2014.00449.
    • (2015) Front Genet , vol.5 , pp. 449
    • Wang, Y.1    Yang, Q.2    Wang, Z.3
  • 159
    • 85006184217 scopus 로고    scopus 로고
    • Species-level resolution of 16S rRNA gene amplicons sequenced through MinION portable nanopore sequencer
    • Benitez-Paez A, Portune K, Sanz Y. 2016. Species-level resolution of 16S rRNA gene amplicons sequenced through MinION portable nanopore sequencer. Gigascience 5:4. https://doi.org/10.1186/s13742-016-0111-z.
    • (2016) Gigascience , vol.5 , pp. 4
    • Benitez-Paez, A.1    Portune, K.2    Sanz, Y.3
  • 160
    • 85044216891 scopus 로고    scopus 로고
    • A portable system for metagenomic analyses using nanopore-based sequencer and laptop computers can realize rapid on-site determination of bacterial compositions
    • Mitsuhashi, S, Kryukov K, Nakagawa S, Takeuchi JS, Shiraishi Y, Asano K, Imanishi T. 2017. A portable system for metagenomic analyses using nanopore-based sequencer and laptop computers can realize rapid on-site determination of bacterial compositions. bioRxiv https://doi.org/10.1101/101865.
    • (2017) Biorxiv
    • Mitsuhashi, S.1    Kryukov, K.2    Nakagawa, S.3    Takeuchi, J.S.4    Shiraishi, Y.5    Asano, K.6    Imanishi, T.7
  • 162
    • 84924388692 scopus 로고    scopus 로고
    • MinION nanopore sequencing identifies the position and structure of a bacterial antibiotic resistance island
    • Ashton, PM, Nair S, Dallman T, Rubino S, Rabsch W, Mwaigwisya S, Wain J, O’Grady J. 2015. MinION nanopore sequencing identifies the position and structure of a bacterial antibiotic resistance island. Nat Biotechnol 33:296–300. https://doi.org/10.1038/nbt.3103.
    • (2015) Nat Biotechnol , vol.33 , pp. 296-300
    • Ashton, P.M.1    Nair, S.2    Dallman, T.3    Rubino, S.4    Rabsch, W.5    Mwaigwisya, S.6    Wain, J.7    O’Grady, J.8
  • 165
    • 85011899871 scopus 로고    scopus 로고
    • Massively parallel digital high resolution melt for rapid and absolutely quantitative sequence profiling
    • Velez, DO, Mack H, Jupe J, Hawker S, Kulkarni N, Hedayatnia B, Zhang Y, Lawrence S, Fraley SI. 2017. Massively parallel digital high resolution melt for rapid and absolutely quantitative sequence profiling. Sci Rep 7:42326. https://doi.org/10.1038/srep42326.
    • (2017) Sci Rep , vol.7 , pp. 42326
    • Velez, D.O.1    Mack, H.2    Jupe, J.3    Hawker, S.4    Kulkarni, N.5    Hedayatnia, B.6    Zhang, Y.7    Lawrence, S.8    Fraley, S.I.9
  • 166
    • 46949105560 scopus 로고    scopus 로고
    • High resolution melting applications for clinical laboratory medicine
    • Erali, M, Voelkerding KV, Wittwer CT. 2008. High resolution melting applications for clinical laboratory medicine. Exp Mol Pathol 85:50–58. https://doi.org/10.1016/j.yexmp.2008.03.012.
    • (2008) Exp Mol Pathol , vol.85 , pp. 50-58
    • Erali, M.1    Voelkerding, K.V.2    Wittwer, C.T.3
  • 167
    • 0037371570 scopus 로고    scopus 로고
    • Amplicon melting analysis with labeled primers: A closed-tube method for differentiating homozygotes and heterozygotes
    • Gundry, CN, Vandersteen JG, Reed GH, Pryor RJ, Chen J, Wittwer CT. 2003. Amplicon melting analysis with labeled primers: a closed-tube method for differentiating homozygotes and heterozygotes. Clin Chem 49:396–406. https://doi.org/10.1373/49.3.396.
    • (2003) Clin Chem , vol.49 , pp. 396-406
    • Gundry, C.N.1    Vandersteen, J.G.2    Reed, G.H.3    Pryor, R.J.4    Chen, J.5    Wittwer, C.T.6
  • 168
    • 52049113295 scopus 로고    scopus 로고
    • SNP genotyping by unlabeled probe melting analysis
    • Erali, M, Palais R, Wittwer C. 2008. SNP genotyping by unlabeled probe melting analysis. Methods Mol Biol 429:199–206. https://doi.org/10.1007/978-1-60327-040-3_14.
    • (2008) Methods Mol Biol , vol.429 , pp. 199-206
    • Erali, M.1    Palais, R.2    Wittwer, C.3
  • 169
    • 79953313021 scopus 로고    scopus 로고
    • UMELT: Prediction of highresolution melting curves and dynamic melting profiles of PCR products in a rich Web application
    • Dwight, Z, Palais R, Wittwer CT. 2011. uMELT: prediction of highresolution melting curves and dynamic melting profiles of PCR products in a rich Web application. Bioinformatics 27:1019–1020. https://doi.org/10.1093/bioinformatics/btr065.
    • (2011) Bioinformatics , vol.27 , pp. 1019-1020
    • Dwight, Z.1    Palais, R.2    Wittwer, C.T.3
  • 170
    • 84962106981 scopus 로고    scopus 로고
    • The point-ofcare laboratory in clinical microbiology
    • Drancourt, M, Michel-Lepage A, Boyer S, Raoult D. 2016. The point-ofcare laboratory in clinical microbiology. Clin Microbiol Rev 29:429–447. https://doi.org/10.1128/CMR.00090-15.
    • (2016) Clin Microbiol Rev , vol.29 , pp. 429-447
    • Drancourt, M.1    Michel-Lepage, A.2    Boyer, S.3    Raoult, D.4
  • 171
    • 84943545585 scopus 로고    scopus 로고
    • Performance requirements to achieve cost-effectiveness of point-of-care tests for sepsis among patients with febrile illness in low-resource settings
    • Penno, EC, Crump JA, Baird SJ. 2015. Performance requirements to achieve cost-effectiveness of point-of-care tests for sepsis among patients with febrile illness in low-resource settings. Am J Trop Med Hyg 93:841–849. https://doi.org/10.4269/ajtmh.15-0082.
    • (2015) Am J Trop Med Hyg , vol.93 , pp. 841-849
    • Penno, E.C.1    Crump, J.A.2    Baird, S.J.3
  • 172
    • 34248387298 scopus 로고    scopus 로고
    • Analysis of 16S rRNA gene sequences and circulating cell-free DNA from plasma of chronic fatigue syndrome and non-fatigued subjects
    • Vernon, SD, Shukla SK, Conradt J, Unger ER, Reeves WC. 2002. Analysis of 16S rRNA gene sequences and circulating cell-free DNA from plasma of chronic fatigue syndrome and non-fatigued subjects. BMC Microbiol 2:39. https://doi.org/10.1186/1471-2180-2-39.
    • (2002) BMC Microbiol , vol.2 , pp. 39
    • Vernon, S.D.1    Shukla, S.K.2    Conradt, J.3    Unger, E.R.4    Reeves, W.C.5
  • 173
    • 77955266472 scopus 로고    scopus 로고
    • The exclusion of dead bacterial cells is essential for accurate molecular analysis of clinical samples
    • Rogers, GB, Marsh P, Stressmann AF, Allen CE, Daniels TVW, Carroll MP, Bruce KD. 2010. The exclusion of dead bacterial cells is essential for accurate molecular analysis of clinical samples. Clin Microbiol Infect 16:1656–1658. https://doi.org/10.1111/j.1469-0691.2010.03189.x.
    • (2010) Clin Microbiol Infect , vol.16 , pp. 1656-1658
    • Rogers, G.B.1    Marsh, P.2    Stressmann, A.F.3    Allen, C.E.4    Daniels, T.5    Carroll, M.P.6    Bruce, K.D.7
  • 174
    • 85019695817 scopus 로고    scopus 로고
    • Rapid degradation of longer DNA fragments enables the improved estimation of distribution and biomass using environmental DNA
    • Jo, T, Murakami H, Masuda R, Sakata MK, Yamamoto S, Minamoto T. 2017. Rapid degradation of longer DNA fragments enables the improved estimation of distribution and biomass using environmental DNA. Mol Ecol Resour 17:e25–e33. https://doi.org/10.1111/1755-0998.12685.
    • (2017) Mol Ecol Resour , vol.17 , pp. e25-e33
    • Jo, T.1    Murakami, H.2    Masuda, R.3    Sakata, M.K.4    Yamamoto, S.5    Minamoto, T.6
  • 175
    • 84899124239 scopus 로고    scopus 로고
    • Quantitative data from the SeptiFast real-time PCR is associated with disease severity in patients with sepsis
    • Ziegler, I, Josefson P, Olcén P, Mölling P, Strålin K. 2014. Quantitative data from the SeptiFast real-time PCR is associated with disease severity in patients with sepsis. BMC Infect Dis 14:155. https://doi.org/10.1186/1471-2334-14-155.
    • (2014) BMC Infect Dis , vol.14 , pp. 155
    • Ziegler, I.1    Josefson, P.2    Olcén, P.3    Mölling, P.4    Strålin, K.5
  • 177
    • 84904651901 scopus 로고    scopus 로고
    • Diagnostic utility of broad range bacterial 16S rRNA gene PCR with degradation of human and free bacterial DNA in bloodstream infection is more sensitive than an in-house developed PCR without degradation of human and free bacterial DNA
    • Rogina, P, Skvarc M, Stubljar D, Kofol R, Kaasch A. 2014. Diagnostic utility of broad range bacterial 16S rRNA gene PCR with degradation of human and free bacterial DNA in bloodstream infection is more sensitive than an in-house developed PCR without degradation of human and free bacterial DNA. Mediators Inflamm 2014:108592. https://doi.org/10.1155/2014/108592.
    • (2014) Mediators Inflamm , vol.2014
    • Rogina, P.1    Skvarc, M.2    Stubljar, D.3    Kofol, R.4    Kaasch, A.5
  • 178
    • 85020721725 scopus 로고    scopus 로고
    • Use of presepsin and procalcitonin for prediction of SeptiFast results in critically ill patients
    • Mihajlovic, D, Brkic S, Uvelin A, Draskovic B, Vrsajkov V. 2017. Use of presepsin and procalcitonin for prediction of SeptiFast results in critically ill patients. J Crit Care 40:197–201. https://doi.org/10.1016/j.jcrc.2017.04.008.
    • (2017) J Crit Care , vol.40 , pp. 197-201
    • Mihajlovic, D.1    Brkic, S.2    Uvelin, A.3    Draskovic, B.4    Vrsajkov, V.5
  • 179
    • 84879479751 scopus 로고    scopus 로고
    • Comparison of three different commercial PCR assays for the detection of pathogens in critically ill sepsis patients
    • Schreiber, J, Nierhaus A, Braune SA, de Heer G, Kluge S. 2013. Comparison of three different commercial PCR assays for the detection of pathogens in critically ill sepsis patients. Med Klin Intensivmed Notfmed 108:311–318. https://doi.org/10.1007/s00063-013-0227-1.
    • (2013) Med Klin Intensivmed Notfmed , vol.108 , pp. 311-318
    • Schreiber, J.1    Nierhaus, A.2    Braune, S.A.3    de Heer, G.4    Kluge, S.5
  • 180
    • 0030748867 scopus 로고    scopus 로고
    • Inhibition and facilitation of nucleic acid amplification
    • Wilson, IG. 1997. Inhibition and facilitation of nucleic acid amplification. Appl Environ Microbiol 63:3741–3751.
    • (1997) Appl Environ Microbiol , vol.63 , pp. 3741-3751
    • Wilson, I.G.1
  • 181
    • 0036841729 scopus 로고    scopus 로고
    • Optimal, DNA isolation method for detection of bacteria in clinical specimens by broad-range PCR
    • Rantakokko-Jalava K, Jalava J. 2002. Optimal, DNA isolation method for detection of bacteria in clinical specimens by broad-range PCR. J Clin Microbiol 40:4211–4217. https://doi.org/10.1128/JCM.40.11.4211-4217.2002.
    • (2002) J Clin Microbiol , vol.40 , pp. 4211-4217
    • Rantakokko-Jalava, K.1    Jalava, J.2
  • 182
    • 0031874238 scopus 로고    scopus 로고
    • Strategy for optimizing DNA amplification in a peripheral blood PCR assay used for diagnosis of human brucellosis
    • Morata, P, Queipo-Ortuño MI, de Dios Colmenero J. 1998. Strategy for optimizing DNA amplification in a peripheral blood PCR assay used for diagnosis of human brucellosis. J Clin Microbiol 36:2443–2446.
    • (1998) J Clin Microbiol , vol.36 , pp. 2443-2446
    • Morata, P.1    Queipo-Ortuño, M.I.2    de Dios Colmenero, J.3
  • 183
    • 84865064820 scopus 로고    scopus 로고
    • Simultaneous multiple target detection in real-time loop-mediated isothermal amplification
    • Tanner, NA, Zhang Y, Evans TC, Jr. 2012. Simultaneous multiple target detection in real-time loop-mediated isothermal amplification. Biotechniques 53:81–89.
    • (2012) Biotechniques , vol.53 , pp. 81-89
    • Tanner, N.A.1    Zhang, Y.2    Evans, T.C.3
  • 184
    • 84938674862 scopus 로고    scopus 로고
    • Paper machine for molecular diagnostics
    • Connelly, JT, Rolland JP, Whitesides GM. 2015. “Paper machine” for molecular diagnostics. Anal Chem 87:7595–7601. https://doi.org/10.1021/acs.analchem.5b00411.
    • (2015) Anal Chem , vol.87 , pp. 7595-7601
    • Connelly, J.T.1    Rolland, J.P.2    Whitesides, G.M.3
  • 185
    • 84863692703 scopus 로고    scopus 로고
    • Loop-mediated isothermal amplification technology: Towards point of care diagnostics
    • Njiru, ZK. 2012. Loop-mediated isothermal amplification technology: towards point of care diagnostics. PLoS Negl Trop Dis 6:e1572. https://doi.org/10.1371/journal.pntd.0001572.
    • (2012) Plos Negl Trop Dis , vol.6
    • Njiru, Z.K.1
  • 187
    • 84988596362 scopus 로고    scopus 로고
    • Diagnostic accuracy of a host gene expression signature that discriminates clinical severe sepsis syndrome and infection-negative systemic inflammation among critically ill children
    • Zimmerman, JJ, Sullivan E, Yager TD, Cheng C, Permut L, Cermelli S, McHugh L, Sampson D, Seldon T, Brandon RB, Brandon RA. 2017. Diagnostic accuracy of a host gene expression signature that discriminates clinical severe sepsis syndrome and infection-negative systemic inflammation among critically ill children. Crit Care Med 45:e418–e425. https://doi.org/10.1097/CCM.0000000000002100.
    • (2017) Crit Care Med , vol.45 , pp. e418-e425
    • Zimmerman, J.J.1    Sullivan, E.2    Yager, T.D.3    Cheng, C.4    Permut, L.5    Cermelli, S.6    McHugh, L.7    Sampson, D.8    Seldon, T.9    Brandon, R.B.10    Brandon, R.A.11
  • 188
    • 85044228197 scopus 로고    scopus 로고
    • Sensitive and specific diagnosis of sepsis in critically ill children utilizing host gene expression
    • Zimmerman, J, Sullivan E, Sampson D, McHugh L, Yager T, Seldon T. 2015. Sensitive and specific diagnosis of sepsis in critically ill children utilizing host gene expression. Crit Care Med 43:258. https://doi.org/10.1097/01.ccm.0000474855.13970.46.
    • (2015) Crit Care Med , vol.43 , pp. 258
    • Zimmerman, J.1    Sullivan, E.2    Sampson, D.3    McHugh, L.4    Yager, T.5    Seldon, T.6
  • 189
    • 85044235365 scopus 로고    scopus 로고
    • Validation of a novel host response assay to distinguish SIRS and sepsis in critically ill patients
    • Miller, R, Lopansri B, McHugh L, Rapisarda A, Seldon T, Burke J. 2015. Validation of a novel host response assay to distinguish SIRS and sepsis in critically ill patients. Crit Care Med 43:252. https://doi.org/10.1097/01.ccm.0000474833.48035.b5.
    • (2015) Crit Care Med , vol.43 , pp. 252
    • Miller, R.1    Lopansri, B.2    McHugh, L.3    Rapisarda, A.4    Seldon, T.5    Burke, J.6
  • 190
    • 84923212067 scopus 로고    scopus 로고
    • Rapid detection of single bacteria in unprocessed blood using integrated comprehensive droplet digital detection
    • Kang, D-K, Ali MM, Zhang K, Huang SS, Peterson E, Digman MA, Gratton E, Zhao W. 2014. Rapid detection of single bacteria in unprocessed blood using integrated comprehensive droplet digital detection. Nat Commun 5:5427. https://doi.org/10.1038/ncomms6427.
    • (2014) Nat Commun , vol.5 , pp. 5427
    • Kang, D.-K.1    Ali, M.M.2    Zhang, K.3    Huang, S.S.4    Peterson, E.5    Digman, M.A.6    Gratton, E.7    Zhao, W.8
  • 191
    • 84882272712 scopus 로고    scopus 로고
    • Simplified confocal microscope for counting particles at low concentrations
    • Skinner, JP, Swift KM, Ruan Q, Perfetto S, Gratton E, Tetin SY. 2013. Simplified confocal microscope for counting particles at low concentrations. Rev Sci Instrum 84:74301. https://doi.org/10.1063/1.4812782.
    • (2013) Rev Sci Instrum , vol.84 , pp. 74301
    • Skinner, J.P.1    Swift, K.M.2    Ruan, Q.3    Perfetto, S.4    Gratton, E.5    Tetin, S.Y.6
  • 192
    • 84878248047 scopus 로고    scopus 로고
    • Dual channel detection of ultra low concentration of bacteria in real time by scanning FCS
    • Altamore, I, Lanzano L, Gratton E. 2013. Dual channel detection of ultra low concentration of bacteria in real time by scanning FCS. Meas Sci Technol 24:65702. https://doi.org/10.1088/0957-0233/24/6/065702.193.Referencedeleted.
    • (2013) Meas Sci Technol , vol.24 , pp. 65702
    • Altamore, I.1    Lanzano, L.2    Gratton, E.3
  • 193
    • 52949100612 scopus 로고    scopus 로고
    • Validation, updating and impact of clinical prediction rules: A review
    • Toll, DB, Janssen KJM, Vergouwe Y, Moons KGM. 2008. Validation, updating and impact of clinical prediction rules: a review. J Clin Epidemiol 61:1085–1094. https://doi.org/10.1016/j.jclinepi.2008.04.008.
    • (2008) J Clin Epidemiol , vol.61 , pp. 1085-1094
    • Toll, D.B.1    Janssen, K.2    Vergouwe, Y.3    Moons, K.G.M.4
  • 197
    • 77956628404 scopus 로고    scopus 로고
    • Sepsis biomarkers: A review
    • Pierrakos, C, Vincent J-L. 2010. Sepsis biomarkers: a review. Crit Care 14:R15. https://doi.org/10.1186/cc8872.
    • (2010) Crit Care , vol.14 , pp. R15
    • Pierrakos, C.1    Vincent, J.-L.2
  • 199
    • 85033497248 scopus 로고    scopus 로고
    • Using machine learning to diagnose bacterial sepsis in the critically ill patients
    • Springer, Cham, Switzerland
    • Liu, Y, Choi KS. 2017. Using machine learning to diagnose bacterial sepsis in the critically ill patients, p 223–233. In, International Conference on Smart Health 2017. Springer, Cham, Switzerland. https://doi.org/10.1007/978-3-319-67964-8_22.
    • (2017) International Conference on Smart Health 2017 , pp. 223-233
    • Liu, Y.1    Choi, K.S.2
  • 201
    • 84938704873 scopus 로고    scopus 로고
    • A targeted real-time early warning score (TREWScore) for septic shock
    • Henry, KE, Hager DN, Pronovost PJ, Saria S. 2015. A targeted real-time early warning score (TREWScore) for septic shock. Sci Transl Med 7:299ra122. https://doi.org/10.1126/scitranslmed.aab3719.
    • (2015) Sci Transl Med , vol.7
    • Henry, K.E.1    Hager, D.N.2    Pronovost, P.J.3    Saria, S.4
  • 202
    • 33750698270 scopus 로고    scopus 로고
    • Validation of physiological scoring systems in the accident and emergency department
    • Subbe, CP, Slater A, Menon D, Gemmell L. 2006. Validation of physiological scoring systems in the accident and emergency department. Emerg Med J 23:841–845. https://doi.org/10.1136/emj.2006.035816.
    • (2006) Emerg Med J , vol.23 , pp. 841-845
    • Subbe, C.P.1    Slater, A.2    Menon, D.3    Gemmell, L.4
  • 205
    • 85041409711 scopus 로고    scopus 로고
    • Flexible, cluster-based analysis of the electronic medical record of sepsis with composite mixture models
    • Mayhew, MB, Petersen BK, Sales AP, Greene JD, Liu VX, Wasson TS. 2018. Flexible, cluster-based analysis of the electronic medical record of sepsis with composite mixture models. J Biomed Inform 78:33–42. https://doi.org/10.1016/j.jbi.2017.11.015.
    • (2018) J Biomed Inform , vol.78 , pp. 33-42
    • Mayhew, M.B.1    Petersen, B.K.2    Sales, A.P.3    Greene, J.D.4    Liu, V.X.5    Wasson, T.S.6
  • 207
    • 84896542767 scopus 로고    scopus 로고
    • Infection and other clinical correlates of abnormal heart rate characteristics in preterm infants
    • Sullivan, BA, Grice SM, Lake DE, Moorman JR, Fairchild KD. 2014. Infection and other clinical correlates of abnormal heart rate characteristics in preterm infants. J Pediatr 164:775–780. https://doi.org/10.1016/j.jpeds.2013.11.038.
    • (2014) J Pediatr , vol.164 , pp. 775-780
    • Sullivan, B.A.1    Grice, S.M.2    Lake, D.E.3    Moorman, J.R.4    Fairchild, K.D.5
  • 213
    • 85014773638 scopus 로고    scopus 로고
    • Discharge recommendation based on a novel technique of homeostatic analysis
    • Calvert, JS, Price DA, Barton CW, Chettipally UK, Das R. 2017. Discharge recommendation based on a novel technique of homeostatic analysis. J Am Med Inform Assoc 24:24–29. https://doi.org/10.1093/jamia/ocw014.
    • (2017) J am Med Inform Assoc , vol.24 , pp. 24-29
    • Calvert, J.S.1    Price, D.A.2    Barton, C.W.3    Chettipally, U.K.4    Das, R.5
  • 214
    • 85044240544 scopus 로고    scopus 로고
    • Reducing patient mortality, length of stay and readmissions through machine learning-based sepsis prediction in the emergency department, intensive care unit and hospital floor units
    • McCoy A, Das R. 2017. Reducing patient mortality, length of stay and readmissions through machine learning-based sepsis prediction in the emergency department, intensive care unit and hospital floor units. BMJ Open Qual 6:e000158. https://doi.org/10.1136/bmjoq-2017-000158.
    • (2017) BMJ Open Qual , vol.6
    • McCoy, A.1    Das, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.