The value of combining blood culture and septifast data for predicting complicated bloodstream infections caused by gram-positive bacteria or candida species

Journal of Clinical Microbiology

Volumn 51, Issue 4, 2013, Pages 1130-1136

  Fernández Cruz, Ana ^a   Marín, Mercedes ^a,b   Kestler, Martha ^a   Alcalá, Luis ^a,b   Rodriguez Créixems, Marta ^a,b,c   Bouza, Emilio ^a,b,c  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b Red Española de Investigación en Patología Infecciosa ^*  (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BLOOD CULTURE; BLOODSTREAM INFECTION; CANDIDA; COMPLICATED BLOODSTREAM INFECTION; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ENTEROCOCCUS; FEMALE; FOLLOW UP; GRAM POSITIVE BACTERIUM; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SEPTIFAST; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS;

AGED; AGED, 80 AND OVER; BACTEREMIA; BLOOD; CANDIDA; CANDIDEMIA; DNA, BACTERIAL; DNA, FUNGAL; FEMALE; GRAM-POSITIVE BACTERIA; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; MALE; MICROBIOLOGICAL TECHNIQUES; MIDDLE AGED; MOLECULAR DIAGNOSTIC TECHNIQUES; SENSITIVITY AND SPECIFICITY;

CANDIDA; ENTEROCOCCUS; POSIBACTERIA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS;

EID: 84875823959     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.02882-12     Document Type: Article

References (19)

1. Naber CK. 2008. Future strategies for treating Staphylococcus aureus bloodstream infections. Clin. Microbiol. Infect. 14(Suppl 2):26-34.
2. Cabell CH, Fowler VG, Jr. 2004. Importance of aggressive evaluation in patients with Staphylococcus aureus bacteremia. Am. Heart J. 147:379-380.
3. Fowler VG, Jr, Olsen MK, Corey GR, Woods CW, Cabell CH, Reller LB, Cheng AC, Dudley T, Oddone EZ. 2003. Clinical identifiers of complicated Staphylococcus aureus bacteremia. Arch. Intern. Med. 163:2066-2072.
4. Chang FY, MacDonald BB, Peacock JE, Jr, Musher DM, Triplett P, Mylotte JM, O'Donnell A, Wagener MM, Yu VL. 2003. A prospective multicenter study of Staphylococcus aureus bacteremia: Incidence of endocarditis, risk factors for mortality, and clinical impact of methicillin resistance. Medicine (Baltimore) 82:322-332.
5. Hawkins C, Huang J, Jin N, Noskin GA, Zembower TR, Bolon M. 2007. Persistent Staphylococcus aureus bacteremia: An analysis of risk factors and outcomes. Arch. Intern. Med. 167:1861-1867.
6. Vince A, Lepej SZ, Barsic B, Dusek D, Mitrovic Z, Serventi-Seiwerth R, Labar B. 2008. LightCycler SeptiFast assay as a tool for the rapid diagnosis of sepsis in patients during antimicrobial therapy. J. Med. Microbiol. 57: 1306-1307.
7. Lehmann LE, Hunfeld KP, Emrich T, Haberhausen G, Wissing H, Hoeft A, Stuber F. 2008. A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples. Med. Microbiol. Immunol. 197:313-324.
8. Fowler VG, Jr, Justice A, Moore C, Benjamin DK, Jr, Woods CW, Campbell S, Reller LB, Corey GR, Day NP, Peacock SJ. 2005. Risk factors for hematogenous complications of intravascular catheterassociated Staphylococcus aureus bacteremia. Clin. Infect. Dis. 40:695-703.
9. Li JS, Sexton DJ, Mick N, Nettles R, Fowler VG, Jr, Ryan T, Bashore T, Corey GR. 2000. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin. Infect. Dis. 30:633-638.
10. McCabe WR. 1973. Gram-negative bacteremia. Dis. Mon. 1973:1-38.
11. Charlson M, Szatrowski TP, Peterson J, Gold J. 1994. Validation of a combined comorbidity index. J. Clin. Epidemiol. 47:1245-1251.
12. Bone RC. 1996. The sepsis syndrome: Definition and general approach to management. Clin. Chest Med. 17:175-181.
13. Hill EE, Vanderschueren S, Verhaegen J, Herijgers P, Claus P, Herregods MC, Peetermans WE. 2007. Risk factors for infective endocarditis and outcome of patients with Staphylococcus aureus bacteremia. Mayo Clin. Proc. 82:1165-1169.
14. Mancini NC, Ghidoli N. 2010. The era of molecular and other nonculture-based methods in diagnosis of sepsis. Clin. Microbiol. Rev. 23: 235-251.
15. Casalta JP, Gouriet F, Roux V, Thuny F, Habib G, Raoult D. 2009. Evaluation of the LightCycler SeptiFast test in the rapid etiologic diagnostic of infectious endocarditis. Eur. J. Clin. Microbiol. Infect. Dis. 28:569-573.
16. Ho YC, Chang SC, Lin SR, Wang WK. High levels of mecA DNA detected by a quantitative real-time PCR assay are associated with mortality in patients with methicillin-resistant Staphylococcus aureus bacteremia. J. Clin. Microbiol. 47:1443-1451.
17. Carrol ED, Guiver M, Nkhoma S, Mankhambo LA, Marsh J, Balmer P, Banda DL, Jeffers G, White SA, Molyneux EM, Molyneux ME, Smyth RL, Hart CA. High pneumococcal DNA loads are associated with mortality in Malawian children with invasive pneumococcal disease. Pediatr. Infect. Dis. J. 26:416-422.
18. Hackett SJ, Guiver M, Marsh J, Sills JA, Thomson AP, Kaczmarski EB, Hart CA. Meningococcal bacterial DNA load at presentation correlates with disease severity. Arch. Dis. Child 86:44-46.
19. Ovstebo R, Brandtzaeg P, Brusletto B, Haug KB, Lande K, Hoiby EA, Kierulf P. Use of robotized DNA isolation and real-time PCR to quantify and identify close correlation between levels of Neisseria meningitidisDNA and lipopolysaccharides in plasma and cerebrospinal fluid from patients with systemic meningococcal disease. J. Clin. Microbiol. 42:2980-2987.