Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis

Critical Care Medicine

Volumn 42, Issue 11, 2014, Pages 2409-2417

  Weiss, Scott L ^a   Fitzgerald, Julie C ^a   Balamuth, Fran ^a   Alpern, Elizabeth R ^b   Lavelle, Jane ^a   Chilutti, Marianne ^c   Grundmeier, Robert ^a,c   Nadkarni, Vinay M ^a   Thomas, Neal J ^d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Antimicrobial; Critically ill children; Delay; Mortality; Sepsis; Timing

Indexed keywords

ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIVIRUS AGENT; ANTIINFECTIVE AGENT;

ADOLESCENT; ANTIBIOTIC THERAPY; ANTIMICROBIAL THERAPY; ANTIVIRAL THERAPY; ARTICLE; ARTIFICIAL VENTILATION; CHILD; CHILDHOOD MORTALITY; CLINICAL PATHWAY; COMORBIDITY; CRITICALLY ILL PATIENT; DELAYED DIAGNOSIS; DISEASE DURATION; FEMALE; GRAM NEGATIVE INFECTION; GRAM POSITIVE INFECTION; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MYCOSIS; OBSERVATIONAL STUDY; ORGAN DYSFUNCTION; ORGAN DYSFUNCTION SCORE; PHYSICAL DISEASE BY BODY FUNCTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEPTIC SHOCK; THERAPY DELAY; VIRUS INFECTION; CAUSE OF DEATH; COHORT ANALYSIS; CRITICAL ILLNESS; DRUG ADMINISTRATION; HOSPITAL; HOSPITAL MORTALITY; INFANT; INTRAVENOUS DRUG ADMINISTRATION; KAPLAN MEIER METHOD; MORTALITY; MULTIPLE ORGAN FAILURE; MULTIVARIATE ANALYSIS; PEDIATRIC INTENSIVE CARE UNIT; PENNSYLVANIA; PRESCHOOL CHILD; RISK ASSESSMENT; SEPSIS; SHOCK, SEPTIC; STATISTICAL MODEL; SURVIVAL RATE; TIME FACTOR; UNIVERSITY HOSPITAL;

ACADEMIC MEDICAL CENTERS; ADOLESCENT; ANTI-BACTERIAL AGENTS; CAUSE OF DEATH; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; CRITICAL ILLNESS; DRUG ADMINISTRATION SCHEDULE; FEMALE; HOSPITAL MORTALITY; HOSPITALS, PEDIATRIC; HUMANS; INFANT; INFUSIONS, INTRAVENOUS; INTENSIVE CARE UNITS, PEDIATRIC; KAPLAN-MEIER ESTIMATE; LOGISTIC MODELS; MALE; MULTIPLE ORGAN FAILURE; MULTIVARIATE ANALYSIS; PHILADELPHIA; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SEPSIS; SHOCK, SEPTIC; SURVIVAL RATE; TIME FACTORS;

EID: 84927731307     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000509     Document Type: Article

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