메뉴 건너뛰기




Volumn 17, Issue 12, 2017, Pages 774-785

Regulation of immunity and inflammation by hypoxia in immunological niches

Author keywords

[No Author keywords available]

Indexed keywords

AKB 4924; AKEBIA; AKT 4924; DAPRODUSTAT; DIMETHYLOXALYLGLYCINE; FG 4497; HYPOXIA INDUCIBLE FACTOR; METFORMIN; PROLYL HYDROXYLASE INHIBITOR; RECOMBINANT ERYTHROPOIETIN; ROSMARINIC ACID; ROXADUSTAT; TRC 160334; UNCLASSIFIED DRUG; VADADUSTAT; HYPOXIA INDUCIBLE FACTOR 1;

EID: 85034865719     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri.2017.103     Document Type: Review
Times cited : (477)

References (163)
  • 2
    • 84899561969 scopus 로고    scopus 로고
    • An overview of the intrathymic intricacies of T cell development
    • Shah, D. K. & Zúñiga-Pflücker, J. C. An overview of the intrathymic intricacies of T cell development. J. Immunol. 192, 4017-4023 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 4017-4023
    • Shah, D.K.1    Zúñiga-Pflücker, J.C.2
  • 3
    • 84983534959 scopus 로고    scopus 로고
    • Neutrophils and the inflammatory tissue microenvironment in the mucosa
    • Campbell, E. L., Kao, D. J. & Colgan, S. P. Neutrophils and the inflammatory tissue microenvironment in the mucosa. Immunol. Rev. 273, 112-120 (2016).
    • (2016) Immunol. Rev. , vol.273 , pp. 112-120
    • Campbell, E.L.1    Kao, D.J.2    Colgan, S.P.3
  • 5
    • 84946489574 scopus 로고    scopus 로고
    • The lung metastatic niche
    • Maru, Y. The lung metastatic niche. J. Mol. Med. (Berl.) 93, 1185-1192 (2015).
    • (2015) J. Mol. Med. (Berl.) , vol.93 , pp. 1185-1192
    • Maru, Y.1
  • 6
    • 84940891850 scopus 로고    scopus 로고
    • Microenvironmental control of stem cell fate in intestinal homeostasis and disease
    • Biswas, S. et al. Microenvironmental control of stem cell fate in intestinal homeostasis and disease. J. Pathol. 237, 135-145 (2015).
    • (2015) J. Pathol. , vol.237 , pp. 135-145
    • Biswas, S.1
  • 7
    • 24744440988 scopus 로고    scopus 로고
    • Immunology of ischemic vascular disease: Plaque to attack
    • Hallenbeck, J. M., Hansson, G. K. & Becker, K. J. Immunology of ischemic vascular disease: plaque to attack. Trends Immunol. 26, 550-556 (2005).
    • (2005) Trends Immunol. , vol.26 , pp. 550-556
    • Hallenbeck, J.M.1    Hansson, G.K.2    Becker, K.J.3
  • 8
    • 84963575145 scopus 로고    scopus 로고
    • The immune battle against Helicobacter pylori infection: NO offense
    • Gobert, A. P. & Wilson, K. T. The immune battle against Helicobacter pylori infection: NO offense. Trends Microbiol. 24, 366-376 (2016).
    • (2016) Trends Microbiol. , vol.24 , pp. 366-376
    • Gobert, A.P.1    Wilson, K.T.2
  • 9
    • 57749093121 scopus 로고    scopus 로고
    • Inflammation and stem cells in gastrointestinal carcinogenesis
    • Quante, M. & Wang, T. C. Inflammation and stem cells in gastrointestinal carcinogenesis. Physiology (Bethesda) 23, 350-359 (2008).
    • (2008) Physiology (Bethesda) , vol.23 , pp. 350-359
    • Quante, M.1    Wang, T.C.2
  • 10
    • 84863601838 scopus 로고    scopus 로고
    • Chronic inflammation in cancer development
    • Multhoff, G., Molls, M. & Radons, J. Chronic inflammation in cancer development. Front. Immunol. 2, 98 (2012).
    • (2012) Front. Immunol. , vol.2 , pp. 98
    • Multhoff, G.1    Molls, M.2    Radons, J.3
  • 11
    • 84991571929 scopus 로고    scopus 로고
    • Hypoxia-dependent regulation of inflammatory pathways in immune cells
    • Taylor, C. T., Doherty. G., Fallon, P. G. & Cummins, E. P. Hypoxia-dependent regulation of inflammatory pathways in immune cells. J. Clin. Invest. 126, 3716-3724 (2016).
    • (2016) J. Clin. Invest. , vol.126 , pp. 3716-3724
    • Taylor, C.T.1    Doherty, G.2    Fallon, P.G.3    Cummins, E.P.4
  • 13
    • 84885950065 scopus 로고    scopus 로고
    • Targeting the HIF pathway in inflammation and immunity
    • Scholz, C. C. & Taylor, C. T. Targeting the HIF pathway in inflammation and immunity. Curr. Opin. Pharmacol. 13, 646-653 (2013).
    • (2013) Curr. Opin. Pharmacol. , vol.13 , pp. 646-653
    • Scholz, C.C.1    Taylor, C.T.2
  • 14
    • 77958042201 scopus 로고    scopus 로고
    • Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans
    • Taylor, C. T. & McElwain, J. C. Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans. Physiology (Bethesda) 25, 272-279 (2010).
    • (2010) Physiology (Bethesda) , vol.25 , pp. 272-279
    • Taylor, C.T.1    McElwain, J.C.2
  • 15
    • 77952092406 scopus 로고    scopus 로고
    • Hypoxia: An alarm signal during intestinal inflammation
    • Colgan, S. P. & Taylor, C. T. Hypoxia: an alarm signal during intestinal inflammation. Nat. Rev. Gastroenterol. Hepatol. 7, 281-287 (2010).
    • (2010) Nat. Rev. Gastroenterol. Hepatol. , vol.7 , pp. 281-287
    • Colgan, S.P.1    Taylor, C.T.2
  • 16
    • 84941618050 scopus 로고    scopus 로고
    • Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A review in the theme: Cellular responses to hypoxia
    • Zheng, L., Kelly, C. J. & Colgan, S. P. Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A review in the theme: cellular responses to hypoxia. Am. J. Physiol. Cell Physiol. 309, C350-C360 (2015).
    • (2015) Am. J. Physiol. Cell Physiol. , vol.309 , pp. C350-C360
    • Zheng, L.1    Kelly, C.J.2    Colgan, S.P.3
  • 17
    • 84955192227 scopus 로고    scopus 로고
    • The hypoxic tumor microenvironment: A driving force for breast cancer progression
    • Semenza, G. L. The hypoxic tumor microenvironment: a driving force for breast cancer progression. Biochim. Biophys. Acta 1863, 382-391 (2016).
    • (2016) Biochim. Biophys. Acta , vol.1863 , pp. 382-391
    • Semenza, G.L.1
  • 18
    • 84865575592 scopus 로고    scopus 로고
    • Molecular mechanisms mediating metastasis of hypoxic breast cancer cells
    • Semenza, G. L. Molecular mechanisms mediating metastasis of hypoxic breast cancer cells. Trends Mol. Med. 18, 534-543 (2012).
    • (2012) Trends Mol. Med. , vol.18 , pp. 534-543
    • Semenza, G.L.1
  • 21
    • 78650887484 scopus 로고    scopus 로고
    • The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal Trichoplax adhaerens
    • Loenarz, C. et al. The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens. EMBO Rep. 12, 63-70 (2011).
    • (2011) EMBO Rep. , vol.12 , pp. 63-70
    • Loenarz, C.1
  • 22
    • 25644446823 scopus 로고    scopus 로고
    • Hypoxia-responsive transcription factors
    • Cummins, E. P. & Taylor, C. T. Hypoxia-responsive transcription factors. Pflugers Arch. 450, 363-371 (2005).
    • (2005) Pflugers Arch. , vol.450 , pp. 363-371
    • Cummins, E.P.1    Taylor, C.T.2
  • 23
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • Semenza, G. L. Hypoxia-inducible factors in physiology and medicine. Cell 148, 399-408 (2012).
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 24
    • 84876325985 scopus 로고    scopus 로고
    • Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer
    • Ratcliffe, P. J. Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer. J. Physiol. 591, 2027-2042 (2013).
    • (2013) J. Physiol. , vol.591 , pp. 2027-2042
    • Ratcliffe, P.J.1
  • 25
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hypoxia
    • Bunn, H. F. & Poyton, R. O. Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76, 839-885 (1996).
    • (1996) Physiol. Rev. , vol.76 , pp. 839-885
    • Bunn, H.F.1    Poyton, R.O.2
  • 26
    • 77950890499 scopus 로고    scopus 로고
    • Nitric oxide, cytochrome C oxidase, and the cellular response to hypoxia
    • Taylor, C. T. & Moncada, S. Nitric oxide, cytochrome C oxidase, and the cellular response to hypoxia. Arterioscler. Thromb. Vasc. Biol. 30, 643-647 (2010).
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 643-647
    • Taylor, C.T.1    Moncada, S.2
  • 27
    • 54549113030 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
    • Kaelin, W. G. Jr. The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat. Rev. Cancer 8, 865-873 (2008).
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 865-873
    • Kaelin, W.G.1
  • 28
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
    • Kaelin, W. G. Jr & Ratcliffe, P. J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 30, 393-402 (2008).
    • (2008) Mol. Cell , vol.30 , pp. 393-402
    • Kaelin, W.G.1    Ratcliffe, P.J.2
  • 29
    • 84971268711 scopus 로고    scopus 로고
    • Hypercapnia suppresses the HIF-dependent adaptive response to hypoxia
    • Selfridge, A. C. et al. Hypercapnia suppresses the HIF-dependent adaptive response to hypoxia. J. Biol. Chem. 291, 11800-11808 (2016).
    • (2016) J. Biol. Chem. , vol.291 , pp. 11800-11808
    • Selfridge, A.C.1
  • 30
    • 84943750048 scopus 로고    scopus 로고
    • An essential role for chaperone-mediated autophagy in cell cycle progression
    • Hubbi, M. E. & Semenza, G. L. An essential role for chaperone-mediated autophagy in cell cycle progression. Autophagy 11, 850-851 (2015).
    • (2015) Autophagy , vol.11 , pp. 850-851
    • Hubbi, M.E.1    Semenza, G.L.2
  • 31
    • 84905976385 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1 a to promote cell-cycle progression
    • Hubbi, M. E., Gilkes, D. M., Hu, H., Kshitiz, Ahmed, I. & Semenza, G. L. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1 a to promote cell-cycle progression. Proc. Natl Acad. Sci. USA 111, E3325-E3334 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. E3325-E3334
    • Hubbi, M.E.1    Gilkes, D.M.2    Hu, H.3    Kshitiz Ahmed, I.4    Semenza, G.L.5
  • 32
    • 85014514282 scopus 로고    scopus 로고
    • L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
    • Intlekofer, A. M. et al. L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH. Nat. Chem. Biol. 13, 494-500 (2017).
    • (2017) Nat. Chem. Biol. , vol.13 , pp. 494-500
    • Intlekofer, A.M.1
  • 33
    • 85017251482 scopus 로고    scopus 로고
    • S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
    • Tyrakis, P. A. et al. S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate. Nature 540, 236-241 (2016).
    • (2016) Nature , vol.540 , pp. 236-241
    • Tyrakis, P.A.1
  • 34
    • 84862776918 scopus 로고    scopus 로고
    • Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
    • Koivunen, P. et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature 483, 484-488 (2012).
    • (2012) Nature , vol.483 , pp. 484-488
    • Koivunen, P.1
  • 35
    • 84876285741 scopus 로고    scopus 로고
    • Succinate is an inflammatory signal that induces IL-1p through HIF-1a
    • Tannahill, G. M. et al. Succinate is an inflammatory signal that induces IL-1p through HIF-1a. Nature 496, 238-242 (2013).
    • (2013) Nature , vol.496 , pp. 238-242
    • Tannahill, G.M.1
  • 36
    • 77951238575 scopus 로고    scopus 로고
    • Mitochondrial regulation of oxygen sensing
    • Chandel, N. S. Mitochondrial regulation of oxygen sensing. Adv. Exp. Med. Biol. 661, 339-354 (2010).
    • (2010) Adv. Exp. Med. Biol. , vol.661 , pp. 339-354
    • Chandel, N.S.1
  • 37
    • 84882239297 scopus 로고    scopus 로고
    • Pan-genomic binding of hypoxia-inducible transcription factors
    • Schödel, J., Mole, D. R. & Ratcliffe, P. J. Pan-genomic binding of hypoxia-inducible transcription factors. Biol. Chem. 394, 507-517 (2013).
    • (2013) Biol. Chem. , vol.394 , pp. 507-517
    • Schödel, J.1    Mole, D.R.2    Ratcliffe, P.J.3
  • 38
    • 67650531089 scopus 로고    scopus 로고
    • Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts
    • Mole, D. R. et al. Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts. J. Biol. Chem. 284, 16767-16775 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 16767-16775
    • Mole, D.R.1
  • 39
    • 84958551663 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 3 biology: Complexities and emerging themes
    • Duan, C. Hypoxia-inducible factor 3 biology: complexities and emerging themes. Am. J. Physiol. Cell Physiol. 310, C260-269 (2016).
    • (2016) Am. J. Physiol. Cell Physiol. , vol.310 , pp. C260-269
    • Duan, C.1
  • 40
    • 84908141221 scopus 로고    scopus 로고
    • HIF transcription factors, inflammation, and immunity
    • Palazon, A., Goldrath, A. W., Nizet, V. & Johnson, R. S. HIF transcription factors, inflammation, and immunity. Immunity 41, 518-528 (2014).
    • (2014) Immunity , vol.41 , pp. 518-528
    • Palazon, A.1    Goldrath, A.W.2    Nizet, V.3    Johnson, R.S.4
  • 41
    • 84875395170 scopus 로고    scopus 로고
    • The impact of hypoxia on cell death pathways
    • Lenihan, C. R. & Taylor, C. T. The impact of hypoxia on cell death pathways. Biochem. Soc. Trans. 41, 657-663 (2013).
    • (2013) Biochem. Soc. Trans. , vol.41 , pp. 657-663
    • Lenihan, C.R.1    Taylor, C.T.2
  • 42
    • 84872134149 scopus 로고    scopus 로고
    • Regulation of erythropoiesis by hypoxia-inducible factors
    • Haase, V. H. Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev. 27, 41-53 (2013).
    • (2013) Blood Rev. , vol.27 , pp. 41-53
    • Haase, V.H.1
  • 43
    • 85000893948 scopus 로고    scopus 로고
    • Hypoxia and inflammatory bowel disease
    • Cummins, E. P. & Crean, D. Hypoxia and inflammatory bowel disease. Microbes Infect. 19, 210-221 (2017).
    • (2017) Microbes Infect. , vol.19 , pp. 210-221
    • Cummins, E.P.1    Crean, D.2
  • 44
    • 84991677503 scopus 로고    scopus 로고
    • Oxygen metabolism and barrier regulation in the intestinal mucosa
    • Glover, L. E. Lee, J. S. & Colgan, S. P. Oxygen metabolism and barrier regulation in the intestinal mucosa. J. Clin. Invest. 126, 3680-3688 (2016).
    • (2016) J. Clin. Invest. , vol.126 , pp. 3680-3688
    • Glover, L.E.1    Lee, J.S.2    Colgan, S.P.3
  • 45
    • 84958644571 scopus 로고    scopus 로고
    • Role of intestinal HIF-2a in health and disease
    • Ramakrishnan, S. K. & Shah, Y. M. Role of intestinal HIF-2a in health and disease. Annu. Rev. Physiol. 78, 301-325 (2016).
    • (2016) Annu. Rev. Physiol. , vol.78 , pp. 301-325
    • Ramakrishnan, S.K.1    Shah, Y.M.2
  • 46
    • 85020774193 scopus 로고    scopus 로고
    • The EGLN-HIF O2-sensing system: Multiple inputs and feedbacks
    • Ivan, M. & Kaelin, W. G. Jr. The EGLN-HIF O2-sensing system: multiple inputs and feedbacks. Mol. Cell 66, 772-779 (2017).
    • (2017) Mol. Cell , vol.66 , pp. 772-779
    • Ivan, M.1    Kaelin, W.G.2
  • 47
    • 84989182329 scopus 로고    scopus 로고
    • HIF-mediated innate immune responses: Cell signaling and therapeutic implications
    • Harris, A. J., Thompson, A. R., Whyte, M. K. & Walmsley, S. R. HIF-mediated innate immune responses: cell signaling and therapeutic implications. Hypoxia (Auckl.) 2, 47-58 (2014).
    • (2014) Hypoxia (Auckl.) , vol.2 , pp. 47-58
    • Harris, A.J.1    Thompson, A.R.2    Whyte, M.K.3    Walmsley, S.R.4
  • 48
    • 84991712912 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Key regulators of myeloid cells during inflammation
    • Lin, N. & Simon, M. C. Hypoxia-inducible factors: key regulators of myeloid cells during inflammation. J. Clin. Invest. 126, 3661-3671 (2016).
    • (2016) J. Clin. Invest. , vol.126 , pp. 3661-3671
    • Lin, N.1    Simon, M.C.2
  • 49
    • 84899473768 scopus 로고    scopus 로고
    • Succinate: A metabolic signal in inflammation
    • Mills, E. & O'Neill, L. A. Succinate: a metabolic signal in inflammation. Trends Cell Biol. 24, 313-320 (2014).
    • (2014) Trends Cell Biol. , vol.24 , pp. 313-320
    • Mills, E.1    O'Neill, L.A.2
  • 50
    • 84936766497 scopus 로고    scopus 로고
    • IRF-5-mediated inflammation limits CD8+ T Cell expansion by inducing HIF-1 a and impairing dendritic cell functions during Leishmania infection
    • Hammami, A., Charpentier, T, Smans, M. & Stäger, S. IRF-5-mediated inflammation limits CD8+ T Cell expansion by inducing HIF-1 a and impairing dendritic cell functions during Leishmania infection. PLoS Pathog. 11, e1004938 (2015).
    • (2015) PLoS Pathog. , vol.11 , pp. e1004938
    • Hammami, A.1    Charpentier, T.2    Smans, M.3    Stäger, S.4
  • 51
    • 84882269271 scopus 로고    scopus 로고
    • Role of hypoxia inducible factor-1 a for interferon synthesis in mouse dendritic cells
    • Wobben, R. et al. Role of hypoxia inducible factor-1 a for interferon synthesis in mouse dendritic cells. Biol. Chem. 394, 495-505 (2013).
    • (2013) Biol. Chem. , vol.394 , pp. 495-505
    • Wobben, R.1
  • 52
    • 84986575883 scopus 로고    scopus 로고
    • Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system
    • Cho, S. H. et al. Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system. Nature 537, 234-238 (2016).
    • (2016) Nature , vol.537 , pp. 234-238
    • Cho, S.H.1
  • 53
    • 79551633354 scopus 로고    scopus 로고
    • Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea
    • Ward, J. B. et al. Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea. FASEB J. 25, 535-543 (2011).
    • (2011) FASEB J. , vol.25 , pp. 535-543
    • Ward, J.B.1
  • 54
    • 84884236749 scopus 로고    scopus 로고
    • Fundamental role for HIF-1a in constitutive expression of human p defensin-1
    • Kelly, C. J. et al. Fundamental role for HIF-1a in constitutive expression of human p defensin-1. Mucosal Immunol. 6, 1110-1118 (2013).
    • (2013) Mucosal Immunol. , vol.6 , pp. 1110-1118
    • Kelly, C.J.1
  • 55
    • 84938923735 scopus 로고    scopus 로고
    • PVHL negatively regulates antiviral signaling by targeting MAVS for proteasomal degradation
    • Du, J. et al. pVHL negatively regulates antiviral signaling by targeting MAVS for proteasomal degradation. J. Immunol. 195, 1782-1790 (2015).
    • (2015) J. Immunol. , vol.195 , pp. 1782-1790
    • Du, J.1
  • 56
    • 84952894746 scopus 로고    scopus 로고
    • VHL-dependent alterations in the secretome of renal cell carcinoma: Association with immune cell response?
    • Stehle, F et al. VHL-dependent alterations in the secretome of renal cell carcinoma: association with immune cell response? Oncotarget 6, 43420-43437 (2015).
    • (2015) Oncotarget , vol.6 , pp. 43420-43437
    • Stehle, F.1
  • 57
    • 84879415483 scopus 로고    scopus 로고
    • Hydroxylase-dependent regulation of the NF-KB pathway
    • Scholz, C. C. & Taylor, C. T. Hydroxylase-dependent regulation of the NF-KB pathway. Biol. Chem. 394, 479-493 (2013).
    • (2013) Biol. Chem. , vol.394 , pp. 479-493
    • Scholz, C.C.1    Taylor, C.T.2
  • 58
    • 84991619006 scopus 로고    scopus 로고
    • HIF1α and metabolic reprogramming in inflammation
    • Corcoran, S. E. & O'Neill, L. A. HIF1α and metabolic reprogramming in inflammation. J. Clin. Invest. 126, 3699-3707 (2016).
    • (2016) J. Clin. Invest. , vol.126 , pp. 3699-3707
    • Corcoran, S.E.1    O'Neill, L.A.2
  • 59
    • 84990845578 scopus 로고    scopus 로고
    • Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
    • Mills, E. L. et al. Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell 167, 457-470 (2016).
    • (2016) Cell , vol.167 , pp. 457-470
    • Mills, E.L.1
  • 61
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza, G. L., Roth, P. H., Fang, H. M. & Wang, G. L. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269, 23757-23763 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 62
    • 85000979473 scopus 로고    scopus 로고
    • The hypoxia-inducible factor (HIF) couples immunity with metabolism
    • Halligan, D. N., Murphy, S. J. & Taylor, C. T. The hypoxia-inducible factor (HIF) couples immunity with metabolism. Semin. Immunol. 28, 469-477 (2016).
    • (2016) Semin. Immunol. , vol.28 , pp. 469-477
    • Halligan, D.N.1    Murphy, S.J.2    Taylor, C.T.3
  • 63
    • 84976465917 scopus 로고    scopus 로고
    • Cycling hypoxia: A key feature of the tumor microenvironment
    • Michiels, C., Tellier, C. & Feron, O. Cycling hypoxia: a key feature of the tumor microenvironment. Biochim. Biophys. Acta 1866, 76-86 (2016).
    • (2016) Biochim. Biophys. Acta , vol.1866 , pp. 76-86
    • Michiels, C.1    Tellier, C.2    Feron, O.3
  • 64
    • 44349151470 scopus 로고    scopus 로고
    • Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours
    • Toffoli, S. & Michiels, C. Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours. FEBS J. 275, 2991-3002 (2008).
    • (2008) FEBS J. , vol.275 , pp. 2991-3002
    • Toffoli, S.1    Michiels, C.2
  • 65
    • 27444448072 scopus 로고    scopus 로고
    • Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome
    • Ryan, S., Taylor, C. T. & McNicholas, W. T. Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation 112, 2660-2667 (2005).
    • (2005) Circulation , vol.112 , pp. 2660-2667
    • Ryan, S.1    Taylor, C.T.2    McNicholas, W.T.3
  • 66
    • 84900451310 scopus 로고    scopus 로고
    • Human adipocytes are highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression
    • Taylor, C. T., Kent, B. D., Crinion, S. J., McNicholas, W. T. & Ryan, S. Human adipocytes are highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression. Biochem. Biophys. Res. Commun. 447, 660-665 (2014).
    • (2014) Biochem. Biophys. Res. Commun. , vol.447 , pp. 660-665
    • Taylor, C.T.1    Kent, B.D.2    Crinion, S.J.3    McNicholas, W.T.4    Ryan, S.5
  • 67
    • 84960402826 scopus 로고    scopus 로고
    • NF-κB and HIF crosstalk in immune responses
    • D'Ignazio, L., Bandarra, D. & Rocha, S. NF-κB and HIF crosstalk in immune responses. FEBS J. 283, 413-424 (2016).
    • (2016) FEBS J. , vol.283 , pp. 413-424
    • D'Ignazio, L.1    Bandarra, D.2    Rocha, S.3
  • 68
    • 51749089798 scopus 로고    scopus 로고
    • Interdependent roles for hypoxia inducible factor and nuclear factor-kappaB in hypoxic inflammation
    • Taylor, C. T. Interdependent roles for hypoxia inducible factor and nuclear factor-kappaB in hypoxic inflammation. J. Physiol. 586, 4055-4059 (2008).
    • (2008) J. Physiol. , vol.586 , pp. 4055-4059
    • Taylor, C.T.1
  • 69
    • 84978197362 scopus 로고    scopus 로고
    • Autophagy, inflammation, and immunity: A troika governing cancer and its treatment
    • Zhong, Z., Sanchez-Lopez, E. & Karin, M. Autophagy, inflammation, and immunity: a troika governing cancer and its treatment. Cell 166, 288-298 (2016).
    • (2016) Cell , vol.166 , pp. 288-298
    • Zhong, Z.1    Sanchez-Lopez, E.2    Karin, M.3
  • 70
    • 84941660341 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer: An eternal fight between good and evil
    • Shalapour, S. & Karin, M. Immunity, inflammation, and cancer: an eternal fight between good and evil. J. Clin. Invest. 125, 3347-3355 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 3347-3355
    • Shalapour, S.1    Karin, M.2
  • 71
    • 33745003285 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB
    • Frede, S., Stockmann, C., Freitag, P. & Fandrey, J. Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB. Biochem. J. 396, 517-527 (2006).
    • (2006) Biochem. J. , vol.396 , pp. 517-527
    • Frede, S.1    Stockmann, C.2    Freitag, P.3    Fandrey, J.4
  • 74
    • 84857789085 scopus 로고    scopus 로고
    • The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
    • Masson, N. et al. The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity. EMBO Rep. 13, 251-257 (2012).
    • (2012) EMBO Rep. , vol.13 , pp. 251-257
    • Masson, N.1
  • 75
    • 0348134741 scopus 로고    scopus 로고
    • Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1alpha
    • Hagen, T., Taylor, C. T., Lam, F. & Moncada, S. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science 302, 1975-1978 (2003).
    • (2003) Science , vol.302 , pp. 1975-1978
    • Hagen, T.1    Taylor, C.T.2    Lam, F.3    Moncada, S.4
  • 76
    • 84925858947 scopus 로고    scopus 로고
    • Hydrogen sulphide induces HIF-1α and Nrf2 in THP-1 macrophages
    • Lohninger, L. et al. Hydrogen sulphide induces HIF-1α and Nrf2 in THP-1 macrophages. Biochimie 112, 187-195 (2015).
    • (2015) Biochimie , vol.112 , pp. 187-195
    • Lohninger, L.1
  • 77
    • 84931478550 scopus 로고    scopus 로고
    • Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1α
    • Flannigan, K. L. et al. Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1α. FASEB J. 29, 1591-1602 (2015).
    • (2015) FASEB J. , vol.29 , pp. 1591-1602
    • Flannigan, K.L.1
  • 78
    • 84868651324 scopus 로고    scopus 로고
    • Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1α
    • Wu, B., Teng, H., Yang, G., Wu, L. & Wang, R. Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1α. Br. J. Pharmacol. 167, 1492-1505 (2012).
    • (2012) Br. J. Pharmacol. , vol.167 , pp. 1492-1505
    • Wu, B.1    Teng, H.2    Yang, G.3    Wu, L.4    Wang, R.5
  • 79
    • 73949121249 scopus 로고    scopus 로고
    • The hematopoietic stem cell niche: Low in oxygen but a nice place to be
    • Eliasson, P. & Jönsson, J. I. The hematopoietic stem cell niche: low in oxygen but a nice place to be. J. Cell. Physiol. 222, 17-22 (2010).
    • (2010) J. Cell. Physiol. , vol.222 , pp. 17-22
    • Eliasson, P.1    Jönsson, J.I.2
  • 80
    • 34248359065 scopus 로고    scopus 로고
    • Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
    • Parmar, K., Mauch, P., Vergilio, J. A., Sackstein, R. & Down, J. D. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc. Natl Acad. Sci. USA 104, 5431-5436 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 5431-5436
    • Parmar, K.1    Mauch, P.2    Vergilio, J.A.3    Sackstein, R.4    Down, J.D.5
  • 81
    • 0031822253 scopus 로고    scopus 로고
    • Changing bone marrow micro-environment during development of acute myeloid leukaemia in rats
    • Mortensen, B. T. et al. Changing bone marrow micro-environment during development of acute myeloid leukaemia in rats. Br. J. Haematol. 102, 458-464 (1998).
    • (1998) Br. J. Haematol. , vol.102 , pp. 458-464
    • Mortensen, B.T.1
  • 82
    • 84952984655 scopus 로고    scopus 로고
    • Hypoxia regulates the hematopoietic stem cell niche
    • Morikawa, T. & Takubo, K. Hypoxia regulates the hematopoietic stem cell niche. Pflugers Arch. 468, 13-22 (2015).
    • (2015) Pflugers Arch. , vol.468 , pp. 13-22
    • Morikawa, T.1    Takubo, K.2
  • 83
    • 84873545852 scopus 로고    scopus 로고
    • Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation
    • Forristal, C. E. et al. Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation. Blood 121, 759-769 (2013).
    • (2013) Blood , vol.121 , pp. 759-769
    • Forristal, C.E.1
  • 84
    • 77956217067 scopus 로고    scopus 로고
    • Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
    • Takubo, K. et al. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell. 7, 391-402 (2010).
    • (2010) Cell Stem Cell. , vol.7 , pp. 391-402
    • Takubo, K.1
  • 85
    • 84894049819 scopus 로고    scopus 로고
    • Targeting the hypoxia-sensing pathway in clinical hematology
    • Forristal, C. E. & Levesque, J. P. Targeting the hypoxia-sensing pathway in clinical hematology. Stem Cells Transl Med. 3, 135-140 (2014).
    • (2014) Stem Cells Transl Med. , vol.3 , pp. 135-140
    • Forristal, C.E.1    Levesque, J.P.2
  • 86
    • 84901466176 scopus 로고    scopus 로고
    • Concise review: Genetic dissection of hypoxia signaling pathways in normal and leukemic stem cells
    • Gezer, D., Vukovic, M., Soga, T., Pollard, P. J. & Kranc, K. R. Concise review: genetic dissection of hypoxia signaling pathways in normal and leukemic stem cells. Stem Cells 32, 1390-1397 (2014).
    • (2014) Stem Cells , vol.32 , pp. 1390-1397
    • Gezer, D.1    Vukovic, M.2    Soga, T.3    Pollard, P.J.4    Kranc, K.R.5
  • 87
    • 85017628617 scopus 로고    scopus 로고
    • Physiological plasticity of neural-crest-derived stem cells in the adult mammalian carotid body
    • Annese, V., Navarro-Guerrero, E., Rodríguez-Prieto, I. & Pardal, R. Physiological plasticity of neural-crest-derived stem cells in the adult mammalian carotid body. Cell Rep. 19, 471-478 (2017).
    • (2017) Cell Rep. , vol.19 , pp. 471-478
    • Annese, V.1    Navarro-Guerrero, E.2    Rodríguez-Prieto, I.3    Pardal, R.4
  • 88
    • 77957584397 scopus 로고    scopus 로고
    • O2 regulates stem cells through Wnt/β-catenin signalling
    • Mazumdar, J. et al. O2 regulates stem cells through Wnt/β-catenin signalling. Nat. Cell Biol. 12, 1007-1013 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 1007-1013
    • Mazumdar, J.1
  • 89
    • 77956205122 scopus 로고    scopus 로고
    • The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
    • Simsek, T. et al. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell. 7, 380-390 (2010).
    • (2010) Cell Stem Cell. , vol.7 , pp. 380-390
    • Simsek, T.1
  • 90
    • 84943612165 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor nuclear translocator is an essential regulator of murine hematopoietic stem cell viability
    • Krock, B. L. et al. The aryl hydrocarbon receptor nuclear translocator is an essential regulator of murine hematopoietic stem cell viability. Blood 125, 3263-3272 (2015).
    • (2015) Blood , vol.125 , pp. 3263-3272
    • Krock, B.L.1
  • 91
    • 84886024954 scopus 로고    scopus 로고
    • Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance
    • Guitart, A. V. et al. Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance. Blood 122, 1741-1745 (2013).
    • (2013) Blood , vol.122 , pp. 1741-1745
    • Guitart, A.V.1
  • 92
    • 84994472525 scopus 로고    scopus 로고
    • Germinal center hypoxia potentiates immunoglobulin class switch recombination
    • Abbott, R. K. et al. Germinal center hypoxia potentiates immunoglobulin class switch recombination. J. Immunol. 197, 4014-4020 (2016).
    • (2016) J. Immunol. , vol.197 , pp. 4014-4020
    • Abbott, R.K.1
  • 93
    • 84655169213 scopus 로고    scopus 로고
    • Placental immunology and maternal alloimmune responses
    • Kumpel, B. M. & Manoussaka, M. S. Placental immunology and maternal alloimmune responses. Vox Sang. 102, 2-12 (2012).
    • (2012) Vox Sang. , vol.102 , pp. 2-12
    • Kumpel, B.M.1    Manoussaka, M.S.2
  • 94
    • 33644781731 scopus 로고    scopus 로고
    • Hypoxia, HIF and the placenta
    • Fryer, B. H. & Simon, M. C. Hypoxia, HIF and the placenta. Cell Cycle 5, 495-498 (2006).
    • (2006) Cell Cycle , vol.5 , pp. 495-498
    • Fryer, B.H.1    Simon, M.C.2
  • 95
    • 85015619923 scopus 로고    scopus 로고
    • Hypoxia and HIF pathway in cancer and the placenta
    • Macklin, P. S., McAuliffe, J., Pugh, C. W. & Yamamoto, A. Hypoxia and HIF pathway in cancer and the placenta. Placenta 56, 8-13 (2017).
    • (2017) Placenta , vol.56 , pp. 8-13
    • MacKlin, P.S.1    McAuliffe, J.2    Pugh, C.W.3    Yamamoto, A.4
  • 96
    • 84993953205 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2
    • Yaghi, L. et al. Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2. Oncotarget 7, 63690-63707 (2016).
    • (2016) Oncotarget , vol.7 , pp. 63690-63707
    • Yaghi, L.1
  • 97
    • 84893872087 scopus 로고    scopus 로고
    • A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells
    • Barsoum, I. B., Smallwood, C. A., Siemens, D. R. & Graham, C. H. A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells. Cancer Res. 74, 665-674 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 665-674
    • Barsoum, I.B.1    Smallwood, C.A.2    Siemens, D.R.3    Graham, C.H.4
  • 99
    • 84937640378 scopus 로고    scopus 로고
    • Interactions of innate and adaptive immunity in brain development and function
    • Filiano, A. J., Gadani, S. P. & Kipnis, J. Interactions of innate and adaptive immunity in brain development and function. Brain Res. 1617, 18-27 (2015).
    • (2015) Brain Res. , vol.1617 , pp. 18-27
    • Filiano, A.J.1    Gadani, S.P.2    Kipnis, J.3
  • 100
    • 84903533463 scopus 로고    scopus 로고
    • Ontogeny of early life immunity
    • Dowling, D. J. & Levy, O. Ontogeny of early life immunity. Trends Immunol. 35, 299-310 (2014).
    • (2014) Trends Immunol. , vol.35 , pp. 299-310
    • Dowling, D.J.1    Levy, O.2
  • 101
    • 0019959154 scopus 로고
    • Metabolic control of intestinal oxygenation and blood flow
    • Shepherd, A. P. Metabolic control of intestinal oxygenation and blood flow. Fed. Proc. 41, 2084-2089 (1982).
    • (1982) Fed. Proc. , vol.41 , pp. 2084-2089
    • Shepherd, A.P.1
  • 102
    • 9644302527 scopus 로고    scopus 로고
    • Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
    • Karhausen, J. et al. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J. Clin. Invest. 114, 1098-1106 (2004).
    • (2004) J. Clin. Invest. , vol.114 , pp. 1098-1106
    • Karhausen, J.1
  • 103
    • 0034029848 scopus 로고    scopus 로고
    • Detection of hypoxia in human squamous cell carcinoma by EF5 binding
    • Evans, S. M. et al. Detection of hypoxia in human squamous cell carcinoma by EF5 binding. Cancer Res. 60, 2018-2024 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 2018-2024
    • Evans, S.M.1
  • 104
    • 84908306828 scopus 로고    scopus 로고
    • Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota
    • Albenberg, L. et al. Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology 147, 1055-1063 (2014).
    • (2014) Gastroenterology , vol.147 , pp. 1055-1063
    • Albenberg, L.1
  • 105
    • 0028835416 scopus 로고
    • In vivo oximetry using EPR and India ink
    • Goda, F. et al. In vivo oximetry using EPR and India ink. Magn. Reson. Med. 33, 237-245 (1995).
    • (1995) Magn. Reson. Med. , vol.33 , pp. 237-245
    • Goda, F.1
  • 106
    • 0033551085 scopus 로고    scopus 로고
    • Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging
    • He, G. et al. Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging. Proc. Natl Acad. Sci. USA 96, 4586-4591 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 4586-4591
    • He, G.1
  • 107
    • 84929145736 scopus 로고    scopus 로고
    • Immune response regulation in the tumor microenvironment by hypoxia
    • Labiano, S., Palazon, A. & Melero, I. Immune response regulation in the tumor microenvironment by hypoxia. Semin. Oncol. 42, 378-386 (2015).
    • (2015) Semin. Oncol. , vol.42 , pp. 378-386
    • Labiano, S.1    Palazon, A.2    Melero, I.3
  • 108
    • 84924871326 scopus 로고    scopus 로고
    • The potential role of HIF on tumour progression and dissemination
    • Unwith, S., Zhao, H., Hennah, L. & Ma, D. The potential role of HIF on tumour progression and dissemination. Int. J. Cancer. 136, 2491-2503 (2015).
    • (2015) Int. J. Cancer. , vol.136 , pp. 2491-2503
    • Unwith, S.1    Zhao, H.2    Hennah, L.3    Ma, D.4
  • 109
    • 84930277289 scopus 로고    scopus 로고
    • Cancer metabolism and the Warburg effect: The role of HIF-1 and PI3K
    • Courtnay, R. et al. Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K. Mol. Biol. Rep. 42, 841-851 (2015).
    • (2015) Mol. Biol. Rep. , vol.42 , pp. 841-851
    • Courtnay, R.1
  • 110
    • 84928056873 scopus 로고    scopus 로고
    • The journey from discoveries in fundamental immunology to cancer immunotherapy
    • Miller, J. F. & Sadelain, M. The journey from discoveries in fundamental immunology to cancer immunotherapy. Cancer Cell 27, 439-449 (2015).
    • (2015) Cancer Cell , vol.27 , pp. 439-449
    • Miller, J.F.1    Sadelain, M.2
  • 111
    • 84897002504 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer or viruses
    • Maus, M. V. et al. Adoptive immunotherapy for cancer or viruses. Annu. Rev. Immunol. 32, 189-225 (2014).
    • (2014) Annu. Rev. Immunol. , vol.32 , pp. 189-225
    • Maus, M.V.1
  • 112
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • Corzo, C. A. et al. HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J. Exp. Med. 207, 2439-2453 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 2439-2453
    • Corzo, C.A.1
  • 114
    • 84975138840 scopus 로고    scopus 로고
    • AMP-activated protein kinase and Glycogen Synthase Kinase 3β modulate the severity of sepsis-induced lung injury
    • Liu, Z. et al. AMP-activated protein kinase and Glycogen Synthase Kinase 3β modulate the severity of sepsis-induced lung injury. Mol. Med. 21, 937-950 (2015).
    • (2015) Mol. Med. , vol.21 , pp. 937-950
    • Liu, Z.1
  • 115
    • 84892447705 scopus 로고    scopus 로고
    • Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation
    • Campbell, E. L. et al. Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity 40, 66-77 (2014).
    • (2014) Immunity , vol.40 , pp. 66-77
    • Campbell, E.L.1
  • 116
    • 3543023938 scopus 로고    scopus 로고
    • Chronic granulomatous disease caused by a deficiency in p47(phox) mimicking Crohn's disease
    • Huang, J. S. et al. Chronic granulomatous disease caused by a deficiency in p47(phox) mimicking Crohn's disease. Clin. Gastroenterol. Hepatol. 2, 690-695 (2004).
    • (2004) Clin. Gastroenterol. Hepatol. , vol.2 , pp. 690-695
    • Huang, J.S.1
  • 118
    • 85007608335 scopus 로고    scopus 로고
    • Hypoxia and HIF-1 activation in bacterial infections
    • Devraj, G., Beerlage, C., Brüne, B. & Kempf, V. A. Hypoxia and HIF-1 activation in bacterial infections. Microbes Infect. 19, 144-156 (2017).
    • (2017) Microbes Infect. , vol.19 , pp. 144-156
    • Devraj, G.1    Beerlage, C.2    Brüne, B.3    Kempf, V.A.4
  • 119
    • 77955384915 scopus 로고    scopus 로고
    • Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens
    • Werth, N. et al. Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens. PLoS ONE. 5, e11576 (2010).
    • (2010) PLoS ONE. , vol.5 , pp. e11576
    • Werth, N.1
  • 120
    • 84935878792 scopus 로고    scopus 로고
    • The impact of hypoxia on bacterial infection
    • Schaffer, K. & Taylor, C. T. The impact of hypoxia on bacterial infection. FEBS J. 282, 2260-2266 (2015).
    • (2015) FEBS J. , vol.282 , pp. 2260-2266
    • Schaffer, K.1    Taylor, C.T.2
  • 121
    • 0036167851 scopus 로고    scopus 로고
    • Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
    • Worlitzsch, D. et al. Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J. Clin. Invest. 109, 317-325 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 317-325
    • Worlitzsch, D.1
  • 123
    • 84873897903 scopus 로고    scopus 로고
    • Hypoxia modulates infection of epithelial cells by Pseudomonas aeruginosa
    • Schaible, B. et al. Hypoxia modulates infection of epithelial cells by Pseudomonas aeruginosa. PLoS ONE. 8, e56491 (2013).
    • (2013) PLoS ONE. , vol.8 , pp. e56491
    • Schaible, B.1
  • 124
    • 84858692238 scopus 로고    scopus 로고
    • Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumps
    • Schaible, B., Taylor, C. T. & Schaffer, K. Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumps. Antimicrob. Agents Chemother. 56, 2114-2118 (2012).
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 2114-2118
    • Schaible, B.1    Taylor, C.T.2    Schaffer, K.3
  • 125
    • 85021899398 scopus 로고    scopus 로고
    • Hypoxia reduces the pathogenicity of Pseudomonas aeruginosa by decreasing the expression of multiple virulence factors
    • Schaible, B. et al. Hypoxia reduces the pathogenicity of Pseudomonas aeruginosa by decreasing the expression of multiple virulence factors. J. Infect. Dis. 215, 1459-1467 (2017).
    • (2017) J. Infect. Dis. , vol.215 , pp. 1459-1467
    • Schaible, B.1
  • 126
    • 84925250962 scopus 로고    scopus 로고
    • The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia
    • Koh, H. S. et al. The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia. Nat. Commun. 6, 6340 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6340
    • Koh, H.S.1
  • 127
    • 84954427967 scopus 로고    scopus 로고
    • Hypoxia-Inducible Factor-2α limits natural killer T cell cytotoxicity in renal ischemia/reperfusion injury
    • Zhang, J. et al. Hypoxia-Inducible Factor-2α limits natural killer T cell cytotoxicity in renal ischemia/reperfusion injury. J. Am. Soc. Nephrol. 27, 92-106 (2016).
    • (2016) J. Am. Soc. Nephrol. , vol.27 , pp. 92-106
    • Zhang, J.1
  • 128
    • 78549270472 scopus 로고    scopus 로고
    • The role of HIF-1 in up-regulating MICA expression on human renal proximal tubular epithelial cells during hypoxia/reoxygenation
    • Luo, L. et al. The role of HIF-1 in up-regulating MICA expression on human renal proximal tubular epithelial cells during hypoxia/reoxygenation. BMC Cell Biol. 11, 91 (2010).
    • (2010) BMC Cell Biol. , vol.11 , pp. 91
    • Luo, L.1
  • 129
    • 84958117511 scopus 로고    scopus 로고
    • Pharmacological targeting of the HIF hydroxylases-A new field in medicine 1development
    • Chan, M. C., Holt-Martyn, J. P., Schofield, C. J. & Ratcliffe, P. J. Pharmacological targeting of the HIF hydroxylases-A new field in medicine 1development. Mol. Aspects Med. 47-48, 54-75 (2016).
    • (2016) Mol. Aspects Med. , vol.47-48 , pp. 54-75
    • Chan, M.C.1    Holt-Martyn, J.P.2    Schofield, C.J.3    Ratcliffe, P.J.4
  • 130
    • 79953649414 scopus 로고    scopus 로고
    • HIF prolyl hydroxylase inhibitors for anemia
    • Muchnik, E. & Kaplan, J. HIF prolyl hydroxylase inhibitors for anemia. Expert Opin. Investig. Drugs 20, 645-656 (2011).
    • (2011) Expert Opin. Investig. Drugs , vol.20 , pp. 645-656
    • Muchnik, E.1    Kaplan, J.2
  • 131
    • 84958920828 scopus 로고    scopus 로고
    • HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
    • Maxwell, P. H. & Eckardt, K. U. HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond. Nat. Rev. Nephrol. 12, 157-168 (2016).
    • (2016) Nat. Rev. Nephrol. , vol.12 , pp. 157-168
    • Maxwell, P.H.1    Eckardt, K.U.2
  • 132
    • 84994626953 scopus 로고    scopus 로고
    • On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
    • Cho, H. et al. On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models. Nature. 539, 107-111 (2016).
    • (2016) Nature. , vol.539 , pp. 107-111
    • Cho, H.1
  • 133
    • 84994669316 scopus 로고    scopus 로고
    • Targeting renal cell carcinoma with a HIF-2 antagonist
    • Chen, W. et al. Targeting renal cell carcinoma with a HIF-2 antagonist. Nature 539, 112-117 (2016).
    • (2016) Nature , vol.539 , pp. 112-117
    • Chen, W.1
  • 134
    • 84875758986 scopus 로고    scopus 로고
    • Hydroxylases as therapeutic targets in inflammatory bowel disease
    • Cummins, E. P., Doherty, G. A. & Taylor, C. T. Hydroxylases as therapeutic targets in inflammatory bowel disease. Lab. Invest. 93, 378-383 (2013).
    • (2013) Lab. Invest. , vol.93 , pp. 378-383
    • Cummins, E.P.1    Doherty, G.A.2    Taylor, C.T.3
  • 135
    • 80051988912 scopus 로고    scopus 로고
    • The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells
    • Hams, E. et al. The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells. Shock 36, 295-302 (2011).
    • (2011) Shock , vol.36 , pp. 295-302
    • Hams, E.1
  • 136
    • 84973320456 scopus 로고    scopus 로고
    • Oral hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) for the treatment of anemia in patients with CKD
    • Provenzano, R. et al. Oral hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) for the treatment of anemia in patients with CKD. Clin. J. Am. Soc. Nephrol. 11, 982-991 (2016).
    • (2016) Clin. J. Am. Soc. Nephrol. , vol.11 , pp. 982-991
    • Provenzano, R.1
  • 137
    • 84962073517 scopus 로고    scopus 로고
    • A novel hypoxia-inducible factor-prolyl hydroxylase inhibitor (GSK1278863) for anemia in CKD: 28 day, phase 2A randomized trial
    • Brigandi, R. A. et al. A novel hypoxia-inducible factor-prolyl hydroxylase inhibitor (GSK1278863) for anemia in CKD: 28 day, phase 2A randomized trial. Am. J. Kidney Dis. 67, 861-871 (2016).
    • (2016) Am. J. Kidney Dis. , vol.67 , pp. 861-871
    • Brigandi, R.A.1
  • 138
    • 84994143390 scopus 로고    scopus 로고
    • Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease
    • Pergola, P. E., Spinowitz, B. S., Hartman, C. S., Maroni, B. J. & Haase, V. H. Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease. Kidney Int. 90, 1115-1122 (2016).
    • (2016) Kidney Int. , vol.90 , pp. 1115-1122
    • Pergola, P.E.1    Spinowitz, B.S.2    Hartman, C.S.3    Maroni, B.J.4    Haase, V.H.5
  • 139
    • 84941950636 scopus 로고    scopus 로고
    • Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis
    • Tambuwala, M. M. et al. Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis. J. Control. Release 217, 221-227 (2015).
    • (2015) J. Control. Release , vol.217 , pp. 221-227
    • Tambuwala, M.M.1
  • 140
    • 0031019656 scopus 로고    scopus 로고
    • Sites of erythropoietin production
    • Maxwell, P. H. et al. Sites of erythropoietin production. Kidney Int. 51, 393-401 (1997).
    • (1997) Kidney Int. , vol.51 , pp. 393-401
    • Maxwell, P.H.1
  • 141
    • 84900342698 scopus 로고    scopus 로고
    • Direct measurement of local oxygen concentration in the bone marrow of live animals
    • Spencer, J. A. et al. Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature 508, 269-273 (2014).
    • (2014) Nature , vol.508 , pp. 269-273
    • Spencer, J.A.1
  • 142
    • 84866689485 scopus 로고    scopus 로고
    • Hypoxia in the eye: A two-sided coin
    • Grimm, C. & Willmann, G. Hypoxia in the eye: a two-sided coin. High Alt. Med. Biol. 13169-13175 (2012).
    • (2012) High Alt. Med. Biol. , pp. 13169-13175
    • Grimm, C.1    Willmann, G.2
  • 143
    • 33845321931 scopus 로고    scopus 로고
    • Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity
    • Cummins, E. P. et al. Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc. Natl Acad. Sci. USA 103, 18154-18159 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 18154-18159
    • Cummins, E.P.1
  • 144
    • 33749518516 scopus 로고    scopus 로고
    • Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
    • Cockman, M. E. et al. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc. Natl Acad. Sci. USA;103, 14767-14772.
    • Proc. Natl Acad. Sci. USA; , vol.103 , pp. 14767-14772
    • Cockman, M.E.1
  • 145
    • 84880684167 scopus 로고    scopus 로고
    • Tumor necrosis factor α-induced hypoxia-inducible factor 1α-β-catenin axis regulates major histocompatibility complex class I gene activation through chromatin remodeling
    • Ghosh, S., Paul, A. & Sen, E. Tumor necrosis factor α-induced hypoxia-inducible factor 1α-β-catenin axis regulates major histocompatibility complex class I gene activation through chromatin remodeling. Mol. Cell. Biol. 33, 2718-2731 (2013).
    • (2013) Mol. Cell. Biol. , vol.33 , pp. 2718-2731
    • Ghosh, S.1    Paul, A.2    Sen, E.3
  • 146
    • 80052277906 scopus 로고    scopus 로고
    • Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
    • Dang, E. V. et al. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell 146, 772-784 (2011).
    • (2011) Cell , vol.146 , pp. 772-784
    • Dang, E.V.1
  • 147
    • 84867381718 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    • Clambey, E. T. et al. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc. Natl Acad. Sci. USA 109, E2784-E2793 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. E2784-E2793
    • Clambey, E.T.1
  • 148
    • 37349118314 scopus 로고    scopus 로고
    • The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis
    • Cummins, E. P. et al. The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology 134, 156-165 (2008).
    • (2008) Gastroenterology , vol.134 , pp. 156-165
    • Cummins, E.P.1
  • 149
    • 80052754529 scopus 로고    scopus 로고
    • Longitudinal quantification of inflammation in the murine dextran sodium sulfate-induced colitis model using muPET/CT
    • Hindryckx, P. et al. Longitudinal quantification of inflammation in the murine dextran sodium sulfate-induced colitis model using muPET/CT. Inflamm. Bowel Dis. 17, 2058-2064 (2011).
    • (2011) Inflamm. Bowel Dis. , vol.17 , pp. 2058-2064
    • Hindryckx, P.1
  • 150
    • 85025812572 scopus 로고    scopus 로고
    • Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation
    • Cosin-Roger, J. et al. Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation. Nat. Commun. 8, 98 (2017).
    • (2017) Nat. Commun. , vol.8 , pp. 98
    • Cosin-Roger, J.1
  • 151
    • 37349048502 scopus 로고    scopus 로고
    • Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition
    • Robinson, A. et al. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology 134, 145-155 (2008).
    • (2008) Gastroenterology , vol.134 , pp. 145-155
    • Robinson, A.1
  • 152
    • 78650654512 scopus 로고    scopus 로고
    • Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD
    • Hindryckx, P. et al. Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD. J. Immunol. 185, 6306-6316 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 6306-6316
    • Hindryckx, P.1
  • 153
    • 77953910490 scopus 로고    scopus 로고
    • Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury
    • Hirota, S. A. et al. Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury. Gastroenterology 139, 259-269 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 259-269
    • Hirota, S.A.1
  • 154
    • 79954994463 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha dependent protection from intestinal ischemia/reperfusion injury involves ecto-5?-nucleotidase (CD73) and the A2B adenosine receptor
    • Hart, M. L. et al. Hypoxia-inducible factor-1 alpha dependent protection from intestinal ischemia/reperfusion injury involves ecto-5?-nucleotidase (CD73) and the A2B adenosine receptor. J. Immunol. 186, 4367-4374 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 4367-4374
    • Hart, M.L.1
  • 155
    • 82355181386 scopus 로고    scopus 로고
    • Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms
    • Marchbank, T., Mahmood, A., Harten, S., Maxwell, P. H. & Playford, R. J. Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms. Lab. Invest. 91, 1684-1694 (2011).
    • (2011) Lab. Invest. , vol.91 , pp. 1684-1694
    • Marchbank, T.1    Mahmood, A.2    Harten, S.3    Maxwell, P.H.4    Playford, R.J.5
  • 156
    • 84886073769 scopus 로고    scopus 로고
    • Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis
    • Keely, S. et al. Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis. Mucosal Immunol. 7, 114-123 (2014).
    • (2014) Mucosal Immunol. , vol.7 , pp. 114-123
    • Keely, S.1
  • 157
    • 84927738288 scopus 로고    scopus 로고
    • Oral delivery of prolyl hydroxylase inhibitor: AKB-4924 promotes localized mucosal healing in a mouse model of colitis
    • Marks, E. et al. Oral delivery of prolyl hydroxylase inhibitor: AKB-4924 promotes localized mucosal healing in a mouse model of colitis. Inflamm. Bowel Dis. 21, 267-275 (2015).
    • (2015) Inflamm. Bowel Dis. , vol.21 , pp. 267-275
    • Marks, E.1
  • 158
    • 84901227921 scopus 로고    scopus 로고
    • PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2
    • Taniguchi, C. M. et al. PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2. Sci. Transl Med. 6, 236ra64 (2014).
    • (2014) Sci. Transl Med. , vol.6 , pp. 236ra64
    • Taniguchi, C.M.1
  • 159
    • 84919338076 scopus 로고    scopus 로고
    • Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity
    • Jeong, S. et al. Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity. Eur. J. Pharmacol. 747, 114-122 (2015).
    • (2015) Eur. J. Pharmacol. , vol.747 , pp. 114-122
    • Jeong, S.1
  • 160
    • 84893356598 scopus 로고    scopus 로고
    • Therapeutic treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates murine colitis
    • Gupta, R. et al. Therapeutic treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates murine colitis. Clin. Exp. Gastroenterol. 7, 13-23 (2014).
    • (2014) Clin. Exp. Gastroenterol. , vol.7 , pp. 13-23
    • Gupta, R.1
  • 161
    • 84865601727 scopus 로고    scopus 로고
    • Treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates ischemic acute kidney injury
    • Jamadarkhana, P. et al. Treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates ischemic acute kidney injury. Am. J. Nephrol. 36, 208-218 (2012).
    • (2012) Am. J. Nephrol. , vol.36 , pp. 208-218
    • Jamadarkhana, P.1
  • 162
    • 75849163295 scopus 로고    scopus 로고
    • Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model
    • Bernhardt, W. M. et al. Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model. Proc. Natl Acad. Sci. USA 106, 21276-21281 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 21276-21281
    • Bernhardt, W.M.1
  • 163
    • 85006279493 scopus 로고    scopus 로고
    • Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling [corrected]
    • Manresa, M. C. et al. Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling [corrected]. Am. J. Physiol. Gastrointest. Liver Physiol. 3 11, G1076-G1090 (2016).
    • (2016) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.311 , pp. G1076-G1090
    • Manresa, M.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.