-
1
-
-
85015664972
-
The evolving view of the hematopoietic stem cell niche
-
Beerman, I., Luis, T. C., Singbrant, S., Lo Celso, C. & Méndez-Ferrer, S. The evolving view of the hematopoietic stem cell niche. Exp. Hematol. 50, 22-26 (2017).
-
(2017)
Exp. Hematol.
, vol.50
, pp. 22-26
-
-
Beerman, I.1
Luis, T.C.2
Singbrant, S.3
Lo Celso, C.4
Méndez-Ferrer, S.5
-
2
-
-
84899561969
-
An overview of the intrathymic intricacies of T cell development
-
Shah, D. K. & Zúñiga-Pflücker, J. C. An overview of the intrathymic intricacies of T cell development. J. Immunol. 192, 4017-4023 (2014).
-
(2014)
J. Immunol.
, vol.192
, pp. 4017-4023
-
-
Shah, D.K.1
Zúñiga-Pflücker, J.C.2
-
3
-
-
84983534959
-
Neutrophils and the inflammatory tissue microenvironment in the mucosa
-
Campbell, E. L., Kao, D. J. & Colgan, S. P. Neutrophils and the inflammatory tissue microenvironment in the mucosa. Immunol. Rev. 273, 112-120 (2016).
-
(2016)
Immunol. Rev.
, vol.273
, pp. 112-120
-
-
Campbell, E.L.1
Kao, D.J.2
Colgan, S.P.3
-
4
-
-
84959224681
-
The tumor microenvironment in esophageal cancer
-
Lin, E. W., Karakasheva, T. A., Hicks, P. D., Bass, A. J. & Rustgi, A. K. The tumor microenvironment in esophageal cancer. Oncogene 35, 5337-5349 (2016).
-
(2016)
Oncogene
, vol.35
, pp. 5337-5349
-
-
Lin, E.W.1
Karakasheva, T.A.2
Hicks, P.D.3
Bass, A.J.4
Rustgi, A.K.5
-
5
-
-
84946489574
-
The lung metastatic niche
-
Maru, Y. The lung metastatic niche. J. Mol. Med. (Berl.) 93, 1185-1192 (2015).
-
(2015)
J. Mol. Med. (Berl.)
, vol.93
, pp. 1185-1192
-
-
Maru, Y.1
-
6
-
-
84940891850
-
Microenvironmental control of stem cell fate in intestinal homeostasis and disease
-
Biswas, S. et al. Microenvironmental control of stem cell fate in intestinal homeostasis and disease. J. Pathol. 237, 135-145 (2015).
-
(2015)
J. Pathol.
, vol.237
, pp. 135-145
-
-
Biswas, S.1
-
7
-
-
24744440988
-
Immunology of ischemic vascular disease: Plaque to attack
-
Hallenbeck, J. M., Hansson, G. K. & Becker, K. J. Immunology of ischemic vascular disease: plaque to attack. Trends Immunol. 26, 550-556 (2005).
-
(2005)
Trends Immunol.
, vol.26
, pp. 550-556
-
-
Hallenbeck, J.M.1
Hansson, G.K.2
Becker, K.J.3
-
8
-
-
84963575145
-
The immune battle against Helicobacter pylori infection: NO offense
-
Gobert, A. P. & Wilson, K. T. The immune battle against Helicobacter pylori infection: NO offense. Trends Microbiol. 24, 366-376 (2016).
-
(2016)
Trends Microbiol.
, vol.24
, pp. 366-376
-
-
Gobert, A.P.1
Wilson, K.T.2
-
9
-
-
57749093121
-
Inflammation and stem cells in gastrointestinal carcinogenesis
-
Quante, M. & Wang, T. C. Inflammation and stem cells in gastrointestinal carcinogenesis. Physiology (Bethesda) 23, 350-359 (2008).
-
(2008)
Physiology (Bethesda)
, vol.23
, pp. 350-359
-
-
Quante, M.1
Wang, T.C.2
-
10
-
-
84863601838
-
Chronic inflammation in cancer development
-
Multhoff, G., Molls, M. & Radons, J. Chronic inflammation in cancer development. Front. Immunol. 2, 98 (2012).
-
(2012)
Front. Immunol.
, vol.2
, pp. 98
-
-
Multhoff, G.1
Molls, M.2
Radons, J.3
-
11
-
-
84991571929
-
Hypoxia-dependent regulation of inflammatory pathways in immune cells
-
Taylor, C. T., Doherty. G., Fallon, P. G. & Cummins, E. P. Hypoxia-dependent regulation of inflammatory pathways in immune cells. J. Clin. Invest. 126, 3716-3724 (2016).
-
(2016)
J. Clin. Invest.
, vol.126
, pp. 3716-3724
-
-
Taylor, C.T.1
Doherty, G.2
Fallon, P.G.3
Cummins, E.P.4
-
12
-
-
84958118013
-
The role of HIF in immunity and inflammation
-
Cummins, E. P., Keogh, C. E., Crean, D. & Taylor, C. T. The role of HIF in immunity and inflammation. Mol. Aspects Med. 47-48, 24-34 (2016).
-
(2016)
Mol. Aspects Med.
, vol.47-48
, pp. 24-34
-
-
Cummins, E.P.1
Keogh, C.E.2
Crean, D.3
Taylor, C.T.4
-
13
-
-
84885950065
-
Targeting the HIF pathway in inflammation and immunity
-
Scholz, C. C. & Taylor, C. T. Targeting the HIF pathway in inflammation and immunity. Curr. Opin. Pharmacol. 13, 646-653 (2013).
-
(2013)
Curr. Opin. Pharmacol.
, vol.13
, pp. 646-653
-
-
Scholz, C.C.1
Taylor, C.T.2
-
14
-
-
77958042201
-
Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans
-
Taylor, C. T. & McElwain, J. C. Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans. Physiology (Bethesda) 25, 272-279 (2010).
-
(2010)
Physiology (Bethesda)
, vol.25
, pp. 272-279
-
-
Taylor, C.T.1
McElwain, J.C.2
-
15
-
-
77952092406
-
Hypoxia: An alarm signal during intestinal inflammation
-
Colgan, S. P. & Taylor, C. T. Hypoxia: an alarm signal during intestinal inflammation. Nat. Rev. Gastroenterol. Hepatol. 7, 281-287 (2010).
-
(2010)
Nat. Rev. Gastroenterol. Hepatol.
, vol.7
, pp. 281-287
-
-
Colgan, S.P.1
Taylor, C.T.2
-
16
-
-
84941618050
-
Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A review in the theme: Cellular responses to hypoxia
-
Zheng, L., Kelly, C. J. & Colgan, S. P. Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A review in the theme: cellular responses to hypoxia. Am. J. Physiol. Cell Physiol. 309, C350-C360 (2015).
-
(2015)
Am. J. Physiol. Cell Physiol.
, vol.309
, pp. C350-C360
-
-
Zheng, L.1
Kelly, C.J.2
Colgan, S.P.3
-
17
-
-
84955192227
-
The hypoxic tumor microenvironment: A driving force for breast cancer progression
-
Semenza, G. L. The hypoxic tumor microenvironment: a driving force for breast cancer progression. Biochim. Biophys. Acta 1863, 382-391 (2016).
-
(2016)
Biochim. Biophys. Acta
, vol.1863
, pp. 382-391
-
-
Semenza, G.L.1
-
18
-
-
84865575592
-
Molecular mechanisms mediating metastasis of hypoxic breast cancer cells
-
Semenza, G. L. Molecular mechanisms mediating metastasis of hypoxic breast cancer cells. Trends Mol. Med. 18, 534-543 (2012).
-
(2012)
Trends Mol. Med.
, vol.18
, pp. 534-543
-
-
Semenza, G.L.1
-
19
-
-
84963590058
-
Hypoxia and mucosal inflammation
-
Colgan, S. P., Campbell, E. L. & Kominsky, D. J. Hypoxia and mucosal inflammation. Annu. Rev. Pathol. 11, 77-100 (2016).
-
(2016)
Annu. Rev. Pathol.
, vol.11
, pp. 77-100
-
-
Colgan, S.P.1
Campbell, E.L.2
Kominsky, D.J.3
-
21
-
-
78650887484
-
The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal Trichoplax adhaerens
-
Loenarz, C. et al. The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens. EMBO Rep. 12, 63-70 (2011).
-
(2011)
EMBO Rep.
, vol.12
, pp. 63-70
-
-
Loenarz, C.1
-
22
-
-
25644446823
-
Hypoxia-responsive transcription factors
-
Cummins, E. P. & Taylor, C. T. Hypoxia-responsive transcription factors. Pflugers Arch. 450, 363-371 (2005).
-
(2005)
Pflugers Arch.
, vol.450
, pp. 363-371
-
-
Cummins, E.P.1
Taylor, C.T.2
-
23
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza, G. L. Hypoxia-inducible factors in physiology and medicine. Cell 148, 399-408 (2012).
-
(2012)
Cell
, vol.148
, pp. 399-408
-
-
Semenza, G.L.1
-
24
-
-
84876325985
-
Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer
-
Ratcliffe, P. J. Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer. J. Physiol. 591, 2027-2042 (2013).
-
(2013)
J. Physiol.
, vol.591
, pp. 2027-2042
-
-
Ratcliffe, P.J.1
-
25
-
-
0029842459
-
Oxygen sensing and molecular adaptation to hypoxia
-
Bunn, H. F. & Poyton, R. O. Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76, 839-885 (1996).
-
(1996)
Physiol. Rev.
, vol.76
, pp. 839-885
-
-
Bunn, H.F.1
Poyton, R.O.2
-
26
-
-
77950890499
-
Nitric oxide, cytochrome C oxidase, and the cellular response to hypoxia
-
Taylor, C. T. & Moncada, S. Nitric oxide, cytochrome C oxidase, and the cellular response to hypoxia. Arterioscler. Thromb. Vasc. Biol. 30, 643-647 (2010).
-
(2010)
Arterioscler. Thromb. Vasc. Biol.
, vol.30
, pp. 643-647
-
-
Taylor, C.T.1
Moncada, S.2
-
27
-
-
54549113030
-
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
-
Kaelin, W. G. Jr. The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat. Rev. Cancer 8, 865-873 (2008).
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 865-873
-
-
Kaelin, W.G.1
-
28
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
Kaelin, W. G. Jr & Ratcliffe, P. J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 30, 393-402 (2008).
-
(2008)
Mol. Cell
, vol.30
, pp. 393-402
-
-
Kaelin, W.G.1
Ratcliffe, P.J.2
-
29
-
-
84971268711
-
Hypercapnia suppresses the HIF-dependent adaptive response to hypoxia
-
Selfridge, A. C. et al. Hypercapnia suppresses the HIF-dependent adaptive response to hypoxia. J. Biol. Chem. 291, 11800-11808 (2016).
-
(2016)
J. Biol. Chem.
, vol.291
, pp. 11800-11808
-
-
Selfridge, A.C.1
-
30
-
-
84943750048
-
An essential role for chaperone-mediated autophagy in cell cycle progression
-
Hubbi, M. E. & Semenza, G. L. An essential role for chaperone-mediated autophagy in cell cycle progression. Autophagy 11, 850-851 (2015).
-
(2015)
Autophagy
, vol.11
, pp. 850-851
-
-
Hubbi, M.E.1
Semenza, G.L.2
-
31
-
-
84905976385
-
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1 a to promote cell-cycle progression
-
Hubbi, M. E., Gilkes, D. M., Hu, H., Kshitiz, Ahmed, I. & Semenza, G. L. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1 a to promote cell-cycle progression. Proc. Natl Acad. Sci. USA 111, E3325-E3334 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. E3325-E3334
-
-
Hubbi, M.E.1
Gilkes, D.M.2
Hu, H.3
Kshitiz Ahmed, I.4
Semenza, G.L.5
-
32
-
-
85014514282
-
L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
-
Intlekofer, A. M. et al. L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH. Nat. Chem. Biol. 13, 494-500 (2017).
-
(2017)
Nat. Chem. Biol.
, vol.13
, pp. 494-500
-
-
Intlekofer, A.M.1
-
33
-
-
85017251482
-
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
-
Tyrakis, P. A. et al. S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate. Nature 540, 236-241 (2016).
-
(2016)
Nature
, vol.540
, pp. 236-241
-
-
Tyrakis, P.A.1
-
34
-
-
84862776918
-
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
-
Koivunen, P. et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature 483, 484-488 (2012).
-
(2012)
Nature
, vol.483
, pp. 484-488
-
-
Koivunen, P.1
-
35
-
-
84876285741
-
Succinate is an inflammatory signal that induces IL-1p through HIF-1a
-
Tannahill, G. M. et al. Succinate is an inflammatory signal that induces IL-1p through HIF-1a. Nature 496, 238-242 (2013).
-
(2013)
Nature
, vol.496
, pp. 238-242
-
-
Tannahill, G.M.1
-
36
-
-
77951238575
-
Mitochondrial regulation of oxygen sensing
-
Chandel, N. S. Mitochondrial regulation of oxygen sensing. Adv. Exp. Med. Biol. 661, 339-354 (2010).
-
(2010)
Adv. Exp. Med. Biol.
, vol.661
, pp. 339-354
-
-
Chandel, N.S.1
-
37
-
-
84882239297
-
Pan-genomic binding of hypoxia-inducible transcription factors
-
Schödel, J., Mole, D. R. & Ratcliffe, P. J. Pan-genomic binding of hypoxia-inducible transcription factors. Biol. Chem. 394, 507-517 (2013).
-
(2013)
Biol. Chem.
, vol.394
, pp. 507-517
-
-
Schödel, J.1
Mole, D.R.2
Ratcliffe, P.J.3
-
38
-
-
67650531089
-
Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts
-
Mole, D. R. et al. Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts. J. Biol. Chem. 284, 16767-16775 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 16767-16775
-
-
Mole, D.R.1
-
39
-
-
84958551663
-
Hypoxia-inducible factor 3 biology: Complexities and emerging themes
-
Duan, C. Hypoxia-inducible factor 3 biology: complexities and emerging themes. Am. J. Physiol. Cell Physiol. 310, C260-269 (2016).
-
(2016)
Am. J. Physiol. Cell Physiol.
, vol.310
, pp. C260-269
-
-
Duan, C.1
-
40
-
-
84908141221
-
HIF transcription factors, inflammation, and immunity
-
Palazon, A., Goldrath, A. W., Nizet, V. & Johnson, R. S. HIF transcription factors, inflammation, and immunity. Immunity 41, 518-528 (2014).
-
(2014)
Immunity
, vol.41
, pp. 518-528
-
-
Palazon, A.1
Goldrath, A.W.2
Nizet, V.3
Johnson, R.S.4
-
41
-
-
84875395170
-
The impact of hypoxia on cell death pathways
-
Lenihan, C. R. & Taylor, C. T. The impact of hypoxia on cell death pathways. Biochem. Soc. Trans. 41, 657-663 (2013).
-
(2013)
Biochem. Soc. Trans.
, vol.41
, pp. 657-663
-
-
Lenihan, C.R.1
Taylor, C.T.2
-
42
-
-
84872134149
-
Regulation of erythropoiesis by hypoxia-inducible factors
-
Haase, V. H. Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev. 27, 41-53 (2013).
-
(2013)
Blood Rev.
, vol.27
, pp. 41-53
-
-
Haase, V.H.1
-
43
-
-
85000893948
-
Hypoxia and inflammatory bowel disease
-
Cummins, E. P. & Crean, D. Hypoxia and inflammatory bowel disease. Microbes Infect. 19, 210-221 (2017).
-
(2017)
Microbes Infect.
, vol.19
, pp. 210-221
-
-
Cummins, E.P.1
Crean, D.2
-
44
-
-
84991677503
-
Oxygen metabolism and barrier regulation in the intestinal mucosa
-
Glover, L. E. Lee, J. S. & Colgan, S. P. Oxygen metabolism and barrier regulation in the intestinal mucosa. J. Clin. Invest. 126, 3680-3688 (2016).
-
(2016)
J. Clin. Invest.
, vol.126
, pp. 3680-3688
-
-
Glover, L.E.1
Lee, J.S.2
Colgan, S.P.3
-
45
-
-
84958644571
-
Role of intestinal HIF-2a in health and disease
-
Ramakrishnan, S. K. & Shah, Y. M. Role of intestinal HIF-2a in health and disease. Annu. Rev. Physiol. 78, 301-325 (2016).
-
(2016)
Annu. Rev. Physiol.
, vol.78
, pp. 301-325
-
-
Ramakrishnan, S.K.1
Shah, Y.M.2
-
46
-
-
85020774193
-
The EGLN-HIF O2-sensing system: Multiple inputs and feedbacks
-
Ivan, M. & Kaelin, W. G. Jr. The EGLN-HIF O2-sensing system: multiple inputs and feedbacks. Mol. Cell 66, 772-779 (2017).
-
(2017)
Mol. Cell
, vol.66
, pp. 772-779
-
-
Ivan, M.1
Kaelin, W.G.2
-
47
-
-
84989182329
-
HIF-mediated innate immune responses: Cell signaling and therapeutic implications
-
Harris, A. J., Thompson, A. R., Whyte, M. K. & Walmsley, S. R. HIF-mediated innate immune responses: cell signaling and therapeutic implications. Hypoxia (Auckl.) 2, 47-58 (2014).
-
(2014)
Hypoxia (Auckl.)
, vol.2
, pp. 47-58
-
-
Harris, A.J.1
Thompson, A.R.2
Whyte, M.K.3
Walmsley, S.R.4
-
48
-
-
84991712912
-
Hypoxia-inducible factors: Key regulators of myeloid cells during inflammation
-
Lin, N. & Simon, M. C. Hypoxia-inducible factors: key regulators of myeloid cells during inflammation. J. Clin. Invest. 126, 3661-3671 (2016).
-
(2016)
J. Clin. Invest.
, vol.126
, pp. 3661-3671
-
-
Lin, N.1
Simon, M.C.2
-
49
-
-
84899473768
-
Succinate: A metabolic signal in inflammation
-
Mills, E. & O'Neill, L. A. Succinate: a metabolic signal in inflammation. Trends Cell Biol. 24, 313-320 (2014).
-
(2014)
Trends Cell Biol.
, vol.24
, pp. 313-320
-
-
Mills, E.1
O'Neill, L.A.2
-
50
-
-
84936766497
-
IRF-5-mediated inflammation limits CD8+ T Cell expansion by inducing HIF-1 a and impairing dendritic cell functions during Leishmania infection
-
Hammami, A., Charpentier, T, Smans, M. & Stäger, S. IRF-5-mediated inflammation limits CD8+ T Cell expansion by inducing HIF-1 a and impairing dendritic cell functions during Leishmania infection. PLoS Pathog. 11, e1004938 (2015).
-
(2015)
PLoS Pathog.
, vol.11
, pp. e1004938
-
-
Hammami, A.1
Charpentier, T.2
Smans, M.3
Stäger, S.4
-
51
-
-
84882269271
-
Role of hypoxia inducible factor-1 a for interferon synthesis in mouse dendritic cells
-
Wobben, R. et al. Role of hypoxia inducible factor-1 a for interferon synthesis in mouse dendritic cells. Biol. Chem. 394, 495-505 (2013).
-
(2013)
Biol. Chem.
, vol.394
, pp. 495-505
-
-
Wobben, R.1
-
52
-
-
84986575883
-
Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system
-
Cho, S. H. et al. Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system. Nature 537, 234-238 (2016).
-
(2016)
Nature
, vol.537
, pp. 234-238
-
-
Cho, S.H.1
-
53
-
-
79551633354
-
Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea
-
Ward, J. B. et al. Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea. FASEB J. 25, 535-543 (2011).
-
(2011)
FASEB J.
, vol.25
, pp. 535-543
-
-
Ward, J.B.1
-
54
-
-
84884236749
-
Fundamental role for HIF-1a in constitutive expression of human p defensin-1
-
Kelly, C. J. et al. Fundamental role for HIF-1a in constitutive expression of human p defensin-1. Mucosal Immunol. 6, 1110-1118 (2013).
-
(2013)
Mucosal Immunol.
, vol.6
, pp. 1110-1118
-
-
Kelly, C.J.1
-
55
-
-
84938923735
-
PVHL negatively regulates antiviral signaling by targeting MAVS for proteasomal degradation
-
Du, J. et al. pVHL negatively regulates antiviral signaling by targeting MAVS for proteasomal degradation. J. Immunol. 195, 1782-1790 (2015).
-
(2015)
J. Immunol.
, vol.195
, pp. 1782-1790
-
-
Du, J.1
-
56
-
-
84952894746
-
VHL-dependent alterations in the secretome of renal cell carcinoma: Association with immune cell response?
-
Stehle, F et al. VHL-dependent alterations in the secretome of renal cell carcinoma: association with immune cell response? Oncotarget 6, 43420-43437 (2015).
-
(2015)
Oncotarget
, vol.6
, pp. 43420-43437
-
-
Stehle, F.1
-
57
-
-
84879415483
-
Hydroxylase-dependent regulation of the NF-KB pathway
-
Scholz, C. C. & Taylor, C. T. Hydroxylase-dependent regulation of the NF-KB pathway. Biol. Chem. 394, 479-493 (2013).
-
(2013)
Biol. Chem.
, vol.394
, pp. 479-493
-
-
Scholz, C.C.1
Taylor, C.T.2
-
58
-
-
84991619006
-
HIF1α and metabolic reprogramming in inflammation
-
Corcoran, S. E. & O'Neill, L. A. HIF1α and metabolic reprogramming in inflammation. J. Clin. Invest. 126, 3699-3707 (2016).
-
(2016)
J. Clin. Invest.
, vol.126
, pp. 3699-3707
-
-
Corcoran, S.E.1
O'Neill, L.A.2
-
59
-
-
84990845578
-
Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
-
Mills, E. L. et al. Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell 167, 457-470 (2016).
-
(2016)
Cell
, vol.167
, pp. 457-470
-
-
Mills, E.L.1
-
61
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
Semenza, G. L., Roth, P. H., Fang, H. M. & Wang, G. L. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269, 23757-23763 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 23757-23763
-
-
Semenza, G.L.1
Roth, P.H.2
Fang, H.M.3
Wang, G.L.4
-
62
-
-
85000979473
-
The hypoxia-inducible factor (HIF) couples immunity with metabolism
-
Halligan, D. N., Murphy, S. J. & Taylor, C. T. The hypoxia-inducible factor (HIF) couples immunity with metabolism. Semin. Immunol. 28, 469-477 (2016).
-
(2016)
Semin. Immunol.
, vol.28
, pp. 469-477
-
-
Halligan, D.N.1
Murphy, S.J.2
Taylor, C.T.3
-
63
-
-
84976465917
-
Cycling hypoxia: A key feature of the tumor microenvironment
-
Michiels, C., Tellier, C. & Feron, O. Cycling hypoxia: a key feature of the tumor microenvironment. Biochim. Biophys. Acta 1866, 76-86 (2016).
-
(2016)
Biochim. Biophys. Acta
, vol.1866
, pp. 76-86
-
-
Michiels, C.1
Tellier, C.2
Feron, O.3
-
64
-
-
44349151470
-
Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours
-
Toffoli, S. & Michiels, C. Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours. FEBS J. 275, 2991-3002 (2008).
-
(2008)
FEBS J.
, vol.275
, pp. 2991-3002
-
-
Toffoli, S.1
Michiels, C.2
-
65
-
-
27444448072
-
Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome
-
Ryan, S., Taylor, C. T. & McNicholas, W. T. Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation 112, 2660-2667 (2005).
-
(2005)
Circulation
, vol.112
, pp. 2660-2667
-
-
Ryan, S.1
Taylor, C.T.2
McNicholas, W.T.3
-
66
-
-
84900451310
-
Human adipocytes are highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression
-
Taylor, C. T., Kent, B. D., Crinion, S. J., McNicholas, W. T. & Ryan, S. Human adipocytes are highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression. Biochem. Biophys. Res. Commun. 447, 660-665 (2014).
-
(2014)
Biochem. Biophys. Res. Commun.
, vol.447
, pp. 660-665
-
-
Taylor, C.T.1
Kent, B.D.2
Crinion, S.J.3
McNicholas, W.T.4
Ryan, S.5
-
67
-
-
84960402826
-
NF-κB and HIF crosstalk in immune responses
-
D'Ignazio, L., Bandarra, D. & Rocha, S. NF-κB and HIF crosstalk in immune responses. FEBS J. 283, 413-424 (2016).
-
(2016)
FEBS J.
, vol.283
, pp. 413-424
-
-
D'Ignazio, L.1
Bandarra, D.2
Rocha, S.3
-
68
-
-
51749089798
-
Interdependent roles for hypoxia inducible factor and nuclear factor-kappaB in hypoxic inflammation
-
Taylor, C. T. Interdependent roles for hypoxia inducible factor and nuclear factor-kappaB in hypoxic inflammation. J. Physiol. 586, 4055-4059 (2008).
-
(2008)
J. Physiol.
, vol.586
, pp. 4055-4059
-
-
Taylor, C.T.1
-
69
-
-
84978197362
-
Autophagy, inflammation, and immunity: A troika governing cancer and its treatment
-
Zhong, Z., Sanchez-Lopez, E. & Karin, M. Autophagy, inflammation, and immunity: a troika governing cancer and its treatment. Cell 166, 288-298 (2016).
-
(2016)
Cell
, vol.166
, pp. 288-298
-
-
Zhong, Z.1
Sanchez-Lopez, E.2
Karin, M.3
-
70
-
-
84941660341
-
Immunity, inflammation, and cancer: An eternal fight between good and evil
-
Shalapour, S. & Karin, M. Immunity, inflammation, and cancer: an eternal fight between good and evil. J. Clin. Invest. 125, 3347-3355 (2015).
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 3347-3355
-
-
Shalapour, S.1
Karin, M.2
-
71
-
-
33745003285
-
Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB
-
Frede, S., Stockmann, C., Freitag, P. & Fandrey, J. Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB. Biochem. J. 396, 517-527 (2006).
-
(2006)
Biochem. J.
, vol.396
, pp. 517-527
-
-
Frede, S.1
Stockmann, C.2
Freitag, P.3
Fandrey, J.4
-
72
-
-
85008952981
-
Redox signaling in the gastrointestinal tract
-
Pérez, S., Taléns-Visconti, R., Rius-Pérez, S., Finamor, I. & Sastre, J. Redox signaling in the gastrointestinal tract. Free Radic. Biol. Med. 104, 75-103 (2017).
-
(2017)
Free Radic. Biol. Med.
, vol.104
, pp. 75-103
-
-
Pérez, S.1
Taléns-Visconti, R.2
Rius-Pérez, S.3
Finamor, I.4
Sastre, J.5
-
74
-
-
84857789085
-
The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
-
Masson, N. et al. The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity. EMBO Rep. 13, 251-257 (2012).
-
(2012)
EMBO Rep.
, vol.13
, pp. 251-257
-
-
Masson, N.1
-
75
-
-
0348134741
-
Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1alpha
-
Hagen, T., Taylor, C. T., Lam, F. & Moncada, S. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science 302, 1975-1978 (2003).
-
(2003)
Science
, vol.302
, pp. 1975-1978
-
-
Hagen, T.1
Taylor, C.T.2
Lam, F.3
Moncada, S.4
-
76
-
-
84925858947
-
Hydrogen sulphide induces HIF-1α and Nrf2 in THP-1 macrophages
-
Lohninger, L. et al. Hydrogen sulphide induces HIF-1α and Nrf2 in THP-1 macrophages. Biochimie 112, 187-195 (2015).
-
(2015)
Biochimie
, vol.112
, pp. 187-195
-
-
Lohninger, L.1
-
77
-
-
84931478550
-
Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1α
-
Flannigan, K. L. et al. Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1α. FASEB J. 29, 1591-1602 (2015).
-
(2015)
FASEB J.
, vol.29
, pp. 1591-1602
-
-
Flannigan, K.L.1
-
78
-
-
84868651324
-
Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1α
-
Wu, B., Teng, H., Yang, G., Wu, L. & Wang, R. Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1α. Br. J. Pharmacol. 167, 1492-1505 (2012).
-
(2012)
Br. J. Pharmacol.
, vol.167
, pp. 1492-1505
-
-
Wu, B.1
Teng, H.2
Yang, G.3
Wu, L.4
Wang, R.5
-
79
-
-
73949121249
-
The hematopoietic stem cell niche: Low in oxygen but a nice place to be
-
Eliasson, P. & Jönsson, J. I. The hematopoietic stem cell niche: low in oxygen but a nice place to be. J. Cell. Physiol. 222, 17-22 (2010).
-
(2010)
J. Cell. Physiol.
, vol.222
, pp. 17-22
-
-
Eliasson, P.1
Jönsson, J.I.2
-
80
-
-
34248359065
-
Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
-
Parmar, K., Mauch, P., Vergilio, J. A., Sackstein, R. & Down, J. D. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc. Natl Acad. Sci. USA 104, 5431-5436 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 5431-5436
-
-
Parmar, K.1
Mauch, P.2
Vergilio, J.A.3
Sackstein, R.4
Down, J.D.5
-
81
-
-
0031822253
-
Changing bone marrow micro-environment during development of acute myeloid leukaemia in rats
-
Mortensen, B. T. et al. Changing bone marrow micro-environment during development of acute myeloid leukaemia in rats. Br. J. Haematol. 102, 458-464 (1998).
-
(1998)
Br. J. Haematol.
, vol.102
, pp. 458-464
-
-
Mortensen, B.T.1
-
82
-
-
84952984655
-
Hypoxia regulates the hematopoietic stem cell niche
-
Morikawa, T. & Takubo, K. Hypoxia regulates the hematopoietic stem cell niche. Pflugers Arch. 468, 13-22 (2015).
-
(2015)
Pflugers Arch.
, vol.468
, pp. 13-22
-
-
Morikawa, T.1
Takubo, K.2
-
83
-
-
84873545852
-
Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation
-
Forristal, C. E. et al. Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation. Blood 121, 759-769 (2013).
-
(2013)
Blood
, vol.121
, pp. 759-769
-
-
Forristal, C.E.1
-
84
-
-
77956217067
-
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
-
Takubo, K. et al. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell. 7, 391-402 (2010).
-
(2010)
Cell Stem Cell.
, vol.7
, pp. 391-402
-
-
Takubo, K.1
-
85
-
-
84894049819
-
Targeting the hypoxia-sensing pathway in clinical hematology
-
Forristal, C. E. & Levesque, J. P. Targeting the hypoxia-sensing pathway in clinical hematology. Stem Cells Transl Med. 3, 135-140 (2014).
-
(2014)
Stem Cells Transl Med.
, vol.3
, pp. 135-140
-
-
Forristal, C.E.1
Levesque, J.P.2
-
86
-
-
84901466176
-
Concise review: Genetic dissection of hypoxia signaling pathways in normal and leukemic stem cells
-
Gezer, D., Vukovic, M., Soga, T., Pollard, P. J. & Kranc, K. R. Concise review: genetic dissection of hypoxia signaling pathways in normal and leukemic stem cells. Stem Cells 32, 1390-1397 (2014).
-
(2014)
Stem Cells
, vol.32
, pp. 1390-1397
-
-
Gezer, D.1
Vukovic, M.2
Soga, T.3
Pollard, P.J.4
Kranc, K.R.5
-
87
-
-
85017628617
-
Physiological plasticity of neural-crest-derived stem cells in the adult mammalian carotid body
-
Annese, V., Navarro-Guerrero, E., Rodríguez-Prieto, I. & Pardal, R. Physiological plasticity of neural-crest-derived stem cells in the adult mammalian carotid body. Cell Rep. 19, 471-478 (2017).
-
(2017)
Cell Rep.
, vol.19
, pp. 471-478
-
-
Annese, V.1
Navarro-Guerrero, E.2
Rodríguez-Prieto, I.3
Pardal, R.4
-
88
-
-
77957584397
-
O2 regulates stem cells through Wnt/β-catenin signalling
-
Mazumdar, J. et al. O2 regulates stem cells through Wnt/β-catenin signalling. Nat. Cell Biol. 12, 1007-1013 (2010).
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 1007-1013
-
-
Mazumdar, J.1
-
89
-
-
77956205122
-
The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
-
Simsek, T. et al. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell. 7, 380-390 (2010).
-
(2010)
Cell Stem Cell.
, vol.7
, pp. 380-390
-
-
Simsek, T.1
-
90
-
-
84943612165
-
The aryl hydrocarbon receptor nuclear translocator is an essential regulator of murine hematopoietic stem cell viability
-
Krock, B. L. et al. The aryl hydrocarbon receptor nuclear translocator is an essential regulator of murine hematopoietic stem cell viability. Blood 125, 3263-3272 (2015).
-
(2015)
Blood
, vol.125
, pp. 3263-3272
-
-
Krock, B.L.1
-
91
-
-
84886024954
-
Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance
-
Guitart, A. V. et al. Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance. Blood 122, 1741-1745 (2013).
-
(2013)
Blood
, vol.122
, pp. 1741-1745
-
-
Guitart, A.V.1
-
92
-
-
84994472525
-
Germinal center hypoxia potentiates immunoglobulin class switch recombination
-
Abbott, R. K. et al. Germinal center hypoxia potentiates immunoglobulin class switch recombination. J. Immunol. 197, 4014-4020 (2016).
-
(2016)
J. Immunol.
, vol.197
, pp. 4014-4020
-
-
Abbott, R.K.1
-
93
-
-
84655169213
-
Placental immunology and maternal alloimmune responses
-
Kumpel, B. M. & Manoussaka, M. S. Placental immunology and maternal alloimmune responses. Vox Sang. 102, 2-12 (2012).
-
(2012)
Vox Sang.
, vol.102
, pp. 2-12
-
-
Kumpel, B.M.1
Manoussaka, M.S.2
-
94
-
-
33644781731
-
Hypoxia, HIF and the placenta
-
Fryer, B. H. & Simon, M. C. Hypoxia, HIF and the placenta. Cell Cycle 5, 495-498 (2006).
-
(2006)
Cell Cycle
, vol.5
, pp. 495-498
-
-
Fryer, B.H.1
Simon, M.C.2
-
95
-
-
85015619923
-
Hypoxia and HIF pathway in cancer and the placenta
-
Macklin, P. S., McAuliffe, J., Pugh, C. W. & Yamamoto, A. Hypoxia and HIF pathway in cancer and the placenta. Placenta 56, 8-13 (2017).
-
(2017)
Placenta
, vol.56
, pp. 8-13
-
-
MacKlin, P.S.1
McAuliffe, J.2
Pugh, C.W.3
Yamamoto, A.4
-
96
-
-
84993953205
-
Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2
-
Yaghi, L. et al. Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2. Oncotarget 7, 63690-63707 (2016).
-
(2016)
Oncotarget
, vol.7
, pp. 63690-63707
-
-
Yaghi, L.1
-
97
-
-
84893872087
-
A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells
-
Barsoum, I. B., Smallwood, C. A., Siemens, D. R. & Graham, C. H. A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells. Cancer Res. 74, 665-674 (2014).
-
(2014)
Cancer Res.
, vol.74
, pp. 665-674
-
-
Barsoum, I.B.1
Smallwood, C.A.2
Siemens, D.R.3
Graham, C.H.4
-
99
-
-
84937640378
-
Interactions of innate and adaptive immunity in brain development and function
-
Filiano, A. J., Gadani, S. P. & Kipnis, J. Interactions of innate and adaptive immunity in brain development and function. Brain Res. 1617, 18-27 (2015).
-
(2015)
Brain Res.
, vol.1617
, pp. 18-27
-
-
Filiano, A.J.1
Gadani, S.P.2
Kipnis, J.3
-
100
-
-
84903533463
-
Ontogeny of early life immunity
-
Dowling, D. J. & Levy, O. Ontogeny of early life immunity. Trends Immunol. 35, 299-310 (2014).
-
(2014)
Trends Immunol.
, vol.35
, pp. 299-310
-
-
Dowling, D.J.1
Levy, O.2
-
101
-
-
0019959154
-
Metabolic control of intestinal oxygenation and blood flow
-
Shepherd, A. P. Metabolic control of intestinal oxygenation and blood flow. Fed. Proc. 41, 2084-2089 (1982).
-
(1982)
Fed. Proc.
, vol.41
, pp. 2084-2089
-
-
Shepherd, A.P.1
-
102
-
-
9644302527
-
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
-
Karhausen, J. et al. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J. Clin. Invest. 114, 1098-1106 (2004).
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1098-1106
-
-
Karhausen, J.1
-
103
-
-
0034029848
-
Detection of hypoxia in human squamous cell carcinoma by EF5 binding
-
Evans, S. M. et al. Detection of hypoxia in human squamous cell carcinoma by EF5 binding. Cancer Res. 60, 2018-2024 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 2018-2024
-
-
Evans, S.M.1
-
104
-
-
84908306828
-
Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota
-
Albenberg, L. et al. Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology 147, 1055-1063 (2014).
-
(2014)
Gastroenterology
, vol.147
, pp. 1055-1063
-
-
Albenberg, L.1
-
105
-
-
0028835416
-
In vivo oximetry using EPR and India ink
-
Goda, F. et al. In vivo oximetry using EPR and India ink. Magn. Reson. Med. 33, 237-245 (1995).
-
(1995)
Magn. Reson. Med.
, vol.33
, pp. 237-245
-
-
Goda, F.1
-
106
-
-
0033551085
-
Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging
-
He, G. et al. Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging. Proc. Natl Acad. Sci. USA 96, 4586-4591 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 4586-4591
-
-
He, G.1
-
107
-
-
84929145736
-
Immune response regulation in the tumor microenvironment by hypoxia
-
Labiano, S., Palazon, A. & Melero, I. Immune response regulation in the tumor microenvironment by hypoxia. Semin. Oncol. 42, 378-386 (2015).
-
(2015)
Semin. Oncol.
, vol.42
, pp. 378-386
-
-
Labiano, S.1
Palazon, A.2
Melero, I.3
-
108
-
-
84924871326
-
The potential role of HIF on tumour progression and dissemination
-
Unwith, S., Zhao, H., Hennah, L. & Ma, D. The potential role of HIF on tumour progression and dissemination. Int. J. Cancer. 136, 2491-2503 (2015).
-
(2015)
Int. J. Cancer.
, vol.136
, pp. 2491-2503
-
-
Unwith, S.1
Zhao, H.2
Hennah, L.3
Ma, D.4
-
109
-
-
84930277289
-
Cancer metabolism and the Warburg effect: The role of HIF-1 and PI3K
-
Courtnay, R. et al. Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K. Mol. Biol. Rep. 42, 841-851 (2015).
-
(2015)
Mol. Biol. Rep.
, vol.42
, pp. 841-851
-
-
Courtnay, R.1
-
110
-
-
84928056873
-
The journey from discoveries in fundamental immunology to cancer immunotherapy
-
Miller, J. F. & Sadelain, M. The journey from discoveries in fundamental immunology to cancer immunotherapy. Cancer Cell 27, 439-449 (2015).
-
(2015)
Cancer Cell
, vol.27
, pp. 439-449
-
-
Miller, J.F.1
Sadelain, M.2
-
111
-
-
84897002504
-
Adoptive immunotherapy for cancer or viruses
-
Maus, M. V. et al. Adoptive immunotherapy for cancer or viruses. Annu. Rev. Immunol. 32, 189-225 (2014).
-
(2014)
Annu. Rev. Immunol.
, vol.32
, pp. 189-225
-
-
Maus, M.V.1
-
112
-
-
78149330949
-
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
-
Corzo, C. A. et al. HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J. Exp. Med. 207, 2439-2453 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2439-2453
-
-
Corzo, C.A.1
-
114
-
-
84975138840
-
AMP-activated protein kinase and Glycogen Synthase Kinase 3β modulate the severity of sepsis-induced lung injury
-
Liu, Z. et al. AMP-activated protein kinase and Glycogen Synthase Kinase 3β modulate the severity of sepsis-induced lung injury. Mol. Med. 21, 937-950 (2015).
-
(2015)
Mol. Med.
, vol.21
, pp. 937-950
-
-
Liu, Z.1
-
115
-
-
84892447705
-
Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation
-
Campbell, E. L. et al. Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity 40, 66-77 (2014).
-
(2014)
Immunity
, vol.40
, pp. 66-77
-
-
Campbell, E.L.1
-
116
-
-
3543023938
-
Chronic granulomatous disease caused by a deficiency in p47(phox) mimicking Crohn's disease
-
Huang, J. S. et al. Chronic granulomatous disease caused by a deficiency in p47(phox) mimicking Crohn's disease. Clin. Gastroenterol. Hepatol. 2, 690-695 (2004).
-
(2004)
Clin. Gastroenterol. Hepatol.
, vol.2
, pp. 690-695
-
-
Huang, J.S.1
-
117
-
-
84919459521
-
Hypoxia-sensitive pathways in inflammation-driven fibrosis
-
Manresa, M. C., Godson, C. & Taylor, C. T. Hypoxia-sensitive pathways in inflammation-driven fibrosis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 307, R1369-R1380 (2014).
-
(2014)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.307
, pp. R1369-R1380
-
-
Manresa, M.C.1
Godson, C.2
Taylor, C.T.3
-
118
-
-
85007608335
-
Hypoxia and HIF-1 activation in bacterial infections
-
Devraj, G., Beerlage, C., Brüne, B. & Kempf, V. A. Hypoxia and HIF-1 activation in bacterial infections. Microbes Infect. 19, 144-156 (2017).
-
(2017)
Microbes Infect.
, vol.19
, pp. 144-156
-
-
Devraj, G.1
Beerlage, C.2
Brüne, B.3
Kempf, V.A.4
-
119
-
-
77955384915
-
Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens
-
Werth, N. et al. Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens. PLoS ONE. 5, e11576 (2010).
-
(2010)
PLoS ONE.
, vol.5
, pp. e11576
-
-
Werth, N.1
-
120
-
-
84935878792
-
The impact of hypoxia on bacterial infection
-
Schaffer, K. & Taylor, C. T. The impact of hypoxia on bacterial infection. FEBS J. 282, 2260-2266 (2015).
-
(2015)
FEBS J.
, vol.282
, pp. 2260-2266
-
-
Schaffer, K.1
Taylor, C.T.2
-
121
-
-
0036167851
-
Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
-
Worlitzsch, D. et al. Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J. Clin. Invest. 109, 317-325 (2002).
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 317-325
-
-
Worlitzsch, D.1
-
122
-
-
78449276907
-
Hypoxia, innate immunity and infection in the lung
-
Schaible, B., Schaffer, K. & Taylor, C. T. Hypoxia, innate immunity and infection in the lung. Respir. Physiol. Neurobiol. 174, 235-243 (2010).
-
(2010)
Respir. Physiol. Neurobiol.
, vol.174
, pp. 235-243
-
-
Schaible, B.1
Schaffer, K.2
Taylor, C.T.3
-
123
-
-
84873897903
-
Hypoxia modulates infection of epithelial cells by Pseudomonas aeruginosa
-
Schaible, B. et al. Hypoxia modulates infection of epithelial cells by Pseudomonas aeruginosa. PLoS ONE. 8, e56491 (2013).
-
(2013)
PLoS ONE.
, vol.8
, pp. e56491
-
-
Schaible, B.1
-
124
-
-
84858692238
-
Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumps
-
Schaible, B., Taylor, C. T. & Schaffer, K. Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumps. Antimicrob. Agents Chemother. 56, 2114-2118 (2012).
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 2114-2118
-
-
Schaible, B.1
Taylor, C.T.2
Schaffer, K.3
-
125
-
-
85021899398
-
Hypoxia reduces the pathogenicity of Pseudomonas aeruginosa by decreasing the expression of multiple virulence factors
-
Schaible, B. et al. Hypoxia reduces the pathogenicity of Pseudomonas aeruginosa by decreasing the expression of multiple virulence factors. J. Infect. Dis. 215, 1459-1467 (2017).
-
(2017)
J. Infect. Dis.
, vol.215
, pp. 1459-1467
-
-
Schaible, B.1
-
126
-
-
84925250962
-
The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia
-
Koh, H. S. et al. The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia. Nat. Commun. 6, 6340 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 6340
-
-
Koh, H.S.1
-
127
-
-
84954427967
-
Hypoxia-Inducible Factor-2α limits natural killer T cell cytotoxicity in renal ischemia/reperfusion injury
-
Zhang, J. et al. Hypoxia-Inducible Factor-2α limits natural killer T cell cytotoxicity in renal ischemia/reperfusion injury. J. Am. Soc. Nephrol. 27, 92-106 (2016).
-
(2016)
J. Am. Soc. Nephrol.
, vol.27
, pp. 92-106
-
-
Zhang, J.1
-
128
-
-
78549270472
-
The role of HIF-1 in up-regulating MICA expression on human renal proximal tubular epithelial cells during hypoxia/reoxygenation
-
Luo, L. et al. The role of HIF-1 in up-regulating MICA expression on human renal proximal tubular epithelial cells during hypoxia/reoxygenation. BMC Cell Biol. 11, 91 (2010).
-
(2010)
BMC Cell Biol.
, vol.11
, pp. 91
-
-
Luo, L.1
-
129
-
-
84958117511
-
Pharmacological targeting of the HIF hydroxylases-A new field in medicine 1development
-
Chan, M. C., Holt-Martyn, J. P., Schofield, C. J. & Ratcliffe, P. J. Pharmacological targeting of the HIF hydroxylases-A new field in medicine 1development. Mol. Aspects Med. 47-48, 54-75 (2016).
-
(2016)
Mol. Aspects Med.
, vol.47-48
, pp. 54-75
-
-
Chan, M.C.1
Holt-Martyn, J.P.2
Schofield, C.J.3
Ratcliffe, P.J.4
-
130
-
-
79953649414
-
HIF prolyl hydroxylase inhibitors for anemia
-
Muchnik, E. & Kaplan, J. HIF prolyl hydroxylase inhibitors for anemia. Expert Opin. Investig. Drugs 20, 645-656 (2011).
-
(2011)
Expert Opin. Investig. Drugs
, vol.20
, pp. 645-656
-
-
Muchnik, E.1
Kaplan, J.2
-
131
-
-
84958920828
-
HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
-
Maxwell, P. H. & Eckardt, K. U. HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond. Nat. Rev. Nephrol. 12, 157-168 (2016).
-
(2016)
Nat. Rev. Nephrol.
, vol.12
, pp. 157-168
-
-
Maxwell, P.H.1
Eckardt, K.U.2
-
132
-
-
84994626953
-
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
-
Cho, H. et al. On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models. Nature. 539, 107-111 (2016).
-
(2016)
Nature.
, vol.539
, pp. 107-111
-
-
Cho, H.1
-
133
-
-
84994669316
-
Targeting renal cell carcinoma with a HIF-2 antagonist
-
Chen, W. et al. Targeting renal cell carcinoma with a HIF-2 antagonist. Nature 539, 112-117 (2016).
-
(2016)
Nature
, vol.539
, pp. 112-117
-
-
Chen, W.1
-
134
-
-
84875758986
-
Hydroxylases as therapeutic targets in inflammatory bowel disease
-
Cummins, E. P., Doherty, G. A. & Taylor, C. T. Hydroxylases as therapeutic targets in inflammatory bowel disease. Lab. Invest. 93, 378-383 (2013).
-
(2013)
Lab. Invest.
, vol.93
, pp. 378-383
-
-
Cummins, E.P.1
Doherty, G.A.2
Taylor, C.T.3
-
135
-
-
80051988912
-
The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells
-
Hams, E. et al. The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells. Shock 36, 295-302 (2011).
-
(2011)
Shock
, vol.36
, pp. 295-302
-
-
Hams, E.1
-
136
-
-
84973320456
-
Oral hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) for the treatment of anemia in patients with CKD
-
Provenzano, R. et al. Oral hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) for the treatment of anemia in patients with CKD. Clin. J. Am. Soc. Nephrol. 11, 982-991 (2016).
-
(2016)
Clin. J. Am. Soc. Nephrol.
, vol.11
, pp. 982-991
-
-
Provenzano, R.1
-
137
-
-
84962073517
-
A novel hypoxia-inducible factor-prolyl hydroxylase inhibitor (GSK1278863) for anemia in CKD: 28 day, phase 2A randomized trial
-
Brigandi, R. A. et al. A novel hypoxia-inducible factor-prolyl hydroxylase inhibitor (GSK1278863) for anemia in CKD: 28 day, phase 2A randomized trial. Am. J. Kidney Dis. 67, 861-871 (2016).
-
(2016)
Am. J. Kidney Dis.
, vol.67
, pp. 861-871
-
-
Brigandi, R.A.1
-
138
-
-
84994143390
-
Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease
-
Pergola, P. E., Spinowitz, B. S., Hartman, C. S., Maroni, B. J. & Haase, V. H. Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease. Kidney Int. 90, 1115-1122 (2016).
-
(2016)
Kidney Int.
, vol.90
, pp. 1115-1122
-
-
Pergola, P.E.1
Spinowitz, B.S.2
Hartman, C.S.3
Maroni, B.J.4
Haase, V.H.5
-
139
-
-
84941950636
-
Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis
-
Tambuwala, M. M. et al. Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis. J. Control. Release 217, 221-227 (2015).
-
(2015)
J. Control. Release
, vol.217
, pp. 221-227
-
-
Tambuwala, M.M.1
-
140
-
-
0031019656
-
Sites of erythropoietin production
-
Maxwell, P. H. et al. Sites of erythropoietin production. Kidney Int. 51, 393-401 (1997).
-
(1997)
Kidney Int.
, vol.51
, pp. 393-401
-
-
Maxwell, P.H.1
-
141
-
-
84900342698
-
Direct measurement of local oxygen concentration in the bone marrow of live animals
-
Spencer, J. A. et al. Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature 508, 269-273 (2014).
-
(2014)
Nature
, vol.508
, pp. 269-273
-
-
Spencer, J.A.1
-
142
-
-
84866689485
-
Hypoxia in the eye: A two-sided coin
-
Grimm, C. & Willmann, G. Hypoxia in the eye: a two-sided coin. High Alt. Med. Biol. 13169-13175 (2012).
-
(2012)
High Alt. Med. Biol.
, pp. 13169-13175
-
-
Grimm, C.1
Willmann, G.2
-
143
-
-
33845321931
-
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity
-
Cummins, E. P. et al. Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc. Natl Acad. Sci. USA 103, 18154-18159 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 18154-18159
-
-
Cummins, E.P.1
-
144
-
-
33749518516
-
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
-
Cockman, M. E. et al. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc. Natl Acad. Sci. USA;103, 14767-14772.
-
Proc. Natl Acad. Sci. USA;
, vol.103
, pp. 14767-14772
-
-
Cockman, M.E.1
-
145
-
-
84880684167
-
Tumor necrosis factor α-induced hypoxia-inducible factor 1α-β-catenin axis regulates major histocompatibility complex class I gene activation through chromatin remodeling
-
Ghosh, S., Paul, A. & Sen, E. Tumor necrosis factor α-induced hypoxia-inducible factor 1α-β-catenin axis regulates major histocompatibility complex class I gene activation through chromatin remodeling. Mol. Cell. Biol. 33, 2718-2731 (2013).
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 2718-2731
-
-
Ghosh, S.1
Paul, A.2
Sen, E.3
-
146
-
-
80052277906
-
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
-
Dang, E. V. et al. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell 146, 772-784 (2011).
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
-
147
-
-
84867381718
-
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
-
Clambey, E. T. et al. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc. Natl Acad. Sci. USA 109, E2784-E2793 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. E2784-E2793
-
-
Clambey, E.T.1
-
148
-
-
37349118314
-
The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis
-
Cummins, E. P. et al. The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology 134, 156-165 (2008).
-
(2008)
Gastroenterology
, vol.134
, pp. 156-165
-
-
Cummins, E.P.1
-
149
-
-
80052754529
-
Longitudinal quantification of inflammation in the murine dextran sodium sulfate-induced colitis model using muPET/CT
-
Hindryckx, P. et al. Longitudinal quantification of inflammation in the murine dextran sodium sulfate-induced colitis model using muPET/CT. Inflamm. Bowel Dis. 17, 2058-2064 (2011).
-
(2011)
Inflamm. Bowel Dis.
, vol.17
, pp. 2058-2064
-
-
Hindryckx, P.1
-
150
-
-
85025812572
-
Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation
-
Cosin-Roger, J. et al. Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation. Nat. Commun. 8, 98 (2017).
-
(2017)
Nat. Commun.
, vol.8
, pp. 98
-
-
Cosin-Roger, J.1
-
151
-
-
37349048502
-
Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition
-
Robinson, A. et al. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology 134, 145-155 (2008).
-
(2008)
Gastroenterology
, vol.134
, pp. 145-155
-
-
Robinson, A.1
-
152
-
-
78650654512
-
Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD
-
Hindryckx, P. et al. Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD. J. Immunol. 185, 6306-6316 (2010).
-
(2010)
J. Immunol.
, vol.185
, pp. 6306-6316
-
-
Hindryckx, P.1
-
153
-
-
77953910490
-
Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury
-
Hirota, S. A. et al. Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury. Gastroenterology 139, 259-269 (2010).
-
(2010)
Gastroenterology
, vol.139
, pp. 259-269
-
-
Hirota, S.A.1
-
154
-
-
79954994463
-
Hypoxia-inducible factor-1 alpha dependent protection from intestinal ischemia/reperfusion injury involves ecto-5?-nucleotidase (CD73) and the A2B adenosine receptor
-
Hart, M. L. et al. Hypoxia-inducible factor-1 alpha dependent protection from intestinal ischemia/reperfusion injury involves ecto-5?-nucleotidase (CD73) and the A2B adenosine receptor. J. Immunol. 186, 4367-4374 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 4367-4374
-
-
Hart, M.L.1
-
155
-
-
82355181386
-
Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms
-
Marchbank, T., Mahmood, A., Harten, S., Maxwell, P. H. & Playford, R. J. Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms. Lab. Invest. 91, 1684-1694 (2011).
-
(2011)
Lab. Invest.
, vol.91
, pp. 1684-1694
-
-
Marchbank, T.1
Mahmood, A.2
Harten, S.3
Maxwell, P.H.4
Playford, R.J.5
-
156
-
-
84886073769
-
Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis
-
Keely, S. et al. Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis. Mucosal Immunol. 7, 114-123 (2014).
-
(2014)
Mucosal Immunol.
, vol.7
, pp. 114-123
-
-
Keely, S.1
-
157
-
-
84927738288
-
Oral delivery of prolyl hydroxylase inhibitor: AKB-4924 promotes localized mucosal healing in a mouse model of colitis
-
Marks, E. et al. Oral delivery of prolyl hydroxylase inhibitor: AKB-4924 promotes localized mucosal healing in a mouse model of colitis. Inflamm. Bowel Dis. 21, 267-275 (2015).
-
(2015)
Inflamm. Bowel Dis.
, vol.21
, pp. 267-275
-
-
Marks, E.1
-
158
-
-
84901227921
-
PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2
-
Taniguchi, C. M. et al. PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2. Sci. Transl Med. 6, 236ra64 (2014).
-
(2014)
Sci. Transl Med.
, vol.6
, pp. 236ra64
-
-
Taniguchi, C.M.1
-
159
-
-
84919338076
-
Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity
-
Jeong, S. et al. Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity. Eur. J. Pharmacol. 747, 114-122 (2015).
-
(2015)
Eur. J. Pharmacol.
, vol.747
, pp. 114-122
-
-
Jeong, S.1
-
160
-
-
84893356598
-
Therapeutic treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates murine colitis
-
Gupta, R. et al. Therapeutic treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates murine colitis. Clin. Exp. Gastroenterol. 7, 13-23 (2014).
-
(2014)
Clin. Exp. Gastroenterol.
, vol.7
, pp. 13-23
-
-
Gupta, R.1
-
161
-
-
84865601727
-
Treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates ischemic acute kidney injury
-
Jamadarkhana, P. et al. Treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates ischemic acute kidney injury. Am. J. Nephrol. 36, 208-218 (2012).
-
(2012)
Am. J. Nephrol.
, vol.36
, pp. 208-218
-
-
Jamadarkhana, P.1
-
162
-
-
75849163295
-
Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model
-
Bernhardt, W. M. et al. Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model. Proc. Natl Acad. Sci. USA 106, 21276-21281 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 21276-21281
-
-
Bernhardt, W.M.1
-
163
-
-
85006279493
-
Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling [corrected]
-
Manresa, M. C. et al. Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling [corrected]. Am. J. Physiol. Gastrointest. Liver Physiol. 3 11, G1076-G1090 (2016).
-
(2016)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.311
, pp. G1076-G1090
-
-
Manresa, M.C.1
|