-
1
-
-
84876758617
-
Metabolic pathways in immune cell activation and quiescence
-
Pearce EL, Pearce EJ. Metabolic pathways in immune cell activation and quiescence. Immunity. 2013;38(4):633-643.
-
(2013)
Immunity
, vol.38
, Issue.4
, pp. 633-643
-
-
Pearce, E.L.1
Pearce, E.J.2
-
2
-
-
84942982260
-
Metabolic reprogramming in macrophages and dendritic cells in innate immunity
-
Kelly B, O'Neill LA. Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res. 2015;25(7):771-784.
-
(2015)
Cell Res
, vol.25
, Issue.7
, pp. 771-784
-
-
Kelly, B.1
O'Neill, L.A.2
-
3
-
-
19944399717
-
6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia
-
Obach M, et al. 6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia. J Biol Chem. 2004;279(51):53562-53570.
-
(2004)
J Biol Chem.
, vol.279
, Issue.51
, pp. 53562-53570
-
-
Obach, M.1
-
4
-
-
0034014624
-
Hypoxia induces hexokinase II gene expression in human lung cell line A549
-
Riddle SR, et al. Hypoxia induces hexokinase II gene expression in human lung cell line A549. Am J Physiol Lung Cell Mol Physiol. 2000;278(2):L407-L416.
-
(2000)
Am J Physiol Lung Cell Mol Physiol
, vol.278
, Issue.2
, pp. L407-L416
-
-
Riddle, S.R.1
-
5
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helixloop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helixloop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A. 1995;92(12):5510-5514.
-
(1995)
Proc Natl Acad Sci U S A.
, vol.92
, Issue.12
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
6
-
-
0029753008
-
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
-
Huang LE, Arany Z, Livingston DM, Bunn HF. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem. 1996;271(50):32253-32259.
-
(1996)
J Biol Chem
, vol.271
, Issue.50
, pp. 32253-32259
-
-
Huang, L.E.1
Arany, Z.2
Livingston, D.M.3
Bunn, H.F.4
-
7
-
-
85006768050
-
The metabolism of tumors in the body
-
Warburg O, Wind F, Negelein E. The metabolism of tumors in the body. J Gen Physiol. 1927;8(6):519-530.
-
(1927)
J Gen Physiol
, vol.8
, Issue.6
, pp. 519-530
-
-
Warburg, O.1
Wind, F.2
Negelein, E.3
-
8
-
-
84923193781
-
Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: From biology to clinical use
-
Pastorek J, Pastorekova S. Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: from biology to clinical use. Semin Cancer Biol. 2015;31:52-64.
-
(2015)
Semin Cancer Biol
, vol.31
, pp. 52-64
-
-
Pastorek, J.1
Pastorekova, S.2
-
9
-
-
84940752779
-
Targeting tumour hypoxia to prevent cancer metastasis. from biology, biosensing and technology to drug development: The METOXIA consortium
-
Pettersen EO, et al. Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium. J Enzyme Inhib Med Chem. 2015;30(5):689-721.
-
(2015)
J Enzyme Inhib Med Chem
, vol.30
, Issue.5
, pp. 689-721
-
-
Pettersen, E.O.1
-
10
-
-
33646917296
-
The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
-
Ullah MS, Davies AJ, Halestrap AP. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem. 2006;281(14):9030-9037.
-
(2006)
J Biol Chem
, vol.281
, Issue.14
, pp. 9030-9037
-
-
Ullah, M.S.1
Davies, A.J.2
Halestrap, A.P.3
-
11
-
-
84893872087
-
A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells
-
Barsoum IB, Smallwood CA, Siemens DR, Graham CH. A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells. Cancer Res. 2014;74(3):665-674.
-
(2014)
Cancer Res
, vol.74
, Issue.3
, pp. 665-674
-
-
Barsoum, I.B.1
Smallwood, C.A.2
Siemens, D.R.3
Graham, C.H.4
-
12
-
-
67651166780
-
Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition
-
Rapisarda A, et al. Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition. Mol Cancer Ther. 2009;8(7):1867-1877.
-
(2009)
Mol Cancer Ther.
, vol.8
, Issue.7
, pp. 1867-1877
-
-
Rapisarda, A.1
-
13
-
-
84959322427
-
Hypoxiainducible factor (HIF) inhibitors: A patent survey 2011-2015
-
Ban HS, Uto Y, Won M, Nakamura H. Hypoxiainducible factor (HIF) inhibitors: a patent survey (2011-2015). Expert Opin Ther Pat. 2016;26(3):309-322.
-
(2016)
Expert Opin Ther Pat.
, vol.26
, Issue.3
, pp. 309-322
-
-
Ban, H.S.1
Uto, Y.2
Won, M.3
Nakamura, H.4
-
14
-
-
84942585419
-
Regulation of innate immune cell function by mTOR
-
Weichhart T, Hengstschläger M, Linke M. Regulation of innate immune cell function by mTOR. Nat Rev Immunol. 2015;15(10):599-614.
-
(2015)
Nat Rev Immunol
, vol.15
, Issue.10
, pp. 599-614
-
-
Weichhart, T.1
Hengstschläger, M.2
Linke, M.3
-
15
-
-
84903437266
-
MTORC2 in the center of cancer metabolic reprogramming
-
Masui K, Cavenee WK, Mischel PS. mTORC2 in the center of cancer metabolic reprogramming. Trends Endocrinol Metab. 2014;25(7):364-373.
-
(2014)
Trends Endocrinol Metab
, vol.25
, Issue.7
, pp. 364-373
-
-
Masui, K.1
Cavenee, W.K.2
Mischel, P.S.3
-
16
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
-
Selak MA, et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell. 2005;7(1):77-85.
-
(2005)
Cancer Cell.
, vol.7
, Issue.1
, pp. 77-85
-
-
Selak, M.A.1
-
17
-
-
84876285741
-
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
-
Tannahill GM, et al. Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature. 2013;496(7444):238-242.
-
(2013)
Nature
, vol.496
, Issue.7444
, pp. 238-242
-
-
Tannahill, G.M.1
-
18
-
-
84920481006
-
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
-
Gerriets VA, et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest. 2015;125(1):194-207.
-
(2015)
J Clin Invest.
, vol.125
, Issue.1
, pp. 194-207
-
-
Gerriets, V.A.1
-
19
-
-
0037423948
-
HIF-1alpha is essential for myeloid cell-mediated inflammation
-
Cramer T, et al. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell. 2003;112(5):645-657.
-
(2003)
Cell.
, vol.112
, Issue.5
, pp. 645-657
-
-
Cramer, T.1
-
20
-
-
44449117540
-
Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function
-
Jantsch J, et al. Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function. J Immunol. 2008;180(7):4697-4705.
-
(2008)
J Immunol.
, vol.180
, Issue.7
, pp. 4697-4705
-
-
Jantsch, J.1
-
21
-
-
19944432390
-
Hypoxia-induced neutrophil survival is mediated by HIF-1alphadependent NF-kappaB activity
-
Walmsley SR, et al. Hypoxia-induced neutrophil survival is mediated by HIF-1alphadependent NF-kappaB activity. J Exp Med. 2005;201(1):105-115.
-
(2005)
J Exp Med
, vol.201
, Issue.1
, pp. 105-115
-
-
Walmsley, S.R.1
-
22
-
-
80052277906
-
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
-
Dang EV, et al. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell. 2011;146(5):772-784.
-
(2011)
Cell.
, vol.146
, Issue.5
, pp. 772-784
-
-
Dang, E.V.1
-
23
-
-
84858630049
-
A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation?
-
Wen H, Ting JP, O'Neill LA. A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation? Nat Immunol. 2012;13(4):352-357.
-
(2012)
Nat Immunol
, vol.13
, Issue.4
, pp. 352-357
-
-
Wen, H.1
Ting, J.P.2
O'Neill, L.A.3
-
24
-
-
84857913810
-
Hypoxia -A key regulator of angiogenesis and inflammation in rheumatoid arthritis
-
Konisti S, Kiriakidis S, Paleolog EM. Hypoxia-a key regulator of angiogenesis and inflammation in rheumatoid arthritis. Nat Rev Rheumatol. 2012;8(3):153-162.
-
(2012)
Nat Rev Rheumatol
, vol.8
, Issue.3
, pp. 153-162
-
-
Konisti, S.1
Kiriakidis, S.2
Paleolog, E.M.3
-
25
-
-
84884390272
-
Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice
-
Xue X, et al. Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice. Gastroenterology. 2013;145(4):831-841.
-
(2013)
Gastroenterology.
, vol.145
, Issue.4
, pp. 831-841
-
-
Xue, X.1
-
26
-
-
0033939095
-
High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein
-
Hartmann G, et al. High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein. Cytokine. 2000;12(3):246-252.
-
(2000)
Cytokine.
, vol.12
, Issue.3
, pp. 246-252
-
-
Hartmann, G.1
-
27
-
-
0035849994
-
High-altitude illness
-
Hackett PH, Roach RC. High-altitude illness. N Engl J Med. 2001;345(2):107-114.
-
(2001)
N Engl J Med.
, vol.345
, Issue.2
, pp. 107-114
-
-
Hackett, P.H.1
Roach, R.C.2
-
28
-
-
84954286237
-
Oxidative dimerization of PHD2 is responsible for its inactivation and contributes to metabolic reprogramming via HIF-1α activation
-
Lee G, et al. Oxidative dimerization of PHD2 is responsible for its inactivation and contributes to metabolic reprogramming via HIF-1α activation. Sci Rep. 2016;6:18928.
-
(2016)
Sci Rep.
, vol.6
, pp. 18928
-
-
Lee, G.1
-
29
-
-
37849022071
-
Loss of the SdhB, but not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis
-
Guzy RD, Sharma B, Bell E, Chandel NS, Schumacker PT. Loss of the SdhB, but not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol Cell Biol. 2008;28(2):718-731.
-
(2008)
Mol Cell Biol
, vol.28
, Issue.2
, pp. 718-731
-
-
Guzy, R.D.1
Sharma, B.2
Bell, E.3
Chandel, N.S.4
Schumacker, P.T.5
-
30
-
-
84867787091
-
Oxygen versus reactive oxygen in the regulation of HIF-1α: The balance tips
-
Hagen T. Oxygen versus reactive oxygen in the regulation of HIF-1α: the balance tips. Biochem Res Int. 2012;2012:436981.
-
(2012)
Biochem Res Int
, vol.2012
, pp. 436981
-
-
Hagen, T.1
-
31
-
-
84945306969
-
Suppressors of superoxide production from mitochondrial complex III
-
Orr AL, et al. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015;11(11):834-836.
-
(2015)
Nat Chem Biol.
, vol.11
, Issue.11
, pp. 834-836
-
-
Orr, A.L.1
-
32
-
-
0034682786
-
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: A mechanism of O2 sensing
-
Chandel NS, et al. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem. 2000;275(33):25130-25138.
-
(2000)
J Biol Chem
, vol.275
, Issue.33
, pp. 25130-25138
-
-
Chandel, N.S.1
-
33
-
-
84957439277
-
TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions
-
Martínez-Reyes I, et al. TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions. Mol Cell. 2016;61(2):199-209.
-
(2016)
Mol Cell
, vol.61
, Issue.2
, pp. 199-209
-
-
Martínez-Reyes, I.1
-
34
-
-
33947724515
-
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
-
Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell. 2007;129(1):111-122.
-
(2007)
Cell
, vol.129
, Issue.1
, pp. 111-122
-
-
Fukuda, R.1
Zhang, H.2
Kim, J.W.3
Shimoda, L.4
Dang, C.V.5
Semenza, G.L.6
-
35
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
Semenza GL, Roth PH, Fang HM, Wang GL. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem. 1994;269(38):23757-23763.
-
(1994)
J Biol Chem.
, vol.269
, Issue.38
, pp. 23757-23763
-
-
Semenza, G.L.1
Roth, P.H.2
Fang, H.M.3
Wang, G.L.4
-
36
-
-
33751117499
-
HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes
-
Shimoda LA, Fallon M, Pisarcik S, Wang J, Semenza GL. HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol. 2006;291(5):L941-L949.
-
(2006)
Am J Physiol Lung Cell Mol Physiol.
, vol.291
, Issue.5
, pp. L941-L949
-
-
Shimoda, L.A.1
Fallon, M.2
Pisarcik, S.3
Wang, J.4
Semenza, G.L.5
-
37
-
-
0024273450
-
Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
-
Goldberg MA, Dunning SP, Bunn HF. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science. 1988;242(4884):1412-1415.
-
(1988)
Science
, vol.242
, Issue.4884
, pp. 1412-1415
-
-
Goldberg, M.A.1
Dunning, S.P.2
Bunn, H.F.3
-
38
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996;16(9):4604-4613.
-
(1996)
Mol Cell Biol.
, vol.16
, Issue.9
, pp. 4604-4613
-
-
Forsythe, J.A.1
-
39
-
-
77949383238
-
Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor
-
Kim SY, Choi YJ, Joung SM, Lee BH, Jung YS, Lee JY. Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor. Immunology. 2010;129(4):516-524.
-
(2010)
Immunology
, vol.129
, Issue.4
, pp. 516-524
-
-
Kim, S.Y.1
Choi, Y.J.2
Joung, S.M.3
Lee, B.H.4
Jung, Y.S.5
Lee, J.Y.6
-
40
-
-
79953172571
-
Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
-
Michalek RD, et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol. 2011;186(6):3299-3303.
-
(2011)
J Immunol.
, vol.186
, Issue.6
, pp. 3299-3303
-
-
Michalek, R.D.1
-
42
-
-
0023140462
-
Rates of utilization and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages
-
Newsholme P, Gordon S, Newsholme EA. Rates of utilization and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages. Biochem J. 1987;242(3):631-636.
-
(1987)
Biochem J
, vol.242
, Issue.3
, pp. 631-636
-
-
Newsholme, P.1
Gordon, S.2
Newsholme, E.A.3
-
43
-
-
0000054142
-
The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes
-
Sbarra AJ, Karnovsky ML. The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes. J Biol Chem. 1959;234(6):1355-1362.
-
(1959)
J Biol Chem
, vol.234
, Issue.6
, pp. 1355-1362
-
-
Sbarra, A.J.1
Karnovsky, M.L.2
-
44
-
-
0023029455
-
Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages
-
Newsholme P, Curi R, Gordon S, Newsholme EA. Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages. Biochem J. 1986;239(1):121-125.
-
(1986)
Biochem J
, vol.239
, Issue.1
, pp. 121-125
-
-
Newsholme, P.1
Curi, R.2
Gordon, S.3
Newsholme, E.A.4
-
45
-
-
84885377829
-
The Warburg effect then and now: From cancer to inflammatory diseases
-
Palsson-McDermott EM, O'Neill LA. The Warburg effect then and now: from cancer to inflammatory diseases. Bioessays. 2013;35(11):965-973.
-
(2013)
Bioessays
, vol.35
, Issue.11
, pp. 965-973
-
-
Palsson-McDermott, E.M.1
O'Neill, L.A.2
-
46
-
-
0013882960
-
2-Deoxyglucose and inflammation
-
Kellett DN. 2-Deoxyglucose and inflammation. J Pharm Pharmacol. 1966;18(3):199-200.
-
(1966)
J Pharm Pharmacol
, vol.18
, Issue.3
, pp. 199-200
-
-
Kellett, D.N.1
-
47
-
-
33646117271
-
Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures
-
Zhang W, et al. Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures. J Neuroimmunol. 2006;174(1-2):63-73.
-
(2006)
J Neuroimmunol
, vol.174
, Issue.1-2
, pp. 63-73
-
-
Zhang, W.1
-
48
-
-
84919452312
-
Metabolic reprograming in macrophage polarization
-
Galván-Peña S, O'Neill LA. Metabolic reprograming in macrophage polarization. Front Immunol. 2014;5:420.
-
(2014)
Front Immunol
, vol.5
, pp. 420
-
-
Galván-Peña, S.1
O'Neill, L.A.2
-
49
-
-
33845321931
-
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity
-
Cummins EP, et al. Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc Natl Acad Sci U S A. 2006;103(48):18154-18159.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.48
, pp. 18154-18159
-
-
Cummins, E.P.1
-
50
-
-
44849100198
-
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
-
Rius J, et al. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008;453(7196):807-811.
-
(2008)
Nature
, vol.453
, Issue.7196
, pp. 807-811
-
-
Rius, J.1
-
51
-
-
79251549807
-
An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia
-
Fitzpatrick SF, et al. An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia. J Immunol. 2011;186(2):1091-1096.
-
(2011)
J Immunol
, vol.186
, Issue.2
, pp. 1091-1096
-
-
Fitzpatrick, S.F.1
-
52
-
-
84862016400
-
The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism
-
Haschemi A, et al. The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. Cell Metab. 2012;15(6):813-826.
-
(2012)
Cell Metab
, vol.15
, Issue.6
, pp. 813-826
-
-
Haschemi, A.1
-
53
-
-
33745428666
-
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
-
Vats D, et al. Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab. 2006;4(1):13-24.
-
(2006)
Cell Metab
, vol.4
, Issue.1
, pp. 13-24
-
-
Vats, D.1
-
54
-
-
84962450023
-
Fatty acid oxidation in macrophage polarization
-
Nomura M, et al. Fatty acid oxidation in macrophage polarization. Nat Immunol. 2016;17(3):216-217.
-
(2016)
Nat Immunol
, vol.17
, Issue.3
, pp. 216-217
-
-
Nomura, M.1
-
55
-
-
84906319549
-
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
-
Huang SC, et al. Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nat Immunol. 2014;15(9):846-855.
-
(2014)
Nat Immunol
, vol.15
, Issue.9
, pp. 846-855
-
-
Huang, S.C.1
-
56
-
-
84960399221
-
Immunometabolism governs dendritic cell and macrophage function
-
O'Neill LA, Pearce EJ. Immunometabolism governs dendritic cell and macrophage function. J Exp Med. 2016;213(1):15-23.
-
(2016)
J Exp Med
, vol.213
, Issue.1
, pp. 15-23
-
-
O'Neill, L.A.1
Pearce, E.J.2
-
57
-
-
77955295091
-
Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation
-
Imtiyaz HZ, et al. Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest. 2010;120(8):2699-2714.
-
(2010)
J Clin Invest
, vol.120
, Issue.8
, pp. 2699-2714
-
-
Imtiyaz, H.Z.1
-
58
-
-
77649177217
-
Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis
-
Takeda N, et al. Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev. 2010;24(5):491-501.
-
(2010)
Genes Dev
, vol.24
, Issue.5
, pp. 491-501
-
-
Takeda, N.1
-
59
-
-
84925858150
-
Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle regeneration
-
Gondin J, et al. Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle regeneration. J Immunol. 2015;194(7):3389-3399.
-
(2015)
J Immunol
, vol.194
, Issue.7
, pp. 3389-3399
-
-
Gondin, J.1
-
60
-
-
36248996487
-
Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1alpha-dependent manner
-
Anand RJ, et al. Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1alpha-dependent manner. J Leukoc Biol. 2007;82(5):1257-1265.
-
(2007)
J Leukoc Biol
, vol.82
, Issue.5
, pp. 1257-1265
-
-
Anand, R.J.1
-
61
-
-
34250158361
-
Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis
-
Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel AS, Johnson RS, Nizet V. Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J Immunol. 2007;178(12):7516-7519.
-
(2007)
J Immunol
, vol.178
, Issue.12
, pp. 7516-7519
-
-
Peyssonnaux, C.1
Cejudo-Martin, P.2
Doedens, A.3
Zinkernagel, A.S.4
Johnson, R.S.5
Nizet, V.6
-
62
-
-
84924935721
-
Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization
-
Jha AK, et al. Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity. 2015;42(3):419-430.
-
(2015)
Immunity
, vol.42
, Issue.3
, pp. 419-430
-
-
Jha, A.K.1
-
63
-
-
84877343356
-
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
-
Michelucci A, et al. Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proc Natl Acad Sci U S A. 2013;110(19):7820-7825.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.19
, pp. 7820-7825
-
-
Michelucci, A.1
-
64
-
-
84973450882
-
Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage
-
Németh B, et al. Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage. FASEB J. 2016;30(1):286-300.
-
(2016)
FASEB J
, vol.30
, Issue.1
, pp. 286-300
-
-
Németh, B.1
-
65
-
-
80052170775
-
The mitochondrial citrate carrier: A new player in inflammation
-
Infantino V, et al. The mitochondrial citrate carrier: a new player in inflammation. Biochem J. 2011;438(3):433-436.
-
(2011)
Biochem J
, vol.438
, Issue.3
, pp. 433-436
-
-
Infantino, V.1
-
66
-
-
84868147963
-
Time-dependent stabilization of hypoxia inducible factor-1α by different intracellular sources of reactive oxygen species
-
Calvani M, Comito G, Giannoni E, Chiarugi P. Time-dependent stabilization of hypoxia inducible factor-1α by different intracellular sources of reactive oxygen species. PLoS ONE. 2012;7(10):e38388.
-
(2012)
PLoS ONE
, vol.7
, Issue.10
, pp. e38388
-
-
Calvani, M.1
Comito, G.2
Giannoni, E.3
Chiarugi, P.4
-
67
-
-
79957567239
-
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
-
Luo W, et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell. 2011;145(5):732-744.
-
(2011)
Cell
, vol.145
, Issue.5
, pp. 732-744
-
-
Luo, W.1
-
68
-
-
23044500915
-
Pyruvate kinase type M2 and its role in tumor growth and spreading
-
Mazurek S, Boschek CB, Hugo F, Eigenbrodt E. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol. 2005;15(4):300-308.
-
(2005)
Semin Cancer Biol
, vol.15
, Issue.4
, pp. 300-308
-
-
Mazurek, S.1
Boschek, C.B.2
Hugo, F.3
Eigenbrodt, E.4
-
69
-
-
84920591180
-
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages
-
Palsson-McDermott EM, et al. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015;21(1):65-80.
-
(2015)
Cell Metab
, vol.21
, Issue.1
, pp. 65-80
-
-
Palsson-McDermott, E.M.1
-
70
-
-
7944226627
-
Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes
-
Altenberg B, Greulich KO. Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics. 2004;84(6):1014-1020.
-
(2004)
Genomics
, vol.84
, Issue.6
, pp. 1014-1020
-
-
Altenberg, B.1
Greulich, K.O.2
-
71
-
-
84955566833
-
Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling
-
Fábián Z, Taylor CT, Nguyen LK. Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling. J Mol Med. 2016;94(4):377-390.
-
(2016)
J Mol Med
, vol.94
, Issue.4
, pp. 377-390
-
-
Fábián, Z.1
Taylor, C.T.2
Nguyen, L.K.3
-
72
-
-
79960369458
-
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
-
Shi LZ, et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med. 2011;208(7):1367-1376.
-
(2011)
J Exp Med
, vol.208
, Issue.7
, pp. 1367-1376
-
-
Shi, L.Z.1
-
73
-
-
84903277871
-
Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
-
Pollizzi KN, Powell JD. Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nat Rev Immunol. 2014;14(7):435-446.
-
(2014)
Nat Rev Immunol
, vol.14
, Issue.7
, pp. 435-446
-
-
Pollizzi, K.N.1
Powell, J.D.2
-
74
-
-
84922080059
-
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
-
Berod L, et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med. 2014;20(11):1327-1333.
-
(2014)
Nat Med
, vol.20
, Issue.11
, pp. 1327-1333
-
-
Berod, L.1
-
75
-
-
84945583836
-
Preventing allograft rejection by targeting immune metabolism
-
Lee CF, et al. Preventing allograft rejection by targeting immune metabolism. Cell Rep. 2015;13(4):760-770.
-
(2015)
Cell Rep
, vol.13
, Issue.4
, pp. 760-770
-
-
Lee, C.F.1
-
76
-
-
84978634373
-
T cell receptor signalling in the control of regulatory T cell differentiation and function
-
Li MO, Rudensky AY. T cell receptor signalling in the control of regulatory T cell differentiation and function. Nat Rev Immunol. 2016;16(4):220-233.
-
(2016)
Nat Rev Immunol
, vol.16
, Issue.4
, pp. 220-233
-
-
Li, M.O.1
Rudensky, A.Y.2
-
77
-
-
0035167967
-
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
-
Bennett CL, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet. 2001;27(1):20-21.
-
(2001)
Nat Genet
, vol.27
, Issue.1
, pp. 20-21
-
-
Bennett, C.L.1
-
78
-
-
84937576224
-
E3 ubiquitin ligase VHL regulates hypoxia-inducible factor-1α to maintain regulatory T cell stability and suppressive capacity
-
Lee JH, Elly C, Park Y, Liu YC. E3 ubiquitin ligase VHL regulates hypoxia-inducible factor-1α to maintain regulatory T cell stability and suppressive capacity. Immunity. 2015;42(6):1062-1074.
-
(2015)
Immunity
, vol.42
, Issue.6
, pp. 1062-1074
-
-
Lee, J.H.1
Elly, C.2
Park, Y.3
Liu, Y.C.4
-
80
-
-
84859387081
-
Neutrophil function: From mechanisms to disease
-
Amulic B, Cazalet C, Hayes GL, Metzler KD, Zychlinsky A. Neutrophil function: from mechanisms to disease. Annu Rev Immunol. 2012;30:459-489.
-
(2012)
Annu Rev Immunol
, vol.30
, pp. 459-489
-
-
Amulic, B.1
Cazalet, C.2
Hayes, G.L.3
Metzler, K.D.4
Zychlinsky, A.5
-
81
-
-
1542287347
-
Neutrophil extracellular traps kill bacteria
-
Brinkmann V, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303(5663):1532-1535.
-
(2004)
Science
, vol.303
, Issue.5663
, pp. 1532-1535
-
-
Brinkmann, V.1
-
82
-
-
0021684935
-
Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme
-
Guthrie LA, McPhail LC, Henson PM, Johnston RB. Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme. J Exp Med. 1984;160(6):1656-1671.
-
(1984)
J Exp Med
, vol.160
, Issue.6
, pp. 1656-1671
-
-
Guthrie, L.A.1
McPhail, L.C.2
Henson, P.M.3
Johnston, R.B.4
-
83
-
-
79952215345
-
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
-
Walmsley SR, et al. Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest. 2011;121(3):1053-1063.
-
(2011)
J Clin Invest
, vol.121
, Issue.3
, pp. 1053-1063
-
-
Walmsley, S.R.1
-
84
-
-
84892447705
-
Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation
-
Campbell EL, et al. Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity. 2014;40(1):66-77.
-
(2014)
Immunity.
, vol.40
, Issue.1
, pp. 66-77
-
-
Campbell, E.L.1
-
85
-
-
9644302527
-
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
-
Karhausen J, Furuta GT, Tomaszewski JE, Johnson RS, Colgan SP, Haase VH. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest. 2004;114(8):1098-1106.
-
(2004)
J Clin Invest
, vol.114
, Issue.8
, pp. 1098-1106
-
-
Karhausen, J.1
Furuta, G.T.2
Tomaszewski, J.E.3
Johnson, R.S.4
Colgan, S.P.5
Haase, V.H.6
-
86
-
-
77952092406
-
Hypoxia: An alarm signal during intestinal inflammation
-
Colgan SP, Taylor CT. Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol. 2010;7(5):281-287.
-
(2010)
Nat Rev Gastroenterol Hepatol
, vol.7
, Issue.5
, pp. 281-287
-
-
Colgan, S.P.1
Taylor, C.T.2
-
87
-
-
84889673983
-
Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis
-
Glover LE, et al. Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis. Proc Natl Acad Sci U S A. 2013;110(49):19820-19825.
-
(2013)
Proc Natl Acad Sci U S A.
, vol.110
, Issue.49
, pp. 19820-19825
-
-
Glover, L.E.1
-
88
-
-
84959378595
-
EGLN1 inhibition and rerouting of α-ketoglutarate suffice for remote ischemic protection
-
Olenchock BA, et al. EGLN1 inhibition and rerouting of α-ketoglutarate suffice for remote ischemic protection. Cell. 2016;164(5):884-895.
-
(2016)
Cell
, vol.164
, Issue.5
, pp. 884-895
-
-
Olenchock, B.A.1
-
89
-
-
0023550802
-
Kynurenate inhibition of cell excitation decreases stroke size and deficits
-
Germano IM, Pitts LH, Meldrum BS, Bartkowski HM, Simon RP. Kynurenate inhibition of cell excitation decreases stroke size and deficits. Ann Neurol. 1987;22(6):730-734.
-
(1987)
Ann Neurol
, vol.22
, Issue.6
, pp. 730-734
-
-
Germano, I.M.1
Pitts, L.H.2
Meldrum, B.S.3
Bartkowski, H.M.4
Simon, R.P.5
-
90
-
-
79958021894
-
Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration
-
Zwilling D, et al. Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Cell. 2011;145(6):863-874.
-
(2011)
Cell
, vol.145
, Issue.6
, pp. 863-874
-
-
Zwilling, D.1
-
91
-
-
3042547565
-
Induction of the glucose-6-phosphate dehydrogenase gene expression by chronic hypoxia in PC12 cells
-
Gao L, Mejías R, Echevarría M, López-Barneo J. Induction of the glucose-6-phosphate dehydrogenase gene expression by chronic hypoxia in PC12 cells. FEBS Lett. 2004;569(1-3):256-260.
-
(2004)
FEBS Lett
, vol.569
, Issue.1-3
, pp. 256-260
-
-
Gao, L.1
Mejías, R.2
Echevarría, M.3
López-Barneo, J.4
-
92
-
-
0029101515
-
Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements
-
Firth JD, Ebert BL, Ratcliffe PJ. Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. J Biol Chem. 1995;270(36):21021-21027.
-
(1995)
J Biol Chem
, vol.270
, Issue.36
, pp. 21021-21027
-
-
Firth, J.D.1
Ebert, B.L.2
Ratcliffe, P.J.3
-
93
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006;3(3):177-185.
-
(2006)
Cell Metab
, vol.3
, Issue.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
94
-
-
0035937715
-
Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
-
Chen C, Pore N, Behrooz A, Ismail-Beigi F, Maity A. Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem. 2001;276(12):9519-9525.
-
(2001)
J Biol Chem
, vol.276
, Issue.12
, pp. 9519-9525
-
-
Chen, C.1
Pore, N.2
Behrooz, A.3
Ismail-Beigi, F.4
Maity, A.5
-
95
-
-
44449174536
-
Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia
-
Kuhlicke J, Frick JS, Morote-Garcia JC, Rosenberger P, Eltzschig HK. Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia. PLoS ONE. 2007;2(12):e1364.
-
(2007)
PLoS ONE
, vol.2
, Issue.12
, pp. e1364
-
-
Kuhlicke, J.1
Frick, J.S.2
Morote-Garcia, J.C.3
Rosenberger, P.4
Eltzschig, H.K.5
-
96
-
-
20444445920
-
Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha
-
Phillips RJ, et al. Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. J Biol Chem. 2005;280(23):22473-22481.
-
(2005)
J Biol Chem
, vol.280
, Issue.23
, pp. 22473-22481
-
-
Phillips, R.J.1
-
97
-
-
3142752573
-
Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression
-
Kong T, Eltzschig HK, Karhausen J, Colgan SP, Shelley CS. Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression. Proc Natl Acad Sci U S A. 2004;101(28):10440-10445.
-
(2004)
Proc Natl Acad Sci U S A.
, vol.101
, Issue.28
, pp. 10440-10445
-
-
Kong, T.1
Eltzschig, H.K.2
Karhausen, J.3
Colgan, S.P.4
Shelley, C.S.5
|