Mitochondrial regulation of oxygen sensing

Advances in Experimental Medicine and Biology

Volumn 661, Issue , 2010, Pages 339-354

  Chandel, Navdeep S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

HIF; Mitochondria; Na K ATPase; ROS

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; ASPARAGINE; DIPHENYLIODONIUM SALT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOCHONDRIAL ENZYME; MITOQUINONE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; ROTENONE; STIGMATELLIN; UBIQUINONE; UNCLASSIFIED DRUG; VASCULOTROPIN; OXYGEN;

CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HYPOXIA; MITOCHONDRION; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN SENSING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RESPIRATORY CHAIN; ANIMAL; ANOXIA; ELECTRON TRANSPORT; METABOLISM; PHYSIOLOGY; REVIEW;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANOXIA; ELECTRON TRANSPORT; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MITOCHONDRIA; OXYGEN; PROCOLLAGEN-PROLINE DIOXYGENASE; REACTIVE OXYGEN SPECIES; SODIUM-POTASSIUM-EXCHANGING ATPASE; UBIQUINONE;

EID: 77951238575     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60761-500-2_22     Document Type: Conference Paper

References (62)

1. Schroedl C, McClintock DS, Budinger GRS, Chandel NS (2002) Hypoxic but not anoxic stabilization of HIF-1a requires mitochondrial reactive oxygen species. Am J Physiol Lung Cell Mol Physiol 283:L922-L931 (Pubitemid 35204884)
2. Semenza GL (1999) Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15:551-578 (Pubitemid 32250386)
3. Planès C, Friedlander G, Loiseau A, Amiel C, Clerici C (1996) Inhibition of Na,K-ATPase activity after prolonged hypoxia in an alveolar epithelial cell line. Am J Physiol 271:L71-L78
4. Chandel NS, Budinger GR, Schumacker PT (1996) Molecular oxygen modulates cytochrome c oxidase function. J Biol Chem 271:18672-18677 (Pubitemid 26322733)
5. Aw TY, Jones DP (1982) Secondary bioenergetic hypoxia. Inhibition of sulfation and glucuronidation reactions in isolated hepatocytes at low O2 concentration. J Biol Chem 257:8997-9004 (Pubitemid 12001868)
6. Forsythe JA, Jiang BH, Iyer NV et al (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16:4604-4613 (Pubitemid 26272112)
7. Wang GL, Jiang BH, Rue EA, Semenza GL (1995) Hypoxia-inducible factor 1 is a basichelix- loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 92:5510-5514
8. Jiang BH, Zheng JZ, Leung SW, Roe R, Semenza GL (1997) Transactivation and inhibitory domains of hypoxia-inducible factor 1a modulation of transcriptional activity by oxygen tension. J Biol Chem 272:19253-19260 (Pubitemid 27337716)
9. Maxwell PH, Wiesener MS, Chang GW et al (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271-275 (Pubitemid 29246458)
10. Jaakkola P, Mole DR, Tian YM et al (2001) Targeting of HIF-a to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292:468-472 (Pubitemid 32335942)
11. Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ (2001) Independent function of two destruction domains in hypoxia-inducible factor-a chains activated by prolyl hydroxylation. EMBO J 20:5197-5206 (Pubitemid 32910914)
12. Ivan M, Kondo K, Yang H et al (2001) HIFa targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292:464-468 (Pubitemid 32335941)
13. Epstein AC, Gleadle JM, McNeill LA et al (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107:43-54 (Pubitemid 32972036)
14. Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick R (2002) FIH-1 is an asparaginyl hydroxylase that regulates the transcriptional activity of hypoxia inducible factor. Genes Dev 16:1466-1471 (Pubitemid 34686328)
15. Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML (2002) Asparagine hydroxylation of the HIF transactivation domain: a hypoxic switch. Science 295:858-861 (Pubitemid 34118367)
16. Mahon PC, Hirota K, Semenza GL (2001) FIH-1: a novel protein that interacts with HIF-1a and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15:2675-2686 (Pubitemid 32988878)
17. Bunn HF, Poyton RO (1996) Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 76:839-885 (Pubitemid 26286080)
18. Srinivas V, Zhu X, Salceda S, Nakamura R, Caro J (1998) Hypoxia-inducible factor 1a (HIF-1a) is a non-heme iron protein. Implications for oxygen sensing. J Biol Chem 273:18019-18022 (Pubitemid 28334715)
19. Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT (1998) Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A 95:5015-5019
20. Chandel NS, McClintock DS, Feliciano SE et al (2000) Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1a during hypoxia: a mechanism of O2 sensing. J Biol Chem 275:25130-25138
21. King MP, Attardi G (1988) Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA. Cell 52:811-819 (Pubitemid 18095348)
22. Turrens JF (2003) Mitochondrial formation of reactive oxygen species. J Physiol 552:335-344 (Pubitemid 37321833)
23. Hunte C, Palsdottir H, Trumpower BL (2003) Protonmotive pathways and mechanisms in the cytochrome bc1 complex. FEBS Lett 545:39-46 (Pubitemid 36629634)
24. Han D, Antunes F, Canali R, Rettori D, Cadenas E (2003) Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol. J Biol Chem 278:5557-5563 (Pubitemid 36800797)
25. Turrens JF, Alexandre A, Lehninger AL (1985) Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria. Arch Biochem Biophys 237:408-414 (Pubitemid 15144894)
26. Boveris A, Cadenas E, Stoppani AO (1976) Role of ubiquinone in the mitochondrial generation of hydrogen peroxide. Biochem J 156:435-444
27. Gupte S, Wu ES, Hoechli L et al (1984) Relationship between lateral diffusion, collision frequency, and electron transfer of mitochondrial inner membrane oxidation-reduction components. Proc Natl Acad Sci U S A 81:2606-2610
28. Kroger A, Klingenberg M (1973) Further evidence for the pool function of ubiquinone as derived from the inhibition of the electron transport by antimycin. Eur J Biochem 39:313-323
29. Mansfield KD, Guzy RD, Pan Y et al (2005) Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab 1:393-399 (Pubitemid 43960625)
30. Guzy RD, Hoyos B, Robin E et al (2005) Mitochondrial complex III is required for hypoxiainduced ROS production and cellular oxygen sensing. Cell Metab 1:401-408 (Pubitemid 43960623)
31. Brunelle JK, Bell EL, Quesada NM et al (2005) Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab 1:409-414 (Pubitemid 43960624)
32. Rana M, de Coo I, Diaz F, Smeets H, Moraes CT (2000) An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production. Ann Neurol 48:774-781
33. Bell EL, Klimova TA, Eisenbart J et al (2007) The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol 177:1029-1036 (Pubitemid 46955707)
34. Hirota K, Semenza GL (2001) Rac1 activity is required for the activation of hypoxia-inducible factor 1. J Biol Chem 276:21166-21172
35. Turcotte S, Desrosiers RR, Beliveau R (2003) HIF-1a mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma. J Cell Sci 116:2247-2260 (Pubitemid 36722371)
36. Chandel NS, Budinger GR, Choe SH, Schumacker PT (1997) Cellular respiration during hypoxia. Role of cytochrome oxidase as the oxygen sensor in hepatocytes. J Biol Chem 272:18808-18816 (Pubitemid 27318228)
37. Milligan LP, McBride BW (1985) Energy costs of ion pumping by animal tissues. J Nutr 115:1374-1382
38. Kaplan JH (2002) Biochemistry of Na,K-ATPase. Annu Rev Biochem 71:511-535 (Pubitemid 34800229)
39. Carpenter TC, Schomberg S, Nichols C, Stenmark KR, Weil JV (2003) Hypoxia reversibly inhibits epithelial sodium transport but does not inhibit lung ENaC or Na-K-ATPase expression. Am J Physiol Lung Cell Mol Physiol 284:L77-L83 (Pubitemid 35471260)
40. Mairbaurl H, Wodopia R, Eckes S, Schulz S, Bartsch P (1997) Impairment of cation transport in A549 cells and rat alveolar epithelial cells by hypoxia. Am J Physiol Lung Cell Mol Physiol 273:L797-L806
41. Dada LA, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI (2003) Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-V. J Clin Invest 111:1057-1064 (Pubitemid 36397482)
42. Chibalin AV, Ogimoto G, Pedemonte CH et al (1999) Dopamine-induced endocytosis of Na+,K+-ATPase is initiated by phosphorylation of Ser-18 in the rat a subunit and is responsible for the decreased activity in epithelial cells. J Biol Chem 274:1920-1927
43. Konishi H, Tanaka M, Takemura Y et al (1997) Activation of protein kinase C by tyrosine phosphorylation in response to H2O2. Proc Natl Acad Sci U S A 94:11233-11237 (Pubitemid 27450981)
44. Feschenko MS, Sweadner KJ (1997) Phosphorylation of Na,K-ATPase by protein kinase C at Ser18 occurs in intact cells but does not result in direct inhibition of ATP hydrolysis. J Biol Chem 272:17726-17733 (Pubitemid 27311211)
45. Bruick RK (2003) Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor. Genes Dev 17:2614-2623 (Pubitemid 37363065)
46. Hirsila M, Koivunen P, Gunzler V, Kivirikko KI, Myllyharju J (2003) Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem 278:30772-30780 (Pubitemid 36994584)
47. Jiang BH, Semenza GL, Bauer C, Marti HH (1996) Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. Am J Physiol 271:C1172-C1180
48. Gleadle JM, Ebert BL, Ratcliffe PJ (1995) Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing. Eur J Biochem 234:92-99
49. Killilea DW, Hester R, Balczon R, Babal P, Gillespie MN (2000) Free radical production in hypoxic pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 279:L408-L412
50. Wood JG, Johnson JS, Mattioli LF, Gonzalez NC (1999) Systemic hypoxia promotes leukocyte- endothelial adherence via reactive oxidant generation. J Appl Physiol 87:1734-1740
51. Fandrey J, Frede S, Jelkmann W (1994) Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem J 303:507-510 (Pubitemid 24317332)
52. Tarpey MM, Fridovich I (2001) Methods of detection of vascular reactive species: nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite. Circ Res 89:224-236 (Pubitemid 34133992)
53. Dirmeier R, O'Brien KM, Engle M, Dodd A, Spears E, Poyton RO (2002) Exposure of yeast cells to anoxia induces transient oxidative stress. Implications for the induction of hypoxic genes. J Biol Chem 277:34773-34784
54. Grishko V, Solomon M, Breit JF et al (2001) Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene. FASEB J 15:1267-1269
55. Liu Q, Kuppusamy P, Sham JSK, Shimoda LA, Zweier JL, Sylvester JT (2001) Increased production of reactive oxygen species (ROS) by pulmonary arterial smooth muscle is required for hypoxic pulmonary vasoconstriction (HPV). Am J Respir Crit Care Med 163:A395
56. Agani FH, Pichiule P, Chavez JC, LaManna JC (2000) The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia. J Biol Chem 275:35863-35867
57. Enomoto N, Koshikawa N, Gassmann M, Hayashi J, Takenaga K (2002) Hypoxic induction of hypoxia-inducible factor-1a and oxygen-regulated gene expression in mitochondrial DNAdepleted HeLa cells. Biochem Biophys Res Commun 297:346-352 (Pubitemid 35216177)
58. Srinivas V, Leshchinsky I, Sang N, King MP, Minchenko A, Caro J (2001) Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electrontransfer pathway. J Biol Chem 276:21995-21998
59. Vaux EC, Metzen E, Yeates KM, Ratcliffe PJ (2001) Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. Blood 98:296-302
60. Miranda S, Foncea R, Guerrero J, Leighton F (1999) Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells. Biochem Biophys Res Commun 258:44-49 (Pubitemid 29286999)
61. Paddenberg R, Ishaq B, Goldenberg A et al (2003) Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature. Am J Physiol Lung Cell Mol Physiol 284:L710-L719 (Pubitemid 36459016)
62. Hagen T, Taylor CT, Lam F, Moncada S (2003) Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1a.Science 302:1975-1978 (Pubitemid 37523507)