S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

Nature

Volumn 540, Issue 7632, 2016, Pages 236-241

  Tyrakis, Petros A ^a,b   Palazon, Asis ^a   Macias, David ^a   Lee, Kian L ^c   Phan, Anthony T ^d   Veliça, Pedro ^e   You, Jia ^c   Chia, Grace S ^c   Sim, Jingwei ^a   Doedens, Andrew ^d   Abelanet, Alice ^a   Evans, Colin E ^a   Griffiths, John R ^b   Poellinger, Lorenz ^c,e   Goldrath, Ananda W ^d   Johnson, Randall S ^a,e  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYGLUTARIC ACID; 5 METHYLCYTOSINE; GAMMA INTERFERON; GENOMIC DNA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 2; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; L SELECTIN; LACTATE DEHYDROGENASE; MALATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; T LYMPHOCYTE RECEPTOR; VON HIPPEL LINDAU PROTEIN; 2 OXOGLUTARIC ACID; ALPHA-HYDROXYGLUTARATE; ALPHA-KETOGLUTARIC ACID; DIOXYGENASE; DNA; GLUTARIC ACID DERIVATIVE; HIF1A PROTEIN, MOUSE; HISTONE; LYMPHOCYTE ANTIGEN RECEPTOR; LYSINE; OXYGEN; VHL PROTEIN, MOUSE;

CANCER; CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; GENE EXPRESSION; IMMUNE SYSTEM; METABOLITE; OXYGEN; PHYSIOLOGICAL RESPONSE; RODENT; TUMOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL EXPANSION; CELL FATE; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CITRIC ACID CYCLE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DNA DEMETHYLATION; DNA METHYLATION; DNA REPLICATION; FIBROBLAST; GENE MUTATION; GENE SILENCING; HISTONE DEMETHYLATION; HISTONE METHYLATION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOUSE; NONHUMAN; OXYGENATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; THYMOCYTE; TRANSCRIPTION INITIATION SITE; ANIMAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; HOMEOSTASIS; HYPOXIA; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; DIOXYGENASES; DNA; DNA METHYLATION; GLUTARATES; HISTONES; HOMEOSTASIS; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KETOGLUTARIC ACIDS; LYMPHOCYTE ACTIVATION; LYSINE; MICE; OXYGEN; PROTEIN STABILITY; RECEPTORS, ANTIGEN, T-CELL; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 85017251482     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature20165     Document Type: Article

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