Concise review: Genetic dissection of hypoxia signaling pathways in normal and leukemic stem cells

Stem Cells

Volumn 32, Issue 6, 2014, Pages 1390-1397

  Gezer, Deniz ^a,b,c   Vukovic, Milica ^a   Soga, Tomoyoshi ^d   Pollard, Patrick J ^e   Kranc, Kamil R ^a,e  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^d KEIO UNIVERSITY   (Japan)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Acute myeloid leukemia; Cited2; Hematological malignancies; Hematopoietic progenitors; Hematopoietic stem cells; HIF 1; HIF 2; Hypoxia

Indexed keywords

2 OXOGLUTARIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISOCITRATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE;

ACUTE GRANULOCYTIC LEUKEMIA; CANCER STEM CELL; CELL DIFFERENTIATION; CELL HYPOXIA; CELL RENEWAL; CHRONIC MYELOID LEUKEMIA; CITRIC ACID CYCLE; ENHANCER REGION; GENE MUTATION; GENOTYPE; HEMATOLOGIC MALIGNANCY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; INTRACELLULAR SIGNALING; KNOCKOUT MOUSE; LEUKEMIA CELL; LEUKEMIC STEM CELL; LEUKEMOGENESIS; MULTIPOTENT STEM CELL; NONHUMAN; PHENOTYPE; PROMOTER REGION; REVIEW; TRANSCRIPTION INITIATION; TUMOR MICROENVIRONMENT; ANIMAL; GENETICS; LEUKEMIA; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CELL HYPOXIA; HEMATOPOIETIC STEM CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LEUKEMIA; NEOPLASTIC STEM CELLS; SIGNAL TRANSDUCTION;

EID: 84901466176     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1657     Document Type: Review

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