Germinal center hypoxia potentiates immunoglobulin class switch recombination

Journal of Immunology

Volumn 197, Issue 10, 2016, Pages 4014-4020

  Abbott, Robert K ^a   Thayer, Molly ^a   Labuda, Jasmine ^a   Silva, Murillo ^a   Philbrook, Phaethon ^a   Cain, Derek W ^b   Kojima, Hidefumi ^c   Hatfield, Stephen ^a   Sethumadhavan, Shalini ^a   Ohta, Akio ^a   Reinherz, Ellis L ^d   Kelsoe, Garnett ^b   Sitkovsky, Michail ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DOKKYO MEDICAL UNIVERSITY   (Japan)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOL SALICYLATE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN M; INDUCIBLE T CELL COSTIMULATOR; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; OXYGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; APOPTOSIS; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE REARRANGEMENT; GENETIC RECOMBINATION; GERMINAL CENTER; HELPER CELL; HYPOXIA; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; UPREGULATION; ANIMAL; BLOOD; C57BL MOUSE; CELL HYPOXIA; CYTOLOGY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY;

ANIMALS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL HYPOXIA; GERMINAL CENTER; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; IMMUNOGLOBULINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; OXYGEN; PLASMA CELLS; RECOMBINATION, GENETIC;

EID: 84994472525     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1601401     Document Type: Article

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