Hypercapnia suppresses the HIF-dependent adaptive response to hypoxia

Journal of Biological Chemistry

Volumn 291, Issue 22, 2016, Pages 11800-11808

  Selfridge, Andrew C ^a   Cavadas, Miguel A S ^a,f   Scholz, Carsten C ^a,b   Campbell, Eric L ^c   Welch, Lynn C ^d   Lecuona, Emilia ^d   Colgan, Sean P ^c   Barrett, Kim E ^a,g   Sporn, Peter H S ^d,e   Sznajder, Jacob I ^d   Cummins, Eoin P ^a   Taylor, Cormac T ^a,b  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF COLORADO   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e JESSE BROWN VA MEDICAL CENTER   (United States)

^f INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^g UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; MAMMALS; PROTEINS; TRANSCRIPTION;

DEGRADATION PATHWAYS; GENE TRANSCRIPTIONS; HYPOXIA-INDUCIBLE FACTORS; LYSOSOMAL DEGRADATION; OXIDATIVE METABOLISM; SPECIFIC INHIBITORS; TARGET GENE EXPRESSION; TRANSCRIPTIONAL RESPONSE;

MOLECULAR OXYGEN;

ADENOSINE TRIPHOSPHATASE; BAFILOMYCIN A1; CARBON DIOXIDE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; OXYGEN;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL PH; CHRONIC RESPIRATORY TRACT DISEASE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HYPERCAPNIA; HYPOXIA; LYSOSOME; MALE; MOUSE; NONHUMAN; PARTIAL PRESSURE; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN TARGETING; ANIMAL; BLOOD; C57BL MOUSE; GENETICS; HCT 116 CELL LINE; HELA CELL LINE; HUMAN; METABOLISM; PATHOPHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARBON DIOXIDE; CELLS, CULTURED; FEMALE; HCT116 CELLS; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERCAPNIA; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MICE; MICE, INBRED C57BL; OXYGEN; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84971268711     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.713941     Document Type: Article

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