Human adipocytes are highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression

Biochemical and Biophysical Research Communications

Volumn 447, Issue 4, 2014, Pages 660-665

  Taylor, Cormac T ^a   Kent, Brian D ^a,b   Crinion, Sophie J ^a,b   McNicholas, Walter T ^a,b   Ryan, Silke ^a,b  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Adipocytes; Inflammation; Intermittent hypoxia; Obstructive sleep apnea

Indexed keywords

ADIPOCYTOKINE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; SYNAPTOTAGMIN I; VASCULOTROPIN;

ADIPOCYTE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOKINE RELEASE; DNA BINDING; ENDOTHELIUM CELL; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; INTERMITTENT HYPOXIA; INTRAABDOMINAL FAT; LUNG ALVEOLUS CELL; PRIMARY CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ADIPOCYTES; INFLAMMATION; INTERMITTENT HYPOXIA; OBSTRUCTIVE SLEEP APNEA;

ACTIVE TRANSPORT, CELL NUCLEUS; ADIPOCYTES, WHITE; ADIPOKINES; CARDIOVASCULAR DISEASES; CELL HYPOXIA; CELLS, CULTURED; DNA; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; INTERLEUKIN-8; PHOSPHORYLATION; RNA, MESSENGER; SLEEP APNEA, OBSTRUCTIVE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84900451310     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.04.062     Document Type: Article

References (41)

1. J. Nanduri, G. Yuan, and G.K. Kumar et al. Transcriptional responses to intermittent hypoxia Respir. Physiol. Neurobiol. 164 2008 277 281
2. S. Toffoli, and C. Michiels Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours FEBS J. 275 2008 2991 3002
3. N.R. Prabhakar Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms J. Appl. Physiol. 90 2001 1985 1986 1994
4. P.E. Peppard, T. Young, and J.H. Barnet et al. Increased prevalence of sleep-disordered breathing in adults Am. J. Epidemiol. 177 2013 1006 1014
5. W.T. McNicholas, and M.R. Bonsignore Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities Eur. Respir. J. 29 2007 156 178
6. S. Ryan, C.T. Taylor, and W.T. McNicholas Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome? Thorax 64 2009 631 636
7. S. Ryan, C.T. Taylor, and W.T. McNicholas Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome Circulation 112 2005 2660 2667
8. E.P. Cummins, and C.T. Taylor Hypoxia-responsive transcription factors Pflugers Arch. 450 2005 363 371
9. S. Ryan, C.T. Taylor, and W.T. McNicholas Predictors of elevated nuclear factor-kappaB-dependent genes in obstructive sleep apnea syndrome Am. J. Respir. Crit. Care Med. 174 2006 824 830
10. S. Ryan, G.M. Nolan, and E. Hannigan et al. Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity Thorax 62 2007 509 514
11. P.E. Peppard, T. Young, and M. Palta et al. Longitudinal study of moderate weight change and sleep-disordered breathing JAMA 284 2000 3015 3021
12. P. Trayhurn, and J.H. Beattie Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ Proc. Nutr. Soc. 60 2001 329 339
13. P. Trayhurn, B. Wang, and I.S. Wood Hypoxia and the endocrine and signalling role of white adipose tissue Arch. Physiol. Biochem. 114 2008 267 276
14. S. Ryan, W.T. McNicholas, and C.T. Taylor A critical role for p38 map kinase in NF-kappaB signaling during intermittent hypoxia/reoxygenation Biochem. Biophys. Res. Commun. 355 2007 728 733
15. L.F. Drager, Q. Yao, and K.L. Hernandez et al. Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4 Am. J. Respir. Crit. Care Med. 188 2013 240 248
16. G. Yuan, S.A. Khan, and W. Luo et al. Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia J. Cell. Physiol. 226 2011 2925 2933
17. S. Jelic, and T.H. Le Jemtel Inflammation, oxidative stress, and the vascular endothelium in obstructive sleep apnea Trends Cardiovasc. Med. 18 2008 253 260
18. B.D. Kent, J.F. Garvey, and S. Ryan et al. Severity of obstructive sleep apnoea predicts coronary artery plaque burden: a coronary CT angiography study Eur. Respir. J. 42 2013 1263 1270
19. P. Levy, M.R. Bonsignore, and J. Eckel Sleep, sleep-disordered breathing and metabolic consequences Eur. Respir. J. 34 2009 243 260
20. E.S. Arnardottir, G. Maislin, and R.J. Schwab et al. The interaction of obstructive sleep apnea and obesity on the inflammatory markers C-reactive protein and interleukin-6: the icelandic sleep apnea cohort Sleep 35 2012 921 932
21. R. Bhattacharjee, J. Kim, and W.H. Alotaibi et al. Endothelial dysfunction in children without hypertension: potential contributions of obesity and obstructive sleep apnea Chest 141 2012 682 691
22. D. Gozal, O.S. Capdevila, and L. Kheirandish-Gozal Metabolic alterations and systemic inflammation in obstructive sleep apnea among nonobese and obese prepubertal children Am. J. Respir. Crit. Care Med. 177 2008 1142 1149
23. C. Arnaud, L. Poulain, and P. Levy et al. Inflammation contributes to the atherogenic role of intermittent hypoxia in apolipoprotein-E knock out mice Atherosclerosis 219 2011 425 431
24. J. Jun, C. Reinke, and D. Bedja et al. Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice Atherosclerosis 209 2010 381 386
25. L.F. Drager, J. Li, and C. Reinke et al. Intermittent hypoxia exacerbates metabolic effects of diet-induced obesity Obesity (Silver Spring) 19 2011 2167 2174
26. V.Y. Polotsky, J. Li, and N.M. Punjabi et al. Intermittent hypoxia increases insulin resistance in genetically obese mice J. Physiol. 552 2003 253 264
27. U.J. Magalang, J.P. Cruff, and R. Rajappan et al. Intermittent hypoxia suppresses adiponectin secretion by adipocytes Exp. Clin. Endocrinol. Diabetes 117 2009 129 134
28. Q. He, Q.C. Yang, and Q. Zhou et al. Effects of varying degrees of intermittent hypoxia on proinflammatory cytokines and adipokines in rats and 3T3-L1 adipocytes PLoS One 9 2014 e86326
29. L. Poulain, A. Thomas, and J. Rieusset et al. Visceral white fat remodeling contributes to intermittent hypoxia-induced atherogenesis Eur. Respir. J. 43 2014 513 522
30. M. Pasarica, O.R. Sereda, and L.M. Redman et al. Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response Diabetes 58 2009 718 725
31. J. Ye, Z. Gao, and J. Yin et al. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice Am. J. Physiol. Endocrinol. Metab. 293 2007 E1118 E1128
32. C. Reinke, S. Bevans-Fonti, and L.F. Drager et al. Effects of different acute hypoxic regimens on tissue oxygen profiles and metabolic outcomes J. Appl. Physiol. 111 2011 1985 881 890
33. R.N. Bergman, S.P. Kim, and K.J. Catalano et al. Why visceral fat is bad: mechanisms of the metabolic syndrome Obesity (Silver Spring) 14 Suppl. 1 2006 16S 19S
34. V.Y. Polotsky, V. Savransky, and S. Bevans-Fonti et al. Intermittent and sustained hypoxia induce a similar gene expression profile in the human aortic endothelial cells Physiol. Genomics 41 2010 306 314
35. I. Almendros, J.M. Montserrat, and M. Torres et al. Obesity and intermittent hypoxia increase tumor growth in a mouse model of sleep apnea Sleep Med. 13 2012 1254 1260
36. E. Kaczmarek, J.P. Bakker, and D.N. Clarke et al. Molecular biomarkers of vascular dysfunction in obstructive sleep apnea PLoS One 8 2013 e70559
37. L. Lavie, H. Kraiczi, and A. Hefetz et al. Plasma vascular endothelial growth factor in sleep apnea syndrome: effects of nasal continuous positive air pressure treatment Am. J. Respir. Crit. Care Med. 165 2002 1624 1628
38. G. Pages, and J. Pouyssegur Transcriptional regulation of the vascular endothelial growth factor gene - a concert of activating factors Cardiovasc. Res. 65 2005 564 573
39. P.C. Beguin, E. Belaidi, and D. Godin-Ribuot et al. Intermittent hypoxia-induced delayed cardioprotection is mediated by PKC and triggered by p38 MAP kinase and Erk1/2 J. Mol. Cell. Cardiol. 42 2007 343 351
40. L. Dyugovskaya, A. Polyakov, and D. Ginsberg et al. Molecular pathways of spontaneous and TNF-{alpha}-mediated neutrophil apoptosis under intermittent hypoxia Am. J. Respir. Cell Mol. Biol. 45 2011 154 162
41. M. Hayakawa, H. Miyashita, and I. Sakamoto et al. Evidence that reactive oxygen species do not mediate NF-kappaB activation EMBO J. 22 2003 3356 3366