-
1
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein B., Papadopoulos N., Velculescu V.E., Zhou S., Diaz L.A., Kinzler K.W. Cancer genome landscapes. Science 2013, 339:1546-1558.
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
Papadopoulos, N.2
Velculescu, V.E.3
Zhou, S.4
Diaz, L.A.5
Kinzler, K.W.6
-
2
-
-
80053144962
-
A decade of exploring the cancer epigenome - biological and translational implications
-
Baylin S.B., Jones P.A. A decade of exploring the cancer epigenome - biological and translational implications. Nat. Rev. Cancer 2011, 11:726-734.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 726-734
-
-
Baylin, S.B.1
Jones, P.A.2
-
3
-
-
79952392467
-
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
-
Bissell M.J., Hines W.C. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat. Med. 2011, 17:320-329.
-
(2011)
Nat. Med.
, vol.17
, pp. 320-329
-
-
Bissell, M.J.1
Hines, W.C.2
-
4
-
-
84877028141
-
Comprehensive molecular portrait of human breast tumors
-
The Cancer Genome Atlas Network Comprehensive molecular portrait of human breast tumors. Nature 2012, 490:61-70.
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
-
5
-
-
84858590826
-
Accessories to the crime: functions of cells recruited to the tumor microenvironment
-
Hanahan D., Coussens L.M. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 2012, 21:309-322.
-
(2012)
Cancer Cell
, vol.21
, pp. 309-322
-
-
Hanahan, D.1
Coussens, L.M.2
-
6
-
-
31444447160
-
Extending survival with chemotherapy in metastatic breast cancer
-
O'Shaughnessy J. Extending survival with chemotherapy in metastatic breast cancer. Oncologist 2005, 10(Suppl. 3):20-29.
-
(2005)
Oncologist
, vol.10
, pp. 20-29
-
-
O'Shaughnessy, J.1
-
8
-
-
1642565876
-
Tumor hypoxia and malignant progression
-
Vaupel P., Mayer A., Höckel M. Tumor hypoxia and malignant progression. Methods Enzymol. 2004, 381:335-354.
-
(2004)
Methods Enzymol.
, vol.381
, pp. 335-354
-
-
Vaupel, P.1
Mayer, A.2
Höckel, M.3
-
9
-
-
0036359548
-
Hypoxia - a key regulatory factor in tumor growth
-
Harris A.L. Hypoxia - a key regulatory factor in tumor growth. Nat. Rev. Cancer 2002, 2:38-47.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
10
-
-
84864131464
-
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2
-
Prabhakar N.R., Semenza G.L. Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol. Rev. 2012, 92:967-1003.
-
(2012)
Physiol. Rev.
, vol.92
, pp. 967-1003
-
-
Prabhakar, N.R.1
Semenza, G.L.2
-
11
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza G.L. Hypoxia-inducible factors in physiology and medicine. Cell 2012, 148:399-408.
-
(2012)
Cell
, vol.148
, pp. 399-408
-
-
Semenza, G.L.1
-
12
-
-
43649093915
-
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
-
Kaelin W.G., Ratcliffe P.J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 2008, 30:393-402.
-
(2008)
Mol. Cell
, vol.30
, pp. 393-402
-
-
Kaelin, W.G.1
Ratcliffe, P.J.2
-
13
-
-
84886412451
-
Hypoxia-inducible factor 1 and cardiovascular disease
-
Semenza G.L. Hypoxia-inducible factor 1 and cardiovascular disease. Annu. Rev. Physiol. 2014, 76:39-56.
-
(2014)
Annu. Rev. Physiol.
, vol.76
, pp. 39-56
-
-
Semenza, G.L.1
-
14
-
-
23244463512
-
Overexpression of hypoxia-inducible factor HIF-1α predicts early relapse in breast cancer: retrospective study in a series of 745 patients
-
Dales J.P., Garcia S., Meunier-Carpentier S., Andrac-Meyer L., Haddad O., Lavaut M.N., Allasia C., Bonnier P., Charpin C. Overexpression of hypoxia-inducible factor HIF-1α predicts early relapse in breast cancer: retrospective study in a series of 745 patients. Int. J. Cancer 2005, 116:734-739.
-
(2005)
Int. J. Cancer
, vol.116
, pp. 734-739
-
-
Dales, J.P.1
Garcia, S.2
Meunier-Carpentier, S.3
Andrac-Meyer, L.4
Haddad, O.5
Lavaut, M.N.6
Allasia, C.7
Bonnier, P.8
Charpin, C.9
-
15
-
-
0036278899
-
Overexpression of hypoxia-inducible factor 1α is associated with an unfavorable prognosis in lymph node-positive breast cancer
-
Schindl M., Schoppmann S.F., Samonigg H., Hausmaninger H., Kwasny W., Gnant M., Jakesj R. Overexpression of hypoxia-inducible factor 1α is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin. Cancer Res. 2002, 8:1831-1837.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 1831-1837
-
-
Schindl, M.1
Schoppmann, S.F.2
Samonigg, H.3
Hausmaninger, H.4
Kwasny, W.5
Gnant, M.6
Jakesj, R.7
-
16
-
-
0037443587
-
Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma
-
Bos R., van der Groep P., Greijer A.E., Shvarts A., Meijer S., Pinedo H.M., Semenza G.L., van Diest P.J., van der Wall E. Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 2003, 97:1573-1581.
-
(2003)
Cancer
, vol.97
, pp. 1573-1581
-
-
Bos, R.1
van der Groep, P.2
Greijer, A.E.3
Shvarts, A.4
Meijer, S.5
Pinedo, H.M.6
Semenza, G.L.7
van Diest, P.J.8
van der Wall, E.9
-
17
-
-
9744250235
-
C-ErbB-2 related aggressiveness in breast cancer is hypoxia-inducible factor-1α dependent
-
Giatromanolaki A., Koukourakis M.I., Simopoulos C., Polychronidis A., Gatter K.C., Harris A.L., Sivridis E. c-ErbB-2 related aggressiveness in breast cancer is hypoxia-inducible factor-1α dependent. Clin. Cancer Res. 2004, 10:7972-7977.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 7972-7977
-
-
Giatromanolaki, A.1
Koukourakis, M.I.2
Simopoulos, C.3
Polychronidis, A.4
Gatter, K.C.5
Harris, A.L.6
Sivridis, E.7
-
18
-
-
33748037026
-
Hypoxia-inducible factor-1α expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer
-
Generali D., Berruti A., Brizzi M.P., Campo L., Bonardi S., Wigfield S., Bersiga A., Allevi G., Milani M., Aguggini S., Gandolfi V., Dogliotti L., Bottini A., Harris A.L., Fox S.B. Hypoxia-inducible factor-1α expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer. Clin. Cancer Res. 2006, 12:4562-4568.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 4562-4568
-
-
Generali, D.1
Berruti, A.2
Brizzi, M.P.3
Campo, L.4
Bonardi, S.5
Wigfield, S.6
Bersiga, A.7
Allevi, G.8
Milani, M.9
Aguggini, S.10
Gandolfi, V.11
Dogliotti, L.12
Bottini, A.13
Harris, A.L.14
Fox, S.B.15
-
19
-
-
46949094778
-
Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer
-
Yamamoto Y., Ibusuki M., Okumura Y., Kawasoe T., Kai K., Ivama K., Iwase H. Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer. Breast Cancer Res. Treat. 2008, 110:465-475.
-
(2008)
Breast Cancer Res. Treat.
, vol.110
, pp. 465-475
-
-
Yamamoto, Y.1
Ibusuki, M.2
Okumura, Y.3
Kawasoe, T.4
Kai, K.5
Ivama, K.6
Iwase, H.7
-
20
-
-
34248172298
-
Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers
-
Winter S.C., Buffa F.M., Silva P., Miller C., Valentine H.R., Turley H., Shah K.A., Cox G.J., Corbridge R.J., Homer J.J., Musgrove B., Slevin N., Sloan P., Price P., West C.M., Harris A.L. Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers. Cancer Res. 2007, 67:3441-3449.
-
(2007)
Cancer Res.
, vol.67
, pp. 3441-3449
-
-
Winter, S.C.1
Buffa, F.M.2
Silva, P.3
Miller, C.4
Valentine, H.R.5
Turley, H.6
Shah, K.A.7
Cox, G.J.8
Corbridge, R.J.9
Homer, J.J.10
Musgrove, B.11
Slevin, N.12
Sloan, P.13
Price, P.14
West, C.M.15
Harris, A.L.16
-
21
-
-
84918530536
-
Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
-
Samanta D., Gilkes D.M., Chaturvedi P., Xiang L., Semenza G.L. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc. Natl. Acad. Sci. U. S. A. 2014, 111:E5429-E5438.
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. E5429-E5438
-
-
Samanta, D.1
Gilkes, D.M.2
Chaturvedi, P.3
Xiang, L.4
Semenza, G.L.5
-
22
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 2003, 3:721-732.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
23
-
-
34547124062
-
Hypoxia: a key regulator of angiogenesis in cancer
-
Liao D., Johnson R.S. Hypoxia: a key regulator of angiogenesis in cancer. Cancer Metastasis Rev. 2007, 26:281-290.
-
(2007)
Cancer Metastasis Rev.
, vol.26
, pp. 281-290
-
-
Liao, D.1
Johnson, R.S.2
-
24
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology
-
Semenza G.L. Defining the role of hypoxia-inducible factor 1 in cancer biology. Oncogene 2010, 29:625-634.
-
(2010)
Oncogene
, vol.29
, pp. 625-634
-
-
Semenza, G.L.1
-
25
-
-
33846652552
-
Hypoxia-inducible factor-1α is a key regulator of metastasis in a transgenic model of cancer initiation and progression
-
Liao D., Corle C., Seagroves T.N., Johnson R.S. Hypoxia-inducible factor-1α is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res. 2007, 67:563-572.
-
(2007)
Cancer Res.
, vol.67
, pp. 563-572
-
-
Liao, D.1
Corle, C.2
Seagroves, T.N.3
Johnson, R.S.4
-
26
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe J.A., Jiang B.H., Iyer N.V., Agani F., Leung S.W., Koos R.D., Semenza G.L. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 1996, 16:4604-4613.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
Semenza, G.L.7
-
27
-
-
0035925072
-
Levels of hypoxia-inducible factor-1α during breast carcinogenesis
-
Bos R., Zhong H., Hanrahan C.F., Mommers E.C., Semenza G.L., Pinedo H.M., Abeloff M.D., Simons J.W., van Diest P.J., van der Wall E. Levels of hypoxia-inducible factor-1α during breast carcinogenesis. J. Natl. Cancer Inst. 2001, 93:309-314.
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 309-314
-
-
Bos, R.1
Zhong, H.2
Hanrahan, C.F.3
Mommers, E.C.4
Semenza, G.L.5
Pinedo, H.M.6
Abeloff, M.D.7
Simons, J.W.8
van Diest, P.J.9
van der Wall, E.10
-
28
-
-
60549092506
-
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
-
Lee K., Qian D.Z., Rey S., Wei H., Liu J.O., Semenza G.L. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:2353-2358.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 2353-2358
-
-
Lee, K.1
Qian, D.Z.2
Rey, S.3
Wei, H.4
Liu, J.O.5
Semenza, G.L.6
-
29
-
-
77955512358
-
Lymphangiogenesis and lymphatic metastasis in breast cancer
-
Ran S., Volk L., Hall K., Flister M.J. Lymphangiogenesis and lymphatic metastasis in breast cancer. Pathophysiology 2010, 17:229-251.
-
(2010)
Pathophysiology
, vol.17
, pp. 229-251
-
-
Ran, S.1
Volk, L.2
Hall, K.3
Flister, M.J.4
-
30
-
-
0016287342
-
Breast tumor cell lines from pleural effusions
-
Cailleau R., Young R., Olivé M., Reeves W.J. Breast tumor cell lines from pleural effusions. J. Natl. Cancer Inst. 1978, 53:661-674.
-
(1978)
J. Natl. Cancer Inst.
, vol.53
, pp. 661-674
-
-
Cailleau, R.1
Young, R.2
Olivé, M.3
Reeves, W.J.4
-
31
-
-
84867087464
-
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
-
Schito L., Rey S., Tafani M., Zhang H., Wong C.C., Russo A., Russo M.A., Semenza G.L. Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:E2707-E2716.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. E2707-E2716
-
-
Schito, L.1
Rey, S.2
Tafani, M.3
Zhang, H.4
Wong, C.C.5
Russo, A.6
Russo, M.A.7
Semenza, G.L.8
-
32
-
-
34249340478
-
Hypoxia and hypoxia-inducible factor 1 expression enhance osteolytic bone metastases of breast cancer
-
Hiraga T., Kizaka-Kondoh S., Hirota K., Hiraoka M., Yoneda T. Hypoxia and hypoxia-inducible factor 1 expression enhance osteolytic bone metastases of breast cancer. Cancer Res. 2007, 67:4157-4163.
-
(2007)
Cancer Res.
, vol.67
, pp. 4157-4163
-
-
Hiraga, T.1
Kizaka-Kondoh, S.2
Hirota, K.3
Hiraoka, M.4
Yoneda, T.5
-
33
-
-
70249108848
-
Hypoxia and TGF-β drive breast cancer metastases through parallel signaling pathways in tumor cells and the bone microenvironment
-
Dunn L.K., Mohammed K.S., Fournier P.G., McKenna C.R., Davis H.W., Niewolna M., Peng X.H., Chirgwin J.M., Guise T.A. Hypoxia and TGF-β drive breast cancer metastases through parallel signaling pathways in tumor cells and the bone microenvironment. PLoS One 2009, 4:e6896.
-
(2009)
PLoS One
, vol.4
, pp. e6896
-
-
Dunn, L.K.1
Mohammed, K.S.2
Fournier, P.G.3
McKenna, C.R.4
Davis, H.W.5
Niewolna, M.6
Peng, X.H.7
Chirgwin, J.M.8
Guise, T.A.9
-
34
-
-
0037279517
-
The hypoxic tumor microenvironment and metastatic progression
-
Subarsky P., Hill R.P. The hypoxic tumor microenvironment and metastatic progression. Clin. Exp. Metastasis 2003, 20:237-250.
-
(2003)
Clin. Exp. Metastasis
, vol.20
, pp. 237-250
-
-
Subarsky, P.1
Hill, R.P.2
-
35
-
-
84860389759
-
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
-
Zhang H., Wong C.C., Wei H., Gilkes D.M., Korangath P., Chaturvedi P., Schito L., Chen J., Krishnamachary B., Winnard P.T., Raman V., Zhen L., Mitzner W.A., Sukumar S., Semenza G.L. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 2012, 31:1757-1770.
-
(2012)
Oncogene
, vol.31
, pp. 1757-1770
-
-
Zhang, H.1
Wong, C.C.2
Wei, H.3
Gilkes, D.M.4
Korangath, P.5
Chaturvedi, P.6
Schito, L.7
Chen, J.8
Krishnamachary, B.9
Winnard, P.T.10
Raman, V.11
Zhen, L.12
Mitzner, W.A.13
Sukumar, S.14
Semenza, G.L.15
-
36
-
-
4944229701
-
A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors
-
Wyckoff J., Wang W., Lin E.Y., Wang Y., Pixley F., Stanley E.R., Graf T., Pollard J.W., Segall J., Condeelis J. A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res. 2004, 64:7022-7029.
-
(2004)
Cancer Res.
, vol.64
, pp. 7022-7029
-
-
Wyckoff, J.1
Wang, W.2
Lin, E.Y.3
Wang, Y.4
Pixley, F.5
Stanley, E.R.6
Graf, T.7
Pollard, J.W.8
Segall, J.9
Condeelis, J.10
-
37
-
-
20444436815
-
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop
-
Goswami S., Sahai E., Wyckoff J.B., Cammer M., Cox D., Pixley F.J., Stanley E.R., Segall J.E., Condeelis J.S. Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res. 2005, 65:5278-5283.
-
(2005)
Cancer Res.
, vol.65
, pp. 5278-5283
-
-
Goswami, S.1
Sahai, E.2
Wyckoff, J.B.3
Cammer, M.4
Cox, D.5
Pixley, F.J.6
Stanley, E.R.7
Segall, J.E.8
Condeelis, J.S.9
-
38
-
-
84904406680
-
Tumor-associated macrophages: from mechanisms to therapy
-
Noy R., Pollard J.W. Tumor-associated macrophages: from mechanisms to therapy. Immunity 2014, 41:49-61.
-
(2014)
Immunity
, vol.41
, pp. 49-61
-
-
Noy, R.1
Pollard, J.W.2
-
39
-
-
34948896045
-
Mesenchymal stem cells within tumor stroma promote breast cancer metastasis
-
Karnoub A.E., Dash A.B., Vo A.P., Sullivan A., Brooks M.W., Bell G.W., Richardson A.L., Polyak K., Tubo R., Weinberg R.A. Mesenchymal stem cells within tumor stroma promote breast cancer metastasis. Nature 2007, 449:557-563.
-
(2007)
Nature
, vol.449
, pp. 557-563
-
-
Karnoub, A.E.1
Dash, A.B.2
Vo, A.P.3
Sullivan, A.4
Brooks, M.W.5
Bell, G.W.6
Richardson, A.L.7
Polyak, K.8
Tubo, R.9
Weinberg, R.A.10
-
40
-
-
84873804360
-
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis
-
Chaturvedi P., Gilkes D.M., Wong C.C., Kshitiz, Luo W., Zhang H., Wei H., Takano N., Schito L., Levchenko A., Semenza G.L. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J. Clin. Invest. 2013, 123:189-205.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 189-205
-
-
Chaturvedi, P.1
Gilkes, D.M.2
Wong, C.C.3
Kshitiz4
Luo, W.5
Zhang, H.6
Wei, H.7
Takano, N.8
Schito, L.9
Levchenko, A.10
Semenza, G.L.11
-
41
-
-
84901046659
-
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
-
Chaturvedi P., Gilkes D.M., Takano N., Semenza G.L. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proc. Natl. Acad. Sci. U. S. A. 2014, 111:E2120-E2129.
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. E2120-E2129
-
-
Chaturvedi, P.1
Gilkes, D.M.2
Takano, N.3
Semenza, G.L.4
-
42
-
-
84864927191
-
An "elite hacker": breast tumors exploit the normal microenvironment program to instruct their progression and biological diversity
-
Boudreau A., van't Veer L.J., Bissell M.J. An "elite hacker": breast tumors exploit the normal microenvironment program to instruct their progression and biological diversity. Cell Adhes. Migr. 2012, 6:236-2489.
-
(2012)
Cell Adhes. Migr.
, vol.6
, pp. 236-2489
-
-
Boudreau, A.1
van't Veer, L.J.2
Bissell, M.J.3
-
43
-
-
84859949610
-
The extracellular matrix: a dynamic niche in cancer progression
-
Lu P., Weaver V.M., Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J. Cell Biol. 2012, 196:395-406.
-
(2012)
J. Cell Biol.
, vol.196
, pp. 395-406
-
-
Lu, P.1
Weaver, V.M.2
Werb, Z.3
-
44
-
-
0030851924
-
Fibrotic focus in invasive ductal carcinoma of the breast: a histopathological prognostic parameter for tumor recurrence and tumor death within three years after the initial operation
-
Hasebe T., Tsuda H., Tsubono Y., Imoto S., Mukai K. Fibrotic focus in invasive ductal carcinoma of the breast: a histopathological prognostic parameter for tumor recurrence and tumor death within three years after the initial operation. Jpn. J. Cancer Res. 1997, 88:590-599.
-
(1997)
Jpn. J. Cancer Res.
, vol.88
, pp. 590-599
-
-
Hasebe, T.1
Tsuda, H.2
Tsubono, Y.3
Imoto, S.4
Mukai, K.5
-
45
-
-
0000766709
-
The structure of fibrous proteins of the collagen-gelatin group
-
Pauling L., Corey R.B. The structure of fibrous proteins of the collagen-gelatin group. Proc. Natl. Acad. Sci. U. S. A. 1951, 37:272-281.
-
(1951)
Proc. Natl. Acad. Sci. U. S. A.
, vol.37
, pp. 272-281
-
-
Pauling, L.1
Corey, R.B.2
-
47
-
-
0344442890
-
Oxygen tension regulates the expression of a group of procollagen hydroxylases
-
Hofbauer K.H., Gess B., Lohaus C., Meyer H.E., Katschinski D., Kurtz A. Oxygen tension regulates the expression of a group of procollagen hydroxylases. Eur. J. Biochem. 2003, 270:4515-4522.
-
(2003)
Eur. J. Biochem.
, vol.270
, pp. 4515-4522
-
-
Hofbauer, K.H.1
Gess, B.2
Lohaus, C.3
Meyer, H.E.4
Katschinski, D.5
Kurtz, A.6
-
48
-
-
84863335041
-
Lysine post-translational modifications of collagen
-
Yamauchi M., Sricholpech M. Lysine post-translational modifications of collagen. Essays Biochem. 2012, 52:113-133.
-
(2012)
Essays Biochem.
, vol.52
, pp. 113-133
-
-
Yamauchi, M.1
Sricholpech, M.2
-
50
-
-
84901594345
-
Hypoxia and the extracellular matrix: drivers of tumor metastasis
-
Gilkes D.M., Semenza G.L., Wirtz D. Hypoxia and the extracellular matrix: drivers of tumor metastasis. Nat. Rev. Cancer 2014, 14:430-439.
-
(2014)
Nat. Rev. Cancer
, vol.14
, pp. 430-439
-
-
Gilkes, D.M.1
Semenza, G.L.2
Wirtz, D.3
-
51
-
-
33646365644
-
Lysyl oxidase is essential for hypoxia-induced metastasis
-
Erler J.T., Bennewith K.L., Nicolau M., Dornhöfer N., Kong C., Le Q.T., Chi J.T., Jeffrey S.S., Giaccia A.J. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 2006, 440:1222-1226.
-
(2006)
Nature
, vol.440
, pp. 1222-1226
-
-
Erler, J.T.1
Bennewith, K.L.2
Nicolau, M.3
Dornhöfer, N.4
Kong, C.5
Le, Q.T.6
Chi, J.T.7
Jeffrey, S.S.8
Giaccia, A.J.9
-
52
-
-
77949879672
-
The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1
-
Schietke R., Warnecke C., Wacker I., Schödel J., Mole D.R., Campean V., Amann K., Goppelt-Struebe M., Behrens J., Eckardt K.U., Wiesener M.S. The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1. J. Biol. Chem. 2010, 285:6658-6669.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 6658-6669
-
-
Schietke, R.1
Warnecke, C.2
Wacker, I.3
Schödel, J.4
Mole, D.R.5
Campean, V.6
Amann, K.7
Goppelt-Struebe, M.8
Behrens, J.9
Eckardt, K.U.10
Wiesener, M.S.11
-
53
-
-
80053645045
-
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
-
Wong C.C., Gilkes D.M., Zhang H., Chen J., Wei H., Chaturvedi P., Fraley S.J., Wong C.M., Khoo U.S., Ng I.O., Wirtz D., Semenza G.L. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:16369-16374.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 16369-16374
-
-
Wong, C.C.1
Gilkes, D.M.2
Zhang, H.3
Chen, J.4
Wei, H.5
Chaturvedi, P.6
Fraley, S.J.7
Wong, C.M.8
Khoo, U.S.9
Ng, I.O.10
Wirtz, D.11
Semenza, G.L.12
-
54
-
-
84878619137
-
Collagen prolyl hydroxylases are essential for breast cancer metastasis
-
Gilkes D.M., Chaturvedi P., Bajpai S., Wong C.C., Wei H., Pitcairn S., Hubbi M.E., Wirtz D., Semenza G.L. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res. 2013, 73:3285-3296.
-
(2013)
Cancer Res.
, vol.73
, pp. 3285-3296
-
-
Gilkes, D.M.1
Chaturvedi, P.2
Bajpai, S.3
Wong, C.C.4
Wei, H.5
Pitcairn, S.6
Hubbi, M.E.7
Wirtz, D.8
Semenza, G.L.9
-
55
-
-
84877899680
-
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
-
Gilkes D.M., Bajpai S., Wong C.C., Chaturvedi P., Hubbi M.E., Wirtz D., Semenza G.L. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Mol. Cancer Res. 2013, 11:456-466.
-
(2013)
Mol. Cancer Res.
, vol.11
, pp. 456-466
-
-
Gilkes, D.M.1
Bajpai, S.2
Wong, C.C.3
Chaturvedi, P.4
Hubbi, M.E.5
Wirtz, D.6
Semenza, G.L.7
-
56
-
-
67650456890
-
MDA-MB-435 and M14 cell lines: identical but not M14 melanoma?
-
Chambers A.F. MDA-MB-435 and M14 cell lines: identical but not M14 melanoma?. Cancer Res. 2009, 69:5292-5293.
-
(2009)
Cancer Res.
, vol.69
, pp. 5292-5293
-
-
Chambers, A.F.1
-
57
-
-
28644432204
-
VEGFR1-positive hematopoietic bone marrow progenitors initiate the pre-metastatic niche
-
Kaplan R.N., Riba R.D., Zacharoulis S., Bramley A.H., Vincent L., Costa C., MacDonald D.D., Jin D.K., Shido K., Kerns S.A., Zhu Z., Hicklin D., Wu Y., Port J.L., Altorki N., Port E.R., Ruggero D., Shmelkov S.V., Jensen K.K., Rafii S., Lyden D. VEGFR1-positive hematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005, 438:820-827.
-
(2005)
Nature
, vol.438
, pp. 820-827
-
-
Kaplan, R.N.1
Riba, R.D.2
Zacharoulis, S.3
Bramley, A.H.4
Vincent, L.5
Costa, C.6
MacDonald, D.D.7
Jin, D.K.8
Shido, K.9
Kerns, S.A.10
Zhu, Z.11
Hicklin, D.12
Wu, Y.13
Port, J.L.14
Altorki, N.15
Port, E.R.16
Ruggero, D.17
Shmelkov, S.V.18
Jensen, K.K.19
Rafii, S.20
Lyden, D.21
more..
-
59
-
-
57849100048
-
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
-
Erler J.T., Bennewith K.L., Cox T.R., Lang G., Bird D., Koong A., Le Q.T., Giaccia A.J. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 2009, 15:35-44.
-
(2009)
Cancer Cell
, vol.15
, pp. 35-44
-
-
Erler, J.T.1
Bennewith, K.L.2
Cox, T.R.3
Lang, G.4
Bird, D.5
Koong, A.6
Le, Q.T.7
Giaccia, A.J.8
-
60
-
-
84865149277
-
Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis
-
Wong C.C., Zhang H., Gilkes D.M., Chen J., Wei H., Chaturvedi P., Hubbi M.E., Semenza G.L. Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. J. Mol. Med. 2012, 90:803-815.
-
(2012)
J. Mol. Med.
, vol.90
, pp. 803-815
-
-
Wong, C.C.1
Zhang, H.2
Gilkes, D.M.3
Chen, J.4
Wei, H.5
Chaturvedi, P.6
Hubbi, M.E.7
Semenza, G.L.8
-
61
-
-
84867902937
-
Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy
-
El-Haibi C.P., Bell G.W., Zhang J., Collmann A.Y., Wood D., Scherber C.M., Csizmadia E., Mariani O., Zhu C., Campagne A., Toner M., Bhatia S.N., Irimia D., Vincent-Salomon A., Karnoub A.E. Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:17460-17465.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 17460-17465
-
-
El-Haibi, C.P.1
Bell, G.W.2
Zhang, J.3
Collmann, A.Y.4
Wood, D.5
Scherber, C.M.6
Csizmadia, E.7
Mariani, O.8
Zhu, C.9
Campagne, A.10
Toner, M.11
Bhatia, S.N.12
Irimia, D.13
Vincent-Salomon, A.14
Karnoub, A.E.15
-
62
-
-
84915809785
-
Crosstalk of oncogenic signaling pathways during epithelial-mesenchymal transition
-
Lindsey S., Langhans S.A. Crosstalk of oncogenic signaling pathways during epithelial-mesenchymal transition. Front. Oncol. 2014, 4:358.
-
(2014)
Front. Oncol.
, vol.4
, pp. 358
-
-
Lindsey, S.1
Langhans, S.A.2
-
63
-
-
68549122708
-
Rho signaling, ROCK, and mDia1, in transformation, metastasis and invasion
-
Narumiya S., Tanji M., Ishizaki T. Rho signaling, ROCK, and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev. 2009, 28:65-76.
-
(2009)
Cancer Metastasis Rev.
, vol.28
, pp. 65-76
-
-
Narumiya, S.1
Tanji, M.2
Ishizaki, T.3
-
64
-
-
62449294770
-
The actin cytoskeleton in cancer cell motility
-
Olson M.F., Sahai E. The actin cytoskeleton in cancer cell motility. Clin. Exp. Metastasis 2009, 26:273-287.
-
(2009)
Clin. Exp. Metastasis
, vol.26
, pp. 273-287
-
-
Olson, M.F.1
Sahai, E.2
-
66
-
-
9244222742
-
Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors
-
Wang W., Goswami S., Lapidus K., Wells A.L., Wyckoff J.B., Sahai E., Singer R.H., Segall J.E., Condeelis J.S. Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer Res. 2004, 64:8585-8594.
-
(2004)
Cancer Res.
, vol.64
, pp. 8585-8594
-
-
Wang, W.1
Goswami, S.2
Lapidus, K.3
Wells, A.L.4
Wyckoff, J.B.5
Sahai, E.6
Singer, R.H.7
Segall, J.E.8
Condeelis, J.S.9
-
67
-
-
52049085776
-
RhoA protein expression in primary breast cancers and matched lymphocytes is associated with progression of the disease
-
Belizzi A., Mangia A., Chiriatti A., Petroni S., Quaranta M., Schittulli F., Malfettone A., Cardone R.A., Paradiso A., Reshkin S.J. RhoA protein expression in primary breast cancers and matched lymphocytes is associated with progression of the disease. Int. J. Mol. Med. 2008, 22:25-31.
-
(2008)
Int. J. Mol. Med.
, vol.22
, pp. 25-31
-
-
Belizzi, A.1
Mangia, A.2
Chiriatti, A.3
Petroni, S.4
Quaranta, M.5
Schittulli, F.6
Malfettone, A.7
Cardone, R.A.8
Paradiso, A.9
Reshkin, S.J.10
-
68
-
-
54849186600
-
The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer
-
Lane J., Martin T.A., Watkins G., Mansel R.E., Jiang W.G. The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer. Int. J. Oncol. 2008, 33:585-593.
-
(2008)
Int. J. Oncol.
, vol.33
, pp. 585-593
-
-
Lane, J.1
Martin, T.A.2
Watkins, G.3
Mansel, R.E.4
Jiang, W.G.5
-
69
-
-
0032079312
-
Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway
-
Graham C.H., Fitzpatrick T.E., McCrae K.R. Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway. Blood 1998, 91:3300-3307.
-
(1998)
Blood
, vol.91
, pp. 3300-3307
-
-
Graham, C.H.1
Fitzpatrick, T.E.2
McCrae, K.R.3
-
70
-
-
0037374289
-
Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1
-
Krishnamachary B., Berg-Dixon S., Kelly B., Agani F., Feldser D., Ferreira G., Iyer N., LaRusch J., Pak B., Taghavi P., Semenza G.L. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res. 2003, 63:1138-1143.
-
(2003)
Cancer Res.
, vol.63
, pp. 1138-1143
-
-
Krishnamachary, B.1
Berg-Dixon, S.2
Kelly, B.3
Agani, F.4
Feldser, D.5
Ferreira, G.6
Iyer, N.7
LaRusch, J.8
Pak, B.9
Taghavi, P.10
Semenza, G.L.11
-
71
-
-
0034733872
-
Hypoxia affects tumor cell invasiveness in vitro: the role of hypoxia-activated ligand HAL1/13 (Ku86 autoantigen)
-
Ginis I., Faller D.V. Hypoxia affects tumor cell invasiveness in vitro: the role of hypoxia-activated ligand HAL1/13 (Ku86 autoantigen). Cancer Lett. 2000, 154:163-174.
-
(2000)
Cancer Lett.
, vol.154
, pp. 163-174
-
-
Ginis, I.1
Faller, D.V.2
-
72
-
-
84867569483
-
A novel microfluidic platform for high-resolution imaging of a three-dimensional cell culture under a controlled hypoxic environment
-
Funamoto K., Zervantonakis I.K., Liu Y., Ochs C.J., Kim C., Kamm R.D. A novel microfluidic platform for high-resolution imaging of a three-dimensional cell culture under a controlled hypoxic environment. Lab Chip 2012, 12:4855-4863.
-
(2012)
Lab Chip
, vol.12
, pp. 4855-4863
-
-
Funamoto, K.1
Zervantonakis, I.K.2
Liu, Y.3
Ochs, C.J.4
Kim, C.5
Kamm, R.D.6
-
73
-
-
84892930021
-
Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells
-
Gilkes D.M., Xiang L., Lee S.J., Chaturvedi P., Hubbi M.E., Wirtz D., Semenza G.L. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proc. Natl. Acad. Sci. U. S. A. 2014, 111:E384-E393.
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. E384-E393
-
-
Gilkes, D.M.1
Xiang, L.2
Lee, S.J.3
Chaturvedi, P.4
Hubbi, M.E.5
Wirtz, D.6
Semenza, G.L.7
-
74
-
-
0037478437
-
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
-
Pennacchietti S., Michieli P., Galluzzo M., Mazzone M., Giordano S., Comoglio P.M. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003, 3:347-361.
-
(2003)
Cancer Cell
, vol.3
, pp. 347-361
-
-
Pennacchietti, S.1
Michieli, P.2
Galluzzo, M.3
Mazzone, M.4
Giordano, S.5
Comoglio, P.M.6
-
75
-
-
84884787753
-
Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression
-
Regan Anderson T.M., Peacock D.L., Daniel A.R., Hubbard G.K., Lofgren K.A., Girard B.J., Schörg A., Hoogewijs D., Wenger R.H., Seagroves T.N., Lange C.A. Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression. Cancer Res. 2013, 73:5810-5820.
-
(2013)
Cancer Res.
, vol.73
, pp. 5810-5820
-
-
Regan Anderson, T.M.1
Peacock, D.L.2
Daniel, A.R.3
Hubbard, G.K.4
Lofgren, K.A.5
Girard, B.J.6
Schörg, A.7
Hoogewijs, D.8
Wenger, R.H.9
Seagroves, T.N.10
Lange, C.A.11
-
76
-
-
41149157649
-
TGFβ primes breast tumors for lung metastasis seeding through angiopoietin-like 4
-
Padua D., Zhang X.H., Wang Q., Nadal C., Gerald W.L., Gomis R.R., Massagué J. TGFβ primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 2008, 133:66-77.
-
(2008)
Cell
, vol.133
, pp. 66-77
-
-
Padua, D.1
Zhang, X.H.2
Wang, Q.3
Nadal, C.4
Gerald, W.L.5
Gomis, R.R.6
Massagué, J.7
-
77
-
-
65749106405
-
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
-
Li Z., Bao S., Wu Q., Wang H., Eyler C., Sathornsumetee S., Shi Q., Cao Y., Lathia J., McLendon R.E., Hjelmeland A.B., Rich J.N. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 2009, 15:759-772.
-
(2009)
Cancer Cell
, vol.15
, pp. 759-772
-
-
Li, Z.1
Bao, S.2
Wu, Q.3
Wang, H.4
Eyler, C.5
Sathornsumetee, S.6
Shi, Q.7
Cao, Y.8
Lathia, J.9
McLendon, R.E.10
Hjelmeland, A.B.11
Rich, J.N.12
-
78
-
-
84857407549
-
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
-
Conley S.J., Gheordunescu E., Kakarala P., Newman B., Korkaya H., Heath A.N., Clouthier S.G., Wicha M.S. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:2784-2789.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 2784-2789
-
-
Conley, S.J.1
Gheordunescu, E.2
Kakarala, P.3
Newman, B.4
Korkaya, H.5
Heath, A.N.6
Clouthier, S.G.7
Wicha, M.S.8
-
79
-
-
84855436875
-
Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer
-
Schwab L.P., Peacock D.L., Majumdar D., Ingels J.F., Jensen L.C., Smith K.D., Cushing R.C., Seagroves T.N. Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer. Breast Cancer Res. 2012, 14:R6.
-
(2012)
Breast Cancer Res.
, vol.14
, pp. R6
-
-
Schwab, L.P.1
Peacock, D.L.2
Majumdar, D.3
Ingels, J.F.4
Jensen, L.C.5
Smith, K.D.6
Cushing, R.C.7
Seagroves, T.N.8
-
80
-
-
81055140859
-
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells
-
Cordenonsi M., Zanconato F., Azzolin L., Forcato M., Rosato A., Frasson C., Inui M., Montagner M., Parenti A.R., Poletti A., Daidone M.G., Dupont S., Basso G., Bicciato S., Piccolo S. The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell 2011, 147:759-772.
-
(2011)
Cell
, vol.147
, pp. 759-772
-
-
Cordenonsi, M.1
Zanconato, F.2
Azzolin, L.3
Forcato, M.4
Rosato, A.5
Frasson, C.6
Inui, M.7
Montagner, M.8
Parenti, A.R.9
Poletti, A.10
Daidone, M.G.11
Dupont, S.12
Basso, G.13
Bicciato, S.14
Piccolo, S.15
-
81
-
-
77957883342
-
The Hippo signaling pathway in development and cancer
-
Pan D. The Hippo signaling pathway in development and cancer. Dev. Cell 2010, 19:491-505.
-
(2010)
Dev. Cell
, vol.19
, pp. 491-505
-
-
Pan, D.1
-
82
-
-
84921374070
-
Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype
-
Xiang L., Gilkes D.M., Hu H., Takano N., Luo W., Lu H., Bullen J.W., Samanta D., Liang H., Semenza G.L. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget 2014, 5:12509-12527.
-
(2014)
Oncotarget
, vol.5
, pp. 12509-12527
-
-
Xiang, L.1
Gilkes, D.M.2
Hu, H.3
Takano, N.4
Luo, W.5
Lu, H.6
Bullen, J.W.7
Samanta, D.8
Liang, H.9
Semenza, G.L.10
-
83
-
-
84926137241
-
Hypoxia regulates Hippo signaling through the SIAH2 ubiquitin E3 ligase
-
Ma B., Chen Y., Chen L., Cheng H., Mu C., Li J., Gao R., Zhou C., Cao L., Liu J., Zhu Y., Chen Q., Wu S. Hypoxia regulates Hippo signaling through the SIAH2 ubiquitin E3 ligase. Nat. Cell Biol. 2005, 17:95-103.
-
(2005)
Nat. Cell Biol.
, vol.17
, pp. 95-103
-
-
Ma, B.1
Chen, Y.2
Chen, L.3
Cheng, H.4
Mu, C.5
Li, J.6
Gao, R.7
Zhou, C.8
Cao, L.9
Liu, J.10
Zhu, Y.11
Chen, Q.12
Wu, S.13
-
84
-
-
35848955428
-
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
-
Ginestier C., Hur M.H., Charafe-Jauffret E., Monville F., Dutcher J., Brown M., Jacquemier J., Viens P., Kleer C.G., Liu S., Schott A., Hayes D., Birnbaum B., Wicha M.S., Dontu G. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007, 1:555-567.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 555-567
-
-
Ginestier, C.1
Hur, M.H.2
Charafe-Jauffret, E.3
Monville, F.4
Dutcher, J.5
Brown, M.6
Jacquemier, J.7
Viens, P.8
Kleer, C.G.9
Liu, S.10
Schott, A.11
Hayes, D.12
Birnbaum, B.13
Wicha, M.S.14
Dontu, G.15
-
85
-
-
21344454219
-
Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties
-
Ponti D., Costa A., Zaffaroni N., Pratesi G., Petrangolini G., Coradini D., Pilotti S., Pierotti M.A., Daidone M.G. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res. 2005, 65:5506-5511.
-
(2005)
Cancer Res.
, vol.65
, pp. 5506-5511
-
-
Ponti, D.1
Costa, A.2
Zaffaroni, N.3
Pratesi, G.4
Petrangolini, G.5
Coradini, D.6
Pilotti, S.7
Pierotti, M.A.8
Daidone, M.G.9
-
86
-
-
84879298347
-
Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer
-
Bendinelli P., Maroni P., Matteucci E., Luzatti A., Perrucchini G., Desiderio M.A. Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer. Eur. J. Cancer 2013, 49:2608-2618.
-
(2013)
Eur. J. Cancer
, vol.49
, pp. 2608-2618
-
-
Bendinelli, P.1
Maroni, P.2
Matteucci, E.3
Luzatti, A.4
Perrucchini, G.5
Desiderio, M.A.6
-
87
-
-
84862618600
-
Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers
-
D'Souza-Schorey C., Clancy J.W. Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers. Genes Dev. 2012, 26:1287-1299.
-
(2012)
Genes Dev.
, vol.26
, pp. 1287-1299
-
-
D'Souza-Schorey, C.1
Clancy, J.W.2
-
88
-
-
84879603171
-
Exosomes in tumor microenvironment influence cancer progression and metastasis
-
Kahlert C., Kalluri R. Exosomes in tumor microenvironment influence cancer progression and metastasis. J. Mol. Med. 2013, 91:431-437.
-
(2013)
J. Mol. Med.
, vol.91
, pp. 431-437
-
-
Kahlert, C.1
Kalluri, R.2
-
89
-
-
84878527849
-
Vesicle trafficking and RNA transfer add complexity and connectivity to cell-cell communication
-
Roberts C.T., Kurre P. Vesicle trafficking and RNA transfer add complexity and connectivity to cell-cell communication. Cancer Res. 2013, 73:3200-3205.
-
(2013)
Cancer Res.
, vol.73
, pp. 3200-3205
-
-
Roberts, C.T.1
Kurre, P.2
-
90
-
-
84890313522
-
Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review
-
Azmi A.S., Bao B., Sarkar F.H. Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review. Cancer Metastasis Rev. 2013, 32:623-642.
-
(2013)
Cancer Metastasis Rev.
, vol.32
, pp. 623-642
-
-
Azmi, A.S.1
Bao, B.2
Sarkar, F.H.3
-
91
-
-
79953136097
-
Rab27a and Rab27b control different steps of the exosome secretion pathway
-
Ostrowski M., Carmo N.B., Krumeich S., Fanget I., Raposo G., Savina A., Moita C.F., Schauer K., Hume A.N., Freitas R.P., Gould B., Benaroch P., Hacohen N., Fukuda M., Desnos C., Seabra M.C., Darchen F., Amigorena S., Moita L.F., Thery C. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat. Cell Biol. 2010, 12:19-30.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 19-30
-
-
Ostrowski, M.1
Carmo, N.B.2
Krumeich, S.3
Fanget, I.4
Raposo, G.5
Savina, A.6
Moita, C.F.7
Schauer, K.8
Hume, A.N.9
Freitas, R.P.10
Gould, B.11
Benaroch, P.12
Hacohen, N.13
Fukuda, M.14
Desnos, C.15
Seabra, M.C.16
Darchen, F.17
Amigorena, S.18
Moita, L.F.19
Thery, C.20
more..
-
92
-
-
84862007577
-
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
-
Peinado H., Alečković M., Lavotshkin S., Matei I., Costa-Silva B., Moreno-Bueno G., Hergueta-Redondo M., Williams C., García-Santos G., Ghajar C., Nitadori-Hoshino A., Hoffman C., Badal K., Garcia B.A., Callahan M.K., Yuan J., Martins V.R., Skog J., Kaplan R.N., Brady M.S., Wolchok J.D., Chapman P.B., Kang Y., Bromberg J., Lyden D. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 2012, 18:883-891.
-
(2012)
Nat. Med.
, vol.18
, pp. 883-891
-
-
Peinado, H.1
Alečković, M.2
Lavotshkin, S.3
Matei, I.4
Costa-Silva, B.5
Moreno-Bueno, G.6
Hergueta-Redondo, M.7
Williams, C.8
García-Santos, G.9
Ghajar, C.10
Nitadori-Hoshino, A.11
Hoffman, C.12
Badal, K.13
Garcia, B.A.14
Callahan, M.K.15
Yuan, J.16
Martins, V.R.17
Skog, J.18
Kaplan, R.N.19
Brady, M.S.20
Wolchok, J.D.21
Chapman, P.B.22
Kang, Y.23
Bromberg, J.24
Lyden, D.25
more..
-
93
-
-
68549128599
-
Lung cancer secreted microvesicles: underappreciated modulators of microenvironment in expanding tumors
-
Wysoczynski M., Ratajczak M.Z. Lung cancer secreted microvesicles: underappreciated modulators of microenvironment in expanding tumors. Int. J. Cancer 2009, 125:1595-1603.
-
(2009)
Int. J. Cancer
, vol.125
, pp. 1595-1603
-
-
Wysoczynski, M.1
Ratajczak, M.Z.2
-
94
-
-
77953142134
-
Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes
-
Park J.E., Tan H.S., Datta A., Lai R.C., Zhang H., Meng W., Lim S.K., Sze S.K. Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. Mol. Cell. Proteomics 2010, 9:1085-1099.
-
(2010)
Mol. Cell. Proteomics
, vol.9
, pp. 1085-1099
-
-
Park, J.E.1
Tan, H.S.2
Datta, A.3
Lai, R.C.4
Zhang, H.5
Meng, W.6
Lim, S.K.7
Sze, S.K.8
-
95
-
-
80051971645
-
Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells
-
Svensson K.J., Kucharzewska P., Christianson H.C., Sköld S., Löfstedt T., Johansson M.C., Mörgelin M., Bengzon J., Ruf W., Belting M. Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:13147-13152.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 13147-13152
-
-
Svensson, K.J.1
Kucharzewska, P.2
Christianson, H.C.3
Sköld, S.4
Löfstedt, T.5
Johansson, M.C.6
Mörgelin, M.7
Bengzon, J.8
Ruf, W.9
Belting, M.10
-
96
-
-
84876927914
-
Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development
-
Kucharzewska P., Christianson H.C., Welch J.E., Svensson K.J., Fredlund E., Ringnér M., Mörgelin M., Bourseau-Guilmain F., Bengzon J., Belting M. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:7312-7317.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 7312-7317
-
-
Kucharzewska, P.1
Christianson, H.C.2
Welch, J.E.3
Svensson, K.J.4
Fredlund, E.5
Ringnér, M.6
Mörgelin, M.7
Bourseau-Guilmain, F.8
Bengzon, J.9
Belting, M.10
-
97
-
-
84919680938
-
Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor inhibiting HIF-1
-
Umezu T., Tadokoro H., Azuma K., Yoshikawa S., Ohyashiki K., Ohyashiki J.H. Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor inhibiting HIF-1. Blood 2014, 124:3748-3757.
-
(2014)
Blood
, vol.124
, pp. 3748-3757
-
-
Umezu, T.1
Tadokoro, H.2
Azuma, K.3
Yoshikawa, S.4
Ohyashiki, K.5
Ohyashiki, J.H.6
-
98
-
-
84866502787
-
Hypoxic enhancement of exosome release by breast cancer cells
-
King H.W., Michael M.Z., Gleadle J.M. Hypoxic enhancement of exosome release by breast cancer cells. BMC Cancer 2012, 12:421.
-
(2012)
BMC Cancer
, vol.12
, pp. 421
-
-
King, H.W.1
Michael, M.Z.2
Gleadle, J.M.3
-
99
-
-
84876867466
-
Elevated concentration of microvesicles isolated from peripheral blood in breast cancer patients
-
Galindo-Hernandez O., Villegas-Comonfort S., Candanedo F., González-Vázquez M.C., Chavez-Ocaña S., Jimenez-Villanueva X., Sierra-Martinez M., Salazar E.P. Elevated concentration of microvesicles isolated from peripheral blood in breast cancer patients. Arch. Med. Res. 2013, 44:208-214.
-
(2013)
Arch. Med. Res.
, vol.44
, pp. 208-214
-
-
Galindo-Hernandez, O.1
Villegas-Comonfort, S.2
Candanedo, F.3
González-Vázquez, M.C.4
Chavez-Ocaña, S.5
Jimenez-Villanueva, X.6
Sierra-Martinez, M.7
Salazar, E.P.8
-
100
-
-
84905643012
-
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
-
Wang T., Gilkes D.M., Takano N., Xiang L., Luo W., Bishop C.J., Chaturvedi P., Green J.J., Semenza G.L. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proc. Natl. Acad. Sci. U. S. A. 2014, 111:E3234-E3242.
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. E3234-E3242
-
-
Wang, T.1
Gilkes, D.M.2
Takano, N.3
Xiang, L.4
Luo, W.5
Bishop, C.J.6
Chaturvedi, P.7
Green, J.J.8
Semenza, G.L.9
-
101
-
-
84896408214
-
Exosomal HIF-1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes
-
Aga M., Bentz G.L., Raffa S., Torrisi M.R., Kondo S., Wakisaka N., Yoshizaki T., Pagano J.S., Shackelford J. Exosomal HIF-1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes. Oncogene 2014, 33:4613-4622.
-
(2014)
Oncogene
, vol.33
, pp. 4613-4622
-
-
Aga, M.1
Bentz, G.L.2
Raffa, S.3
Torrisi, M.R.4
Kondo, S.5
Wakisaka, N.6
Yoshizaki, T.7
Pagano, J.S.8
Shackelford, J.9
-
102
-
-
84870608916
-
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
-
Luo W., Chang R., Zhong J., Pandey A., Semenza G.L. Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:E3367-E3376.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. E3367-E3376
-
-
Luo, W.1
Chang, R.2
Zhong, J.3
Pandey, A.4
Semenza, G.L.5
-
103
-
-
84878297133
-
Therapeutic targets in triple negative breast cancer
-
O'Toole S.A., Beith J.M., Millar E.K., West R., McLean A., Cazet A., Swarbrick A., Oakes S.R. Therapeutic targets in triple negative breast cancer. J. Clin. Pathol. 2013, 66:530-542.
-
(2013)
J. Clin. Pathol.
, vol.66
, pp. 530-542
-
-
O'Toole, S.A.1
Beith, J.M.2
Millar, E.K.3
West, R.4
McLean, A.5
Cazet, A.6
Swarbrick, A.7
Oakes, S.R.8
-
104
-
-
84894058948
-
Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer
-
Xiang L., Gilkes D.M., Chaturvedi P., Luo W., Hu H., Takano N., Liang H., Semenza G.L. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. J. Mol. Med. 2014, 92:151-164.
-
(2014)
J. Mol. Med.
, vol.92
, pp. 151-164
-
-
Xiang, L.1
Gilkes, D.M.2
Chaturvedi, P.3
Luo, W.4
Hu, H.5
Takano, N.6
Liang, H.7
Semenza, G.L.8
-
105
-
-
84923061042
-
Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma
-
Zhao T., Ren H., Jia L., Chen J., Xin W., Yan F., Li J., Wang X., Gao S., Qian D., Huang C., Hao J. Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma. Oncotarget 2015, 6:2250-2262.
-
(2015)
Oncotarget
, vol.6
, pp. 2250-2262
-
-
Zhao, T.1
Ren, H.2
Jia, L.3
Chen, J.4
Xin, W.5
Yan, F.6
Li, J.7
Wang, X.8
Gao, S.9
Qian, D.10
Huang, C.11
Hao, J.12
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