Hypoxia, HIF and the placenta

Cell Cycle

Volumn 5, Issue 5, 2006, Pages 495-498

  Fryer, Benjamin H ^a   Simon, M Celeste ^a,b,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c BRB II/III   (United States)

Author keywords

ARNT; HIF; Hypoxia; Placenta; Trophoblast

Indexed keywords

HETERODIMER; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; OXYGEN; PROTEIN SUBUNIT;

ANGIOGENESIS; CELL DIFFERENTIATION; CELL FATE; CELL FUSION; CELL HYPOXIA; CELL INTERACTION; CHORIOALLANTOIS; EMBRYONIC STEM CELL; GENE DISRUPTION; GENE EXPRESSION REGULATION; HUMAN; MAMMAL; MEDICAL RESEARCH; MOTHER; NONHUMAN; NUTRIENT; OBSERVATION; ORGANOGENESIS; OXYGEN TENSION; PROGENY; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; SYNCYTIUM; TROPHOBLAST; UTERUS; WASTE;

MAMMALIA;

EID: 33644781731     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.5.2497     Document Type: Review

References (34)

1. Burton GJ, Hempstock J, Jauniaux E. Nutrition of the human fetus during the first trimester - A review. Placenta 2001; 22:S70-7.
2. Jauniaux E, Gulbis B, Burton GJ. The human first trimester gestational sac limits rather than facilitates oxygen transfer to the foetus - A review. Placenta 2003; 24:S86-93.
3. Gude NM, Roberts CT, Kalionis B, King RG. Growth and function of the normal human placenta. Thromb Res 2004; 114:397-407.
4. Adelman DM, Gertsenstein M, Nagy A, Simon MC, Maltepe E. Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses. Genes Dev 2000; 14:3191-203.
5. Rajakumar A, Conrad KP. Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta. Biol Reprod 2000; 63:559-69.
6. Goldman-Wohl D, Yagel S. Regulation of trophoblast invasion: From normal implantation to preeclampsia. Mol Cell Endocrinol 2002; 187:233-8.
7. Sibai B, Dekker G, Kupferminc M. Preeclampsia. Lancet 2005; 365:785-99.
8. Kunath T, Strumpf D, Rossant J. Early trophoblast determination and stem cell maintenance in the mouse - A review. Placenta 2004; 25:S32-8.
9. Cross JC. Genetic insights into trophoblast differentiation and placental morphogenesis. Semin Cell Dev Biol 2000; 11:105-13.
10. Rinkenberger JL, Cross JC, Werb Z. Molecular genetics of implantation in the mouse. Dev Genet 1997; 21:6-20.
11. Alexander CM, Hansell EJ, Behrendtsen O, Flannery ML, Kishnani NS, Hawkes SP, Werb Z. Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation. Development 1996; 122:1723-36.
12. Cross JC, Hemberger M, Lu Y, Nozaki T, Whiteley K, Masutani M, Adamson SL. Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta. Mol Cell Endocrinol 2002; 187:207-12.
13. Rinkenberger J, Werb Z. The labyrinthine placenta. Nat Genet 2000; 25:248-50.
14. McGrath KE, Koniski AD, Malik J, Palis J. Circulation is established in a stepwise pattern in the mammalian embryo. Blood 2003; 101:1669-76.
15. Adelman DM, Maltepe E, Simon MC. Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. Genes Dev 1999; 13:2478-83.
16. Maltepe E, Schmidt JV, Baunoch D, Bradfield CA, Simon MC. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 1997; 386:403-7.
17. Maltepe E, Krampitz GW, Okazaki KM, Red-Horse K, Mak W, Simon MC, Fisher SJ. Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development 2005; 132:3393-403.
18. Covello KL, Simon MC. HIFs, hypoxia, and vascular development. Curr Top Dev Biol 2004; 62:37-54.
19. Schofield CJ, Ratcliffe PJ. Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 2004; 5:343-54.
20. Yu F, White SB, Zhao Q, Lee FS. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci USA 2001; 98:9630-5.
21. Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ and others. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001; 292:468-72.
22. Min JH, Yang H, Ivan M, Gertler F, Kaelin Jr WG, Pavletich NP. Structure of an HIF-1alpha -pVHL complex: Hydroxyproline recognition in signaling. Science 2002; 296:1886-9.
23. Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin Jr WG. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science 2001; 292:464-8.
24. Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999; 399:271-5.
25. Bruick RK. Oxygen sensing in the hypoxic response pathway: Regulation of the hypoxia-inducible transcription factor. Genes Dev 2003; 17:2614-23.
26. Cowden Dahl KD, Robertson SE, Weaver VM, Simon MC. Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression. Mol Biol Cell 2005; 16:1901-12.
27. Cowden Dahl KD, Fryer BH, Mack FA, Compernolle V, Maltepe E, Adelman DM, Carmeliet P, Simon MC. The Hypoxia-Inducible Factors HIF1alpha and HIF2alpha regulate trophoblast differentiation. Mol Biol Cell 2005; 25:10479-91.
28. Kozak KR, Abbott B, Hankinson O. ARNT-deficient mice and placental differentiation. Dev Biol 1997; 191:297-305.
29. Tanaka S, Kunath T, Hadjantonakis AK, Nagy A, Rossant J. Promotion of trophoblast stem cell proliferation by FGF4. Science 1998; 282:2072-5.
30. Guillemot F, Nagy A, Auerbach A, Rossant J, Joyner AL. Essential role of Mash-2 in extraembryonic development. Nature 1994; 371:333-6.
31. Tanaka M, Gertsenstein M, Rossant J, Nagy A. Mash2 acts cell autonomously in mouse spongiotrophoblast development. Dev Biol 1997; 190:55-65.
32. Gnarra JR, Ward JM, Porter FD, Wagner JR, Devor DE, Grinberg A, Emmert-Buck MR, Westphal H, Klausner RD, Linehan WM. Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci USA 1997; 94:9102-7.
33. Genbacev O, Krtolica A, Kaelin W, Fisher SJ. Human cytotrophoblast expression of the von Hippel-Lindau protein is downregulated during uterine invasion in situ and upregulated by hypoxia in vitro. Dev Biol 2001; 233:526-36.
34. Tang N, Mack F, Haase V, Simon MC, Johnson RS. pVHL function is essential for endothelial extracellular matrix deposition. Mol Cell Biol 2006; In press.