PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2

Science Translational Medicine

Volumn 6, Issue 236, 2014, Pages

  Taniguchi, Cullen M ^a   Miao, Yu Rebecca ^a   Diep, Anh N ^a   Wu, Colleen ^a   Rankin, Erinn B ^a   Atwood, Todd F ^a   Xing, Lei ^a   Giaccia, Amato J ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYLOXALLYLGLYCINE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 2; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE INHIBITOR; UNCLASSIFIED DRUG; VASCULOTROPIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CHELATING AGENT; DICARBOXYLIC AMINO ACID; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; HIF1A PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISOPROTEIN; OXALYLGLYCINE; VASCULOTROPIN A;

ABDOMINAL RADIOTHERAPY; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEATH; ENZYME INHIBITION; GASTROINTESTINAL TOXICITY; GENE SILENCING; INTESTINE EPITHELIUM; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION INJURY; RADIATION PROTECTION; WHOLE BODY RADIATION; ANIMAL; BODY WEIGHT; CHEMISTRY; DRUG EFFECTS; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; GENETICS; HEMATOCRIT; HETEROZYGOTE; HUMAN; KNOCKOUT MOUSE; PROTEIN TERTIARY STRUCTURE; RADIATION INJURIES; RADIATION RESPONSE; TUMOR CELL LINE;

AMINO ACIDS, DICARBOXYLIC; ANIMALS; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BODY WEIGHT; CELL LINE, TUMOR; CHELATING AGENTS; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; HEMATOCRIT; HETEROZYGOTE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, KNOCKOUT; PROLYL-HYDROXYLASE INHIBITORS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RADIATION INJURIES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84901227921     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3008523     Document Type: Article

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