Targeting the hypoxia-sensing pathway in clinical hematology

Stem Cells Translational Medicine

Volumn 3, Issue 2, 2014, Pages 135-140

  Forristal, Catherine E ^a   Levesque, Jean Pierre ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; AKB 6548; CHEMOKINE RECEPTOR CXCR4; CYCLIN DEPENDENT KINASE INHIBITOR 1C; DIMETHYLOXALYLGLYCINE; ERYTHROPOIETIN; FG 2216; GRANULOCYTE COLONY STIMULATING FACTOR; GSK 1278863; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 3ALPHA; MOLIDUSTAT; PIMONIDAZOLE; PLERIXAFOR; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE INHIBITOR; PROTEIN P21; PROTEIN P27; ROXADUSTAT; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

ACUTE KIDNEY FAILURE; ANEMIA; APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; CELL PROLIFERATION; CELL RENEWAL; CYTOTOXICITY; ENZYME ACTIVITY; ERYTHROPOIESIS; HEMATOLOGY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HYPOXIA SENSING PATHWAY; IRRADIATION; MASS SPECTROMETRY; MICROVASCULATURE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); SIGNAL TRANSDUCTION; STEM CELL MOBILIZATION;

AMINO ACIDS, DICARBOXYLIC; ANEMIA; ANOXIA; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; GLYCINE; HEMATOLOGY; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ISOQUINOLINES; SIGNAL TRANSDUCTION; STEM CELL TRANSPLANTATION;

EID: 84894049819     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2013-0134     Document Type: Article

References (60)

1. Webb JD, Coleman ML, Pugh CW. Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. Cell Mol Life Sci 2009;66:3539-3554.
2. Covello KL, Simon MC. HIFs, hypoxia, and vascular development. In: Gerald PS, ed. Current Topics in Developmental Biology. Waltham, MA: Academic Press, 2004:37-54.
3. Jiang BH, Semenza GL, Bauer C et al. Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. Am J Physiol 1996;271:C1172-C1180.
4. Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001;294:1337-1340.
5. D'Angelo G, Duplan E, Boyer N et al. Hypoxia up-regulates prolyl hydroxylase activity: A feedbackmechanism that limits HIF-1 responses during reoxygenation. J Biol Chem 2003;278: 38183-38187.
6. Jaakkola P, Mole DR, Tian YM et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001;292:468-472.
7. Ivan M, Kondo K, Yang H et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science 2001;292:464-468.
8. Bruegge K, Jelkmann W, Metzen E. Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-alpha hydroxylases. Curr Med Chem 2007;14:1853-1862.
9. Takeda K, Aguila HL, Parikh NS et al. Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. Blood 2008;111:3229-3235.
10. Laitala A, Aro E, Walkinshaw G et al. Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis. Blood 2012;120:3336-3344.
11. Oehme F, Ellinghaus P, Kolkhof P et al. Overexpressionof PH-4, a novel putativeproline 4-hydroxylase, modulates activity of hypoxiainducible transcription factors. Biochem Biophys Res Commun 2002;296:343-349.
12. Ramírez-Bergeron DL, Runge A, Adelman DM et al. HIF-dependent hematopoietic factors regulate the development of the embryonic vasculature. Dev Cell 2006;11:81-92.
13. Adelman DM, Maltepe E, Simon MC. Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. Genes Dev 1999; 13:2478-2483.
14. Takubo K, Goda N, YamadaW et al. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell 2010; 7:391-402.
15. Lévesque JP, Winkler IG, Hendy J et al. Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxiainducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow. STEM CELLS 2007;25:1954-1965.
16. Forristal CE, Winkler IG, Nowlan B et al. Pharmacologic stabilization of HIF-1a increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation. Blood 2013;121:759-769.
17. Park SK, Dadak AM, Haase VH et al. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): Role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol 2003;23: 4959-4971.
18. Hara S, Hamada J, Kobayashi C et al. Expression and characterization of hypoxiainducible factor (HIF)-3alpha in human kidney: Suppression of HIF-mediated gene expression by HIF-3alpha. Biochem Biophys Res Commun 2001;287:808-813.
19. Maynard MA, Evans AJ, Hosomi T et al. HumanHIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma. FASEB J 2005;19:1396-1406.
20. Eliasson P, Rehn M, Hammar P et al. Hypoxia mediates low cell-cycle activity and increases the proportion of long-term-reconstituting hematopoietic stem cells during in vitro culture. Exp Hematol 2010;38:301-310.e2.
21. Suda T, Takubo K, Semenza GL. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell 2011;9:298-310.
22. Cipolleschi MG, Dello Sbarba P, Olivotto M. The role of hypoxia in the maintenance of hematopoietic stem cells. Blood 1993;82:2031-2037.
23. Danet GH, Pan Y, Luongo JL et al. Expansion of human SCID-repopulating cells under hypoxic conditions. J Clin Invest 2003;112: 126-135.
24. Singh RP, Franke K, Kalucka J et al. HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. Blood 2013; 121:5158-5166.
25. Bussolati B, Lauritano C, Moggio A et al. Renal CD133(1)/CD73(1) progenitors produce erythropoietin under hypoxia and prolyl hydroxylase inhibition. J Am Soc Nephrol 2013; 24:1234-1241.
26. Scortegagna M, Ding K, Zhang Q et al. HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner. Blood 2005;105:3133-3140.
27. Warnecke C, Zaborowska Z, Kurreck J et al. Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: Erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. FASEB J 2004; 18:1462-1464.
28. Franke K, Kalucka J, Mamlouk S et al. HIF-1a is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2a-induced excessive erythropoiesis. Blood 2013;121:1436-1445.
29. Bigham A, Bauchet M, Pinto D et al. Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet 2010;6:e1001116.
30. Bigham AW, Wilson MJ, Julian CG et al. Andean and Tibetan patterns of adaptation to high altitude. Am J Hum Biol 2013;25:190-197.
31. Branemark P-I. Experimental investigation of microcirculation in bone marrow. Angiology 1961;12:293-305.
32. Hooper AT, Butler JM, Nolan DJ et al. Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell 2009;4:263-274.
33. Kopp HG, Avecilla ST, Hooper AT et al. The bone marrow vascular niche: Home of HSC differentiation and mobilization. Physiology (Bethesda) 2005;20:349-356.
34. Kopp HG, Hooper AT, Avecilla ST et al. Functional heterogeneity of the bone marrow vascular niche. Ann N Y Acad Sci 2009;1176: 47-54.
35. Li XM, Hu Z, Jorgenson ML et al. Highlevels of acetylated low-density lipoprotein uptake and low tyrosine kinase with immunoglobulin and epidermal growth factor homology domains-2 (Tie2) promoter activity distinguish sinusoids from other vessel types in murine bone marrow. Circulation 2009;120:1910-1918.
36. Nombela-Arrieta C, Pivarnik G, Winkel B et al. Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol 2013;15:533-543.
37. Lassailly F, Foster K, Lopez-Onieva L et al. Multimodal imaging reveals structural and functional heterogeneity in different bone marrow compartments: Functional implications on hematopoietic stem cells. Blood 2013;122: 1730-1740.
38. Winkler IG, Barbier V, Wadley R et al. Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: Serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches. Blood 2010; 116:375-385.
39. Xie Y, Yin T, Wiegraebe W et al. Detection of functional haematopoietic stem cell niche using real-time imaging. Nature 2009; 457:97-101.
40. Köhler A, Schmithorst V, Filippi MD et al. Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones. Blood 2009;114:290-298.
41. Kiel MJ, Yilmaz OH, Iwashita T et al. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2005;121:1109-1121.
42. Sugiyama T, Kohara H, Noda M et al. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006;25:977-988.
43. Baader E, Tschank G, Baringhaus KH et al. Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues. Biochem J 1994;300:525-530.
44. Murray JK, Balan C, Allgeier AM et al. Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1a prolyl hydroxylases-1, -2, and -3 with altered selectivity. J Comb Chem 2010;12:676-686.
45. Safran M, Kim WY, O'Connell F et al. Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production. Proc Natl Acad Sci USA 2006;103:105-110.
46. Fraisl P, Aragonés J, Carmeliet P. Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease. Nat Rev Drug Discov 2009;8:139-152.
47. Bernhardt WM, Wiesener MS, Scigalla P et al. Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD. J Am Soc Nephrol 2010;21:2151-2156.
48. Hsieh MM, Linde NS, Wynter A et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. Blood 2007;110:2140-2147.
49. Bernhardt WM, Câmpean V, Kany S et al. Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. J Am Soc Nephrol 2006;17:1970-1978.
50. Sorg H, Harder Y, Krueger C et al. The nonhematopoietic effects of erythropoietin in skin regeneration and repair: From basic research to clinical use. Med Res Rev 2013;33:637-664.
51. Adamcio B, Sperling S, Hagemeyer N et al. Hypoxia inducible factor stabilization leads to lasting improvement of hippocampal memory in healthy mice. Behav Brain Res 2010;208:80-84.
52. Marchbank T, Mahmood A, Harten S et al. Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms. Lab Invest 2011;91:1684-1694.
53. Robinson A, Keely S, Karhausen J et al. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology 2008;134:145-155.
54. Beuck S, Schänzer W, Thevis M. Hypoxiainducible factor stabilizers and other smallmolecule erythropoiesis-stimulating agents in current and preventive doping analysis. Drug Test Anal 2012;4:830-845.
55. Boothman DA, Burrows HL, Yang CR et al. Damage-sensing mechanisms in human cells after ionizing radiation. STEM CELLS 1997;15 (suppl 2):27-42.
56. Forristal CE, Nowlan B, Barbier V et al. FG-4497, a pharmacological stabilizer of HIF-1 {alpha} protein, synergistically enhances hematopoietic stem cells (HSC) mobilization in response to G-CSF and plerixafor. Blood 2012; 120:216a.
57. Cramer T, Yamanishi Y, Clausen BE et al. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 2003;112:645-657.
58. Corzo CA, Condamine T, Lu L et al. HIF- 1a regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med 2010;207:2439-2453.
59. Bosco MC, Pierobon D, Blengio F et al. Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: Identification of TREM-1 as a novel hypoxic marker in vitro and in vivo. Blood 2011;117:2625-2639.
60. Mancino A, Schioppa T, Larghi P et al. Divergent effects of hypoxia on dendritic cell functions. Blood 2008;112:3723-3734.