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Volumn 16, Issue 9, 2016, Pages 553-565

A guide to immunometabolism for immunologists

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 3 (1 PHENYLINDOL 3 YL)ACRYLIC ACID; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYL COENZYME A CARBOXYLASE; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; AMINO ACID; CARNITINE PALMITOYLTRANSFERASE I; CERULENIN; ETOMOXIR; FATTY ACID; FATTY ACID SYNTHASE; GLUCOSE TRANSPORTER 1; GLUTAMINASE; HEXOKINASE; LACTATE DEHYDROGENASE; LONG CHAIN FATTY ACID; METFORMIN; MONOCARBOXYLATE TRANSPORTER; OLIGOMYCIN; PENTOSE PHOSPHATE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RITONAVIR; ROTENONE; SHORT CHAIN FATTY ACID; TRICARBOXYLIC ACID; TRYPTOPHAN; UNINDEXED DRUG;

EID: 84978148203     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri.2016.70     Document Type: Review
Times cited : (2051)

References (99)
  • 1
    • 0023029455 scopus 로고
    • Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages
    • Newsholme, P., Curi, R., Gordon, S. & Newsholme, E. A. Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages. Biochem. J. 239, 121-125 (1986).
    • (1986) Biochem. J. , vol.239 , pp. 121-125
    • Newsholme, P.1    Curi, R.2    Gordon, S.3    Newsholme, E.A.4
  • 2
    • 77049264051 scopus 로고
    • Comparative study of host resistance of Guinea pigs and rats V. The effect of pneumococcal products on glycolysis and oxygen uptake by polymorphonuclear leucocytes
    • Alonso, D. & Nungester, W. J. Comparative study of host resistance of guinea pigs and rats V. The effect of pneumococcal products on glycolysis and oxygen uptake by polymorphonuclear leucocytes. J. Infect. Dis. 99, 174-181 (1956).
    • (1956) J. Infect. Dis. , vol.99 , pp. 174-181
    • Alonso, D.1    Nungester, W.J.2
  • 4
    • 0030048720 scopus 로고    scopus 로고
    • Endotoxin-induced enhancement of glucose influx into murine peritoneal macrophages via GLUT1
    • Fukuzumi, M., Shinomiya, H., Shimizu, Y., Ohishi, K. & Utsumi, S. Endotoxin-induced enhancement of glucose influx into murine peritoneal macrophages via GLUT1. Infect. Immun. 64, 108-112 (1996).
    • (1996) Infect. Immun. , vol.64 , pp. 108-112
    • Fukuzumi, M.1    Shinomiya, H.2    Shimizu, Y.3    Ohishi, K.4    Utsumi, S.5
  • 5
    • 84921281866 scopus 로고    scopus 로고
    • MTOR signaling in T cell immunity and autoimmunity
    • Liu, Y., Zhang, D. T. & Liu, X. G. mTOR signaling in T cell immunity and autoimmunity. Int. Rev. Immunol. 34, 50-66 (2015).
    • (2015) Int. Rev. Immunol. , vol.34 , pp. 50-66
    • Liu, Y.1    Zhang, D.T.2    Liu, X.G.3
  • 7
    • 84872576236 scopus 로고    scopus 로고
    • Metabolism of inflammation limited by AMPK and pseudo-starvation
    • O'Neill, L. A. & Hardie, D. G. Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature 493, 346-355 (2013).
    • (2013) Nature , vol.493 , pp. 346-355
    • O'Neill, L.A.1    Hardie, D.G.2
  • 8
    • 0017041950 scopus 로고
    • 2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages. I. Description of the inhibitory effect
    • Michl, J., Ohlbaum, D. J. & Silverstein, S. C. 2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages. I. Description of the inhibitory effect. J. Exp. Med. 144, 1465-1483 (1976).
    • (1976) J. Exp. Med. , vol.144 , pp. 1465-1483
    • Michl, J.1    Ohlbaum, D.J.2    Silverstein, S.C.3
  • 9
    • 0022499199 scopus 로고
    • CSF-1 stimulates glucose uptake in murine bone marrow-derived macrophages
    • Hamilton, J. A., Vairo, G. & Lingelbach, S. R. CSF-1 stimulates glucose uptake in murine bone marrow-derived macrophages. Biochem. Biophys. Res. Commun. 138, 445-454 (1986).
    • (1986) Biochem. Biophys. Res. Commun. , vol.138 , pp. 445-454
    • Hamilton, J.A.1    Vairo, G.2    Lingelbach, S.R.3
  • 10
    • 77956213727 scopus 로고    scopus 로고
    • Substrate fate in activated macrophages: A comparison between innate, classic, and alternative activation
    • Rodriguez-Prados, J. C. et al. Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation. J. Immunol. 185, 605-614 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 605-614
    • Rodriguez-Prados, J.C.1
  • 11
    • 77954735369 scopus 로고    scopus 로고
    • Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation
    • Krawczyk, C. M. et al. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood 115, 4742-4749 (2010).
    • (2010) Blood , vol.115 , pp. 4742-4749
    • Krawczyk, C.M.1
  • 12
    • 84908123523 scopus 로고    scopus 로고
    • MTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function
    • Donnelly, R. P. et al. mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function. J. Immunol. 193, 4477-4484 (2014).
    • (2014) J. Immunol. , vol.193 , pp. 4477-4484
    • Donnelly, R.P.1
  • 13
    • 79953172571 scopus 로고    scopus 로고
    • Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
    • Michalek, R. D. et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J. Immunol. 186, 3299-3303 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 3299-3303
    • Michalek, R.D.1
  • 14
    • 33744462050 scopus 로고    scopus 로고
    • Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: Role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth
    • Doughty, C. A. et al. Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth. Blood 107, 4458-4465 (2006).
    • (2006) Blood , vol.107 , pp. 4458-4465
    • Doughty, C.A.1
  • 15
    • 79960369458 scopus 로고    scopus 로고
    • HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • Shi, L. Z. et al. HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208, 1367-1376 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1367-1376
    • Shi, L.Z.1
  • 16
    • 84886721392 scopus 로고    scopus 로고
    • Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch
    • Gubser, P. M. et al. Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch. Nat. Immunol. 14, 1064-1072 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 1064-1072
    • Gubser, P.M.1
  • 17
    • 84922930171 scopus 로고    scopus 로고
    • Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses
    • Shrestha, S. et al. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat. Immunol. 16, 178-187 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 178-187
    • Shrestha, S.1
  • 18
    • 84922917657 scopus 로고    scopus 로고
    • Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability
    • Huynh, A. et al. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat. Immunol. 16, 188-196 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 188-196
    • Huynh, A.1
  • 19
    • 84955590563 scopus 로고    scopus 로고
    • Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis
    • Wei, J. et al. Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis. Nat. Immunol. 17, 277-285 (2016).
    • (2016) Nat. Immunol. , vol.17 , pp. 277-285
    • Wei, J.1
  • 20
    • 84896654124 scopus 로고    scopus 로고
    • TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKϵ supports the anabolic demands of dendritic cell activation
    • Everts, B. et al. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKϵ supports the anabolic demands of dendritic cell activation. Nat. Immunol. 15, 323-332 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 323-332
    • Everts, B.1
  • 21
    • 84876285741 scopus 로고    scopus 로고
    • Succinate is an inflammatory signal that induces IL-1β through HIF-1α
    • Tannahill, G. M. et al. Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature 496, 238-242 (2013).
    • (2013) Nature , vol.496 , pp. 238-242
    • Tannahill, G.M.1
  • 22
    • 84920591180 scopus 로고    scopus 로고
    • Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages
    • Palsson-McDermott, E. M. et al. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 21, 65-80 (2015).
    • (2015) Cell Metab. , vol.21 , pp. 65-80
    • Palsson-McDermott, E.M.1
  • 23
    • 79957567239 scopus 로고    scopus 로고
    • Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
    • Luo, W. et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 145, 732-744 (2011).
    • (2011) Cell , vol.145 , pp. 732-744
    • Luo, W.1
  • 24
    • 84961226298 scopus 로고    scopus 로고
    • The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease
    • Shirai, T. et al. The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease. J. Exp. Med. 213, 337-354 (2016).
    • (2016) J. Exp. Med. , vol.213 , pp. 337-354
    • Shirai, T.1
  • 25
    • 84924935721 scopus 로고    scopus 로고
    • Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization
    • Jha, A. K. et al. Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity 42, 419-430 (2015).
    • (2015) Immunity , vol.42 , pp. 419-430
    • Jha, A.K.1
  • 26
    • 84920481006 scopus 로고    scopus 로고
    • Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
    • Gerriets, V. A. et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J. Clin. Invest. 125, 194-207 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 194-207
    • Gerriets, V.A.1
  • 27
    • 84933532719 scopus 로고    scopus 로고
    • Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival
    • Beier, U. H. et al. Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival. FASEB J. 29, 2315-2326 (2015).
    • (2015) FASEB J. , vol.29 , pp. 2315-2326
    • Beier, U.H.1
  • 28
    • 84958624127 scopus 로고    scopus 로고
    • The proteomic landscape of human ex vivo regulatory and conventional T cells reveals specific metabolic requirements
    • Procaccini, C. et al. The proteomic landscape of human ex vivo regulatory and conventional T cells reveals specific metabolic requirements. Immunity 44, 406-421 (2016).
    • (2016) Immunity , vol.44 , pp. 406-421
    • Procaccini, C.1
  • 29
    • 84945474595 scopus 로고    scopus 로고
    • Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants
    • De Rosa, V. et al. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants. Nat. Immunol. 16, 1174-1184 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 1174-1184
    • De Rosa, V.1
  • 31
    • 84878831880 scopus 로고    scopus 로고
    • Posttranscriptional control of T cell effector function by aerobic glycolysis
    • Chang, C. H. et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153, 1239-1251 (2013).
    • (2013) Cell , vol.153 , pp. 1239-1251
    • Chang, C.H.1
  • 32
    • 84937513657 scopus 로고    scopus 로고
    • MTORC1-induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation
    • Moon, J. S. et al. mTORC1-induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation. Cell Rep. 12, 102-115 (2015).
    • (2015) Cell Rep. , vol.12 , pp. 102-115
    • Moon, J.S.1
  • 33
    • 84862016400 scopus 로고    scopus 로고
    • The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism
    • Haschemi, A. et al. The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. Cell Metab. 15, 813-826 (2012).
    • (2012) Cell Metab. , vol.15 , pp. 813-826
    • Haschemi, A.1
  • 34
    • 84904392273 scopus 로고    scopus 로고
    • Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development
    • O'Sullivan, D. et al. Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity 41, 75-88 (2014).
    • (2014) Immunity , vol.41 , pp. 75-88
    • O'Sullivan, D.1
  • 35
    • 80052170775 scopus 로고    scopus 로고
    • The mitochondrial citrate carrier: A new player in inflammation
    • Infantino, V. et al. The mitochondrial citrate carrier: a new player in inflammation. Biochem. J. 438, 433-436 (2011).
    • (2011) Biochem. J. , vol.438 , pp. 433-436
    • Infantino, V.1
  • 36
    • 84877343356 scopus 로고    scopus 로고
    • Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
    • Michelucci, A. et al. Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proc. Natl Acad. Sci. USA 110, 7820-7825 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 7820-7825
    • Michelucci, A.1
  • 37
    • 0032560572 scopus 로고    scopus 로고
    • Persistent inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex i and protective action of glutathione
    • Clementi, E., Brown, G. C., Feelisch, M. & Moncada, S. Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc. Natl Acad. Sci. USA 95, 7631-7636 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 7631-7636
    • Clementi, E.1    Brown, G.C.2    Feelisch, M.3    Moncada, S.4
  • 38
    • 0029618991 scopus 로고
    • Macrophages, lipid oxidation, ceroid accumulation and alpha-tocopherol depletion in human atherosclerotic lesions
    • Carpenter, K. L. et al. Macrophages, lipid oxidation, ceroid accumulation and alpha-tocopherol depletion in human atherosclerotic lesions. Gerontology 41, 53-67 (1995).
    • (1995) Gerontology , vol.41 , pp. 53-67
    • Carpenter, K.L.1
  • 39
    • 0034648768 scopus 로고    scopus 로고
    • Atherosclerosis
    • Lusis, A. J. Atherosclerosis. Nature 407, 233-241 (2000).
    • (2000) Nature , vol.407 , pp. 233-241
    • Lusis, A.J.1
  • 41
    • 84886674980 scopus 로고    scopus 로고
    • Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis
    • Freigang, S. et al. Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis. Nat. Immunol. 14, 1045-1053 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 1045-1053
    • Freigang, S.1
  • 42
    • 84929682990 scopus 로고    scopus 로고
    • Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation
    • Malandrino, M. I. et al. Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation. Am. J. Physiol. Endocrinol. Metab. 308, E756-E769 (2015).
    • (2015) Am. J. Physiol. Endocrinol. Metab. , vol.308 , pp. E756-E769
    • Malandrino, M.I.1
  • 43
    • 33745428666 scopus 로고    scopus 로고
    • Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation
    • Vats, D. et al. Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation. Cell Metab. 4, 13-24 (2006).
    • (2006) Cell Metab. , vol.4 , pp. 13-24
    • Vats, D.1
  • 44
    • 84906319549 scopus 로고    scopus 로고
    • Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
    • Huang, S. C. et al. Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nat. Immunol. 15, 846-855 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 846-855
    • Huang, S.C.1
  • 45
    • 84962450023 scopus 로고    scopus 로고
    • Fatty acid oxidation in macrophage polarization
    • Nomura, M. et al. Fatty acid oxidation in macrophage polarization. Nat. Immunol. 17, 216-217 (2016).
    • (2016) Nat. Immunol. , vol.17 , pp. 216-217
    • Nomura, M.1
  • 46
    • 84255199079 scopus 로고    scopus 로고
    • The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
    • Wang, R. et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35, 871-882 (2011).
    • (2011) Immunity , vol.35 , pp. 871-882
    • Wang, R.1
  • 47
    • 84925688346 scopus 로고    scopus 로고
    • PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
    • Patsoukis, N. et al. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat. Commun. 6, 6692 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6692
    • Patsoukis, N.1
  • 48
    • 0029825152 scopus 로고    scopus 로고
    • Cell division in the compartment of naive and memory T lymphocytes
    • Bruno, L., von Boehmer, H. & Kirberg, J. Cell division in the compartment of naive and memory T lymphocytes. Eur. J. Immunol. 26, 3179-3184 (1996).
    • (1996) Eur. J. Immunol. , vol.26 , pp. 3179-3184
    • Bruno, L.1    Von Boehmer, H.2    Kirberg, J.3
  • 49
    • 84883423963 scopus 로고    scopus 로고
    • CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
    • van der Windt, G. J. et al. CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proc. Natl Acad. Sci. USA 110, 14336-14341 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 14336-14341
    • Van Der Windt, G.J.1
  • 50
    • 84856183120 scopus 로고    scopus 로고
    • Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
    • van der Windt, G. J. et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 36, 68-78 (2012).
    • (2012) Immunity , vol.36 , pp. 68-78
    • Van Der Windt, G.J.1
  • 51
    • 41749112419 scopus 로고    scopus 로고
    • Lipid synthesis in macrophages during inflammation in vivo: Effect of agonists of peroxisome proliferator activated receptors α and γ and of retinoid X receptors
    • Posokhova, E. N., Khoshchenko, O. M., Chasovskikh, M. I., Pivovarova, E. N. & Dushkin, M. I. Lipid synthesis in macrophages during inflammation in vivo: effect of agonists of peroxisome proliferator activated receptors α and γ and of retinoid X receptors. Biochem. (Mosc) 73, 296-304 (2008).
    • (2008) Biochem. (Mosc) , vol.73 , pp. 296-304
    • Posokhova, E.N.1    Khoshchenko, O.M.2    Chasovskikh, M.I.3    Pivovarova, E.N.4    Dushkin, M.I.5
  • 52
    • 84868102857 scopus 로고    scopus 로고
    • Mechanisms of triglyceride accumulation in activated macrophages
    • Feingold, K. R. et al. Mechanisms of triglyceride accumulation in activated macrophages. J. Leukoc. Biol. 92, 829-839 (2012).
    • (2012) J. Leukoc. Biol. , vol.92 , pp. 829-839
    • Feingold, K.R.1
  • 53
    • 77952413531 scopus 로고    scopus 로고
    • Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes
    • Ecker, J. et al. Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes. Proc. Natl Acad. Sci. USA 107, 7817-7822 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 7817-7822
    • Ecker, J.1
  • 54
    • 84961290384 scopus 로고    scopus 로고
    • UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
    • Moon, J. S. et al. UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. J. Clin. Invest. 125, 665-680 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 665-680
    • Moon, J.S.1
  • 55
    • 0011014154 scopus 로고
    • Relationship between sterol synthesis and DNA-synthesis in phytohemagglutinin-stimulated mouse lymphocytes
    • Chen, H. W., Heiniger, H. J. & Kandutsch, A. A. Relationship between sterol synthesis and DNA-synthesis in phytohemagglutinin-stimulated mouse lymphocytes. Proc. Natl Acad. Sci. USA 72, 1950-1954 (1975).
    • (1975) Proc. Natl Acad. Sci. USA , vol.72 , pp. 1950-1954
    • Chen, H.W.1    Heiniger, H.J.2    Kandutsch, A.A.3
  • 56
    • 84896785783 scopus 로고    scopus 로고
    • Glucose-dependent de novo lipogenesis in B lymphocytes: A requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation
    • Dufort, F. J. et al. Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation. J. Biol. Chem. 289, 7011-7024 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 7011-7024
    • Dufort, F.J.1
  • 57
    • 84897505811 scopus 로고    scopus 로고
    • Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity
    • Lee, J. et al. Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. J. Immunol. 192, 3190-3199 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 3190-3199
    • Lee, J.1
  • 58
    • 84922080059 scopus 로고    scopus 로고
    • De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
    • Berod, L. et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat. Med. 20, 1327-1333 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 1327-1333
    • Berod, L.1
  • 59
    • 84949196321 scopus 로고    scopus 로고
    • CD5L/AIM regulates lipid biosynthesis and restrains Th17 cell pathogenicity
    • Wang, C. et al. CD5L/AIM regulates lipid biosynthesis and restrains Th17 cell pathogenicity. Cell 163, 1413-1427 (2015).
    • (2015) Cell , vol.163 , pp. 1413-1427
    • Wang, C.1
  • 60
    • 76949089721 scopus 로고    scopus 로고
    • Th17 cytokines in mucosal immunity and inflammation
    • Guglani, L. & Khader, S. A. Th17 cytokines in mucosal immunity and inflammation. Curr. Opin. HIV- AIDS 5, 120-127 (2010).
    • (2010) Curr. Opin. HIV- AIDS , vol.5 , pp. 120-127
    • Guglani, L.1    Khader, S.A.2
  • 61
    • 84860241847 scopus 로고    scopus 로고
    • Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β
    • Zielinski, C. E. et al. Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β. Nature 484, 514-518 (2012).
    • (2012) Nature , vol.484 , pp. 514-518
    • Zielinski, C.E.1
  • 62
    • 84958161227 scopus 로고    scopus 로고
    • Regulation of adaptive immunity in health and disease by cholesterol metabolism
    • Fessler, M. B. Regulation of adaptive immunity in health and disease by cholesterol metabolism. Curr. Allergy Asthma Rep. 15, 48 (2015).
    • (2015) Curr. Allergy Asthma Rep. , vol.15 , pp. 48
    • Fessler, M.B.1
  • 63
    • 84901936622 scopus 로고    scopus 로고
    • Sphingolipid metabolites in inflammatory disease
    • Maceyka, M. & Spiegel, S. Sphingolipid metabolites in inflammatory disease. Nature 510, 58-67 (2014).
    • (2014) Nature , vol.510 , pp. 58-67
    • Maceyka, M.1    Spiegel, S.2
  • 65
    • 0025150173 scopus 로고
    • Does glutamine contribute to immunosuppression after major burns?
    • Parry-Billings, M., Evans, J., Calder, P. C. & Newsholme, E. A. Does glutamine contribute to immunosuppression after major burns? Lancet 336, 523-525 (1990).
    • (1990) Lancet , vol.336 , pp. 523-525
    • Parry-Billings, M.1    Evans, J.2    Calder, P.C.3    Newsholme, E.A.4
  • 66
    • 0026630585 scopus 로고
    • Glutamine and macrophage function
    • Wallace, C. & Keast, D. Glutamine and macrophage function. Metabolism 41, 1016-1020 (1992).
    • (1992) Metabolism , vol.41 , pp. 1016-1020
    • Wallace, C.1    Keast, D.2
  • 67
    • 0031710853 scopus 로고    scopus 로고
    • Importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production
    • Murphy, C. & Newsholme, P. Importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production. Clin. Sci. (Lond.) 95, 397-407 (1998).
    • (1998) Clin. Sci. (Lond.) , vol.95 , pp. 397-407
    • Murphy, C.1    Newsholme, P.2
  • 68
    • 0032703576 scopus 로고    scopus 로고
    • Glutamine is essential for nitric oxide synthesis by murine macrophages
    • Bellows, C. F. & Jaffe, B. M. Glutamine is essential for nitric oxide synthesis by murine macrophages. J. Surg. Res. 86, 213-219 (1999).
    • (1999) J. Surg. Res. , vol.86 , pp. 213-219
    • Bellows, C.F.1    Jaffe, B.M.2
  • 69
    • 77955475969 scopus 로고    scopus 로고
    • Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation
    • Carr, E. L. et al. Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation. J. Immunol. 185, 1037-1044 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 1037-1044
    • Carr, E.L.1
  • 70
    • 0021845948 scopus 로고
    • The essential role of L-glutamine in lymphocyte differentiation in vitro
    • Crawford, J. & Cohen, H. J. The essential role of L-glutamine in lymphocyte differentiation in vitro. J. Cell. Physiol. 124, 275-282 (1985).
    • (1985) J. Cell. Physiol. , vol.124 , pp. 275-282
    • Crawford, J.1    Cohen, H.J.2
  • 71
    • 84855453655 scopus 로고    scopus 로고
    • Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
    • Le, A. et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 15, 110-121 (2012).
    • (2012) Cell Metab. , vol.15 , pp. 110-121
    • Le, A.1
  • 72
    • 84900440370 scopus 로고    scopus 로고
    • Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation
    • Nakaya, M. et al. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity 40, 692-705 (2014).
    • (2014) Immunity , vol.40 , pp. 692-705
    • Nakaya, M.1
  • 73
    • 84918843257 scopus 로고    scopus 로고
    • Metabolism via arginase or nitric oxide synthase: Two competing arginine pathways in macrophages
    • Rath, M., Muller, I., Kropf, P., Closs, E. I. & Munder, M. Metabolism via arginase or nitric oxide synthase: two competing arginine pathways in macrophages. Front. Immunol. 5, 532 (2014).
    • (2014) Front. Immunol. , vol.5 , pp. 532
    • Rath, M.1    Muller, I.2    Kropf, P.3    Closs, E.I.4    Munder, M.5
  • 75
    • 0028999596 scopus 로고
    • Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
    • MacMicking, J. D. et al. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81, 641-650 (1995).
    • (1995) Cell , vol.81 , pp. 641-650
    • MacMicking, J.D.1
  • 76
    • 0023917679 scopus 로고
    • Arginine metabolism in wounds
    • Albina, J. E. et al. Arginine metabolism in wounds. Am. J. Physiol. 254, E459-E467 (1988).
    • (1988) Am. J. Physiol. , vol.254 , pp. E459-E467
    • Albina, J.E.1
  • 77
    • 66349084135 scopus 로고    scopus 로고
    • Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis
    • Pesce, J. T. et al. Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PLoS Pathog. 5, e1000371 (2009).
    • (2009) PLoS Pathog. , vol.5 , pp. e1000371
    • Pesce, J.T.1
  • 78
    • 84873508298 scopus 로고    scopus 로고
    • Arginase activity in the blood of patients with visceral leishmaniasis and HIV- infection
    • Takele, Y. et al. Arginase activity in the blood of patients with visceral leishmaniasis and HIV- infection. PLoS Negl. Trop. Dis. 7, e1977 (2013).
    • (2013) PLoS Negl. Trop. Dis. , vol.7 , pp. e1977
    • Takele, Y.1
  • 79
    • 0037077192 scopus 로고    scopus 로고
    • Regulation of T cell receptor CD3ζ chain expression by l-arginine
    • Rodriguez, P. C. et al. Regulation of T cell receptor CD3ζ chain expression by l-arginine. J. Biol. Chem. 277, 21123-21129 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 21123-21129
    • Rodriguez, P.C.1
  • 80
    • 33846933459 scopus 로고    scopus 로고
    • L-arginine availability regulates T-lymphocyte cell-cycle progression
    • Rodriguez, P. C., Quiceno, D. G. & Ochoa, A. C. l-arginine availability regulates T-lymphocyte cell-cycle progression. Blood 109, 1568-1573 (2007).
    • (2007) Blood , vol.109 , pp. 1568-1573
    • Rodriguez, P.C.1    Quiceno, D.G.2    Ochoa, A.C.3
  • 81
    • 67749091321 scopus 로고    scopus 로고
    • Infectious tolerance via the consumption of essential amino acids and mTOR signaling
    • Cobbold, S. P. et al. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc. Natl Acad. Sci. USA 106, 12055-12060 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 12055-12060
    • Cobbold, S.P.1
  • 82
    • 0025307579 scopus 로고
    • Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan
    • Silver, R. M. et al. Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan. N. Engl. J. Med. 322, 874-881 (1990).
    • (1990) N. Engl. J. Med. , vol.322 , pp. 874-881
    • Silver, R.M.1
  • 83
  • 84
    • 0018179447 scopus 로고
    • Induction of pulmonary indoleamine 2,3-dioxygenase by intraperitoneal injection of bacterial lipopolysaccharide
    • Yoshida, R. & Hayaishi, O. Induction of pulmonary indoleamine 2,3-dioxygenase by intraperitoneal injection of bacterial lipopolysaccharide. Proc. Natl Acad. Sci. USA 75, 3998-4000 (1978).
    • (1978) Proc. Natl Acad. Sci. USA , vol.75 , pp. 3998-4000
    • Yoshida, R.1    Hayaishi, O.2
  • 86
    • 0024317795 scopus 로고
    • Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-γ
    • Werner, E. R. et al. Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-γ. Biochem. J. 262, 861-866 (1989).
    • (1989) Biochem. J. , vol.262 , pp. 861-866
    • Werner, E.R.1
  • 87
    • 0000056144 scopus 로고
    • Interferon γ blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan
    • Pfefferkorn, E. R. Interferon γ blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc. Natl Acad. Sci. USA 81, 908-912 (1984).
    • (1984) Proc. Natl Acad. Sci. USA , vol.81 , pp. 908-912
    • Pfefferkorn, E.R.1
  • 88
    • 0034828217 scopus 로고    scopus 로고
    • Potential role of human brain microvascular endothelial cells in the pathogenesis of brain abscess: Inhibition of Staphylococcus aureus by activation of indoleamine 2,3-dioxygenase
    • Schroten, H. et al. Potential role of human brain microvascular endothelial cells in the pathogenesis of brain abscess: inhibition of Staphylococcus aureus by activation of indoleamine 2,3-dioxygenase. Neuropediatrics 32, 206-210 (2001).
    • (2001) Neuropediatrics , vol.32 , pp. 206-210
    • Schroten, H.1
  • 89
    • 0036884130 scopus 로고    scopus 로고
    • Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division
    • Lee, G. K. et al. Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division. Immunology 107, 452-460 (2002).
    • (2002) Immunology , vol.107 , pp. 452-460
    • Lee, G.K.1
  • 90
    • 0033519278 scopus 로고    scopus 로고
    • Inhibition of T cell proliferation by macrophage tryptophan catabolism
    • Munn, D. H. et al. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J. Exp. Med. 189, 1363-1372 (1999).
    • (1999) J. Exp. Med. , vol.189 , pp. 1363-1372
    • Munn, D.H.1
  • 91
    • 84892464676 scopus 로고    scopus 로고
    • GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology
    • Liu, H. et al. GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology. Mol. Cell. Biol. 34, 428-438 (2014).
    • (2014) Mol. Cell. Biol. , vol.34 , pp. 428-438
    • Liu, H.1
  • 92
    • 84904216760 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor control of a disease tolerance defence pathway
    • Bessede, A. et al. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Nature 511, 184-190 (2014).
    • (2014) Nature , vol.511 , pp. 184-190
    • Bessede, A.1
  • 93
    • 0142137237 scopus 로고    scopus 로고
    • Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
    • Uyttenhove, C. et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat. Med. 9, 1269-1274 (2003).
    • (2003) Nat. Med. , vol.9 , pp. 1269-1274
    • Uyttenhove, C.1
  • 94
    • 23844451052 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase serves as a marker of poor prognosis in gene expression profiles of serous ovarian cancer cells
    • Okamoto, A. et al. Indoleamine 2,3-dioxygenase serves as a marker of poor prognosis in gene expression profiles of serous ovarian cancer cells. Clin. Cancer Res. 11, 6030-6039 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 6030-6039
    • Okamoto, A.1
  • 95
    • 4043092238 scopus 로고    scopus 로고
    • Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes
    • Munn, D. H. et al. Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J. Clin. Invest. 114, 280-290 (2004).
    • (2004) J. Clin. Invest. , vol.114 , pp. 280-290
    • Munn, D.H.1
  • 96
    • 33845920042 scopus 로고    scopus 로고
    • Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients
    • Weinlich, G., Murr, C., Richardsen, L., Winkler, C. & Fuchs, D. Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients. Dermatology 214, 8-14 (2007).
    • (2007) Dermatology , vol.214 , pp. 8-14
    • Weinlich, G.1    Murr, C.2    Richardsen, L.3    Winkler, C.4    Fuchs, D.5
  • 97
    • 84880664259 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
    • Holmgaard, R. B., Zamarin, D., Munn, D. H., Wolchok, J. D. & Allison, J. P. Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. J. Exp. Med. 210, 1389-1402 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 1389-1402
    • Holmgaard, R.B.1    Zamarin, D.2    Munn, D.H.3    Wolchok, J.D.4    Allison, J.P.5
  • 98
    • 84928641864 scopus 로고    scopus 로고
    • Normalization of CD4+ T cell metabolism reverses lupus
    • Yin, Y. et al. Normalization of CD4+ T cell metabolism reverses lupus. Sci Transl Med. 7, 274ra18 (2015).
    • (2015) Sci Transl Med. , vol.7 , pp. 274ra18
    • Yin, Y.1
  • 99
    • 84945583836 scopus 로고    scopus 로고
    • Preventing allograft rejection by targeting immune metabolism
    • Lee, C. F. et al. Preventing allograft rejection by targeting immune metabolism. Cell Rep. 13, 760-770 (2015).
    • (2015) Cell Rep. , vol.13 , pp. 760-770
    • Lee, C.F.1


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