IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection

PLoS Pathogens

Volumn 11, Issue 6, 2015, Pages

  Hammami, Akil ^a   Charpentier, Tania ^a   Smans, Mélina ^a   Stäger, Simona ^a  

^a INRS INSTITUT ARMAND FRAPPIER   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERFERON REGULATORY FACTOR 5; INTERLEUKIN 12; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR; HIF1A PROTEIN, MOUSE; INTERFERON REGULATORY FACTOR; IRF5 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; HYPOXIA; IMMUNOBLOTTING; INFLAMMATION; LEISHMANIA DONOVANI; LEISHMANIASIS; MOUSE; NONHUMAN; PROMASTIGOTE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; T CELL DEPLETION; UPREGULATION; WESTERN BLOTTING; ADOPTIVE TRANSFER; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; IMMUNE EVASION; IMMUNOLOGY; MUTANT MOUSE STRAIN; VISCERAL LEISHMANIASIS;

LEISHMANIA DONOVANI; MUS;

ADOPTIVE TRANSFER; ANIMALS; BLOTTING, WESTERN; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNE EVASION; INFLAMMATION; INTERFERON REGULATORY FACTORS; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84936766497     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004938     Document Type: Article

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