Cyclic GMP-AMP as an endogenous second messenger in innate immune signaling by cytosolic DNA

Annual Review of Biochemistry

Volumn 86, Issue , 2017, Pages 541-566

  Kato, Kazuki ^a   Omura, Hiroki ^a   Ishitani, Ryuichiro ^a   Nureki, Osamu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

CGAMP; CGAS; Innate immune system; STING; Type I interferon

Indexed keywords

ADENOSINE PHOSPHATE; BACTERIAL ENZYME; CYCLIC GMP; CYCLIC GUANOSINE MONOPHOSPHATE ADENOSINE MONOPHOSPHATE; DINUCLEOTIDE; DOUBLE STRANDED DNA; GUANOSINE 2',3' PHOSPHATE; STING PROTEIN; UNCLASSIFIED DRUG; CYCLIC GUANOSINE MONOPHOSPHATE-ADENOSINE MONOPHOSPHATE; CYCLIC NUCLEOTIDE; DNA; INTERFERON REGULATORY FACTOR 3; IRF3 PROTEIN, HUMAN; MB21D1 PROTEIN, HUMAN; NUCLEOTIDYLTRANSFERASE; PROTEIN SERINE THREONINE KINASE; TBK1 PROTEIN, HUMAN;

BACTERIUM; CATALYSIS; CONFORMATIONAL TRANSITION; CYTOSOL; ENZYME ACTIVATION; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; INVERTEBRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; PROTEIN TARGETING; REGULATORY MECHANISM; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; ANIMAL; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MOLECULAR MODEL; PHOSPHORYLATION; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BACTERIA; CRYSTALLOGRAPHY, X-RAY; CYTOSOL; DNA; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-3; MODELS, MOLECULAR; NUCLEOTIDES, CYCLIC; NUCLEOTIDYLTRANSFERASES; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; SECOND MESSENGER SYSTEMS;

EID: 85021625159     PISSN: 00664154     EISSN: 15454509     Source Type: Book Series    
DOI: 10.1146/annurev-biochem-061516-044813     Document Type: Review

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