The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

Cell Host and Microbe

Volumn 17, Issue 6, 2015, Pages 811-819

  Watson, Robert O ^a   Bell, Samantha L ^a   MacDuff, Donna A ^b   Kimmey, Jacqueline M ^b   Diner, Elie J ^c   Olivas, Joanna ^a   Vance, Russell E ^c   Stallings, Christina L ^b   Virgin, Herbert W ^b   Cox, Jeffery S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CYCLIC GMP AMP SYNTHASE; EXTRACHROMOSOMAL DNA; INTERFERON; INTERFERON REGULATORY FACTOR 3; PROTEIN; STING PROTEIN; SYNTHETASE; TBK1 PROTEIN; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; ESAT-6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; MB21D1 PROTEIN, MOUSE; NUCLEOTIDYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; HOST PATHOGEN INTERACTION; IN VIVO STUDY; INTERFERON PRODUCTION; LEGIONNAIRE DISEASE; MACROPHAGE; MALE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SELECTIVE AUTOPHAGY; SIGNAL TRANSDUCTION; TUBERCULOSIS; ANIMAL; AUTOPHAGY; C57BL MOUSE; CYTOSOL; GENETICS; LEGIONELLA PNEUMOPHILA; METABOLISM; MICROBIOLOGY; MUTANT MOUSE STRAIN; PATHOGENICITY; PHYSIOLOGY;

ANIMALS; ANTIGENS, BACTERIAL; AUTOPHAGY; BACTERIAL PROTEINS; CYTOSOL; DNA, BACTERIAL; FEMALE; HOST-PATHOGEN INTERACTIONS; INTERFERON TYPE I; LEGIONELLA PNEUMOPHILA; MALE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MYCOBACTERIUM TUBERCULOSIS; NUCLEOTIDYLTRANSFERASES; TUBERCULOSIS;

EID: 84930268104     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2015.05.004     Document Type: Article

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