5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential

Journal of Biological Chemistry

Volumn 287, Issue 47, 2012, Pages 39776-39788

  Prantner, Daniel ^a   Perkins, Darren J ^a   Lai, Wendy ^a   Williams, Mark S ^a   Sharma, Shruti ^b   Fitzgerald, Katherine A ^b   Vogel, Stefanie N ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 ,6-DIMETHYLXANTHENONE-4-ACETIC ACIDS; ANTIVIRAL AGENTS; CANCER MODELS; CHEMOTHERAPEUTIC AGENTS; CYTOKINES; CYTOSOLIC; DINUCLEOTIDES; DIPHENYLENE IODONIUM; DIRECT INTERACTIONS; DOUBLE STRANDED DNA; ENDOPLASMIC RETICULUM; HOST PROTEINS; MITOCHONDRIAL ELECTRON TRANSPORT CHAIN; MITOCHONDRIAL MEMBRANE POTENTIAL; N-ACETYLCYSTEINE; NADPH OXIDASE; REACTIVE OXYGEN SPECIES; UP-REGULATION;

ACETIC ACID; CELL MEMBRANES; GENE EXPRESSION; MAGNESIUM PRINTING PLATES; MAMMALS; NUCLEIC ACIDS; PH;

MITOCHONDRIA;

BETA INTERFERON; DIPHENYLIODONIUM SALT; DOUBLE STRANDED DNA; MESSENGER RNA; MITOCHONDRIAL PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; STIMULATOR OF INTERFERON GENE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VADIMEZAN;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM; GENE; GENE EXPRESSION; IFNB1 GENE; IN VITRO STUDY; INNATE IMMUNITY; MACROPHAGE; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; IMMUNITY, INNATE; INTERFERON-BETA; INTERLEUKIN-6; MACROPHAGES, PERITONEAL; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NADPH OXIDASE; ONIUM COMPOUNDS; OXIDANTS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; XANTHONES;

EID: 84869208004     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.382986     Document Type: Article

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