Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 24, 2016, Pages E3403-E3412

  Zhao, Baoyu ^a   Shu, Chang ^a   Gao, Xinsheng ^b   Sankaran, Banumathi ^c   Du, Fenglei ^a   Shelton, Catherine L ^d   Herr, Andrew B ^d   Ji, Jun Yuan ^b   Li, Pingwei ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A M COLLEGE OF MEDICINE   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Crystal structure; Innate immunity; Signaling; Transcription factor; Type I interferon

Indexed keywords

ADAPTOR PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; NONSTRUCTURAL PROTEIN 1; VIRUS PROTEIN; CREBBP PROTEIN, HUMAN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; IRF3 PROTEIN, HUMAN; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; NSP1 PROTEIN, ROTAVIRUS; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TICAM1 PROTEIN, HUMAN; VESICULAR TRANSPORT ADAPTOR PROTEIN; VIRAL PROTEIN; VISA PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; DIMERIZATION; GENE ACTIVATION; GENE MUTATION; GENE STRUCTURE; HUMAN; HUMAN CELL; IMMUNOSURVEILLANCE; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; ROTAVIRUS; SEQUENCE ALIGNMENT; STATIC ELECTRICITY; SURFACE PLASMON RESONANCE; WESTERN BLOTTING; CHEMISTRY; GENETICS; IMMUNE EVASION; IMMUNOLOGY; PROTEIN MOTIF; ROTAVIRUS INFECTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; AMINO ACID MOTIFS; CREB-BINDING PROTEIN; HUMANS; IMMUNE EVASION; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-3; MEMBRANE PROTEINS; PROTEIN DOMAINS; ROTAVIRUS; ROTAVIRUS INFECTIONS; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84974660175     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1603269113     Document Type: Article

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