Structural basis for the catalytic mechanism of DncV, bacterial homolog of cyclic GMP-AMP synthase

Structure

Volumn 23, Issue 5, 2015, Pages 843-850

  Kato, Kazuki ^a   Ishii, Ryohei ^a   Hirano, Seiichi ^a   Ishitani, Ryuichiro ^a   Nureki, Osamu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEIN; CYCLIC AMP; CYCLIC GMP; GUANOSINE TRIPHOSPHATE;

CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; ESCHERICHIA COLI; METABOLISM; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; VIBRIO CHOLERAE; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; CYCLIC GMP; ESCHERICHIA COLI; GUANOSINE TRIPHOSPHATE; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; VIBRIO CHOLERAE;

EID: 84929659603     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2015.01.023     Document Type: Article

References (24)

1. A. Ablasser, M. Goldeck, T. Cavlar, T. Deimling, G. Witte, I. Röhl, K.P. Hopfner, J. Ludwig, and V. Hornung cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING Nature 498 2013 380 384
2. P.D. Adams, P.V. Afonine, G. Bunkóczi, V.B. Chen, I.W. Davis, N. Echols, J.J. Headd, L.W. Hung, G.J. Kapral, and R.W. Grosse-Kunstleve PHENIX: a comprehensive Python-based system for macromolecular structure solution Acta Crystallogr. D Biol. Crystallogr. 66 2010 213 221
3. F. Civril, T. Deimling, C.C. de Oliveira Mann, A. Ablasser, M. Moldt, G. Witte, V. Hornung, and K.P. Hopfner Structural mechanism of cytosolic DNA sensing by cGAS Nature 498 2013 332 337
4. R.M. Corrigan, and A. Gründling Cyclic di-AMP: another second messenger enters the fray Nat. Rev. Microbiol. 11 2013 513 524
5. O. Danilchanka, and J.J. Mekalanos Cyclic dinucleotides and the innate immune response Cell 154 2013 962 970
6. B.W. Davies, R.W. Bogard, T.S. Young, and J.J. Mekalanos Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence Cell 149 2012 358 370
7. E.J. Diner, D.L. Burdette, S.C. Wilson, K.M. Monroe, C.A. Kellenberger, M. Hyodo, Y. Hayakawa, M.C. Hammond, and R.E. Vance The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING Cell Rep. 3 2013 1355 1361
8. P. Emsley, and K. Cowtan Coot: model-building tools for molecular graphics Acta Crystallogr. D Biol. Crystallogr. 60 2004 2126 2132
9. P. Gao, M. Ascano, Y. Wu, W. Barchet, B.L. Gaffney, T. Zillinger, A.A. Serganov, Y. Liu, R.A. Jones, and G. Hartmann Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase Cell 153 2013 1094 1107
10. V. Hornung, R. Hartmann, A. Ablasser, and K.P. Hopfner OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids Nat. Rev. Immunol. 14 2014 521 528
11. W. Kabsch XDS Acta Crystallogr. D Biol. Crystallogr. 66 2010 125 132
12. K. Kato, R. Ishii, E. Goto, R. Ishitani, F. Tokunaga, and O. Nureki Structural and functional analyses of DNA-sensing and immune activation by human cGAS PLoS One 8 2013 e76983
13. P.J. Kranzusch, A.S. Lee, J.M. Berger, and J.A. Doudna Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity Cell Rep. 3 2013 1362 1368
14. P.J. Kranzusch, A.S.Y. Lee, S.C. Wilson, M.S. Solovykh, R.E. Vance, J.M. Berger, and J.A. Doudna Structure-guided reprogramming of human cGAS dinucleotide linkage specificity Cell 158 2014 1011 1021
15. S. Li, C. Yi, D. Shelton, K. Zuo, and L. Herr Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization Immunity 39 2013 1019 1031
16. U. Römling, M.Y. Galperin, and M. Gomelsky Cyclic di-GMP: the first 25 years of a universal bacterial second messenger Microbiol. Mol. Biol. Rev. 77 2013 1 52
17. G.M. Sheldrick A short history of SHELX Acta Crystallogr. A 64 2008 112 122
18. L. Sun, J. Wu, F. Du, X. Chen, and Z.J. Chen Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway Science 339 2013 786 791
19. T.C. Terwilliger, R.W. Grosse-Kunstleve, P.V. Afonine, N.W. Moriarty, P.H. Zwart, L.W. Hung, R.J. Read, and P.D. Adams Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard Acta Crystallogr. D Biol. Crystallogr. 64 2008 61 69
20. A. Vagin, and A. Teplyakov Molecular replacement with MOLREP Acta Crystallogr. D Biol. Crystallogr. 66 2010 22 25
21. C. Vonrhein, E. Blanc, P. Roversi, and G. Bricogne Automated structure solution with autoSHARP Methods Mol. Biol. 364 2007 215 230
22. J. Wu, L. Sun, X. Chen, F. Du, H. Shi, C. Chen, and Z.J. Chen Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA Science 339 2013 826 830
23. W. Zhang, X. Du, C. Sun, Z. Brautigam, and Z.J. Chen The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop Cell Rep. 6 2014 421 430
24. D. Zhu, L. Wang, G. Shang, X. Liu, J. Zhu, D. Lu, L. Wang, B. Kan, J.R. Zhang, and Y. Xiang Structural biochemistry of a Vibrio cholerae dinucleotide cyclase reveals cyclase activity regulation by folates Mol. Cell 55 2014 931 937