Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 29, 2015, Pages 8947-8952

  Shi, Heping ^a   Wu, Jiaxi ^b   Chen, Zhijian J ^b   Chen, Chuo ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

cGAMP; Ligand conformation; Phosphodiester linkage; STING

Indexed keywords

2'3' CGAMP; ADAPTOR PROTEIN; ADAPTOR PROTEIN STING; ADENOSINE PHOSPHATE; CYCLIC GMP; UNCLASSIFIED DRUG; CYCLIC GUANOSINE MONOPHOSPHATE-ADENOSINE MONOPHOSPHATE; CYCLIC NUCLEOTIDE; LIGAND; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN;

ARTICLE; ENERGY COST; ENTHALPY; ENTROPY; HUMAN; INNATE IMMUNITY; ISOMER; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; HYDROGEN BOND; METABOLISM; PROTEIN STABILITY; X RAY CRYSTALLOGRAPHY;

METAZOA;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; IMMUNITY, INNATE; LIGANDS; MEMBRANE PROTEINS; MODELS, MOLECULAR; NUCLEOTIDES, CYCLIC; PROTEIN CONFORMATION; PROTEIN STABILITY;

EID: 84937897202     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1507317112     Document Type: Article

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