Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling

Molecular Cell

Volumn 59, Issue 6, 2015, Pages 891-903

  Kranzusch, Philip J ^a   Wilson, Stephen C ^b   Lee, Amy S Y ^a   Berger, James M ^c   Doudna, Jennifer A ^a,b,d   Vance, Russell E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC GMP; CYCLIC GMP AMP; UNCLASSIFIED DRUG; 2',3'-CYCLIC GMP; APOPROTEIN; GUANINE NUCLEOTIDE; MB21D1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; NUCLEOTIDYLTRANSFERASE;

ARTICLE; CGAS STING SIGNALING PATHWAY; CONFORMATION; CONTROLLED STUDY; NEMATOSTELLA VECTENSIS; NONHUMAN; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANEMONE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONSERVED SEQUENCE; GENETICS; HUMAN; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SECOND MESSENGER; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANEMONE; APOPROTEINS; BINDING SITES; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; GUANINE NUCLEOTIDES; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEOTIDYLTRANSFERASES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SECOND MESSENGER SYSTEMS;

EID: 84941804631     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.07.022     Document Type: Article

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