-
1
-
-
57149109329
-
Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo
-
Fejer G, Drechsel L, Liese J, Schleicher U, Ruzsics Z, Imelli N, Greber UF, Keck S, Hildenbrand B, Krug A, Bogdan C, Freudenberg MA. 2008. Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo. PLoS Pathog. 4:e1000208. http://dx.doi.org/10.1371/journal.ppat.1000208.
-
(2008)
PLoS Pathog.
, vol.4
-
-
Fejer, G.1
Drechsel, L.2
Liese, J.3
Schleicher, U.4
Ruzsics, Z.5
Imelli, N.6
Greber, U.F.7
Keck, S.8
Hildenbrand, B.9
Krug, A.10
Bogdan, C.11
Freudenberg, M.A.12
-
2
-
-
66149151694
-
Adenovirus induction of IRF3 occurs through a binary trigger targeting JNK and TBK-1 kinase cascades and type I IFN autocrine signaling
-
11 February
-
Nociari M, Ocheretina O, Murphy M, Falck-Pedersen E. 11 February 2009. Adenovirus induction of IRF3 occurs through a binary trigger targeting JNK and TBK-1 kinase cascades and type I IFN autocrine signaling. J. Virol. http://dx.doi.org/10.1128/JVI.02591-08.
-
(2009)
J. Virol
-
-
Nociari, M.1
Ocheretina, O.2
Murphy, M.3
Falck-Pedersen, E.4
-
3
-
-
34247116994
-
Sensing infection by adenovirus: Toll-like receptor-independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator
-
Nociari M, Ocheretina O, Schoggins JW, Falck-Pedersen E. 2007. Sensing infection by adenovirus: Toll-like receptor-independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator. J. Virol. 81:4145-4157. http://dx.doi.org/10.1128/JVI.02685-06.
-
(2007)
J. Virol.
, vol.81
, pp. 4145-4157
-
-
Nociari, M.1
Ocheretina, O.2
Schoggins, J.W.3
Falck-Pedersen, E.4
-
4
-
-
33947396347
-
Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways
-
Zhu J, Huang X, Yang Y. 2007. Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways. J. Virol. 81:3170-3180. http://dx.doi.org/10.1128/JVI.02192-06.
-
(2007)
J. Virol.
, vol.81
, pp. 3170-3180
-
-
Zhu, J.1
Huang, X.2
Yang, Y.3
-
5
-
-
84861373256
-
Sensing adenovirus infection: activation of interferon regulatory factor 3 in RAW 264.7 cells
-
Stein SC, Falck-Pedersen E. 2012. Sensing adenovirus infection: activation of interferon regulatory factor 3 in RAW 264.7 cells. J. Virol. 86:4527-4537. http://dx.doi.org/10.1128/JVI.07071-11.
-
(2012)
J. Virol.
, vol.86
, pp. 4527-4537
-
-
Stein, S.C.1
Falck-Pedersen, E.2
-
6
-
-
84870724934
-
Cell-specific regulation of nucleic acid sensor cascades: a controlling interest in the antiviral response
-
Stein SC, Lam E, Falck-Pedersen E. 2012. Cell-specific regulation of nucleic acid sensor cascades: a controlling interest in the antiviral response. J. Virol. 86:13303-13312. http://dx.doi.org/10.1128/JVI.02296-12.
-
(2012)
J. Virol.
, vol.86
, pp. 13303-13312
-
-
Stein, S.C.1
Lam, E.2
Falck-Pedersen, E.3
-
7
-
-
53349178089
-
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
-
Ishikawa H, Barber GN. 2008. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455:674-678. http://dx.doi.org/10.1038/nature07317.
-
(2008)
Nature
, vol.455
, pp. 674-678
-
-
Ishikawa, H.1
Barber, G.N.2
-
8
-
-
70349943834
-
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
-
Ishikawa H, Ma Z, Barber GN. 2009. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461:788-792. http://dx.doi.org/10.1038/nature08476.
-
(2009)
Nature
, vol.461
, pp. 788-792
-
-
Ishikawa, H.1
Ma, Z.2
Barber, G.N.3
-
9
-
-
0345827590
-
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts
-
McWhirter SM, Fitzgerald KA, Rosains J, Rowe DC, Golenbock DT, Maniatis T. 2004. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 101:233-238. http://dx.doi.org/10.1073/pnas.2237236100.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 233-238
-
-
McWhirter, S.M.1
Fitzgerald, K.A.2
Rosains, J.3
Rowe, D.C.4
Golenbock, D.T.5
Maniatis, T.6
-
10
-
-
0038660668
-
Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA
-
Servant MJ, Grandvaux N, ten Oever BR, Duguay D, Lin R, Hiscott J. 2003. Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA. J. Biol. Chem. 278:9441-9447. http://dx.doi.org/10.1074/jbc.M209851200.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 9441-9447
-
-
Servant, M.J.1
Grandvaux, N.2
ten Oever, B.R.3
Duguay, D.4
Lin, R.5
Hiscott, J.6
-
11
-
-
41949092999
-
Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association
-
Clément JF, Bibeau-Poirier A, Gravel SP, Grandvaux N, Bonneil E, Thibault P, Meloche S, Servant MJ. 2008. Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. J. Virol. 82:3984-3996. http://dx.doi.org/10.1128/JVI.02526-07.
-
(2008)
J. Virol.
, vol.82
, pp. 3984-3996
-
-
Clément, J.F.1
Bibeau-Poirier, A.2
Gravel, S.P.3
Grandvaux, N.4
Bonneil, E.5
Thibault, P.6
Meloche, S.7
Servant, M.J.8
-
12
-
-
34250017968
-
An atomic model of the interferon-beta enhanceosome
-
Panne D, Maniatis T, Harrison SC. 2007. An atomic model of the interferon-beta enhanceosome. Cell 129:1111-1123. http://dx.doi.org/10.1016/j.cell.2007.05.019.
-
(2007)
Cell
, vol.129
, pp. 1111-1123
-
-
Panne, D.1
Maniatis, T.2
Harrison, S.C.3
-
14
-
-
80054966913
-
STING is a direct innate immune sensor of cyclic di-GMP
-
Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, Hyodo M, Hayakawa Y, Vance RE. 2011. STING is a direct innate immune sensor of cyclic di-GMP. Nature 478:515-518. http://dx.doi.org/10.1038/nature10429.
-
(2011)
Nature
, vol.478
, pp. 515-518
-
-
Burdette, D.L.1
Monroe, K.M.2
Sotelo-Troha, K.3
Iwig, J.S.4
Eckert, B.5
Hyodo, M.6
Hayakawa, Y.7
Vance, R.E.8
-
15
-
-
79251506939
-
The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides
-
Sauer JD, Sotelo-Troha K, von Moltke J, Monroe KM, Rae CS, Brubaker SW, Hyodo M, Hayakawa Y, Woodward JJ, Portnoy DA, Vance RE. 2011. The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect. Immun. 79:688-694. http://dx.doi.org/10.1128/IAI.00999-10.
-
(2011)
Infect. Immun.
, vol.79
, pp. 688-694
-
-
Sauer, J.D.1
Sotelo-Troha, K.2
von Moltke, J.3
Monroe, K.M.4
Rae, C.S.5
Brubaker, S.W.6
Hyodo, M.7
Hayakawa, Y.8
Woodward, J.J.9
Portnoy, D.A.10
Vance, R.E.11
-
16
-
-
84863722786
-
The structural basis for the sensing and binding of cyclic di-GMP by STING
-
Huang YH, Liu XY, Du XX, Jiang ZF, Su XD. 2012. The structural basis for the sensing and binding of cyclic di-GMP by STING. Nat. Struct. Mol. Biol. 19:728-730. http://dx.doi.org/10.1038/nsmb.2333.
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 728-730
-
-
Huang, Y.H.1
Liu, X.Y.2
Du, X.X.3
Jiang, Z.F.4
Su, X.D.5
-
17
-
-
84869208004
-
5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential
-
Prantner D, Perkins DJ, Lai W, Williams MS, Sharma S, Fitzgerald KA, Vogel SN. 2012. 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential. J. Biol. Chem. 287:39776-39788. http://dx.doi.org/10.1074/jbc.M112.382986.
-
(2012)
J. Biol. Chem. 287:39776-39788
-
-
Prantner, D.1
Perkins, D.J.2
Lai, W.3
Williams, M.S.4
Sharma, S.5
Fitzgerald, K.A.6
Vogel, S.N.7
-
18
-
-
84863726252
-
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
-
Shu C, Yi G, Watts T, Kao CC, Li P. 2012. Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. Nat. Struct. Mol. Biol. 19:722-724. http://dx.doi.org/10.1038/nsmb.2331.
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 722-724
-
-
Shu, C.1
Yi, G.2
Watts, T.3
Kao, C.C.4
Li, P.5
-
19
-
-
84873711885
-
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
-
Sun L, Wu J, Du F, Chen X, Chen ZJ. 2013. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339:786-791. http://dx.doi.org/10.1126/science.1232458.
-
(2013)
Science
, vol.339
, pp. 786-791
-
-
Sun, L.1
Wu, J.2
Du, F.3
Chen, X.4
Chen, Z.J.5
-
20
-
-
84873724533
-
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
-
Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ. 2013. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339:826-830. http://dx.doi.org/10.1126/science.1229963.
-
(2013)
Science
, vol.339
, pp. 826-830
-
-
Wu, J.1
Sun, L.2
Chen, X.3
Du, F.4
Shi, H.5
Chen, C.6
Chen, Z.J.7
-
21
-
-
84879408976
-
Structural mechanism of cytosolic DNA sensing by cGAS
-
Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner KP. 2013. Structural mechanism of cytosolic DNA sensing by cGAS. Nature 498:332-337. http://dx.doi.org/10.1038/nature12305.
-
(2013)
Nature
, vol.498
, pp. 332-337
-
-
Civril, F.1
Deimling, T.2
de Oliveira Mann, C.C.3
Ablasser, A.4
Moldt, M.5
Witte, G.6
Hornung, V.7
Hopfner, K.P.8
-
22
-
-
84882815198
-
Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA
-
Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov AA, Gaffney BL, Shuman S, Jones RA, Deng L, Hartmann G, Barchet W, Tuschl T, Patel DJ. 2013. Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell 154:748-762. http://dx.doi.org/10.1016/j.cell.2013.07.023.
-
(2013)
Cell
, vol.154
, pp. 748-762
-
-
Gao, P.1
Ascano, M.2
Zillinger, T.3
Wang, W.4
Dai, P.5
Serganov, A.A.6
Gaffney, B.L.7
Shuman, S.8
Jones, R.A.9
Deng, L.10
Hartmann, G.11
Barchet, W.12
Tuschl, T.13
Patel, D.J.14
-
23
-
-
84878592773
-
Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity
-
Kranzusch PJ, Lee AS, Berger JM, Doudna JA. 2013. Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Rep. 3:1362-1368. http://dx.doi.org/10.1016/j.celrep.2013.05.008.
-
(2013)
Cell Rep.
, vol.3
, pp. 1362-1368
-
-
Kranzusch, P.J.1
Lee, A.S.2
Berger, J.M.3
Doudna, J.A.4
-
24
-
-
84879385334
-
cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING
-
Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Rohl I, Hopfner KP, Ludwig J, Hornung V. 2013. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature 498:380-384. http://dx.doi.org/10.1038/nature12306.
-
(2013)
Nature
, vol.498
, pp. 380-384
-
-
Ablasser, A.1
Goldeck, M.2
Cavlar, T.3
Deimling, T.4
Witte, G.5
Rohl, I.6
Hopfner, K.P.7
Ludwig, J.8
Hornung, V.9
-
25
-
-
84878309796
-
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
-
Gao P, Ascano M, Wu Y, Barchet W, Gaffney BL, Zillinger T, Serganov AA, Liu Y, Jones RA, Hartmann G, Tuschl T, Patel DJ. 2013. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153:1094-1107. http://dx.doi.org/10.1016/j.cell.2013.04.046.
-
(2013)
Cell
, vol.153
, pp. 1094-1107
-
-
Gao, P.1
Ascano, M.2
Wu, Y.3
Barchet, W.4
Gaffney, B.L.5
Zillinger, T.6
Serganov, A.A.7
Liu, Y.8
Jones, R.A.9
Hartmann, G.10
Tuschl, T.11
Patel, D.J.12
-
26
-
-
84880508067
-
Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING
-
Zhang X, Shi H, Wu J, Zhang X, Sun L, Chen C, Chen ZJ. 2013. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell 51:226-235. http://dx.doi.org/10.1016/j.molcel.2013.05.022.
-
(2013)
Mol. Cell
, vol.51
, pp. 226-235
-
-
Zhang, X.1
Shi, H.2
Wu, J.3
Zhang, X.4
Sun, L.5
Chen, C.6
Chen, Z.J.7
-
27
-
-
84878572947
-
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING
-
Diner EJ, Burdette DL, Wilson SC, Monroe KM, Kellenberger CA, Hyodo M, Hayakawa Y, Hammond MC, Vance RE. 2013. The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep. 3:1355-1361. http://dx.doi.org/10.1016/j.celrep.2013.05.009.
-
(2013)
Cell Rep.
, vol.3
, pp. 1355-1361
-
-
Diner, E.J.1
Burdette, D.L.2
Wilson, S.C.3
Monroe, K.M.4
Kellenberger, C.A.5
Hyodo, M.6
Hayakawa, Y.7
Hammond, M.C.8
Vance, R.E.9
-
28
-
-
33750307313
-
Fiber and penton base capsid modifications yield diminished Ad5 transduction and proinflammatory gene expression with retention of antigen specific humoral immunity
-
Schoggins JW, Falck-Pedersen E. 2006. Fiber and penton base capsid modifications yield diminished Ad5 transduction and proinflammatory gene expression with retention of antigen specific humoral immunity. J. Virol. 80:10634-10644. http://dx.doi.org/10.1128/JVI.01359-06.
-
(2006)
J. Virol.
, vol.80
, pp. 10634-10644
-
-
Schoggins, J.W.1
Falck-Pedersen, E.2
-
29
-
-
3242890471
-
siRNA Selection Server: an automated siRNA oligonucleotide prediction server
-
Yuan B, Latek R, Hossbach M, Tuschl T, Lewitter F. 2004. siRNA Selection Server: an automated siRNA oligonucleotide prediction server. Nucleic Acids Res. 32:W130-W134. http://dx.doi.org/10.1093/nar/gkh366.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Yuan, B.1
Latek, R.2
Hossbach, M.3
Tuschl, T.4
Lewitter, F.5
-
30
-
-
44949231424
-
Analyzing real-time PCR data by the comparative C(T) method
-
Schmittgen TD, Livak KJ. 2008. Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc. 3:1101-1108. http://dx.doi.org/10.1038/nprot.2008.73.
-
(2008)
Nat. Protoc.
, vol.3
, pp. 1101-1108
-
-
Schmittgen, T.D.1
Livak, K.J.2
-
31
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method
-
Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25:402-408. http://dx.doi.org/10.1006/meth.2001.1262.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
32
-
-
77953583256
-
Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity
-
Choubey D, Duan X, Dickerson E, Ponomareva L, Panchanathan R, Shen H, Srivastava R. June 2010. Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity. J. Interferon Cytokine Res. http://dx.doi.org/10.1089/jir.2009.0096.
-
(2010)
J. Interferon Cytokine Res
-
-
Choubey, D.1
Duan, X.2
Dickerson, E.3
Ponomareva, L.4
Panchanathan, R.5
Shen, H.6
Srivastava June, R.7
-
33
-
-
77951269392
-
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
-
Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L, Vanaja SK, Monks BG, Ganesan S, Latz E, Hornung V, Vogel SN, Szomolanyi-Tsuda E, Fitzgerald KA. 2010. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat. Immunol. 11:395-402. http://dx.doi.org/10.1038/ni.1864.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 395-402
-
-
Rathinam, V.A.1
Jiang, Z.2
Waggoner, S.N.3
Sharma, S.4
Cole, L.E.5
Waggoner, L.6
Vanaja, S.K.7
Monks, B.G.8
Ganesan, S.9
Latz, E.10
Hornung, V.11
Vogel, S.N.12
Szomolanyi-Tsuda, E.13
Fitzgerald, K.A.14
-
34
-
-
80052152283
-
The PYHIN protein family as mediators of host defenses
-
Schattgen SA, Fitzgerald KA. 2011. The PYHIN protein family as mediators of host defenses. Immunol. Rev. 243:109-118. http://dx.doi.org/10.1111/j.1600-065X.2011.01053.x.
-
(2011)
Immunol. Rev.
, vol.243
, pp. 109-118
-
-
Schattgen, S.A.1
Fitzgerald, K.A.2
-
35
-
-
70249138036
-
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
-
Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E. 2009. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183:787-791. http://dx.doi.org/10.4049/jimmunol.0901363.
-
(2009)
J. Immunol.
, vol.183
, pp. 787-791
-
-
Bauernfeind, F.G.1
Horvath, G.2
Stutz, A.3
Alnemri, E.S.4
MacDonald, K.5
Speert, D.6
Fernandes-Alnemri, T.7
Wu, J.8
Monks, B.G.9
Fitzgerald, K.A.10
Hornung, V.11
Latz, E.12
-
36
-
-
77951800951
-
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
-
Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nunez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E. 2010. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464:1357-1361. http://dx.doi.org/10.1038/nature08938.
-
(2010)
Nature
, vol.464
, pp. 1357-1361
-
-
Duewell, P.1
Kono, H.2
Rayner, K.J.3
Sirois, C.M.4
Vladimer, G.5
Bauernfeind, F.G.6
Abela, G.S.7
Franchi, L.8
Nunez, G.9
Schnurr, M.10
Espevik, T.11
Lien, E.12
Fitzgerald, K.A.13
Rock, K.L.14
Moore, K.J.15
Wright, S.D.16
Hornung, V.17
Latz, E.18
-
37
-
-
44449165058
-
Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization
-
Watanabe H, Gehrke S, Contassot E, Roques S, Tschopp J, Friedmann PS, French LE, Gaide O. 2008. Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization. J. Immunol. 180:5826-5832.
-
(2008)
J. Immunol.
, vol.180
, pp. 5826-5832
-
-
Watanabe, H.1
Gehrke, S.2
Contassot, E.3
Roques, S.4
Tschopp, J.5
Friedmann, P.S.6
French, L.E.7
Gaide, O.8
-
38
-
-
40449097257
-
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
-
Muruve DA, Petrilli V, Zaiss AK, White LR, Clark SA, Ross PJ, Parks RJ, Tschopp J. 2008. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 452:103-107. http://dx.doi.org/10.1038/nature06664.
-
(2008)
Nature
, vol.452
, pp. 103-107
-
-
Muruve, D.A.1
Petrilli, V.2
Zaiss, A.K.3
White, L.R.4
Clark, S.A.5
Ross, P.J.6
Parks, R.J.7
Tschopp, J.8
-
39
-
-
34547143110
-
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
-
Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, Lu Y, Miyagishi M, Kodama T, Honda K, Ohba Y, Taniguchi T. 2007. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448:501-505. http://dx.doi.org/10.1038/nature06013.
-
(2007)
Nature
, vol.448
, pp. 501-505
-
-
Takaoka, A.1
Wang, Z.2
Choi, M.K.3
Yanai, H.4
Negishi, H.5
Ban, T.6
Lu, Y.7
Miyagishi, M.8
Kodama, T.9
Honda, K.10
Ohba, Y.11
Taniguchi, T.12
-
40
-
-
58749100879
-
Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors
-
Kaiser WJ, Upton JW, Mocarski ES. 2008. Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors. J. Immunol. 181:6427-6434.
-
(2008)
J. Immunol.
, vol.181
, pp. 6427-6434
-
-
Kaiser, W.J.1
Upton, J.W.2
Mocarski, E.S.3
-
41
-
-
68249113997
-
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB
-
Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J. 2009. DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep. 10:916-922. http://dx.doi.org/10.1038/embor.2009.109.
-
(2009)
EMBO Rep.
, vol.10
, pp. 916-922
-
-
Rebsamen, M.1
Heinz, L.X.2
Meylan, E.3
Michallet, M.C.4
Schroder, K.5
Hofmann, K.6
Vazquez, J.7
Benedict, C.A.8
Tschopp, J.9
-
42
-
-
84858420051
-
DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA
-
Upton JW, Kaiser WJ, Mocarski ES. 2012. DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe 11:290-297. http://dx.doi.org/10.1016/j.chom.2012.01.016.
-
(2012)
Cell Host Microbe
, vol.11
, pp. 290-297
-
-
Upton, J.W.1
Kaiser, W.J.2
Mocarski, E.S.3
-
43
-
-
84856431819
-
RNA therapeutics: beyond RNA interference and antisense oligonucleotides
-
Kole R, Krainer AR, Altman S. 2012. RNA therapeutics: beyond RNA interference and antisense oligonucleotides. Nat. Rev. Drug Discov. 11:125-140. http://dx.doi.org/10.1038/nrd3625.
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 125-140
-
-
Kole, R.1
Krainer, A.R.2
Altman, S.3
-
44
-
-
84875792696
-
RNA-based mechanisms regulating host-virus interactions
-
Zhou R, Rana TM. 2013. RNA-based mechanisms regulating host-virus interactions. Immunol. Rev. 253:97-111. http://dx.doi.org/10.1111/imr.12053.
-
(2013)
Immunol. Rev.
, vol.253
, pp. 97-111
-
-
Zhou, R.1
Rana, T.M.2
-
45
-
-
77957785465
-
Emerging role of ISG15 in antiviral immunity
-
Skaug B, Chen ZJ. 2010. Emerging role of ISG15 in antiviral immunity. Cell 143:187-190. http://dx.doi.org/10.1016/j.cell.2010.09.033.
-
(2010)
Cell
, vol.143
, pp. 187-190
-
-
Skaug, B.1
Chen, Z.J.2
-
46
-
-
84884134473
-
Extensive cooperation of immune master regulators IRF3 and NFkappaB in RNA Pol II recruitment and pause release in human innate antiviral transcription
-
Freaney JE, Kim R, Mandhana R, Horvath CM. 2013. Extensive cooperation of immune master regulators IRF3 and NFkappaB in RNA Pol II recruitment and pause release in human innate antiviral transcription. Cell Rep. 4:959-973. http://dx.doi.org/10.1016/j.celrep.2013.07.043.
-
(2013)
Cell Rep.
, vol.4
, pp. 959-973
-
-
Freaney, J.E.1
Kim, R.2
Mandhana, R.3
Horvath, C.M.4
-
47
-
-
0036734498
-
Sensitization of IFN-gamma Jak-STAT signaling during macrophage activation
-
Hu X, Herrero C, Li WP, Antoniv TT, Falck-Pedersen E, Koch AE, Woods JM, Haines GK, Ivashkiv LB. 2002. Sensitization of IFN-gamma Jak-STAT signaling during macrophage activation. Nat. Immunol. 3:859-866. http://dx.doi.org/10.1038/ni828.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 859-866
-
-
Hu, X.1
Herrero, C.2
Li, W.P.3
Antoniv, T.T.4
Falck-Pedersen, E.5
Koch, A.E.6
Woods, J.M.7
Haines, G.K.8
Ivashkiv, L.B.9
-
48
-
-
70349736116
-
Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases
-
Hu X, Ivashkiv LB. 2009. Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity 31:539-550. http://dx.doi.org/10.1016/j.immuni.2009.09.002.
-
(2009)
Immunity
, vol.31
, pp. 539-550
-
-
Hu, X.1
Ivashkiv, L.B.2
-
49
-
-
33846532947
-
Preferential activation of Toll-like receptor nine by CD46-utilizing adenoviruses
-
Iacobelli-Martinez M, Nemerow GR. 2007. Preferential activation of Toll-like receptor nine by CD46-utilizing adenoviruses. J. Virol. 81:1305-1312. http://dx.doi.org/10.1128/JVI.01926-06.
-
(2007)
J. Virol.
, vol.81
, pp. 1305-1312
-
-
Iacobelli-Martinez, M.1
Nemerow, G.R.2
|